The association of activity patterns on female reproductive diseases: a prospective cohort study of UK biobank.

Objective: Little is known about the role of timing of physical activity in female reproductive disorders. These disorders include polycystic ovary syndrome (PCOS), heavy menstrual bleeding (HMB), endometriosis, infertility, and pregnancy-related disorders. This study aims to investigate the associations of activity patterns with female reproductive diseases.

Amplification Bias-Free Sequence-Generic Exponential Amplification Reaction.

Despite the unique advantage of the isothermal exponential amplification reaction (EXPAR) for the rapid detection of short nucleic acids, it severely suffers from the drawback of sequence-dependent amplification bias, mainly arising from the secondary structures of the EXPAR template under the commonly used reaction temperature (55 °C). As such, the limits of detection (LOD) for different target sequences may vary considerably from aM to nM. Here we report a sequence-generic exponential amplification reaction (SG-EXPAR) that eliminates sequence-dependent amplification bias and achieves similar amplification performance for different targets with generally sub-fM LODs.

Identification of Pratylenchus coffeae as a causal agent of root rot disease in Sorghum bicolor in China.

Sorghum (Sorghum bicolor) is an important food and feed crop. Root-lesion nematodes (Pratylenchus spp.) are a group of pathogenic nematodes that cause severe economic losses in various food and cash crops.

Disrupting of IGF2BP3-stabilized CLDN11 mRNA by TNF-α increases intestinal permeability in obesity-related severe acute pancreatitis.

Background: Obesity is a significant risk factor for severe acute pancreatitis (SAP) and is typically associated with increased intestinal permeability. Understanding the role of specific molecules can help reduce the risk of developing SAP. Claudin 11 (CLDN11), a member of the Claudin family, regulates the permeability of various internal barriers.

Effects of subclinical hypothyroidism during pregnancy on mtDNA methylation in the brain of rat offspring.

Objective: This study aims to investigate the impact of subclinical hypothyroidism (SCH) during pregnancy on mitochondrial DNA (mtDNA) methylation in the brain tissues of rat offspring.

Materials And Methods: Sixteen SD rats were randomly divided into two groups: control group (CON) and SCH group. BS-seq sequencing was used to analyze mtDNA methylation levels in the offspring's brain tissues; the 2,7-dichlorofluorescin diacetate (DCFH-DA) probe method was employed to detect reactive oxygen species (ROS) levels in brain tissues; electron microscopy was utilized to observe the mitochondrial structure in the hippocampal tissues of the offspring.

Preparation of CHS-FeO@@ZIF-8 peroxidase-mimic with an ultra-thin hollow layer for ultrasensitive electrochemical detection of kanamycin.

A highly sensitive and selective electrochemical biosensor was developed for the detection of kanamycin using a core-hollow-shell structured peroxidase-mimic nanozyme, CHS-Fe₃O₄@@ZIF-8. The synthesized CHS-FeO@@ZIF-8 was characterized with scanning electron microscopy, transmission electron microscopy, and X-ray photoelectron spectroscopy. It was found that the CHS-FeO@@ZIF-8 exhibits excellent peroxidase-like activity due to  its ultra-thin hollow layer.

Bibliometric analysis of liposarcomas treatment from 2004 to 2023.

Background: Liposarcomas are mesenchymal malignant tumors characterized by varying degrees of adipocytic differentiation that comprises approximately 20% of soft tissue sarcomas. Despite advancements in this field, there remains a need for a comprehensive understanding of the mechanisms, diagnosis, and treatment of liposarcomas. Currently, there is a lack of bibliometric surveys on the development trajectory of liposarcomas treatment, research hotspots, and author and team collaboration.

Aptamer-antibody sandwich immunosensor for electrochemical detection of FT4.

An aptamer-antibody sandwich electrochemical immunosensor was studied. FeO/MWCNTs-COOH/Nafion was modified and fixed on a glassy carbon electrode to amplify electrical signals. The antibody was coupled with AuNPs to form conjugates.

Genomic and transcriptomic insights into vitamin A-induced thermogenesis and gene reuse as a cold adaptation strategy in wild boars.

