Targeting mitochondrial transfer: a new horizon in cardiovascular disease treatment.

Cardiovascular diseases (CVDs) are the leading cause of mortality among individuals with noncommunicable diseases worldwide. Obesity is associated with an increased risk of developing cardiovascular disease (CVD). Mitochondria are integral to the cardiovascular system, and it has been reported that mitochondrial transfer is associated with the pathogenesis of multiple CVDs and obesity.

Impact of titanium mesh cage slotting width on anterior cervical corpectomy and fusion for compression cervical spondylosis with MRI T2WI hyperintensity: a one-year follow-up study.

Background: Anterior cervical corpectomy and fusion (ACCF) is a standard surgical procedure for cervical spondylosis with spinal cord compression (CSWSCC), especially in patients with intensity on T2-weighted imaging high signal (T2WIHS). The titanium mesh cage (TMC) utilized in this procedure is essential in stabilizing the spine; however, the optimal slotting width of the TMC remains unclear.

Objective: This study aimed to investigate the impact of TMC slotting width on the clinical and radiological outcomes of ACCF in patients with spinal cord compression type cervical spondylosis with intensity on T2WIHS (CST2WIHS).

Molten Salt-Assisted Synthesis of Porous Precious Metal-Based Single-Atom Catalysts for Oxygen Reduction Reaction.

Precious metal-based single-atom catalysts (PM-SACs) hosted in N-doped carbon supports have shown new opportunities to revolutionize cathodic oxygen reduction reaction (ORR). However, stabilizing the high density of PM-N sites remains a challenge, primarily due to the inherently high free energy of isolated metal atoms, predisposing them to facile atomic agglomeration. Herein, a molten salt-assisted synthesis strategy is proposed to prepare porous PM/N-C (PM = Ru, Pt, and Pd) electrocatalysts with densely accessible PM-N sites.

Coenzyme Q10 Alleviates Silicosis Fibrosis Inhibiting Ferroptosis in Mice.

Background/aim: Silicosis, the most severe type of occupational pneumoconiosis, leads to diffuse pulmonary fibrosis without specific therapy. Ferroptosis is triggered by reactive oxygen species (ROS) and Fe overload-induced lipid peroxidation, which is involved in the progression of pulmonary fibrosis. As an important coenzyme in the process of aerobic respiration, Coenzyme Q10 (CoQ10) can enhance mitochondrial function and energy supply and reduce malondialdehyde (MDA) to limit the risk of fibrosis.

Preclinical Assessment of Safety and Efficacy of Deferoxamine (DFO)-pretreated Feline Adipose Mesenchymal Stem Cells.

Background/aim: This study aimed to investigate the safety and efficacy of deferoxamine (DFO) pretreated feline adipose tissue derived mesenchymal stem cells (fATMSCs) for the treatment of inflammatory disorders.

Materials And Methods: fATMSCs were isolated from feline adipose tissue and characterized using flow cytometry for surface marker expression and differentiation assays for adipogenic, osteogenic, and chondrogenic lineages. Different concentrations of DFO were used to evaluate its impact on fATMSC activity.

Alternating Oxaliplatin and Irinotecan Chemotherapy Combined With Capecitabine and Bevacizumab for Microsatellite-stable Stage IV Metastatic Colon Cancer With a BRAF V600E Mutation: Two Case Reports Indicating Survival Improvement over Standard Therapy.

Background/aim: Colorectal cancer (CRC) has the third-highest incidence among human cancers. Advancements in chemotherapy and targeted therapy have improved the treatment outcomes for patients with CRC. However, the management of patients with unresectable metastatic CRC (mCRC) continues to be a significant challenge for clinicians worldwide, particularly for those with microsatellite stability (MSS) and the BRAF V600E mutation, as they are associated with the poorest prognosis.

SLC15A2 Serves as a Novel Prognostic Biomarker and Target for Prostate Cancer.

Background/aim: Solute carrier (SLC) family 15 member 2 (SLC15A2) is an integral member of the SLC family that plays a pivotal role in numerous biological processes, including the regulation of cellular signaling pathways. However, its role in prostate cancer (PCa) remains inadequately elucidated. This study aims to investigate the prognostic significance of SLC15A2 in PCa.

Circular RNA hsa_circ_0004650 Enhances 5-Fluorouracil Resistance in Gastric Cancer Sponging miR-145-5p.

Background/aim: Chemotherapy based on 5-fluorouracil (5-Fu) is the first-line treatment for advanced gastric cancer (GC) patients. Importantly, 5-Fu resistance is recognized as a major obstacle for the successful treatment of GC. Circular RNAs (circRNAs) are non-coding RNAs involved in the pathogenesis of GC.

