32 results match your criteria: "P.L.R.; and Baylor College of Medicine[Affiliation]"
Children's perspective of quality of life in epilepsy.
Neurology
May 2015
From Health Care and Outcomes Research (N.F., A.M.D.), University Health Network, Toronto; Departments of Pediatrics (N.F., P.L.R., G.M.R.) and Psychiatry & Behavioural Neurosciences (D.L.S., C.E.C., M.H.B.), CanChild Centre for Childhood Disability Research (N.F., P.L.R., G.M.R.), and Offord Centre for Child Studies (C.E.C., M.H.B.), McMaster University, Hamilton; Institute of Health Policy Management and Evaluation (A.M.D.), Graduate Department of Rehabilitation Science (A.M.D.), and Department of Psychiatry (D.L.S.), University of Toronto; and School of Social Work (L.M.L.) McGill University, Montreal, Canada.
Objective: To study child mental health, parental support, and social support of children with epilepsy as these relate to quality of life (QOL) using child self-report, seizure-related variables, and estimated verbal intelligence based on receptive vocabulary.
Methods: A cross-sectional structural equation model of baseline data from the QUALITÉ cohort study, which includes 6 Canadian child epilepsy ambulatory programs. A sample of 3,481 children were screened for the following eligibility: 8 to 14 years of age, with active or medication-managed epilepsy.
The WWOX gene modulates high-density lipoprotein and lipid metabolism.
Circ Cardiovasc Genet
August 2014
From the Cardiovascular Research Laboratories, Department of Biochemistry, Faculty of Medicine, Division of Cardiology, McGill University, Royal Victoria Hospital, Montreal, Quebec, Canada (I.I., H.Y.C., I.R., Z.A., J.G.); Department of Human Genetics (M.V.P.L.R., D.W.-V., E.N., P.P.) and Department of Medicine (M.V.P.L.R., D.W.-V., E.N., P.P.), David Geffen School of Medicine at University of California at Los Angeles; Department of Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Smithville (H.K., J.L., C.M.A.); The Lautenberg Cancer Research Center, Department of Immunology and Cancer Research, IMRIC, Hebrew University-Hadassah Medical School, Jerusalem, Israel (M.A.O., M.A.-R., R.I.A.); The Lautenberg Center for Immunology and Cancer Research, Department of Immunology and Cancer Research-IMRIC, Hebrew University-Hadassah Medical School, Jerusalem, Israel and Al-Quds-Bard College for Arts and Sciences, Al-Quds University, East Jerusalem-Abu Dis, Palestine (Z.S.); and Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University, Columbus (M.C., C.M.C., R.I.A.).
Article Synopsis
- Low levels of HDL cholesterol are a major risk factor for atherosclerosis, and recent studies linked the WWOX gene to HDL cholesterol levels.
- Through advanced sequencing and mouse models, researchers found that mutations in the WWOX gene are associated with low HDL cholesterol and altered lipid metabolism.
- The study concluded that disruptions in WWOX affect multiple pathways related to cholesterol and triglyceride metabolism, which may contribute to atherosclerotic disease.
Voided midstream urine culture and acute cystitis in premenopausal women.
N Engl J Med
November 2013
From the Department of Medicine, School of Medicine, University of Miami, Miami (T.M.H.); and the Department of Medicine, School of Medicine, University of Washington, Seattle (P.L.R., M.E.C., A.E.S.).
Background: The cause of acute uncomplicated cystitis is determined on the basis of cultures of voided midstream urine, but few data guide the interpretation of such results, especially when gram-positive bacteria grow.
Methods: Women from 18 to 49 years of age with symptoms of cystitis provided specimens of midstream urine, after which we collected urine by means of a urethral catheter for culture (catheter urine). We compared microbial species and colony counts in the paired specimens.
Predicting surgical exploration in renal trauma: assessment and modification of an established nomogram.
J Trauma Acute Care Surg
November 2013
From the Departments of Urology (J.J.S., P.L.R.) and Radiology (J.K.), Alfred Hospital, Melbourne; and Departments of Urology (N.M.C.) and Surgery (N.M.C.), Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia; Urology (M.F.B.), Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom.
