Cytotoxic and antibacterial activity of naturally occurring agglutinin produced from the root of Poir.

Lectins are naturally occurring agglutinins which are produced more from plants sources compared to animal sources. The present study aims to screen the potential applications of lectin isolated from the mangrove plant, Poir. This root agglutinin of showed highest HA titre with buffalo erythrocytes.

Potential Antimicrobial and Cytotoxic Activity of Seed Extract.

Plant-derived phytochemicals are crucial in fighting bacterial infections and in cancer therapy. This study investigates the phytochemical composition of the ethanolic extract obtained from () seeds and assesses its antimicrobial, anticancer, and antioxidant activities. GC-MS analysis found 30 phytochemicals in seeds, including 5 bioactive compounds that have been shown to have antioxidant, antimicrobial, and cytotoxicity properties, through in silico evaluation.

Label-free electrochemical assessment of human serum and cancer cells to determine the folate receptor cancer biomarker.

The folate receptor (FR) is a well-known biomarker that is overexpressed in many cancer cells, making it a valuable target for cancer diagnostics and therapeutic strategies. However, identifying cancer biomarkers remains a challenge due to factors such as lengthy procedures, high costs, and low sensitivity. This study presents the development of a novel, cost-effective biosensor designed for the detection of FR.

Exploring the antidiabetic activity of potential probiotic bacteria isolated from traditional fermented beverage.

Type 2 Diabetes continues to be one of the major public health issues worldwide without any sustainable cure. The modulation of gut microbiota is believed to be caused by probiotic bacteria and several probiotic strains have previously shown antidiabetic activity. The present study aims to isolate potential probiotic bacteria from traditionally used fermented rice beer of Assam, India and to investigate its anti-hyperglycemic effect.

MnCoO Nanostructure Anchored on Functionalized Carbon Black for the Enhanced Bifunctional Electrocatalytic Performance of OER and HER.

The electrocatalytic oxygen and hydrogen evolution reactions (OER and HER) are key processes used in energy storage and conversion. We have developed a highly efficient MnCoO nanostructure anchored with functionalized carbon black (MnCoO/f-CB), which has been characterized by XRD, FT-IR, Raman spectra, FE-SEM, and HR-TEM analyses as robust bifunctional electrocatalysts for both HER and OER. At a characteristic 10 mA cm current density, the MnCoO/f-CB composite ECs exhibit low overpotentials of 330 mV for OER and 360 mV for HER, respectively.

Enhanced Bioactivity of Streptomycin Bioconjugated Metal Nanoparticles Against Streptomycin Resistant Sp.

Unlabelled: The emergence of multidrug resistance in pathogenic organisms has caused growing concern, especially among healthcare providers, necessitating the development of new antimicrobial compounds. Resistance to metal nanoparticles is more challenging for any pathogen and thus paved a new avenue of research to formulate a new line of drugs combined with metal nanoparticles to treat microbial resistance. In this present investigation, green synthesised silver (AgNP), gold (AuNP), and platinum (PtNP) nanoparticles using the rind extract of the fruit of Garcinia mangostana L.

Development and characterization of polyvinyl alcohol/gelatin/chitosan hydrogel for tissue engineering and wound healing applications using a fish cell line model.

Chitosan-based hydrogels have gained considerable attention in biomedical research due to their inherent biocompatibility, biodegradability, and non-toxicity. When combined with polyvinyl alcohol (PVA), the resulting hydrogels exhibit superior mechanical strength, elasticity, and swelling capacity, making them highly suitable for a range of applications, including wound healing, tissue engineering, and controlled drug delivery. In this study, we synthesized and characterized a novel PVA/gelatin/chitosan (PVA/G/C) hydrogel composite using a series of analytical techniques such as Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy-dispersive X-ray analysis (EDAX).

Additions to the taxonomy of the genus Ophionea Klug, 1821 (Coleoptera: Carabidae: Lebiinae) and a new species from India.

