Reduce Flap Necrosis After Autologous Breast Reconstruction: A Systematic Review.

Background: Autologous breast reconstruction provides substantial benefits in terms of aesthetics and longevity. However, the risk of flap necrosis poses potential challenges to patients' appearance and psychological well-being, while also escalating health care costs. Consequently, examining the risk factors, assessment techniques, and therapeutic approaches for flap necrosis is critically important.

Core-Shell Magnetic Particles: Tailored Synthesis and Applications.

Core-shell magnetic particles consisting of magnetic core and functional shells have aroused widespread attention in multidisciplinary fields spanning chemistry, materials science, physics, biomedicine, and bioengineering due to their distinctive magnetic properties, tunable interface features, and elaborately designed compositions. In recent decades, various surface engineering strategies have been developed to endow them desired properties (e.g.

Treatment of Paraclinoid Aneurysms With Stent-Assisted Coiling Versus Flow Diversion Techniques: A Systematic Review and Meta-Analysis.

Background: The stent-assisted coiling (SAC) and flow-diverter stent (FDS) techniques are widely used in the endovascular treatment of paraclinoid aneurysms. This article compares the occlusion rate, periprocedural complications, and clinical outcomes of SAC and FDSs.

Methods: Between January 2010 and December 2020, a systematic search of electronic databases identified 2283 articles for screening.

Global trends and hotspots in robotic surgery over the past decade: a bibliometric and visualized analysis.

Since its introduction, robotic surgery has experienced rapid development and has been extensively implemented across various medical disciplines. It is crucial to comprehend the advancements in research and the evolutionary trajectory of its thematic priorities. This research conducted a bibliometric analysis on the literature pertaining to robotic surgery, spanning the period from 2014 to 2023, sourced from the Web of Science database.

AP-1 activates KCNN4-mediated Ca2 signaling to induce the Th1/Th17 differentiation of CD4 cells in chronic non-bacterial prostatitis.

The intraprostatic inflammatory infiltrate is characterized by Th1 CD4 T cells, and its molecular mechanism is not well defined. This study explored the mechanisms responsible for the alteration of Th1/Th17 differentiation of CD4 T cells in chronic non-bacterial prostatitis (CNP). CNP rats were induced by the administration of testosterone and 17β-estradiol.

Comparative Safety and Efficacy of Non-vitamin K Antagonist Oral Anticoagulants (NOACs) Versus Warfarin in Deep Vein Thrombosis (DVT) Treatment: A Meta-analysis.

Purpose: This meta-analysis aimed to conduct a systematic evaluation of the comparative efficacy and safety of new oral anticoagulants (NOACs) versus warfarin for the treatment of deep venous thrombosis (DVT).

Methods: A systematic computerized search of databases including PubMed, Medline, Web of Science, Embase, Cochrane Library, and www.

Clinicaltrials: gov .

High-Throughput Molecular Dynamics Study and Turbidity Analysis on Clustering and Agglomeration of Cellulose Nanocrystals in Suspensions.

The dispersion of cellulose nanocrystals (CNCs) in suspensions determines the quality of the CNC-reinforced composites. Before being mixed into the composite matrix, stable suspensions must maintain a well-dispersed state, requiring proper design strategies to prevent agglomeration and precipitation. Considering the volume fraction, aspect ratio, and zeta potential, this paper proposes a coarse-grained model to simulate CNC clustering and an experimental program to observe accelerated precipitation of CNCs.

Constructing an Isopolymolybdate-Based Bifunctional Photocatalyst for Promoting Nitroaromatic Reduction and C-H Oxidation.

Amide compounds are widely present in drug molecules and natural products, which can be synthesized by acid-amine condensation. It is urgent to design new photocatalysts for achieving both nitroaromatic reduction and C-H oxidation to obtain raw materials, carboxylic acids, and aromatic amines. Herein, a novel isopolymolybdate-incorporated photoactive metal-organic framework, -TPT, was constructed by combining the oxidation catalyst [MoO], Ni(II) cation, and photosensitive ligand 2,4,6-tri(4-pyridyl)-1,3,5-triazine (TPT).

Bioactive Deep Eutectic Solvent-Involved Sprayable Versatile Hydrogel for Monkeypox Virus Lesions Treatment.

To address the issues of infectious virus, bacterial secondary infections, skin pigmentation, and scarring caused by monkeypox virus (MPXV), a sprayable hydrogel with versatile functions was developed with comprehensive properties. Based on current research, the bioactive deep eutectic solvent (DES) of rosmarinic acid-proanthocyanidin-glycol (RPG) was designed and synthesized as active agent, and molecular docking was applied to discover its binding to MPXV proteins through H-bonds and van der Waals interactions, and the docking results show the binding energies between RA, PC, Gly and MPXV proteins are -58.7188, -50.

