647 results match your criteria: "P. D. Hinduja National Hospital[Affiliation]"

Article Synopsis
  • Home time, or the duration patients with cardiovascular disease spend alive outside of healthcare institutions, is an essential aspect of recovery, particularly for heart failure (HF) patients, yet insufficiently studied in India where HF rates are increasing.
  • Current literature falls short in identifying hospital-level trends and predictors of home time, which complicates the development of personalized care strategies to enhance health outcomes, functional status, and reduce hospitalization risks.
  • While guideline-directed medical therapy, especially sacubitril/valsartan (an angiotensin receptor neprilysin inhibitor), is well-supported for improving life quality and reducing HF-related hospitalizations, its use remains low, indicating a critical need for better integration into clinical practice to improve patient recovery and home time post
View Article and Find Full Text PDF

Objectives: The prevalence and burden of neurological diseases are high among the older age group. Stroke and other neurological diseases significantly impair functional capacity and lead to poor quality of life. This study aims to provide a national-level estimate for palliative and supportive care needs among older Indian adults with stroke and other neurological diseases.

View Article and Find Full Text PDF

In an elderly patient with known cardiac and pulmonary risk, a reversal agent with a faster onset and least hemodynamic effects is preferable. Being inert, the sugammadex-rocuronium complex is associated with minimal muscarinic effects. We report a successful management with rocuronium and sugammadex in an eighty three year old male patient with a history of Ischemic Heart Disease, atrial fibrillation, and Interstitial Lung Disease posted for a cochlear implant surgery.

View Article and Find Full Text PDF

Background: Sepsis is a global health problem with high morbidity and mortality. Low- and middle-income countries have a higher incidence and poorer outcome with sepsis. Large epidemiological studies in sepsis using Sepsis-3 criteria, addressing the process of care and deriving predictors of mortality are scarce in India.

View Article and Find Full Text PDF

In heart failure, sympathetic overdrive is evidenced by norepinephrine spillover, receptor level changes, etc. Beta-blockers continue to be the cornerstone of treatment in patients with chronic heart failure due to their ability to counteract sympathetic overdrive. Extensive clinical research has demonstrated that long-term beta-blocker treatment with metoprolol succinate, carvedilol, or bisoprolol enhances left ventricular function and reverses left ventricular remodeling, decreases hospitalization risk, and increases survival.

View Article and Find Full Text PDF

We describe a patient who underwent plug-assisted retrograde transvenous obliteration for gastric varices. After the procedure, the patient developed hypotension and tachycardia. Contrast-enhanced computed tomography showed a left adrenal hematoma.

View Article and Find Full Text PDF

Background: Skull base meningiomas are chronic conditions that can present with a wide variety of symptoms ranging from near normalcy to chronic and prolonged disability and also often worsen by treatment-related sequelae. Hence, it is necessary to investigate the quality of life (QOL) among patients with skull base meningioma and evaluate the impact of microsurgery on their overall well-being.

Methods: In this prospective observational study, 36 patients undergoing microsurgery for skull base meningioma were assessed for QOL using SF-36 questionnaires.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates how the deep inspiratory breath hold (DIBH) technique can reduce heart radiation doses during treatment for left-sided breast cancer.
  • Physical parameters from DIBH simulations, such as DIBH amplitude and lung volume ratios, were analyzed in 50 patients to determine their predictive value for heart dose reductions.
  • Results showed a significant reduction in heart doses, with specific parameters correlating strongly with dose reduction, suggesting they could help predict heart dose outcomes in future treatments.
View Article and Find Full Text PDF

Objectives: Patients with progressive neurologic illness still lack access to quality palliative care services. Barriers to the comprehensive provision of neuropalliative care include gaps in palliative care education. To address this barrier, a novel international model of neuropalliative care education e-learning program was launched in 2022.

View Article and Find Full Text PDF

Non-technical skills for neurosurgeons: An international survey.

Brain Spine

August 2024

Department of Neurosurgery, Fondazione I.R.C.C.S. Istituto Neurologico "C. Besta", Milano, Italy.