Wild boars inhabit diverse climates, including frigid regions like Siberia, but their migration history and cold adaptation mechanisms into high latitudes remain poorly understood. We constructed the most comprehensive wild boar whole-genome variant dataset to date, comprising 124 samples from tropical to frigid zones, among which 47 Russian, 8 South Chinese and 3 Vietnamese wild boars were newly supplemented. We also gathered 75 high-quality RNA-seq datasets from 10 tissues of 6 wild boars from Russia and 6 from southern China.

Research on multi-source microstructure image recognition of foam ceramics using convolutional network combine with frequency domain.

Foam ceramics are widely used in industrial applications due to their unique properties, including high porosity, lightweight, and high-temperature resistance. However, their complex microstructure presents significant challenges for image analysis. Traditional machine learning methods often fall short in capturing both global feature dependencies and detailed representations.

Design of asymmetric electrolytes for aqueous zinc batteries.

Aqueous Zn batteries are gaining increasing research attention in the energy storage area due to their intrinsic safety, potentially low cost and environmental friendliness; however, the zinc dendrite formation, zinc corrosion, passivation and the hydrogen evolution reaction induced by water at the anode side, and materials dissolution as well as intrinsic poor reaction kinetics at cathode side in aqueous systems, seriously shorten the cycling life and decrease energy density of batteries and greatly hinder their development. Recent advancements in asymmetric electrolytes with various functions are promising to overcome such challenges for zinc batteries at the same time. It has been proved that the applications of asymmetric electrolytes show significant contributions in the field of zinc-based batteries in suppressing side reactions while maintaining electrochemical performance to satisfy both anode and cathode.

Bamboo-inspired ultra-strong nanofiber-reinforced composite hydrogels.

Biological materials, such as bamboo, are naturally optimized composites with exceptional mechanical properties. Inspired by such natural composites, traditional methods involve extracting nanofibers from natural sources and applying them in composite materials, which, however, often results in less ideal mechanical properties. To address this, this study develops a bottom-up nanofiber assembly strategy to create strong fiber-reinforced composite hydrogels inspired by the hierarchical assembly of bamboo.

COFcap2, a recyclable tandem catalysis reactor for nitrogen fixation and conversion to chiral amines.

Two or more catalysts conducting multistep reactions in the same reactor, concurrent tandem catalysis, could enable (bio)pharmaceutical and fine chemical manufacturing to become much more sustainable. Herein we report that co-immobilization of metal nanoparticles and a biocatalytic system within a synthetic covalent organic framework capsule, COFcap-2, functions like an artificial cell in that, whereas the catalysts are trapped within 300-400 nm cavities, substrates/products can ingress/egress through ca. 2 nm windows.

Interaction between Hydrogen and Magnesium Films: From Hydrogenochromism to Applications.

Hydrogen, as a promising clean energy carrier, underscores the critical need for reliable detection technologies to ensure its safe and efficient use. Magnesium (Mg) thin films, with their hydrogenochromic properties, are particularly well-suited for hydrogen sensing applications due to their dramatic optical transitions. However, practical implementation faces challenges in achieving both rapid response and durability under cyclic conditions.

Plant secondary metabolites against biotic stresses for sustainable crop protection.

Sustainable agriculture practices are indispensable for achieving a hunger-free world, especially as the global population continues to expand. Biotic stresses, such as pathogens, insects, and pests, severely threaten global food security and crop productivity. Traditional chemical pesticides, while effective, can lead to environmental degradation and increase pest resistance over time.

Association of Admission Nutritional Status Evaluated by Prognostic Nutritional Index with One-Year Walking Independence after Primary Total Hip Arthroplasty for Osteonecrosis of the Femoral Head: A Retrospective Matched Cohort Study Based on 1,152 Patients.

Background: Malnutrition is significantly associated with unfavorable outcomes, but the relevant prognostic assessment is not emphasized in patients who have osteonecrosis of the femoral head (ONFH). This study aimed to assess the association between preoperative nutritional status evaluated by the prognostic nutritional index (PNI) and walking independence at one year postoperatively in patients who have ONFH undergoing primary total hip arthroplasty (THA).

Methods: This was a retrospective analysis of prospectively collected data from patients admitted to a tertiary referral hospital who had ONFH and underwent primary unilateral THA from October 30, 2014 to April 26, 2019.

Regioselective 1,4-Addition of P(O)-H Species to In SituFormed 1-Benzopyrylium Ion from C3-Substituted 2-Chromene Hemiketals to Construct C3-Functionalized C4-Phosphorylated 4-Chromenes.

