Primary gingival diffuse large B‑cell lymphoma with muscle invasion: A case report.

Primary gingival diffuse large B-cell lymphoma (DLBCL) with muscle invasion is rare and accounts for ~0.5% of all reported cases of extranodal lymphoma. The present study describes the case of a 49-year-old man that initially presented at Yingshan County People's Hospital (Nanchong, China) in August 2017 with a chief complaint of tenderness and swelling of the jaw.

Timing of thoracic radiotherapy combined with immunotherapy influences pulmonary injury.

The present study aimed to assess the impact of chest radiotherapy combined with immunotherapy at different time points in lung injury. This retrospective study analyzed 35 patients with thoracic tumors (29 lung cancer cases and 6 esophageal cancer cases) who received radiotherapy combined with immunotherapy between January 2021 and December 2023 at at Capital Medical University, affiliated with Beijing Luhe Hospital (Beijing, China), with a median follow-up time of 21 months. Patients were divided into two groups: Group A (sequential, n=17), who received immunotherapy 2 weeks to 6 months before or after radiotherapy, and group B (synchronous, n=18), who received immunotherapy within 2 weeks before or after radiotherapy.

Pembrolizumab as an effective treatment for diffuse malignant peritoneal mesothelioma with long‑term survival: A case report and literature review.

Primary diffuse malignant peritoneal mesothelioma (MPEM) is a malignant disease without standard treatments recommended. Recently, immunotherapy has revolutionized the field of tumor therapy. According to current clinical evidence, advanced MPEM may gain potential clinical benefits from immune checkpoint inhibitors.

Carfilzomib inhibits the progression of hepatocellular cancer by upregulating GADD45α expression.

Hepatocellular carcinoma (HCC) ranks among the most prevalent and lethal cancers affecting humans. Currently, there are limited effective treatments available for HCC. Carfilzomib, a proteasome inhibitor, is known to exert anti-HCC activities; however, its underlying mechanisms of action remain unclear.

Effects of circulating RNAs on tumor metabolism in lung cancer (Review).

During the development and progression of lung cancer, cell metabolism function is altered. Thus, cells rely on aerobic glycolysis and abnormal lipid and amino acid metabolism to obtain energy and nutrients for growth, proliferation and drug resistance. Circular RNAs (circRNAs), a class of non-coding RNAs, serve important biological roles in the growth and development of tumors.

Clinical characteristics and survival analysis of cancer of unknown primary.

Cancer of unknown primary (CUP) is a diagnosis that the primary lesion cannot be confirmed by a series of imaging, endoscopic and pathological examinations. The present study aimed to assess the clinical characteristics and survival outcomes of patients with CUP. The present retrospective observational study included patients diagnosed with malignancies confirmed as CUP using histopathology at the Oncology Department of the Fourth Hospital of Hebei Medical University (Shijiazhuang, China) from January 2009 to January 2021.

Rare multiple schwannomas of the left upper extremity: A case report.

Schwannomas are rare benign neoplasms originating from Schwann cells of peripheral nerve sheaths. The current study presents a distinctive case involving multiple schwannomas along the peripheral nerves of the left upper extremity. The patient exhibited multiple gradually enlarging subcutaneous masses distributed along the nerves of the left upper limb, without pain, neurological deficits or a positive Tinel's sign upon physical examination.

Bacterial metabolites: Effects on the development of breast cancer and therapeutic efficacy (Review).

Evidence suggests that various gut metabolites significantly impact breast cancer (BC) and its treatment. However, the underlying mechanisms remain poorly understood and require further investigation. In the present study, the current literature was reviewed to evaluate the roles of microbial metabolites in the development of BC and its response to treatment.

SNS‑032 combined with decitabine induces caspase‑3/gasdermin E‑dependent pyroptosis in breast cancer cells.

SNS-032 is a synthetic compound that specifically inhibits cyclin-dependent kinases 2, 7 and 9. Its primary anticancer activity involves cell cycle arrest, which prevents tumor cell growth. However, there are limited reports on whether SNS-032 induces pyroptosis, a novel inflammation-mediated programmed cell death pathway in breast cancer (BC).