Enhanced Antibody Response to the Conformational Non-RBD Region DNA Prime-Protein Boost Elicits Broad Cross-Neutralization Against SARS-CoV-2 Variants.

Preventing immune escape of SARS-CoV-2 variants is crucial in vaccine development to ensure broad protection against the virus. Conformational epitopes beyond the RBD region are vital components of the spike protein but have received limited attention in the development of broadly protective SARS-CoV-2 vaccines. In this study, we used a DNA prime-protein boost regimen to evaluate the broad cross-neutralization potential of immune response targeting conformational non-RBD region against SARS-CoV-2 viruses in mice.

Conjugated Naphthalenediimide-Pyridinium Salts in Donor-Acceptor Hybrid Materials for Enhanced Photochromic Properties.

As an emerging class of hybrid materials, donor-acceptor (D-A) hybrid crystals with photoactive organic and inorganic components have gradually become an ideal platform for photochromic materials. Wherein the most available organic components are electron-poor naphthalenediimide, pyridinium, and triazine derivatives, inorganic units are electron-rich polyoxometalates and metal halides. Herein, we introduced pyridinium moieties into the naphthalenediimide core by conjugated bonds so as to increase the electron deficiency of organic species for enhanced photochromic properties.

The Interfacial Interpenetration Effect for Controlled Reaction Stability of Palladium Catalysts.

Tailoring well-defined interfacial structures of heterogeneous metal catalysts has become an effective strategy for identifying the interface relationships and facilitating the reactions involving multiple intermediates. Here, a particle-particle heterostructure catalyst consisting of Pd and copper oxide nanoparticles is designed to achieve high-performance alkaline methanol oxidation electrocatalysis. The strong coupling particle-particle heterostructure catalyst induced a unique interfacial interpenetration effect to improve the interfacial charge redistribution and regulate the -band structure for optimizing the adsorption of CO intermediates on the catalyst.

The influence of Kitchon-RCAA on biomechanics of maxillary tissues based on indirect action: A finite element analysis.

This paper creates 3D models of Kitchon Root Controlled Auxiliary Archwire (Kitchon-RCAA) with different material properties and assembles them onto the main archwire equipped with brackets. By setting different loading methods and conducting Finite Element Analysis (FEA), the range of Orthodontic Torque/Support Force (OT/SF) values can be obtained. From the obtained values, it can be seen that changes in material properties have a significant impact on the mechanical properties of Kitchon-RCAA.

Himalaflavones F and G, two new flavonoids from the roots of Edgew with anti-inflammatory activity.

Himalaflavones F () and G (), two new flavonoids, along with eight known ones ()were isolated from the roots of Edgew. The chemical structures of these compounds were elucidated by 1D/2D NMR, UV and HR-ESI-ME data. Meanwhile, the anti-inflammatory activities of all isolates were test by using Griess method.

Enhancing Ferroptosis-Mediated Radiosensitization Synergistic Disulfidptosis Induction.

Ferroptosis plays an important role in radiotherapy (RT), and the induction of ferroptosis can effectively sensitize radiotherapy. However, the therapeutic efficiency is always affected by ferroptosis resistance, especially SLC7A11 (Solute Carrier Family 7 Member 11)-cystine-cysteine-GSH (glutathione)-GPX4 (glutathione peroxidase 4) pathway-mediated resistance. In this study, tumor-microenvironment self-activated high-Z element-containing nanoferroptosis inducers, PEGylated Fe-Bi-SS metal-organic frameworks (FBSP MOFs), were developed to sensitize RT.

Iron-Photocatalyzed Decarboxylative Alkylation of Carboxylic Acids with Morita-Baylis-Hillman Acetates.

We present an iron-photocatalyzed decarboxylative alkylation strategy involving carboxylic acids and Morita-Baylis-Hillman (MBH) acetates to synthesize -type tri- and tetrasubstituted alkenes with moderate to excellent stereoselectivity (/ ratio up to >19:1). This method is applicable to a broad range of structurally diverse primary, secondary, and tertiary alkyl carboxylic acids, as well as complex pharmaceutical and natural carboxylic acids, achieving efficient alkylation of various MBH acetates under mild conditions (>60 examples, with yields up to 96%). This approach offers a powerful strategy for streamlined alkylation.

Atmospheric Pressure Alkaline Etching of MFI Zeolite Under Mild Temperature Toward Hollow Microstructure and Ultralow k Film.

Constructing a hollow structure inside zeolite is very helpful for improving its performance. Unlike the conventional alkaline etching technique usually operated at high temperature (typically 170 °C) and high pressure (autogenerated in autoclave), here, it is discovered that zeolite MFI nano-box can be achieved under mild etching conditions of atmospheric pressure and low temperature of 80 °C, making it very attractive for energy conservation and practical applications. A hollow-structure formation mechanism of protection-dissolution etching is demonstrated by characterizing MFI crystals obtained under different etching time, temperature, and etchant concentration.