Herein, we report the first example that P(O)-H species including -phosphonates and -phosphine oxides could participate in a highly regioselective 1,4-addition to in situ generated 1-benzopyrylium ion from C3-substituted 2-chromene hemiketals, which provides a brand-new and effective approach for the synthesis of C4-phosphorylated 4-chromenes with diverse C3-functionality (ketone, ester, sulfonyl, aryl, and alkyl groups). In total, the reaction features the use of inexpensive Zn(ClO)·6HO as a catalyst, low catalyst loading (only 5 mol %), mild reaction conditions (60 °C, 10 min to 24 h), and broad substrate scope (46 examples) as well as good to high yields (>90% yield on average). More importantly, mechanistic experiments demonstrated the essential role of the C3-substituent on 2-chromene hemiketals in stabilizing the in situ generated 1-benzopyrylium ion and the regioselective 1,4-addition control.

Correlative Raman-Voltage Microscopy Revealing the Localized Structure-Stress Relationship in Silicon Solar Cells.

Knowledge of localized strain at the micrometer scale is essential for tailoring the electrical and mechanical properties of ongoing thinning of crystal silicon (c-Si) solar cells. Thinning c-Si wafers below 110 m are susceptible to cracking in manufacturing due to the nonuniform stress distribution at a micrometer region, necessitating a rigorous technique to reveal the localized stress distribution correlating with its device electrical output. In this context, a Raman microscopy integrated with a photovoltage mapping setup with high resolution to the submicrometer scale is developed to acquire correlative Raman-voltage of the localized physical properties at the microcracks on the rear side of c-Si solar cells.

Superconductor-Insulator Transition Induced by Precise Subtripled Vapor Chemical Gating.

Recent progress in superconductor-insulator transition has shed light on the intermediate metallic state with unique electronic inhomogeneity. The microscopic model, suggesting that carrier spatial distribution plays a decisive role in the intermediate state, has been instrumental in understanding the quantum transition. However, the narrow carrier density window in which the intermediate state exists necessitates precise control of the gate dielectric layer, presenting a challenge to in situ map the carrier spatial distribution.

Low-Cost Preparation of Wafer-Scale Au(111) Single Crystals for the Epitaxy of Two-Dimensional Layered Materials.

Single-crystal Au(111), renowned for its chemically inert surface, long-range "herringbone" reconstruction, and high electrical conductivity, has long served as an exemplary template in diverse fields, , crystal epitaxy, electronics, and electrocatalysis. However, commercial Au(111) products are high-priced and limited to centimeter sizes, largely restricting their broad applications. Herein, a low-cost, high-reproducible method is developed to produce 4 in.

LACCASE35 Enhances Lignification and Resistance Against Pseudomonas syringae pv. actinidiae Infection in Kiwifruit.

Kiwifruit bacterial canker, a highly destructive disease caused by Pseudomonas syringae pv. actinidiae (Psa), seriously affects kiwifruit (Actinidia spp.) production.

The corneal biomechanical changes of phacoemulsification in cataract patients: A systematic review and meta-analysis.

Purpose: To evaluate the corneal biomechanical properties of phacoemulsification in the treatment of cataract patients.

Methods: Pertinent studies were searched in PubMed, EMBASE, Web of Science and clinicaltrials.gov.

Bioprinted optoelectronically active cardiac tissues.

Electrical stimulation of existing three-dimensional bioprinted tissues to alter tissue activities is typically associated with wired delivery, invasive electrode placement, and potential cell damage, minimizing its efficacy in cardiac modulation. Here, we report an optoelectronically active scaffold based on printed gelatin methacryloyl embedded with micro-solar cells, seeded with cardiomyocytes to form light-stimulable tissues. This enables untethered, noninvasive, and damage-free optoelectronic stimulation-induced modulation of cardiac beating behaviors without needing wires or genetic modifications to the tissue solely with light.

A study on the monitoring of LNAPL migration using ERT.

This study employs electrical resistivity tomography (ERT) to experimentally investigate the migration characteristics of light non-aqueous phase liquids (LNAPL) under various groundwater conditions. Through cross-hole measurements and time-lapse inversion, the migration process of LNAPL under three scenarios-unsaturated conditions, constant groundwater levels, and declining water levels-was systematically analyzed. The results indicate that LNAPL migration behavior exhibits significant differences under different conditions.