A new ground beetle species Ophionea vvrei sp. nov. is described from South India, with revised key to the species of the genus Ophionea, revised descriptions of O.

Morphology, biology and phylogeny of Xenos gadagkari sp.nov. (Strepsiptera: Xenidae): an endoparasite of Polistes wattii (Hymenoptera: Vespidae).

We report the morphology, biology and phylogeny of a new strepsipteran endoparasitic species: Xenos gadagkari, which stylopises the primitively eusocial wasp Polistes wattii from Punjab, India. We report a high abundance of the endoparasite in P. wattii population of our study area and provide the morphological description of adult males, male puparium and neotenic females.

Heavy metal contamination in cow and buffalo milk from industrial and residential areas of raipur, India: A health risk assessment.

This study investigated heavy metal contamination in cow and buffalo milk from industrial and residential areas of Raipur, India, assessing health risks and identifying contamination sources. Milk samples were collected from seven sites and analyzed for Zn, Ni, Fe, Mn, Cu, Cr, Cd, Pb, and As using inductively coupled plasma-optical emission spectroscopy (ICP-OES) and atomic absorption spectroscopy (AAS). Results revealed higher contamination in industrial areas, with fodder being a primary source for Zn, Ni, Fe, and Cu, while water contributed to Mn, Cr, and As.

Isolation and identification of the active constituent β-isocostic acid from the hexane extract of the leaves of Sphaeranthus indicus against mosquito vectors.

Mosquitoes, as hematophagous ectoparasites, are significant pests and vectors of numerous pathogens, causing diseases such as dengue, lymphatic filariasis, malaria, chikungunya, and Japanese encephalitis in India. This study investigates the potential of natural insecticides derived from plants to combat mosquito populations, focusing on botanical extract from the leave of Sphaeranthus indicus. Specifically, the hexane extract of S.

Radiation doses received by humans in their dwellings - A baseline report on radionuclides exposure from construction materials used in Chennai, Tamil Nadu, India.

Gamma-ray spectrometry was employed to assess the activity concentrations of primordial radionuclides (U, Th, and K) in various construction materials, including those used for building, roofing, furnishing, flooring, and plastering. The measured activity concentrations of the radionuclides ranged as follows: U (25 to 477 Bq kg), Th (below detection limit to 239 Bq kg), and K (285 to 1915 Bq kg). Based on these values, the materials were categorized in descending order of radioactivity threat as: Furnishing > Roofing > Building > Flooring > Plastering.

A highly lipophilic terpyridine ligand as an efficient fluorescent probe for the selective detection of zinc(II) ions under biological conditions.

The present work describes the synthesis of new terpyridine (tpy) molecules possessing functionalized long alkyl chains at the 4'-position associated with a planar structure with considerable delocalization. Out of the three synthesized tpy derivatives (L1, L2, and L3), L2 containing an ester group at the end of the alkyl chain emerged as an excellent probe for the selective detection of Zn. The detection of Zn ions under biological conditions was achieved by the introduction of a distinct aliphatic undecanoic ester chain at the 4'-position of the core terpyridine ring, thereby making it more lipophilic.

Soil carbon in the world's tidal marshes.

Tidal marshes are threatened coastal ecosystems known for their capacity to store large amounts of carbon in their water-logged soils. Accurate quantification and mapping of global tidal marshes soil organic carbon (SOC) stocks is of considerable value to conservation efforts. Here, we used training data from 3710 unique locations, landscape-level environmental drivers and a global tidal marsh extent map to produce a global, spatially explicit map of SOC storage in tidal marshes at 30 m resolution.

Exploring the effects of homocysteine metabolism in osteoporosis management in Indian adult females.

Women are at a significantly higher risk of osteoporotic fractures, largely due to progressive bone demineralization and impaired bone microarchitecture. Low bone mineral density (BMD) is a common condition in women worldwide. Disrupted homocysteine (Hcy) metabolism has been linked to reduced BMD and increased risk of osteoporotic fractures.