Glycyrrhizin enhances the antitumor activity of cisplatin in non‑small cell lung cancer cells by influencing DNA damage and apoptosis.

The objective of the present study was to elucidate the mechanism by which glycyrrhizin enhances the antitumor activity of cisplatin in non-small cell lung cancer. Initially, A549 cells were treated with different concentrations of glycyrrhizin (0.25-8 mM) or cisplatin (10-160 µM) for 48 h to investigate the effect of glycyrrhizin combined with cisplatin on A549 cells .

A bacteria-based bioorthogonal platform disrupts the flexible lipid homeostasis for potent metabolic therapy.

Cancer cells exhibit altered metabolism and energetics, prominently reprogramming lipid metabolism to support tumor growth and progression, making it a promising target for cancer therapy. However, traditional genetic and pharmaceutical approaches for disrupting lipid metabolism face challenges due to the adaptability of tumor metabolism and potential side effects on normal tissues. Here, we present a bacteria-based bioorthogonal platform combining transition metal catalysts and to disrupt the flexible lipid homeostasis in tumors.

Dissecting ionic favorable hydrogen bond chemistry in hybrid separators for aqueous zinc-ion batteries.

Separators, regulating the ion transport channels between electrodes, are crucial for maintaining the properties of electrochemical batteries. However, sluggish ion transport and desolvation kinetics in aqueous zinc-ion batteries (AZIBs) cause uneven ion flux at the separator-electrode interface, accelerating Zn dendrite growth. Herein, we systematically dissect ionic favorable hydrogen bond chemistry in a hybrid separator engineered through rational boron nitride (BN) doping into polyacrylonitrile (PAN) separators.

Palladium-catalyzed carbon-carbon bond cleavage of primary alcohols: decarbonylative coupling of acetylenic aldehydes with haloarenes.

In the current work, a palladium-catalyzed C-C bond cleavage reaction of primary alcohols has been developed. This transformation was characterized by a broad substrate scope, superior functional group tolerance, and high efficiency for selective C-C bond cleavage and was then followed by alkynyl-aryl cross coupling. Mechanism studies indicated that the propargyl alcohols underwent β-H elimination to form aldehydes rather than having undergone β-C elimination.

Facile preparation of fluorescent carbon dots from water caltrop shells and their application in amikacin sensing.

Amikacin (AMK) effectively treats infections from Gram-negative bacilli and penicillin-resistant . However, prolonged administration of AMK may result in adverse effects such as nausea, headache, ototoxicity, and hearing loss, necessitating a reliable detection method. Carbon dots (CDs), known for their excellent optical properties, are a promising fluorescent probe.

Efficient total synthesis of dehydro--viniferin through metal-halogen exchange cyclization.

Bioactive dehydro--viniferin was synthesized through an efficient and practical eight-step route, achieving an overall yield of 27%. The synthesis process involves an intramolecular cyclization and dehalogenation a metal-halogen exchange, producing 3-arylbenzofuran, with the di-iodinated -aryloxyketone serving as the key intermediate. Long reaction times and the use of excess reagent -PrMgCl·LiCl facilitate metal-halogen exchange cyclization and dehalogenation.

Chinese Medicine for the Treatment of Liver Cirrhosis: The Mechanism of Cellular Autophagy.

Liver cirrhosis is a critical stage in the progression of various chronic liver diseases, often leading to severe complications such as ascites, hepatic encephalopathy, and a high mortality rate, and it thus poses a serious threat to patient life. The activation of hepatic stellate cells is a central driver of disease progression. Cellular autophagy, a lysosome-mediated degradation process, plays a key role in maintaining cellular function and dynamic homeostasis.

Coverage of surfactants on polyoxometalate tunes the selectivity of alkene epoxidation.

Self-assembled nanosheets were formed through the interaction between polyoxometalate (POM) and dodecyltrimethylammonium bromide (DTB), which has hydrophilic groups at both ends of the carbon chain and serves as a "bridge" connecting the POMs. The resulting POM assemblies demonstrated high efficiency in the epoxidation of cyclohexene, with the selectivity of the reaction being tunable by adjusting the coverage of DTB on the POM.