Background: This study aimed to externally validate a previously described nomogram that predicts the need for renal exploration in the trauma setting.
Methods: The predicted probability of nephrectomy was manually calculated using prospectively collected data from consecutive patients with renal trauma who presented to our institution between May 2001 and January 2010. To assess nomogram performance, receiver operating characteristic curves against the observed exploration rate were generated, and areas under the curve were calculated.
Effect of early metoprolol on infarct size in ST-segment-elevation myocardial infarction patients undergoing primary percutaneous coronary intervention: the Effect of Metoprolol in Cardioprotection During an Acute Myocardial Infarction (METOCARD-CNIC) trial.
Circulation
October 2013
From Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain (B.I., G.P., L.F.-F., A.M., A.F.-O., J.M.G.-R., A.G.-A., J.J.B., P.L.-R., R.F.-J., M.D.R., N.E., J.G.-P., D.S.-R., S.P., G.S., V.F.); Hospital Clínico San Carlos-IdISSC, Madrid, Spain (B.I., C.M., A.F.-O., R.F.-J., B.R.-M., C.A., J.C.G.-R., R.H.-A.); Servicio de Urgencia Médica de Madrid (SUMMA 112), Madrid, Spain (V.S.-B., A.M., J.V., M.J.F.-C.); Hospital Universitario Quirón, Madrid, Spain (G.P., J.A.C.); Complejo Hospitalario Universitario de Vigo-Meixoeiro, Pontevedra, Spain (A.I., M.A.); Hospital Universitario de la Princesa, Madrid, Spain (J.J.-B., T.B.); Hospital Universitario Puerta de Hierro, Madrid, Spain (J.G.); Servicio de Emergencia Medica 061 de Galicia-Sur, Galicia, Spain (J.A.I.-V.); Hospital Universitario León, León, Spain (A.P.d.P., C.C., F.F.-V.); Servicio de Atención Médica Urgente (SAMUR)-Protección Civil, Madrid, Spain (I.C.); Hospital Universitario Doce de Octubre, Madrid, Spain (A.A.); Hospital Universitario Marqués de Valdecilla, Santander, Spain (J.M.d.l.T.-H.); London School of Hygiene & Tropical Medicine, London, UK (S.P.); and the Zena and Michael A. Wiener CVI, Mount Sinai School of Medicine, New York, NY (V.F.).
Background: The effect of β-blockers on infarct size when used in conjunction with primary percutaneous coronary intervention is unknown. We hypothesize that metoprolol reduces infarct size when administered early (intravenously before reperfusion).
Methods And Results: Patients with Killip class II or less anterior ST-segment-elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention within 6 hours of symptoms onset were randomized to receive intravenous metoprolol (n=131) or not (control, n=139) before reperfusion.
Effectiveness of antibiotic prophylaxis in cholecystectomy: a prospective population-based study of 1171 cholecystectomies.
Scand J Gastroenterol
October 2012
Department of Surgery, Enköping Hospital, Enköping, Sweden.
Background: The aim of this study was to assess the benefit from antibiotic prophylaxis (AP) during cholecystectomy in a population-based cohort study.
Methods: All cholecystectomies performed in Uppsala County, 2003-2005, were registered prospectively according to a standardized protocol. High-risk procedures (HP) were defined as operations for acute cholecystitis and procedures including exploration of the common bile duct.
Insect Control and Dosage Effects in Transgenic Canola Containing a Synthetic Bacillus thuringiensis cryIAc Gene.
Plant Physiol
September 1996
Department of Crop and Soil Sciences (C.N.S., P.L.R., W.A.P.) and Department of Entomology (M.J.A., J.N.A., S.R.), University of Georgia, Athens, Georgia 30602.
Zygotic hypocotyls of canola (Brassica napus L.) cv Oscar, cv Westar, and the breeding line UGA188-20B were transformed with a truncated synthetic Bacillus thuringiensis insecticidal crystal protein gene (Bt cryIAc) under the control of the cauliflower mosaic virus 35S promoter using Agrobacterium tumefaciens-mediated transformation. Fifty-seven independently transformed lines were produced, containing 1 to 12 copies of the transgenes.
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