Article Synopsis
  • Neurosurgery requires not only technical skills but also non-technical skills (NTSs) to achieve mastery, highlighting the importance of both in surgical practice.
  • An international survey of 372 neurosurgeons indicates that qualities like attention to detail, humility, and self-awareness are vital for surgical precision and effective teamwork.
  • The study advocates for integrated training that includes simulations and mentorship to enhance NTSs, while also stressing the need for research aimed at improving educational methods, especially in regions with unequal access to neurosurgical care.
View Article and Find Full Text PDF
Article Synopsis
  • * Current guidelines recommend early combination therapy using four drug classes, especially ARNI, which significantly reduces morbidity and mortality in patients with heart failure with reduced ejection fraction (HFrEF).
  • * A national consensus by Indian cardiology experts emphasizes that ARNI should be initiated early in HFrEF patients, including those hospitalized, and can also benefit patients with preserved and mildly reduced ejection fractions.
View Article and Find Full Text PDF

Guidelines for Antibiotics Prescription in Critically Ill Patients.

Indian J Crit Care Med

August 2024

Department of Anaesthesiology, Critical Care and Pain, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, Maharashtra, India.

Khilnani GC, Tiwari P, Mittal S, Kulkarni AP, Chaudhry D, Zirpe KG, Guidelines for Antibiotics Prescription in Critically Ill Patients. Indian J Crit Care Med 2024;28(S2):S104-S216.

View Article and Find Full Text PDF

ISCCM Position Statement for Improving Gender Balance in Critical Care Medicine.

Indian J Crit Care Med

August 2024

Department of Anaesthesiology, Critical Care and Pain, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, Maharashtra, India.

Unlabelled: Gender disparity in Critical Care Medicine (CCM) persists globally, with women being underrepresented. Female Intensivists remain a minority, facing challenges in academic and leadership positions at the workplace and within academic societies. The Indian Society of Critical Care Medicine (ISCCM) recognized the need for addressing issues related to gender parity and constituted its first Diversity Equity and Inclusion (DEI) Committee in 2023.

View Article and Find Full Text PDF

Targeted Next Generation Sequencing (tNGS) for detection of drug-resistant tuberculous meningitis: Is this sequencing technology ready for prime time?

Indian J Med Microbiol

September 2024

Microbiology Section, Department of Laboratory Medicine, P.D. Hinduja National Hospital and Medical Research Centre, Mumbai, India. Electronic address:

Purpose: Tuberculous meningitis (TBM) is the most severe form of tuberculosis (TB). Difficulty in diagnosing the condition along with other factors, increases its potential for high morbidity and mortality. Targeted Next Generation Sequencing (tNGS) generates high quality sequence read depths, enabling the identification of low-frequency alleles linked to Drug resistance (DR).

View Article and Find Full Text PDF

Background: Thalamic lesions located in the floor of the lateral ventricle pose significant surgical challenges, given their proximity to critical neurovascular structures. Transcortical approaches are often limited by risks of injuring the eloquent cortex and nearby vessels. Furthermore, lesions extending into the third ventricle further impede accessibility.

View Article and Find Full Text PDF

Artifacts in nuclear medicine imaging are not uncommon. We are aware of some of these, for which we follow necessary protocols to avoid them. However, there are some unusual and unavoidable artifacts that we come across in daily imaging, which may be of concern and need to be detected and corrected on time.

View Article and Find Full Text PDF

Background: Subacute sclerosing panencephalitis (SSPE) is a complication of measles, occurring after a latency of 4-10 years. It continues to occur in developing countries although resurgence is being reported from developed countries. Characteristic features include progressive neuropsychiatric issues, myoclonus, seizures, movement disorders and visual impairment.

View Article and Find Full Text PDF

Background: In recent years, the subspecialty of neuropalliative care has emerged with the goal of improving the quality of life of patients suffering from neurological disease, though gaps remain in neuropalliative care education and training. E-learning has been described as a way to deliver interactive and facilitated lower-cost learning to address global gaps in medical care. We describe here the development of a novel, international, hybrid, and asynchronous curriculum with both self-paced modules and class-based lectures on neuropalliative care topics designed for the neurologist interested in palliative care, the palliative care physician interested in caring for neurological patients, and any other physician or advanced care providers interested in neuropalliative care.

View Article and Find Full Text PDF

Introduction: Prevention of dislocation after total hip arthroplasty (THA) remains a topic of debate. There are various surgical options to manage hip instability such as large femoral heads, and constrained liners, although the best option to tackle this is still controversial. In revision scenarios with previous well-fixed acetabulum shells, the cementation of polyethylene liners or the cementation of dual mobility (DM) into a well-fixed acetabulum shell (Double Socket Technique) has been documented before.

View Article and Find Full Text PDF