Copper-catalyzed chemoselective C-H functionalization/dearomatization sequence: direct access to indole-based spirocyclic scaffolds.

Herein, a copper-catalyzed intermolecular [4+1] spiroannulation of indoles with alkynyldiazoketones affording various indole-based spirocyclic molecules a chemoselective C-H functionalization/dearomatization sequence was developed.

Portable and Self-Powered Sensing AI-Enabled Mask for Emotional Recognition in Virtual Reality.

With the increasing development of metaverse and human-computer interaction (HMI) technologies, artificial intelligence (AI) applications in virtual reality (VR) environments are receiving significant attention. This study presents a self-sensing facial recognition mask (FRM) utilizing triboelectric nanogenerators (TENG) and machine learning algorithms to enhance user immersion and interaction. Various TENG negative electrode materials are evaluated to improve sensor performance, and the efficacy of a single sensor is confirmed.

Efficient synthesis of Au(SR) nanoclusters the cluster-from-cluster approach.

Monodisperse gold nanoclusters constitute a new branch of nanomaterials with atomically precise molecular structures. Recently, we developed a "cluster-from-cluster" approach to assemble gold nanoclusters [Au(SR)] (Au25) atomically precise Au13 precursors. Herein we demonstrated that efficient synthesis of Au(SR) (Au36) nanoclusters can be realized this facile approach.

Strain-Modulated Deposition Mechanism on a Flexible Zinc Anode.

Flexible aqueous zinc-ion batteries (AZIBs) are considered one of the most attractive flexible devices owing to their high theoretical capacity, low cost, and high security. However, the formation of Zn dendrites and the poor flexibility of the Zn material greatly impede the application of wearable AZIBs. Herein, by transferring graphene onto the surface of polyethylene terephthalate-indium tin oxide (PET-ITO-G), a substrate combining excellent flexibility and dendrite suppression ability was prepared.

Switchable Multi-Spectral Electromagnetic Defense in the Ultraviolet, Visible, Infrared, Gigahertz, and Terahertz Bands Using a Magnetically-Controllable Soft Actuator.

Traditional passive single-spectrum electromagnetic defense materials are inadequate to defend against complex multispectral electromagnetic threats. Herein, a bilayer heterofilm (BLH film)-based magnetically controllable soft actuator (MCSA), comprising a defense unit and a drive unit, is constructed. The defense unit offers multispectral electromagnetic protection, while the drive unit enables active defense via magnetic actuation.

MOF-Based Electrocatalysts: An Overview from the Perspective of Structural Design.

The electrocatalytic technique, as an efficient energy storage and conversion technology, has attracted significant attention to address energy exhaustion and environmental pollution. Usually, the activity and selectivity of electrocatalytic reactions are largely dominated by the dynamic process occurring on electrocatalysts. Therefore, high-performance electrocatalysts, which can dominate the pathway and energy barrier of reactions, are of great significance for the advancement of the electrocatalytic technique.

One neuroprotective lignanamide from Solanum Septemlobum Thunb.

The whole plant of Thunb., called Shu Yangquan in traditional Chinese medicine, has the traditional function of clearing away heat and toxic material. Chemical investigation on the ethanol extract of afforded a new lignanamide () and a known compound caffeic acid ethyl ester ().

Danuglipron Ameliorates Pressure Overload-Induced Cardiac Remodelling Through the AMPK Pathway.

Cardiac remodelling, a pathological process induced by various cardiovascular diseases, remains a significant challenge in clinical practice. Here, we investigate the potential of Danuglipron (PF-06882961, PF), a novel oral glucagon-like peptide-1 (GLP-1) receptor agonist, in alleviating pressure overload (PO)-induced cardiac hypertrophy and fibrosis. Using both in vivo and in vitro models, we demonstrate that PF treatment (1 mg/kg/day, orally for 8 weeks) significantly attenuates aortic banding-induced cardiac dysfunction and pathological remodelling in mice.