M, NM-polynomials Based on Reverse, Reduced Reverse Degree and Neighborhood Degree Based Topological Indices with Applications to Bond Energy of Y-Junction Nanotubes.

Background: In graph theory, M polynomials like the matching polynomial are very crucial in examining the matching structures within graphs, while NM polynomials extends this to analyze non-matching edges. These polynomials are important in many fields, including chemistry and network architecture. They support the derivation of topological indices for protein structure analysis, network communication optimization, and drug design in QSAR/QSPR investigations.

Employing Machine Learning Models to Predict Potential α-Glucosidase Inhibitory Plant Secondary Metabolites Targeting Type-2 Diabetes and Their Validation.

The need for new antidiabetic drugs is evident, considering the ongoing global burden of type-2 diabetes mellitus despite notable progress in drug discovery from laboratory research to clinical application. This study aimed to build machine learning (ML) models to predict potential α-glucosidase inhibitors based on the data set comprising over 537 reported plant secondary metabolite (PSM) α-glucosidase inhibitors. We assessed 35 ML models by using seven different fingerprints.

A Rare Lung Malignancy in a Case of Systemic Sclerosis.

Systemic sclerosis (SSc) is one of the chronic autoimmune diseases characterized by the infiltration of excess collagen in various organs, especially the skin. It is found to be associated with a higher prevalence of internal malignancies, particularly lung carcinoma. Herein, we report a case of adenosquamous carcinoma confining within the lung in a patient who had long-standing SSc.

G-Hemin-loaded 2D nanosheets for combined and targeted chemo-photodynamic cancer therapy.

Synergetic combination therapy is emerging as one of the most promising approaches for cancer treatment. Among the various therapeutic approaches, PDT has received particular attention due to its non-invasive nature. However, the therapeutic performance of PDT is severely affected by tumour hypoxia.

Hypothyroidism and Its Impact on Menstrual Irregularities in Reproductive-Age Women: A Comprehensive Analysis at a Tertiary Care Center.

Background: Hypothyroidism is known to affect a wide range of physiological systems, including menstrual function, in women of reproductive age. This study aims to comprehensively analyze the association between hypothyroidism and menstrual irregularities in women attending a tertiary care center.

Methods: The study included 120 women aged 18-45 who presented with menstrual abnormalities.

Unveiling the ecological landscape of bacterial β-lactam resistance in Delhi-national capital region, India: An emerging health concern.

Inappropriate antibiotic use not only amplifies the threat of antimicrobial resistance (AMR), moreover exacerbates the spread of resistant bacterial strains and genes in the environment, underscoring the critical need for effective research and interventions. Our aim is to assess the prevalence and resistance characteristics of β-lactam resistant bacteria (BLRB) and β-lactamase resistant bacterial genes (BLRBGs) under various environmental conditions within Delhi NCR, India. Using a culture-dependent method, we isolated 130 BLRB from 75 different environmental samples, including lakes, ponds, the Yamuna River, agricultural soil, aquatic weeds, drains, dumping yards, STPs, and gaushalas.

Unusual Presentation of Synovial Lipomatosis Mimicking As Septic Arthritis of Knee: A Case Report.

Synovial lipomatosis or lipoma arborescens is a very uncommon pseudo-tumorous lesion of the synovium which more commonly affects the knee joint. The most probable cause of this pathological lesion is degenerative articular disorders of the joint and improper fat accumulation. It is characterized by presence of villous proliferation of the synovium and replacement of the sub-synovial tissue by mature adipocytes which is infiltrated by dense chronic inflammatory cells like lymphocytes, plasma cells and eosinophils.

Multicomponent synthesis acceptorless alcohol dehydrogenation: an easy access to tri-substituted pyridines.

Herein, we report palladium supported on a hydroxyapatite catalyst for synthesizing tri-substituted pyridines using ammonium acetate as the nitrogen source acceptorless alcohol dehydrogenation strategy. The strategy offers a broad substrate scope using inexpensive and readily available alcohols as the starting material. The catalyst was prepared using a simple method and analyzed by several techniques, including FE-SEM, EDS, HR-TEM, BET, XRD, FT-IR, UV-visible spectroscopy, and XPS, demonstrating the anchoring of Pd nanoparticles on hydroxyapatite in the zero oxidation state.

-Alkylation of dithiocarbamates a hydrogen borrowing reaction strategy using alcohols as alkylating agents.

Herein, we report an operationally simple, environmentally benign and scalable approach towards the synthesis of -benzyl/alkyl dithiocarbamates a hydrogen borrowing reaction between alcohols and dithiocarbamate anions catalyzed using a hydroxyapatite-supported copper nano-catalyst. This strategy has a broad substrate scope and offers high yields of products using inexpensive and readily available alcohols as starting materials. The catalyst was prepared by easy and straightforward methods and analyzed by several analytical techniques, , FESEM, HR-TEM, BET, XRD, EDS, and XPS, demonstrating the anchoring of Cu nanoparticles on hydroxyapatite in the zero oxidation state.

Breath VOC analysis and machine learning approaches for disease screening: a review.

Early disease detection is often correlated with a reduction in mortality rate and improved prognosis. Currently, techniques like biopsy and imaging that are used to screen chronic diseases are invasive, costly or inaccessible to a large population. Thus, a non-invasive disease screening technology is the need of the hour.

Development of clove oil based nanoencapsulated biopesticide employing mesoporous nanosilica synthesized from paddy straw via bioinspired sol-gel route.

Paddy straw (PS) burning is a concerning issue in South Asian countries, clamoring for exploring alternative management strategies. Being a rich source of silica, PS can be a potential nanosilica (SiNPs) source. The current study reports a pioneering approach for green synthesis of high-purity mesoporous SiNPs by sol-gel method using the aqueous extract of Sapindus mukorossi seed pericarp as a stabilizer.

