USP5 Deletion Inhibits KD Serum Induced-Human Coronary Artery Endothelial Cell Dysfunction by Regulating the NFATC1/TLR4-Mediated NF-κB Signaling Pathway in Kawasaki Disease.

Kawasaki disease (KD) is an acute febrile illness characterized by systemic vasculitis, especially in coronary arteries. Previous studies have indicated that nuclear factor of activated T cells, cytoplasmic 1 (NFATC1, also known as NFAT2) plays a crucial role in the pathogenesis of KD. However, the molecular mechanism of NFATC1 involved in KD is poorly defined.

GCMS, phytochemical analysis, biological potential of dichloromethane extract of regel roots: and studies.

tThe present research verified the presence of important phytochemicals in the dichloromethane extract of Regel roots through qualitative screening, GC-MS analysis, and evaluation of antioxidant and anti-inflammatory potential. Phytochemical analysis confirmed flavonoids, phenols, saponins, and tannins. GC-MS detected 41 components, including benzaldehyde 2,4-dinitrophenyl hydrazone (100%), heptanoic acid docosyl ester (83.

Corilagin enhances wound healing by modulating the macrophage phenotype in diabetic mice.

Excessive inflammation is a prominent issue in diabetic wounds, leading to delayed healing or amputation. Corilagin (Cori) is a natural polyphenolic compound with diverse pharmacological activities, particularly its anti-inflammatory properties. The aim of this study was to evaluate the anti-inflammatory effect of Cori on diabetic wounds and to explore the potential underlying mechanisms.

Cu-Catalyzed Synthesis of Symmetric Diarylamines from Organoboronic Acids Using NaNO as the Amino Source.

A copper-catalyzed novel synthesis of symmetric diarylamines was achieved from aryl boronic acids and NaNO. This protocol employs aryl boronic acids as the commercially available arylation reagents and sodium nitrite (NaNO) as the cheap, stable, and solid amino source. Under a simple ligand- and base-free copper catalytic system (CuCl as the sole catalyst), a wide range of symmetric diarylamines could be obtained in moderate to good yields.

Two-Dimensional Covalent Organic Frameworks in Organic Electronics.

Two-dimensional covalent organic frameworks (2DCOFs) are a unique class of crystalline porous materials interconnected by covalent bonds, which have attracted significant attention in recent years due to their chemical and structural diversity, as well as their applications in adsorption, separation, catalysis, and drug delivery. However, research on the electrical properties of 2DCOFs remains limited, despite their potential in organic electronics. Early studies recognized the poor electrical conductivity of 2DCOFs as a significant obstacle to their application in this field.

La(OTf)-Catalyzed Benzannulation of 2-Arylidene-1-indene-1,3(2)-diones with Enamino Esters: Direct Access to Functionalized Fluorenone Derivatives.

An attractive method for the preparation of functional fluorenone derivatives has been developed via La(OTf)-catalyzed benzannulation of 2-arylidene-1-indene-1,3(2)-diones with enamino esters. The reaction involves Michael addition, intramolecular cyclization, dehydration, and aromatization in a one-step process and affords a wide range of functional fluorenone derivatives in moderate to good yields. Moreover, this protocol provides several advantages, including broad substrate scope, readily available materials, high atom economy, and applicability for large-scale synthesis.

Fabrication of Biomimetic Protocells via Interfacial Assembly of Protein-Lipid Nanoconjugates.

The construction of functional, synthetic microcompartments is crucial for advancing our understanding of cellular processes and enhancing technological applications across various fields. This study introduces the creation of lipoproteinosomes, which are microscale compartments constructed from bovine serum albumin and stearoyl chloride (BSA-SC) nanoconjugates synthesized by employing thiourea-linkage chemistry. These spherical lipoproteinsomal microcapsules are formed through a water-in-oil Pickering emulsification process and stabilized in aqueous environments by cross-linking.

A facile approach for synthesizing nitrogen-doped carbon supported circular trough-shaped FeCo alloy for the oxygen reduction reaction.

A nitrogen-doped carbon-supported circular trough-shaped FeCo alloy-based electrocatalyst (FeCo/NC) was synthesized by a simple-to-accomplish method. The unique alloy structure and rich Fe/Co-N-based active sites constructed during the pyrolysis process endowed FeCo/NC with comparable electrocatalytic ORR activity in both a three-electrode system and Zn-air batteries to that of previously reported FeCo alloy-based catalysts.

Synthesis of α-N-Heteroaryl Ketones by Nickel-Catalyzed Chemo-, Regio- and Enantioselective Carbonylation of Alkenes and N-Alkenyl Heteroarenes.