Eribulin Induction of Immunogenic Cell Death (ICD): Comparison With Other Cytotoxic Agents and Temporal Relationship of ICD Biomarkers.

Background/aim: Preclinical studies were undertaken to investigate whether eribulin's known cytotoxic antimitotic effects are characterized by immunogenic cell death (ICD) as assessed by three established ICD biomarkers: extracellular released ATP, released HMGB1 and cell surface calreticulin.

Materials And Methods: Using BT-549, Hs578T and MCF-7 breast cancer cell lines, antiproliferative IC's of eribulin, five other microtubule targeting agents (MTAs; ER-076349, vinblastine, vinorelbine, paclitaxel, docetaxel) and three DNA damaging agents (DDAs; doxorubicin, cisplatin, oxaliplatin) were determined.

Results: Treatment of cells with 10×IC concentrations of all drugs in serum-free media resulted in time-dependent induction of cytotoxicity over DMSO controls.

HOXA3 activates USP15 to suppress autophagy and promote M2-type macrophage polarization in renal cell carcinoma via facilitating the deubiquitination of SQSTM1.

The disease burden of renal cell carcinoma (RCC) has decreased in recent years with advances in treatment, but its pathogeny still remains elusive. We aim to study the role of HOXA3/USP15/SQSTM1 axis on autophagy and M2-type macrophage polarization in RCC. In this study, cell apoptosis and proliferation were assessed by flow cytometry and CCK-8.

An Intermediate-Aided Perovskite Phase Purification for High-Performance Solar Cells.

In recent years, perovskite solar cells (PSCs) have garnered considerable attention as a prime candidate for next-generation photovoltaic technology. Ensuring the structural stability of perovskites is crucial to the operational reliability of these devices. However, the nonphotoactive yellow phase (δ-FAPbI) of formamidine (FA)-based perovskites is more favorable in thermodynamics, making it challenging to achieve pure α phase in crystallization.

Magnetic Field-Driven NiCo-3DOMC Modified Separators for Effective Lithium Polysulfide Mitigation and Catalysis.

Lithium-sulfur batteries (LSBs) face challenges from the shuttle effect of lithium polysulfides (LiPSs) and slow redox kinetics. In this study, a NiCo-Doped 3D Ordered Mesoporous Carbon (NiCo-3DOMC) composite material is synthesized using a gel-crystalline template and sol-gel method to modify polypropylene separators in LSBs. Density Functional Theory calculations and experiment results demonstrate that under a magnetic field, the NiCo-3DOMC enhances adsorption and catalyzes the conversion of LiPSs, effectively mitigating the shuttle effect and boosting redox kinetics.

N-Doping Fe-C@NbCT MXenes with High Stability and Strong Activity for Sodium-Ion Storage and Overall Water Splitting.

The development of highly stable and strongly active electrode materials for sodium-ion batteries (SIBs) and overall water splitting (OWS) is critical in sustainable energy storage and conversion systems. Here, a new electrode material N-Fe-C@NbCT is introduced, with a layered sandwich structure consisting of N-doping Fe-MOF derived-nanorods (Fe-C) and NbCT MXenes. Specifically, NbCT obtained by etching NbAlC with HF acid is used as the main body to construct the layered sandwich structure with Fe-C as the filler.

Surface Doping to Suppress Iodine Ion Migration for Stable FAPbI Perovskite Quantum Dot Solar Cells.

Formamidine lead iodide (FAPbI) quantum dots (QDs) have attracted great attention as a new generation of photovoltaic material due to their long carrier diffusion length, benign ambient stability, and light-harvesting ability. However, its large surface area with inherent thermodynamic instability and highly defective ionic termination are still major obstacles to fabricating high-performance devices. Herein, a metallic ion dopant is developed to post-treat FAPbI QDs immediately after their fabrication by using a metal-glutamate salt solution.

Iono-Optic Impedance Spectroscopy (I-OIS): A Model-Less Technique for In Situ Electrochemical Characterization of Mixed Ionic Electronic Conductors.

Functional properties of mixed ionic electronic conductors (MIECs) can be radically modified by (de)insertion of mobile charged defects. A complete control of this dynamic behavior has multiple applications in a myriad of fields including advanced computing, data processing, sensing or energy conversion. However, the effect of different MIEC's state-of-charge is not fully understood yet and there is a lack of strategies for fully controlling the defect content in a material.

Mechano-Responsive Biomaterials for Bone Organoid Construction.

Mechanical force is essential for bone development, bone homeostasis, and bone fracture healing. In the past few decades, various biomaterials have been developed to provide mechanical signals that mimic the natural bone microenvironment, thereby promoting bone regeneration. Bone organoids, emerging as a novel research approach, are 3D micro-bone tissues that possess the ability to self-renew and self-organize, exhibiting biomimetic spatial characteristics.

