Diastereoselective Double Annulation of Allenoates with Povarov Adducts: Modular Synthesis of Multisubstituted Pyrroloquinolines.

Herein, we report an atom-economical, one-pot, four-component, diastereoselective double-annulation reaction to construct polyfused pyrroloquinolines. This reaction highlights the cyclization of in situformed Povarov adducts with allenoates for the first time.

Cloning and expression profiling of peptide YY in the brain of common carp, Cyprinus carpio.

Peptide YY (PYY) is an anorectic brain-gut pancreatic peptide that helps in feeding regulation by reducing appetite and is well characterized in mammals. The role of PYY in relation to brain is least studied in mammals as well as in lower vertebrates including fish, however high expression was evident in male reproductive tissue. In this regard, this study attempts to evaluate the significance of PYY in the brain of common carp, Cyprinus carpio.

Synergy of {Co(HO)} with a Polyoxometalate Leads to Aqueous Homogeneous Hydrogen Evolution: Experiments and Computations.

In this work, we have described a polyoxometalate (POM)-based inexpensive and easily synthesizable compound [Co(HO)][{K(HO)}VO]·2HO (), which exhibits electrocatalytic hydrogen evolution in its aqueous solution without its decomposition (or electrodeposition), acting as a rare homogeneous electrocatalyst. Even though the compound [Co(HO)][{K(HO)}VO]·2HO () (soluble in water) shows electrocatalytic hydrogen evolution reaction (HER) activity because of the Coulombic attraction, including H-bonding interactions, between the [Co(HO)] cationic species and [{K(HO)}VO]anionic species, the individual homogeneous solutions of [VO] (source: Na[VO]·18HO) and [Co(HO)] (source: CoCl·6HO) do not show any electrocatalytic HER activity. We have thus established that the synergy of [VO] with [Co(HO)] in crystal matrix as well as in the aqueous solution of makes the compound a stable and highly active electrocatalyst for homogeneous HER in an aqueous solution.

Mechanochemical Cascade Cyclization of Cyclopropyl Ketones with 1,2-Diamino Arenes for the Direct Synthesis of 1,2-Disubstituted Benzimidazoles†.

A mechanochemical synthesis of 1,2-disubstituted benzimidazoles from donor-acceptor cyclopropyl ketones and 1,2-diaminoarenes under metal-free and solventless conditions is reported. The reaction does not require inert conditions and is promoted by a stoichiometric amount of 1,1,1,3,3,3-hexafluoroisopropanol. This cascade reaction involves ring-opening, cyclization, and retro-Mannich reaction of cyclopropyl ketones with aryl 1,2-diamines.

Genomic and functional insights of a mucin foraging Rhodopirellula halodulae sp. nov.

Nine novel strains were obtained from various algal and seagrass samples. The analysis of the 16S rRNA gene-based phylogenetic tree revealed monophyletic placement of all novel strains within the Rhodopirellula genus. The type strain was identified as JC737, which shared 99.

Mechanochemical Regioselective [3+3] Annulation of 6-Amino Uracil with Propargyl Alcohols Catalyzed by a Brønsted Acid/Hexafluoroisopropanol.

A mechanochemistry approach is developed for regioselective synthesis of functionalized dihydropyrido[2,3-d]pyrimidines by milling propargylic alcohols and 6-aminouracils with HFIP/p-TsOH. In the case of tert-propargyl alcohols, this [3+3] cascade annulation proceeded through allenylation of uracil followed by a 6-endo trig cyclization. With sec-propargyl alcohols, the reaction furnished the propargylation of uracil.

Intercalating a potassium-aqua complex cation into an α-MoO layer without reducing molybdenum: a potential storage system.

We have demonstrated a green aqueous synthesis of rod-shaped MoO material, [MoO{K(HO)}(CHCOO)]·HO (2) intercalating potassium-aqua-complex acetate into its lamellar space, simply by ion-exchange of Co(II)-aqua-complex in compound [MoO(CHCOO){Co(HO)}]·2HO (1) by {K(HO)} in an aqueous solution of 1 and KCl. Compound 2 acts as a potential storage system of alkali metal ions.

