Outcomes and risk factors for functional prognosis at 3 months after intravenous thrombolysis with r-tPA in patients with acute ischemic stroke: a retrospective cohort study.

Intravenous thrombolysis (IVT) with recombinant tissue plasminogen activator (rt-PA) is the preferred treatment for acute ischemic stroke (AIS). Nevertheless, only approximately half of patients undergoing IVT experience positive outcomes. The objective of the study was to examine the clinical characteristics of patients with AIS and identify predictors for unfavorable clinical outcomes at 3 months after IVT.

Intense Uptake of 68Ga-exendin-4 in a Patient With WHO Grade 3 Insulinoma and Extensive Intrahepatic Metastases.

A 24-year-old woman with hyperinsulinemic hypoglycemia was found with a pancreatic mass and multiple intrahepatic lesions in CT and MRI. 68Ga-exendin-4 PET/CT showed intense radioactivity in the pancreatic mass and all the intrahepatic lesions, suggesting a malignant insulinoma with multiple intrahepatic metastases. Subsequent fine needle biopsy confirmed the diagnosis of WHO grade 3 insulinoma.

Manganese-Driven Plasmid Nanofibers Formed for Cancer Gene Delivery and Metalloimmunotherapy.

While nucleic-acid-based cancer vaccines hold therapeutic potential, their limited immunogenicity remains a challenge due in part to the low efficiency of cytoplasmic delivery caused by lysosomal entrapment. In this work, we found that plasmids encoding both an antigen and a STING agonist protein adjuvant can self-assemble into coordination nanofibers, triggered by manganese ions. We developed a strategy to construct a DNA vaccine, termed MnO-OVA-CDA-mem, formed by the coencapsulation of manganese dioxide (MnO), an antigen-expressing plasmid (encoding ovalbumin, OVA), and an adjuvant enzyme-expressing plasmid (encoding STING agonist, CDA) within dendritic cell (DC) membranes.

Video based on the combination of animation and modules is effective in teaching suture technologies to novices without faculty involvement: a new surgical video course.

Background: While video-based instruction has been employed to teach a range of surgical skills, most videos rely on modular demonstrations, which restrict students' comprehension of human tissue structures and their control over intricate procedural details.

Methods: This study described the development, implementation, evaluation, and results of a novel video curriculum based on modular demonstrations combined with animated simulations. Participants were randomly assigned to three groups using a simple lottery-based randomization method, and the efficacy of this novel curriculum was established through pre-and post-teaching outcome analyses.

Integrated bulk RNA sequencing and mass cytometry analysis reveal the circulating immune landscape in ischemic and hemorrhagic Moyamoya disease.

Background: Moyamoya disease (MMD) is increasingly recognized as being influenced by chronic inflammation, with circulating immune cells playing a role in its progression. However, research on the immune characteristics of different MMD subtypes is limited. This study aims to compare the peripheral immune profiles of ischemic and hemorrhagic MMD patients.

Earth-Abundant WO Coupled with Minimal Pt for Enhanced Hydrogen Evolution under Dark and Visible Light Conditions.

The development of cost-effective and efficient electrocatalysts for the hydrogen evolution reaction (HER) is critical to advancing green hydrogen production technologies. Here, we present a plasmonic tungsten oxide (WO) material integrated with ultralow platinum (Pt) loadings (0.4, 0.

Enhancing cybersecurity through script development using machine and deep learning for advanced threat mitigation.

This scholarly paper explores the utilization of Machine Learning (ML) and Deep Learning (DL) methodologies to enhance the cybersecurity aspects of script development. Given the increasing panorama of threats in contemporary software creation, cybersecurity has ascended to a critical realm of concern. Traditional security measures frequently prove inadequate in countering complex breaches.

Giant Exchange Bias in Antiferromagnetic Mixed-Valence MOFs.

Regulating magnetism of a metal-organic framework (MOF) is highly desirable in magnetoelectric devices. Single-crystalline MOFs of [(CH)NH][FeFeCo(HCOO)] ( = 0, 0.2, 0.

PLD2 is a marker for MASLD-HCC with early-stage fibrosis: revealed by lipidomic and gene expression analysis.

