Realgar-indigo naturalis formula for the treatment of patients with relapsed and arsenic trioxide-resistant acute promyelocytic leukemia: A case series.

Introduction: There is currently no standard treatment for relapsed and arsenic trioxide (ATO)-resistant acute promyelocytic leukemia (APL). Here, we report a case series of realgar-indigo naturalis formula (RIF) for the successful treatment of patients with relapsed and ATO-resistant APL.

Case Presentation: Two patients in the first relapse and one in the second relapse failed to achieve hematologic complete remission (HCR) when reinduced by ATO; the other five patients progressed to relapse during ATO-based regimens for post-remission therapy.

Optimal Number of Clusters by Measuring Similarity Among Topographies for Spatio-Temporal ERP Analysis.

Averaging amplitudes over consecutive time samples (i.e., time window) is widely used to calculate the peak amplitude of event-related potentials (ERPs).

Determination of the Time Window of Event-Related Potential Using Multiple-Set Consensus Clustering.

Clustering is a promising tool for grouping the sequence of similar time-points aimed to identify the attention blocks in spatiotemporal event-related potentials (ERPs) analysis. It is most likely to elicit the appropriate time window for ERP of interest if a suitable clustering method is applied to spatiotemporal ERP. However, how to reliably estimate a proper time window from entire individual subjects' data is still challenging.

Relationship between left ventricular isovolumic relaxation flow patterns and mitral inflow patterns studied by using vector flow mapping.

The purpose of this study was to investigate the relationship between isovolumic relaxation flow (IRF) patterns in left ventricle (LV) and mitral inflow patterns. Color Doppler loops were acquired for vector flow mapping in apical long-axis view in 57 patients with coronary artery disease, 31 patients with dilated cardiomyopathy, and 58 healthy controls. IRF patterns were classified into three categories: pattern A, apically directed flow; pattern B, bidirectional flow with small scattered vortices; and pattern C, a large vortex.

Factors influencing the end-diastolic vortex assessed by using vector flow mapping.

Objectives: The purpose of this study was to assess the factors influencing the late diastolic vortex in normal and abnormal ventricles.

Methods: Color Doppler data in left ventricle (LV) were acquired from apical long-axis view and analyzed using vector flow mapping in 57 patients with coronary artery disease, 57 patients with dilated cardiomyopathy, and 53 healthy volunteers.

Results: In normals, corrected area and flux of the end-diastolic vortex were positively correlated with transmitral A velocity and heart rate.

Relationship between left ventricular vortex and preejectional flow velocity during isovolumic contraction studied by using vector flow mapping.

Objectives: The purpose of this study was to investigate the relationship between the vortex in left ventricle (LV) during the isovolumic contraction (IVC) period and the preejectional flow velocity in LV outflow tract (V ).

Methods: Color Doppler loops were acquired for vector flow mapping in apical long-axis view in 76 patients with dilated cardiomyopathy, 61 patients with coronary artery disease and 36 healthy controls.

Results: All normals exhibited an IVC vortex reaching the LV base.