Strong Heteroatomic Bond-Induced Confined Restructuring on Ir-Mn Intermetallics Enable Robust PEM Water Electrolyzers.

Low-iridium acid-stabilized electrocatalysts for efficient oxygen evolution reaction (OER) are crucial for the market deployment of proton exchange membrane (PEM) water electrolysis. Manipulating the in situ reconstruction of Ir-based catalysts with favorable kinetics is highly desirable but remains elusive. Herein, we propose an atomic ordering strategy to modulate the dynamic surface restructuring of catalysts to break the activity/stability trade-off.

What do ultrasound vocalizations really mean in rats with different origins of pain?

Objectives: This study is to assess how 22 kHz and 50 kHz spontaneous ultrasound vocalization (USV) calls would be affected by different origins of pain so as to validate the use of USV in pain studies.

Methods: Five well-established rat models of pain were used to evaluate various parameters of spontaneous 22 kHz and 50 kHz calls in adult male rats in terms of both acute and chronic or inflammatory and neuropathic or somatic and visceral origins. The effects of local lidocaine blockade of the injection site and intraperitoneal administration of antidepressant (amitriptyline) and anticonvulsant (gabapentin) were examined as well in typical inflammatory and neuropathic pain models, respectively.

A Collection of Novel Antitumor Agents That Regulate Lipid Metabolism in the Tumor Microenvironment.

Lipid metabolism disorder is the cause of one of the most significant metabolic changes in tumors. In the process of tumor occurrence and development, tumor cells choose a continuous metabolic adaptation to accommodate the changing environment to the maximum extent possible. In a variety of tumors, the uptake, production, and storage of lipids are generally upregulated.

Salicylaldehyde-Enabled Co(II)-Catalyzed Oxidative C-H Alkenylation of Indoles with Olefins.

A ligand-promoted oxidative dehydrogenation C-H alkenylation of indoles and olefins was achieved using commercial and low-cost Co(NO)·6HO as a catalyst and Mn(OAc) as an oxidant. The design and selection of electrically unique methyl-substituted salicylaldehyde as a ligand is the key to achieve this transformation. This protocol can introduce an indole backbone into diverse bioactive molecules such as ibuprofen, naproxen, and Estrol for late-stage synthetic modification, which has potential applications in the discovery of drug molecules containing an indole motif.

Rapid Hydrolysis of Submicron Magnesium Catalyzed by In Situ-Generated Multi-Nickel Alloys.

The hydrolysis of lightweight metal-based materials is a promising technology for supplying hydrogen to portable fuel cells. Various additives for the catalytic modification of Mg hydrolysis have been investigated. Efficient catalysts and small magnesium particle sizes are key to enhancing the rate of hydrogen production.

An NIR-II Two-Photon Excitable AIE Photosensitizer for Precise and Efficient Treatment of Orthotopic Small-Size Glioblastoma.

The existence of residual small-size tumors after surgery is a major factor contributing to the high recurrence rate of glioblastoma (GBM). Conventional adjuvant therapeutics involving both chemotherapy and radiotherapy usually exhibit unsatisfactory efficacy and severe side effects. Recently, two-photon photodynamic therapy (TP-PDT), especially excited by the second near-infrared (NIR-II) light, offers an unprecedented opportunity to address this challenge, attributed to its combinational merits of PDT and TP excitation.

An "Outer Piezoelectric and Inner Epigenetic" Logic-Gated PANoptosis for Osteosarcoma Sono-Immunotherapy and Bone Regeneration.

The precise manipulation of PANoptosis, a newly defined cell death pathway encompassing pyroptosis, apoptosis, and necroptosis, is highly desired to achieve safer cancer immunotherapy with tumor-specific inflammatory responses and minimal side effects. Nonetheless, this objective remains a formidable challenge. Herein, an "AND" logic-gated strategy for accurately localized PANoptosis activation, utilizing composite 3D-printed bioactive glasses scaffolds integrated with epigenetic regulator-loaded porous piezoelectric SrTiO nanoparticles is proposed.

Harnessing the Electronic Spin States of Single Atoms for Precise Electromagnetic Modulation.

By manipulating their asymmetric electronic spin states, the unique electronic structures and unsaturated coordination environments of single atoms can be effectively harnessed to control their magnetic properties. In this research, the first investigation is presented into the regulation of magnetic properties through the electronic spin states of single atoms. Magnetic single-atom one-dimensional materials, M-N-C/ZrO (M = Fe, Co, Ni), with varying electronic spin states, are design and synthesize based on the electronic orbital structure model.