Introduction: Metabolic steatotic liver disease (MASLD) can progress to hepatocellular carcinoma (HCC). 25% of MASLD-HCCs occur in the absence of fibrosis.

Objectives: This study aimed to explore lipid metabolic pathways through "omics" and to identify biomarkers of MASLD-HCC based on the degree of fibrosis.

AIE and ICT Synergistic Lysosome-Targeted Ratiometric Fluorescence Sensor for the Detection and Imaging of Th in the Liver of Zebrafish and Mice.

The sensitive detection of the radioactive thorium (Th) ion with an oxidation state of +4 (Th) is of great significance for environmental protection and life safety. In this study, five fluorescence sensors with regulated donor-acceptor (D-A) interactions were constructed for Th detection based on intramolecular charge transfer and aggregation-induced emission mechanisms. Among the developed sensors, bearing electron-deficient π-bridge and weak D-A interactions presented ratiometric fluorescence detection behavior toward Th in aqueous solution due to its aggregation-induced emission characteristics and unique D-A-D structures.

Unveiling the power of R: a comprehensive perspective for laboratory medicine data analysis.

R language has gained traction in laboratory medicine for its statistical power and dynamic tools like RMarkdown and RShiny. However, there is limited literature summarizing R packages and functions tailored for laboratory medicine, making it difficult for clinical laboratory workers to access these tools. Additionally, varying algorithms across R packages can lead to inconsistencies in published reports.

Ligand-Solvent Library Design for Tailoring Interparticle Interactions in Colloidal Nanocrystals.

This study explores the critical role of nonpolar ligand-solvent systems in modulating interparticle interactions in colloidal nanocrystals, profoundly affecting colloidal stability and enabling precision self-assembly. A library of 28 ligands with diverse molecular fragments─double bonds, branched chains, benzene rings, and naphthalene rings─and four solvents was developed to investigate how fragment types and positions affect ligand ordering and interparticle attraction. Explicit solvent simulations with enhanced sampling techniques reveal that fragments near the headgroup or midsection disrupt ligand ordering and weaken interparticle attraction, whereas terminal placement fosters ordered ligand packing and enhances attraction.

Enhancement of Impact Resistance and Shock Wave Protection in Strain Rate-Reinforced Leather Composite.

This work develops the Leather/SSG composite with a laminated structure that consists of flexible leather and rate-dependent shear stiffening gel (SSG), which exhibits superior impact resistance and shock wave protection performance. The SSG is tightly bound to the leather fiber network through hydrogen bonding interactions between the interfaces. Owing to the phase change energy absorption effect of SSG and the synergizing impact force dispersion along the disordered fibers, the Leather/SSG can effectively alleviate the impact force (52%) and shows high energy absorption (0.

A Facile Method for Preparing Fluorinated Poly(aryl ether)s Toward High-Frequency Low Dielectric Materials.

Two fluorinated monomers M1 and M2 based on pentafluorostyrene, are synthesized via an aromatic nucleophilic substitution reaction (SNAr) at room temperature, with high yields of up to 90%. Subsequently, M1 and M2 are converted to fluorinated poly(aryl ether)s through thermo-crosslinking. Among the two polymers, cured M2 possessing higher fluorine content, demonstrates superior overall performance with a 5% weight loss temperature (T) of 465 °C, a low water uptake of 0.

Sodium aescinate induces hepatotoxicity through apoptosis and ferroptosis by inhibiting the Nrf2/CTH pathway.

Ethnopharmacological Relevance: The seed of Aesculus wilsonii Rehd., also known as Suoluozi in China, is a traditional Chinese herb included in the Pharmacopoeia of China (2020). Sodium aescinate (SA) is derived from the Aesculus wilsonii Rehd.

Robust half-metallic properties in two-dimensional CuCr₂Se₂X₂ (X = Cl, Br, I).

In recent years, the rapid development of two-dimensional magnetic materials has revolutionized the field of spintronics, driven by their unique ability to combine magnetism and electronic functionality at the atomic scale. Here, we investigate the monolayer CuCr2Se2X2 (X = Cl, Br, I), which exhibit robust ferromagnetic (FM) behavior and half-metallicity with 100% spin polarization. The strong FM coupling, mediated by superexchange interactions, is rooted in the unique electronic structure of the Cr d-orbitals.