Assessment of lapachol's anti-inflammatory effectiveness in mitigating sepsis-induced acute lung injury.

Sepsis-induced Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS) pose life-threatening risks due to an excessive activation of proinflammatory cytokines via the JAK pathway. Currently, no confirmed drug treatment exists for ALI. In this study, we explored JAK1 as a potential therapeutic target to address this issue.

Exploring the cooking energy biomass and its impact on women's health and quality of life in rural households: a micro-environmental study from West Bengal in India.

Exposure to household air pollutants has become a significant environmental health concern in developing nations. This study aimed to understand the growing energy consumption within households, particularly for cooking, and its impact on women's health in rural areas. We conducted real-time monitoring of ambient particulate matter (PM2.

Organic-Inorganic Hybridization of Silkworm Cocoon Filaments Using Nano Pastes of Silica-Phosphate-M (M = Cu, Fe, or Al).

Inorganic-organic hybrid biomaterials have recently attracted much attention because of their widespread use. Silkworm cocoon filaments resulting from sericulture as prospective nanobiomaterials need to be improved, and their properties need to be used for broader purposes. This study was aimed at investigating methods for siliconization of silkworm cocoon filaments and characterizing their cocoon filament properties in terms of their yarn quality, natural dyeing, and antibacterial properties.

Fruit Extract Mediated Formation of Luminescent Titanium Dioxide Nanometer-Sized Particles: An Innovative Strategy in Domain of Photodecomposition and Germicidal Properties.

Discoveries in nanotechnologies are placing a great deal of attention on greener strategies that use harmless substances and moderated reactions to promote healthy development. This work used a straightforward, innovative, and cost-effective sustainable approach to produce bio-augmented TiO nanometer-sized particles (NMSP) by applying a water-based extract of the star fruit as a stabilization and reduction agent. A variety of techniques, comprising UV-Vis, XRD, FT-IR, FE-SEM with EDAX, and TEM, have been employed to investigate the formed TiO NMSP.

Upregulation of ACSL, ND75, Vha26 and sesB genes by antiepileptic drugs resulted in genotoxicity in drosophila.

Clobazam (CLB) and Vigabatrin (VGB) are commonly used antiepileptic drugs (AEDs) in the treatment of epilepsy. Here, we have examined the genotoxic effect of these AEDs in . The Drosophila larvae were exposed to different concentrations of CLB and VGB containing food media.

Early life stress induces decreased expression of CB1R and FAAH and epigenetic changes in the medial prefrontal cortex of male rats.

Several studies in both animal models and in humans have provided substantial evidence that early life stress (ELS) induces long-term changes in behavior and brain function, making it a significant risk factor in the aetiology of various mental disorders, including anxiety and depression. In this study, we tested the hypothesis that ELS in male rats (i) leads to increased anxiety and depressive-like symptoms; and (ii) that these behavioral changes are associated with functional alterations in the endocannabinoid system of the medial prefrontal cortex (mPFC). We further assessed whether the predicted changes in the gene expression of two key components of the endocannabinoid system, cannabinoid receptor 1 (CB1R) and the fatty acid amide hydrolase (FAAH), are regulated by epigenetic mechanisms.

Biogenic Ag-doped ZnO nanostructures induced cytotoxicity in luminal A and triple-negative human breast cancer cells.

To evaluate the apoptosis-inducing properties of undoped and silver-doped-zinc-oxide nanoparticles (SDZONs) synthesized using against MCF-7 (Luminal-A) and MDA-MB-231 (Triple-negative) breast cancer cell lines. Nanostructures were developed by facile biohydrothermal method and characterized by x-ray diffraction (XRD), Fourier transform infrared (FTIR), and high resolution transmission electron microscopy (HR-TEM). The comparative effect of doping and dose concentration of nanostructures on cytotoxicity was measured using MTT and trypan-blue-exclusion assay.