Phylogenomic analysis of metagenome-assembled genomes indicates new taxa in the order Spirochaetales and proposal of Thalassospirochaeta sargassi gen. nov. sp. nov. from seaweeds.

Six metagenome-assembled genomes (JB008, JB007, JB015, JB003, JB004, and JB002) belonging to the order Spirochaetales were generated from seaweed samples collected from the Gulf of Mannar, India. The binned genomes JB008 and JB007 shared highest 16S rRNA gene identity of 94.9 % and 92.

, a Novel Planctomycete Isolated from an Algal Mat, Displays Antimicrobial Activity.

Axenic cultures of two strains, JC673 and JC717, both belonging to the phylum , were isolated from distinct geographical locations in India. Strain JC673 was obtained from algal mats of a wetland situated in the state of Kerala, India, while strain JC717 originated from the Central Marine Fisheries Research Institute (CMFRI), state of Tamil Nadu, India. The two strains share 99.

Cu-Catalyzed Oxidative C(sp)-H Cycloetherification of -Alkenyl Arenols for the Preparation of Fused Furans.

A practically efficient, copper-catalyzed approach for the synthesis of functionally embellished indeno-naphthofurans is developed from 1-(1-inden-3-yl)naphthalen-2-ols. This intramolecular cycloetherification proceeds via C(sp)-H oxygenation (C-H bond breaking and C-O bond forming), which enables the atom-economical synthesis of poly fused furans in high yields with large substrate diversity in the open air.

Calcium-Catalyzed Synthesis of Fused Furo[2,3-]furans and Substituted Furans from 2-Oxo Aldehydes and Cyclic Enols.

We report here an atom-economical, -diastereoselective synthesis of naphtho-fused furo[2,3-]furans along with naphthofurans at room temperature using readily available 2-naphthols and 2-oxo aldehydes using an alkaline earth catalyst [Ca(OTf)]. 2-Oxo aldehydes having both aryl and alkyl substitutions reacted well. A good number of arenols responded to give fused furans, but selected arenols gave only furofurans.

Electrocatalytic Hydrogen Evolution by a Uranium(VI) Polyoxometalate: an Environmental Toxin for Sustainable Energy Generation.

The uranyl ion (UO), a uranium nuclear waste, is one of the serious contaminants in our ecosystem because of its radioactivity, relevant human activities, and highly mobile and complex nature of living cells. In this article, we have reported the synthesis and structural characterization of an uranyl cation-incorporated polyoxometalate (POM) compound, K[{K(HO)}{UO}(α-PWO)]·13HO (), in which the uranyl cations are complexed with an in situ generated [α-PWO] cluster. Single-crystal X-ray diffraction (SCXRD) analysis of compound reveals that the uranyl-potassium complex cationic species, [{K(HO)}{UO}], is sandwiched by two [α-PWO] clusters resulting in a Dawson type of POM.

Sinomonas cellulolyticus sp. nov., isolated from Loktak lake.

A novel cellulolytic strain JC656 was isolated from the rhizosphere soil of Alisma plantago-aquatica of floating island (Phumdis) of Loktak lake, Manipur, India. The 16S rRNA gene sequence similarities between strain JC656 and other Sinomonas type strains ranged between 98.5 and 97.

Hydroxylated Polyoxometalate with Cu(II)- and Cu(I)-Aqua Complexes: A Bifunctional Catalyst for Electrocatalytic Water Splitting at Neutral pH.

A sole inorganic framework material [Li(HO)][{Cu(HO)} {Cu(HO)}{WO(OH)}]·N·HS·3HO () consisting of a hydroxylated polyoxometalate (POM) anion, {WO(OH)}, a mixed-valent Cu(II)- and Cu(I)-aqua cationic complex species, [{Cu(HO)}{Cu(HO)}], a Li(I)-aqua complex cation, and three solvent molecules, has been synthesized and structurally characterized. During its synthesis, the POM cluster anion gets functionalized with six hydroxyl groups, i.e.