THE ASSOCIATION BETWEEN SHIFT WORK AND LIPID HEALTH IN CHINESE RAILWAY WORKERS: A LONGITUDINAL ANALYSIS OF 6 YEARS.

Objective: This study aimed to evaluate the longitudinal association between shift work and lipid health among railway workers.

Methods: Data from 1,126 railway workers with at least two physical examinations from 2016 to 2021 were retrieved. Records of triglycerides, total cholesterol, low-density and high-density lipoprotein cholesterol were extracted, with dyslipidemia defined by Chinese guidelines.

Facet-Selective Growth of Dots-on-Plate II-VI Heterostructures for Efficient Photocatalytic Hydrogen Evolution.

High-level control over the surface and interface of II-VI heterostructures is crucial for enhancing charge separation and optimizing active sites, thus improving photocatalytic performance. However, due to variations in surface energy and atomic arrangement among different crystal facets, achieving selective growth of specific facets remains a significant challenge. Herein, we have achieved the selective growth of CdSe or ZnSe dots on the lateral facets or basal facets of two-dimensional CdS or ZnS nanoplates by carefully selecting Se source precursors with different reaction activities.

Junction Field-Effect Transistors Based on MoSe/WSe Heterostructures for High-Performance Photodetection.

Two-dimensional (2D) materials show great potential in creating high-performance ultracompact photodetectors. Existing 2D photodetectors are usually designed based on a photogating effect or photovoltaic effect. However, achieving a balance between photodetectivity and photoresponsivity presents a significant challenge due to increased dark currents at trap level recombination or the lack of a gain mechanism.

Strong but Reversible Super Fatty Acid Adhesives with Adjustable On-Off Temperature.

Reversible adhesion is highly desired for intelligent engineering, reassembling devices, and recycling resources. However, many reported reversible adhesives require solvent or pH stimuli to achieve adversity switches, which are very inconvenient for practical applications. So far, thermally responsive adhesives are reported to be very appealing in achieving facile reversible adhesion.

Color correction methods for underwater image enhancement: A systematic literature review.

Underwater vision is essential in numerous applications, such as marine resource surveying, autonomous navigation, objective detection, and target monitoring. However, raw underwater images often suffer from significant color deviations due to light attenuation, presenting challenges for practical use. This systematic literature review examines the latest advancements in color correction methods for underwater image enhancement.

Comparative effectiveness of different surgical timings on neurological outcomes for cranioplasty: Protocol for a prospective non-randomized controlled trial.

Background: Cranioplasty (CP), a surgical procedure that restores cranial integrity and potentially enhances neurological outcomes, is commonly performed following decompressive craniectomy for various reasons. However, there is considerable controversy and variation regarding the optimal timing for cranioplasty, particularly concerning its impact on neurological functional outcomes. This paper outlines the protocol for a multicenter, non-randomized controlled trial designed to investigate whether the timing of cranioplasty influences neurological outcomes.

Molybdenum-Catalyzed Asymmetric Amination of α-Hydroxy Esters: Synthesis of α-Amino Acids.

Unnatural α-amino acids are found in a wide variety of bioactive compounds ranging from proteins to pharmaceutical agents to materials science. As a result, the investigation of efficient and simple methods for their synthesis is a major purpose in reaction development. In this study, it is found that a catalyst based on molybdenum, an earth-abundant transition metal, can facilitate the amination of readily accessible α-hydroxy esters to afford N-protected unnatural α-amino acid esters in high yield.

Schistosomiasis trends and control efforts: a global perspective from 1990 to 2050.

Background: Schistosomiasis is a chronic parasitic disease primarily endemic to tropical and subtropical regions, posing significant challenges to public health and economic development. Despite progress in global control efforts, the disease continues to be a major public health concern in high-burden countries such as China, Brazil, and Nigeria. This study seeks to assess the effectiveness of schistosomiasis control measures in these countries and on a global scale.