Enantioenriched α-aminoketones serve as important substructures in life science and precursors for the synthesis of diverse value-added targets in organic and biochemistry. However, direct access to enantioenriched α-aminoketones from simple and readily available starting materials remains a formidable challenge. Herein, we report an unprecedented nickel-catalyzed asymmetric cross-coupling protocol for the synthesis of enantioenriched α-N-heteroaryl ketones from alkenes and enamines in the presence of a carbon monoxide surrogate.

A Universal Strategy for Reversible and Spatiotemporal Electrofluorochromism of Eu Metallogels Driven by Cooperative Chemical Reactions with Biomimetic Information "Memorizing-forgetting" Behavior.

Taking inspiration from the dynamic memory of the human brain, which has the ability to spontaneously forget unimportant information, a universal and straightforward method for creating spatiotemporally regulated hydrogels with electrofluorochromic characteristics that exhibit information "memorizing-forgetting" behavior is presented. The dynamic and reversible electrofluorochromism from blue to red  in Eu-based hydrogels is achieved by rapid changes in fluorescence triggered by electricity, coupled with the gradual disappearance of fluorescence associated with the mass diffusion ability of the hydrogel. This process involves the generation of H from an acidic aqueous solution under electricity, resulting in the conversion of β-diketone derivatives from keto to enol forms and the disruption of hydrogen bonds between ─COOH of polyacrylic acid (PAA) and N of pyridine groups.

Electrodeposited P-Doped CuNi Alloy from Deep Eutectic Solvent for Efficient and Selective Nitrate-to-Ammonia Electroreduction.

Electrochemical nitrate reduction reaction (NORR) offers a promising alternative for ammonia production using electricity generated from renewable energy sources. Active electrocatalysts with high selectivity and high yield are required to selectively catalyze NORR to ammonia. Here, P-doped CuNi alloy thin films are electrodeposited from a deep eutectic solvent of choline chloride-ethylene glycol (ChCl/EG).

Stress-Driven Grain Boundary Structural Transition in Diamond by Machine Learning Potential.

Understanding the structural dynamics of carbon grain boundaries, particularly in diamond, is essential for advancing next-generation device applications. Carbon's diverse allotropes, driven by its versatile chemical bonding, hold immense potential, yet analyzing these boundaries is challenging due to the limitations of experimental techniques and the computational demands of ab initio molecular dynamics simulations. In this study, a machine learning-based molecular dynamics potential, rigorously trained on ab initio data, that accurately predicts structural transitions in incoherent twin boundaries within diamond is introduced.

[Corrigendum] MCMV triggers ROS/NLRP3‑associated inflammasome activation in the inner ear of mice and cultured spiral ganglion neurons, contributing to sensorineural hearing loss.

Subsequently to the publication of this article, the authors have contacted the Editorial Office to inform us that Fig. 6 on p. 3454 was inadvertently assembled incorrectly; essentially, the wrong immunofluorescence data were featured for the 'Control' experiment in Fig.

Osteoking exerts pro‑osteogenic and anti‑adipogenic effects in promoting bone fracture healing via EGF/EGFR/HDAC1/Wnt/β‑catenin signaling.

Bone fractures, as a global public health issue, lead to disability and reduce the quality of life for patients. Chinese patent drug Osteoking has efficacy in bone fracture therapy. However, its therapeutic properties and underlying mechanisms remain unclear.

[Retracted] IQGAP1 plays an important role in the cell proliferation of multiple myeloma via the MAP kinase (ERK) pathway.

Following the publication of the above paper, a concerned reader drew to the Editor's attention that certain discrete western blot data shown in the RT‑qPCR blots in Figs. 1A and 2A, and western blot data in Fig. 5 were strikingly similar to data that had already appeared in previously published papers in different journals written by different authors at different research institutes.

MTHFD2 promotes esophageal squamous cell carcinoma progression via m6A modification‑mediated upregulation and modulation of the PEBP1‑RAF1 interaction.

One‑carbon metabolism plays an important role in cancer progression. Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2), a mitochondrial enzyme in one‑carbon metabolism, is dysregulated in several cancer types. However, the precise role and mechanisms of MTHFD2 in esophageal squamous cell carcinoma (ESCC) remain unclear.

Inhibitors of the ubiquitin‑proteasome system rescue cellular levels and ion transport function of pathogenic pendrin (SLC26A4) protein variants.

Pendrin (SLC26A4) is an anion exchanger abundantly expressed in the inner ear, kidney and thyroid, and its malfunction resulting from genetic mutation leads to Pendred syndrome and non‑syndromic deafness DFNB4. Pathogenic variants of the pendrin protein are less expressed than the wild‑type, but the mechanism underlying this phenomenon is unknown. In the present study, the hypothesis that reduced protein expression stems from increased protein degradation was explored.

