DNA damage triggers the death of green sea turtle-derived cells at high temperature.

As temperatures rise due to increasingly severe global warming, the effect of high temperatures on wildlife, including green sea turtles, is one of the issues that must be addressed to ensure the conservation of biodiversity. In the current study, we found that green sea turtle cell death due to apoptosis occurred at 37 °C, which suppressed cell proliferation. We also found that high temperature-induced heat stress led to the accumulation of DNA damage in green sea turtle cells.

Decoding the blueprint of receptor binding by filoviruses through large-scale binding assays and machine learning.

Evidence suggests that bats are important hosts of filoviruses, yet the specific species involved remain largely unidentified. Niemann-Pick C1 (NPC1) is an essential entry receptor, with amino acid variations influencing viral susceptibility and species-specific tropism. Herein, we conducted combinatorial binding studies with seven filovirus glycoproteins (GPs) and NPC1 orthologs from 81 bat species.

Low maternal iodine intake and subsequent risk of pharmacologically treated hypertension: A population-based prospective cohort study.

Background & Aims: Iodine deficiency is linked to multiple adverse health outcomes, but there is scarce knowledge regarding iodine intake and development of chronic hypertension. We aimed to investigate the prospective association between habitual dietary iodine intake and pharmacologically treated hypertension in mothers up to 10 years after delivery.

Methods: The present study is based on data from an ongoing pregnancy cohort and includes 58,629 women without thyroid dysfunction and hypertension at baseline.

Delays in chemotherapy and radiotherapy of breast cancer during COVID-19 pandemic.

Background: During the COVID-19 pandemic, hospitals were overwhelmed with infected patients, leading to a disruption in the delivery of services. Patients with cancer, including breast cancer, rely on timely treatment, as delays can reduce survival rates. In this study, we investigated delays in treatment and the factors contributing to delays in chemotherapy and radiotherapy for these patients.

Mangrove-based carbon market projects: What stakeholders need to address during pre-feasibility assessment.

Mangrove-based carbon market projects (MbCMP) aim to conserve, protect and restore mangrove habitats in order to generate high quality blue carbon credits via a crediting program, as a contribution to climate change mitigation/adaptation, biodiversity conservation, ecosystem services provision and local socio-economic development. The blue carbon credits generated are transferable, verifiable and sold through carbon markets to earn additional income for governments and local communities. The main aim of the paper is to provide important considerations for pre-field planning, that is, how challenges associated with fieldwork, project implementation, and monitoring reporting and verification (MRV) can be addressed with proper pre-field planning.

Harmful effects of the semiconductor copper tungstate (CuWO) on multiple photosynthetic parameters of the green microalga Raphidocelis subcapitata.

The semiconductor copper tungstate (CuWO) may end up in aquatic ecosystems since it has the potential for water decontamination. The toxic effects of CuWO are totally unknown for eukaryotic organisms. In view of this, we aimed to evaluate the toxicity of CuWO particles (size of 161.

Improvement of the accuracy of breeding value prediction for egg production traits in Muscovy duck using low-coverage whole-genome sequence data.

Low-coverage whole genome sequencing (lcWGS) is an effective low-cost genotyping technology when combined with genotype imputation approaches. It facilitates cost-effective genomic selection (GS) programs in agricultural animal populations. GS based on lcWGS data has been successfully applied to livestock such as pigs and donkeys.

The (in)dependence of single-cell data inferences on model constructs.

Recent developments in single-cell analysis have revolutionized basic research and have garnered the attention of the forensic domain. Though single-cell analysis is not new to forensics, the ways in which these data can be generated and interpreted are. Modern interpretation strategies report likelihood ratios that rely on a model of the world that is a simplification of it.

Studying power-grid synchronization with incremental refinement of model heterogeneity.

The dynamics of electric power systems are widely studied through the phase synchronization of oscillators, typically with the use of the Kuramoto equation. While there are numerous well-known order parameters to characterize these dynamics, shortcoming of these metrics are also recognized. To capture all transitions from phase disordered states over phase locking to fully synchronized systems, new metrics were proposed and demonstrated on homogeneous models.

Ginsenoside Rg3 in Cancer Research: Current Trends and Future Prospects - A Review.

Cancer is one of the most devastating illnesses in the world, impacting millions of individuals every year. Despite various therapies, the final effect is unsatisfactory. Chemotherapy currently dominates as the primary option of treatment.

Productive performance, rumen parameters, carcass quality, antioxidant profile and methane emission in lambs supplemented with triticale hay.

This study aims to measure the effects of different dietary concentrations of triticale hay (TH) on productive performance, carcass characteristics, microbial protein synthesis (MPS), ruminal and blood variables, and antioxidant power in 40 fattening male Gray Shirazi lambs (BW of 33.2 ± 1.1 kg) over 81 days in a completely randomized design (10 animals/diet).

Dynamics and asymptotic profiles of a local-nonlocal dispersal SIR epidemic model with spatial heterogeneity.

This research investigates a novel approach to modeling an SIR epidemic in a heterogeneous environment by imposing certain restrictions on population mobility. Our study reveals the influence of partially restricting the mobility of the infected population, who are allowed to diffuse locally and can be modeled using random dispersion. In contrast, the non-infective population, which includes susceptible and recovered individuals, has more freedom in their movements.

KIF18A and CDK1 as combined therapeutic targets in cervical and endometrial carcinomas: based on bioinformatics analysis and experiments.

Background: Chromosomal instability (CIN) has been identified as a factor that increases the susceptibility of tumor cells to kinesin family member 18A (KIF18A) inhibitors. Limited research exists on genes that are associated with sensitization to KIF18A inhibitors (KIF18Ais). Our study aimed to identify a gene linked to heightened sensitivity to KIF18Ais in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) and uterine corpus endometrial carcinoma (UCEC).

