1 results match your criteria: "P.R. China and PX Beamlines Swiss Light Source at Paul Scherrer Institute[Affiliation]"
Structural insights into VirB-DNA complexes reveal mechanism of transcriptional activation of virulence genes.
Nucleic Acids Res
December 2013
MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, No.9 Dong Dan San Tiao, Beijing 100730, P.R. China and PX Beamlines Swiss Light Source at Paul Scherrer Institute, CH-5232 Villigen, Switzerland.
VirB activates transcription of virulence genes in Shigella flexneri by alleviating heat-stable nucleoid-structuring protein-mediated promoter repression. VirB is unrelated to the conventional transcriptional regulators, but homologous to the plasmid partitioning proteins. We determined the crystal structures of VirB HTH domain bound by the cis-acting site containing the inverted repeat, revealing that the VirB-DNA complex is related to ParB-ParS-like complexes, presenting an example that a ParB-like protein acts exclusively in transcriptional regulation.
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