Fever of Unknown Origin and Hepatitis as the Initial Presentation of Anti-MDA-5 Positive Dermatomyositis: A Case Report.

Petersdorf and Beeson first defined fever of unknown origin (FUO) in 1961, and subsequently, over the next 60 years, the definition of FUO has changed considerably. In the western world, non-infectious inflammatory diseases are the most common cause of FUO; however, in developing countries, infections remain the leading cause of FUO. Dermatomyositis (DM) is an autoimmune inflammatory disease of unknown aetiology which mainly affects skin and muscles.

In vitro and computational studies of the β-lactamase inhibition and β-lactam potentiating properties of plant secondary metabolites.

β-lactam resistance in bacteria is primarily mediated through the production of β-lactamases. Among the several strategies explored to mitigate the issue of β-lactam resistance, the use of plant secondary metabolites in combination with existing β-lactams seem promising. The present study aims to identify possible β-lactam potentiating plant secondary metabolites following and approaches.

Analyzing the potential of selected plant extracts and their structurally diverse secondary metabolites for α-glucosidase inhibitory activity: and approach.

Inhibiting α-glucosidase activity is a therapeutic method to regulate post-prandial hyperglycemia in humans. Here, and studies were used to find α-glucosidase inhibitory plant secondary metabolites (PSM). Among 408 solvent extracts from 70 plants tested for α-glucosidase inhibition, 174 had IC ≤ 3 mg/ml.

Computational and data mining studies to understand the distribution and dynamics of Temoneria (TEM) β-lactamase and their interaction with β-lactam and β-lactamase inhibitors.

β-lactams are large group of antibiotics widely used to suppress the bacterial growth by inhibiting cell wall synthesis. Bacterial resistance against β-lactam antibiotics is primarily mediated through the production of Temoneria (TEM) β-lactamase (BLs), with almost 474 variants identified in Lactamase Engineering Database (LacED). The present study aims to develop a model to track the evolution of TEM BLs and their interactions with β-lactam and BLs inhibitors through data mining and computational approaches.

Modulation of gene expression by thymoquinone conjugated zinc oxide nanoparticles arrested cell cycle, DNA damage and increased apoptosis in triple negative breast cancer cell line MDA-MB-231.

Nanomedicines include the area of science that combines the drugs or diagnostic molecules using nanotechnology approach to improve its ability to target specific cells or tissues. Zinc oxide (ZnO) nanoparticles are known for its non-toxicity, biocompatibility and biosafety. Thymoquinone (TQ) is used in the present study from the seeds of (Black cumin seed).

Shear Bond Strength of Glass Ionomer Cement to Er, Cr:YSGG Laser-irradiated Dentin in Primary Teeth: An Study.

Background: The clinical success of restorative materials depends upon a good adhesion with the dentinal surface to resist various dislodging forces acting within the oral cavity. Shear bond strength is the resistance to forces that slides restorative material past tooth structure. The Er, Cr:YSGG pulsed laser irradiation may be used to prepare enamel, dentin, cementum, and bone effectively and cleanly without leaving a smear layer.

Surgeon Ratings of the Severity of Idiopathic Median Neuropathy at the Carpal Tunnel Are Not Influenced by Magnitude of Incapability.

Background: Accurately distinguishing the severity of pathophysiology from the level of symptom intensity and incapability is a foundation of effective treatment strategies under the biopsychosocial paradigm of illness. With respect to idiopathic median neuropathy at the carpal tunnel (the symptoms and signs of which are referred to as carpal tunnel syndrome), surgeons who are more likely to recommend surgery based on the magnitude of symptoms and incapability rather than the severity of neuropathy may be underappreciating and undertreating mental health opportunities and overtreating mild, and on occasion unmeasurable, disease. A survey-based experiment that randomizes elements of the patient presentation can help determine the relative influence of magnitude of incapability on ratings of pathology severity.

Unraveling the potential role of bioactive molecules produced by spp. as inhibitors of tomatinase enzyme having an important role in wilting disease: an approach.

Tomatinase; a saponin detoxification enzyme produced by f.sp is reported as a causative agent for wilting disease in tomato crops. The disease is instigated by inhibiting the activity of α-tomatine.

A Glucose binding lectin from Leucaena leucocephala seeds and its mitogenic activity against human lymphocytes.

Lectins are a specialized group of proteins with immense biological properties and applications. This study describes the purification and characterization of a lectin from Leucaena leucocephala seeds, a plant belonging to the Fabaceae family. Leucaena leucocephala lectin (LLL) was purified by a two-step purification method involving DEAE-cellulose anion exchange chromatography and Sephadex G-75 size exclusion chromatography.

Medical Image Magnification Based on Original and Estimated Pixel Selection Models.

Background: The issue of medial image resolution enhancement is one of the most important topics for medical imaging that helps improve the performance of many post-processing aspects like classification and segmentation towards medical diagnosis.

Objective: Our aim in this paper is to evaluate different types of pixel selection models in terms of pixel originality in medical image reconstruction problems. A previous investigation showed that selecting far original pixels has highly better performance than using near unoriginal/estimated pixels while magnifying some benchmarks in digital image processing.

Co-occurrence of functionally diverse bacterial community as biofilm on the root surface of Eichhornia crassipes (Mart.) Solms-Laub.

The current study investigates the functional diversity of bacterial community existing as a biofilm on the root surface of water hyacinth (Eichhornia crassipes (Mart.) Solms-Laub.) grown in Yamuna river, Delhi, India.