Engineering geological evaluation of Bowa Dayole dam site, North Shewa Zone, Oromia, Ethiopia.

Developing nations like Ethiopia face food and water shortages due to weather and droughts. The Bowa Dayole masonry gravity dam is expected to irrigate farmland downstream. Despite this, the engineering geology is complicated by the presence of highly fractured and weathered aphanitic basaltic rock, along with a weak unwelded to welded tuff rock mass in the dam foundation.

A comparative study of proximate compositions, phytochemical constituents, and anti-nutritional contents of pulps and seeds of fruit.

is a tropical wild edible plant that is locally consumed in the Southern Nations, Nationalities, and Peoples Regional state of Ethiopia. However, there is limited information comparing nutritional, phytochemical, and anti-nutritional factors present in fruit pulps and seeds of the fruit. Therefore, this study aimed to investigate and compare the proximate compositions, phytochemical constituents, and anti-nutritional contents of the fruit pulp and seeds.

The role of MgO nanoparticles on the corrosion resistance of hot-dip Al-Zn coating.

This study investigates the impact of MgO nanoparticles (0, 0.1, 0.5, and 1 wt%) on the corrosion behavior of hot-dipped galvalume (Zn-55Al-1.

Ni-Mo nanostructure alloys as effective electrocatalysts for green hydrogen production in an acidic medium.

Achieving a net-zero emissions economy requires significant decarbonization of the transportation sector, which depends on the development of highly efficient electrocatalysts. Electrolytic water splitting is a promising approach to this end, with Ni-Mo alloys emerging as strong candidates for hydrogen production catalysts. This study investigates the electrodeposition of Ni and Ni-Mo nanostructured alloys with high molybdenum content onto low-carbon steel cathodes using a novel alkaline green lactate bath.

synthesis of ultrafine Cu(ii) metal immobilized on pectin hydrogel, modified by a CoFeO/Pr-SOH nanocomposite as a green catalyst for reduction of nitro compounds and synthesis of 1-tetrazoles.

Synthesis of 5-substituted 1-tetrazoles and reduction of a variety of nitro compounds presents a promising solution for the pharmaceutical and agricultural industries. However, the development of green catalysts with superior catalytic performance for this reaction remains a significant challenge. This research introduces a green protocol for the creation of ultrafine Cu(ii) metal immobilized on the surface of pectin hydrogel (HPEC), modified by a CoFeO/Pr-SOH magnetic nanocomposite, enabling the synthesis of tetrazoles and reduction of nitro compounds.

Scalable ultrasound-assisted synthesis of hydroxy imidazole -oxides and evaluation of their anti-proliferative activities; mechanistic insights into the deoximation of dioximes.

The development of synthetic methodologies that promote greener reactions have become so essential that it has slowly shaped the way chemists think about the construction of physiologically and chemically active compounds. The acid-catalyzed iminoketone - aldehyde condensations leading to Hydroxy imidazole -oxides serve as robust strategies for forming C-N bonds. Considering all the existing challenges that come with the use of solvent and energy-intensive methodologies, herein a green synthetic strategy using ultrasound with optimization of reaction conditions and thorough investigation into the mechanism for obtaining the best yields are reported.

Multi-Targeting Phytochemicals for Alzheimer's Disease.

Alzheimer's disease (AD) is a type of neurodegenerative illness in which β-amyloid (Aβ) and tau protein accumulate in neurons in the form of tangles. The pathophysiological pathway of AD consists of Aβ-amyloid peptides, tau proteins, and oxidative stress in neurons and increased neuro-inflammatory response. Food and Drug Administration in the United States has authorized various drugs for the effective treatment of AD, which include galantamine, rivastigmine, donepezil, memantine, sodium oligomannate, lecanemab, and aducanumab.

Advanced MASnI and PTAA-Integrated ZnO Perovskite Composite: Optimizing Stability and Charge Dynamics for Next-Gen Photobatteries.

To advance off-grid energy solutions, developing flexible photobatteries capable of direct light charging is essential. This study presents an innovative photobattery architecture that incorporates zinc oxide (ZnO) as an electron-transporting and hole-blocking layer, combined with a hybrid methylammonium tin iodide composite with poly-triarylamine (MASnI/PTAA) for light absorption and hole transport. PTAA facilitates efficient hole transport to the anode, thereby enhancing charge separation and reducing recombination losses.

Derivation and validation of a clinical predictive model for longer duration diarrhea among pediatric patients in Kenya using machine learning algorithms.

Background: Despite the adverse health outcomes associated with longer duration diarrhea (LDD), there are currently no clinical decision tools for timely identification and better management of children with increased risk. This study utilizes machine learning (ML) to derive and validate a predictive model for LDD among children presenting with diarrhea to health facilities.

Methods: LDD was defined as a diarrhea episode lasting ≥ 7 days.

Resistance mechanisms to immune checkpoint inhibitors: updated insights.

The last decade has witnessed unprecedented succusses with the use of immune checkpoint inhibitors in treating cancer. Nevertheless, the proportion of patients who respond favorably to the treatment remained rather modest, partially due to treatment resistance. This has fueled a wave of research into potential mechanisms of resistance to immune checkpoint inhibitors which can be classified into primary resistance or acquired resistance after an initial response.

Development of autonomic innervation at the venous pole of the heart: bridging the gap from mice to human.

Background: Prenatal development of autonomic innervation of sinus venosus-related structures might be related to atrial arrhythmias later in life. Most of the pioneering studies providing embryological background are conducted in animal models. To date, a detailed comparison with the human cardiac autonomic nervous system (cANS) is lacking.