In silico analysis of sporulene biosynthesis pathway genes in the members of the class Bacilli.

Sporulene, a pentacyclic triterpenoid, was discovered in Bacillus subtilis and is associated with bacterial endospores. However, the study was not further extended, leaving a trail of questions. One such question is what diversity of sporulenes exists among spore-forming members? Considering the sporulene biosynthesis pathway as a fundamental tool to survey the distribution of this molecule, a genome mining study was conducted.

Divergent Cyclizative Approaches of In Situ Formed β-Keto-Allenes: Chemo- and Regioselective Synthesis of Bicyclic Furans, and Pyrroles.

A unified strategy for the construction of bicyclic furans and pyrroles is developed from -propargyl alcohols and α-acyl cyclic ketones using an alkaline earth catalyst under solvent-free conditions. The reaction proceeds via the formation of a β-keto allene intermediate, which upon treatment with a -amine underwent thermodynamic enol formation and a subsequent annulation to form bicyclic furans. Interestingly, the same allene forms bicyclic pyrrole with primary amines.

Genome analysis revealed a repertoire of oligosaccharide utilizing CAZymes in CCK931 and YRK005.

Unlabelled: bacteria are gram-positive, anaerobic, fermentative, and have probiotic potential. This study aimed to compare the genomes of YRK005 and CCK931 isolated from young radish and kimchi, respectively. The genomic size of YRK005 and CCK931 with GC content is 2.

Blastopirellula sediminis sp. nov. a new member of Pirellulaceae isolated from the Andaman and Nicobar Islands.

Two cream-coloured strains (JC732, JC733) of Gram-stain negative, mesophilic, catalase and oxidase positive, aerobic bacteria which divide by budding, form crateriform structures, and cell aggregates were isolated from marine habitats of Andaman and Nicobar Islands, India. Both strains had genome size of 7.1 Mb and G + C content of 58.

Phylogenomic analysis of the genus : proposal for division of this genus into the emended genus and two novel genera gen. nov. and gen. nov.

The members of the genus are key players in the removal of petroleum hydrocarbons from polluted marine environments. More than half of the species were described in the last decade using 16S rRNA gene phylogeny and genomic-based metrics. However, the 16S rRNA gene identity (<94 %) between some members of the genus suggested their imprecise taxonomic status.

Oxidative Cleavage of C-C and C-H Bonds with KOBu: Highly Robust and Practical Synthesis of Diaryl/(het-Ar) Ketones.

Herein, we report an efficient and practical approach for synthesizing diaryl(het) ketones from R-CO-CHR-Ar through a simultaneous oxidative cleavage of C-C and C-H bonds using KOBu. This method enables synthesizing a variety of unsymmetrical and symmetrical (hetero)aryl ketones in excellent yields, which are otherwise difficult to make. Besides, we synthesized natural products using this method.

Revisiting the taxonomy of the genus Rhodopirellula with the proposal for reclassification of the genus to Rhodopirellula sensu stricto, Aporhodopirellula gen. nov., Allorhodopirellula gen. nov. and Neorhodopirellula gen. nov.

The current genus Rhodopirellula consists of marine bacteria which belong to the family Pirellulaceae of the phylum Planctomycetota. Members of the genus Rhodopirellula are aerobic, mesophiles and chemoheterotrophs. The here conducted analysis built on 16S rRNA gene sequence and multi-locus sequence analysis based phylogenomic trees suggested that the genus is subdivided into four clades.

MPTP induces neurodegeneration by modulating dopaminergic activity in catfish brain.

Tyrosine hydroxylase (Th) is an allosteric rate-limiting enzyme in catecholamine (CA) biosynthesis. The CAs, dopamine (DA), norepinephrine (NE), and epinephrine are important neurotransmitters wherein DA contributes a key role in the central nervous system of vertebrates. The present study evaluated DA and Th's significance in DA-ergic activity and neurodegeneration upon 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) exposure in catfish.