Oxidative stress in endometriosis: Sources, mechanisms and therapeutic potential of antioxidants (Review).

Endometriosis affects ~15% of women of reproductive age worldwide, impacting ~190 million individuals. Despite its high prevalence, the precise pathogenesis of endometriosis remains unclear. Emerging evidence has highlighted oxidative stress as a pivotal factor in the initiation and progression of this disease.

Role of lysine lactylation in neoplastic and inflammatory pulmonary diseases (Review).

Protein lysine lactylation is a ubiquitous and post‑translational modification of lysine residues that involves the addition of a lactyl group on both histone and non‑histone proteins. This process plays a pivotal role in human health and disease and was first discovered in 2019. This epigenetic modification regulates gene transcription from chromatin or directly influences non‑histone proteins by modulating protein‑DNA/protein interactions, activity and stability.

Pan‑cancer analysis of oncogene SFXN1 to identify its prognostic and immunological roles in lung adenocarcinoma.

As cancer incidence and mortality rates continue to rise, the urgency for research in this field has increased globally. Sideroflexin 1 (SFXN1), a pivotal member of the SFXN protein family, serves a crucial role in transporting serine to mitochondria and participates in one‑carbon metabolism, thereby influencing cell proliferation and differentiation. While SFXN1 is linked to lung cancer and glioma, its role in other malignancies remains largely unexplored.

[Retracted] Genotoxicity of chloroacetamide herbicides and their metabolites and .

Following the publication of the above paper, it was drawn to the Editor's attention by a concerned reader that certain of the JNK and phosphorylated (pho)‑JNK western blotting data shown in Fig. 8 on p. 7 were strikingly similar to data featured in a pair of other articles written by different authors at different research institutes, one of which (submitted to the journal ) has been subsequently retracted, whereas the other (submitted to the journal Renal Failure) was received at that journal prior to the receipt of the above article at International Journal of Molecular Medicine.

Tunable Integrin-Ligand Coupling Strength Modulates Cellular Adaptive Mechanosensing.

Cells sense and respond to the matrix by exerting traction force through binding of integrins to an integrin-specific ligand. Here, Arg-Gly-Asp (RGD) peptide is covalently conjugated to the double-stranded DNA (dsDNA) and stem-loop DNA (slDNA) tethers with a tension tolerance of 43pN and immobilized on a PEG substrate. Unlike dsDNA, which is ruptured under high tension, leading to the removal of RGD, slDNA remains bound even when ruptured.

Role of GLP‑1 receptor agonists in sepsis and their therapeutic potential in sepsis‑induced muscle atrophy (Review).

Sepsis‑induced myopathy (SIM) is a common complication in intensive care units, which is often associated with adverse outcomes, primarily manifested as skeletal muscle weakness and atrophy. Currently, the management of SIM focuses on prevention strategies, as effective therapeutic options remain elusive. Glucagon‑like peptide‑1 (GLP‑1) receptor agonists (GLP‑1RAs) have garnered attention as hypoglycemic and weight‑loss agents, with an increasing body of research focusing on the extrapancreatic effects of GLP‑1.

N‑methyladenosine reader YTHDF2‑mediated AC026691.1 degradation promotes gastric cancer cell proliferation, migration and M2 macrophage polarization.

The present study aimed to explore the effects of key N6‑methyladenosine (m6A)‑related long non‑coding RNAs (lncRNAs) on the malignant behavior and macrophage polarization of gastric cancer cells, and their preliminary mechanisms. Gastric cancer‑related lncRNA datasets were downloaded from The Cancer Genome Atlas database, and m6A‑related differentially expressed lncRNAs (DElncRNAs) were analyzed. Subsequently, Cox regression and lasso regression analyses were used to screen the m6A‑related DElncRNAs associated with the prognosis of patients with gastric cancer.

Multimodal Metagenomic Analysis Reveals Microbial InDels as Superior Biomarkers for Pediatric Crohn's Disease.

Background And Aims: The gut microbiome is closely associated with pediatric Crohn's disease (CD), while the multidimensional microbial signature and their capabilities for distinguishing pediatric CD are underexplored. This study aims to characterize the microbial alterations in pediatric CD and develop a robust classification model.

Methods: A total of 1,175 fecal metagenomic sequencing samples, predominantly from three cohorts of pediatric CD patients, were re-analyzed from raw sequencing data using uniform process pipelines to obtain multidimensional microbial alterations in pediatric CD, including taxonomic profiles, functional profiles, and multi-type genetic variants.