Skin necrosis after autologous fat grafting for augmentation rhinoplasty: a case report and review of the literature.

Background: Autologous fat transplantation has gained increasing attention in the field of cosmetic surgery. However, a series of complications can occur after fat transplantation.

Case Presentation: A 24-year-old woman presented at our Hospital with nasal skin necrosis and ulceration.

The dysregulation of PARP9 expression is linked to apoptosis and DNA damage in gastric cancer cells.

Background: Gastric cancer (GC) is a highly malignant gastrointestinal tumor characterized by difficult early diagnosis and poor prognosis. Therefore, it is imperative to explore potential therapeutic targets for gastric cancer. PARP9 is abnormally expressed in a variety of tumors and is associated with tumor cell apoptosis and DNA damage.

miR-1247-3p regulation of CCND1 affects chemoresistance in colorectal cancer.

The effectiveness of chemotherapy involving 5-fluorouracil and cisplatin (DDP) for the treatment of colorectal cancer (CRC) is often limited due to the emergence of drug resistance. An increasing body of research highlights the crucial role of abnormally expressed microRNAs (miR/miRNAs) in fostering drug resistance in various types of cancer. The present study was the first to explore the potential roles and mechanisms of the small non-coding RNA miR-1247-3p in CRC, particularly its association with DDP resistance in CRC.

Neurological Nurses' Perspectives on Communication of Stroke Recurrence Risks: A Mixed-Method Study.

Aim: To gain a comprehensive understanding of the practices, attitudes, and thoughts of neurological nurses regarding communication about the risk of stroke recurrence.

Design: This is a mixed-method study with a sequential explanatory design.

Methods: An electronic survey was conducted amongst 280 neurological nurses from 30 hospitals to explore their clinical practice and attitudes towards stroke recurrence risk communication (RC).

Rare-Earth Substitution Induced Symmetry Breaking for The First Sc-Based Nonlinear Optical Chalcogenide with High-Performance.

Chalcogenides are the most important infrared nonlinear optical (NLO) material candidates, and the exploration of high-performance ones is attractive and challengeable. Hitherto, there is no NLO scandium (Sc) chalcogenides experimentally studied. Here, new quaternary Sc thiophosphate CsScPS (CSPS) was synthesized by the facile metal oxide-boron-sulfur/reactive flux hybrid solid-state method.

TRIM21 Promotes Tumor Growth and Gemcitabine Resistance in Pancreatic Cancer by Inhibiting EPHX1-Mediated Arachidonic Acid Metabolism.

Pancreatic cancer (PC) progresses rapidly, and gemcitabine-based chemotherapy has brought only limited efficacy. Identifying key drivers and therapeutic targets holds significant clinical value. In this study, through comprehensive analysis of multiple PC databases, this work identifies TRIM21 as a promising driver mediator.

Low-Cost Intrinsic Flame-Retardant Bio-Based High Performance Polyurethane and its Application in Triboelectric Nanogenerators.

Flammability is a significant challenge in polymer-based electronics. In this regard, triboelectric nanogenerators (TENGs) have enabled a safe means for harvesting mechanical energy for conversion into electrical energy. However, most existing polymers used for TENGs are sourced from petroleum-based raw materials and are highly flammable, which can further accelerate the spread of fire and harm the ecological environment.

Manipulation of Surface Potential Distribution Enhances Osteogenesis by Promoting Pro-Angiogenic Macrophage Polarization via Activation of the PI3K-Akt Signaling Pathway.

Regulation of the immune response is key to promoting bone regeneration by electroactive biomaterials. However, how electrical signals at the micro- and nanoscale regulate the immune response and subsequent angiogenesis during bone regeneration remains to be elucidated. Here, the distinctly different surface potential distributions on charged poly(vinylidene fluoridetrifluoroethylene) (P(VDF-TrFE)) matrix surfaces are established by altering the dimensions of ferroelectric nanofillers from 0D BaTiO nanoparticles (homogeneous surface potential distribution, HOPD) to 1D BaTiO nanofibers (heterogeneous surface potential distribution, HEPD).

N-methyladenosine in 28S rRNA promotes oncogenic mRNA translation and tyrosine catabolism.

Aberrant N-methyladenosine (mA) modification on mRNA results in dysregulated mRNA translation and cancer progression; however, the role of mA modification on rRNA remains unclear in cancers. Here, we show that ZCCHC4 and its mediated mA modification on 28S rRNA are upregulated in various cancers and correlated with poor survival. Functionally, ZCCHC4 promotes intrahepatic cholangiocarcinoma (ICC) progression via its catalytic activity.