Synthesis, Molecular Docking Studies and Biological Evaluation of Thiazolyl Hydrazone Derivatives of Chromone-3-carbaldehyde as Potent Anti-Oxidant and Anti-Inflammatory Agents.

Introduction: A series of 15 thiazolyl hydrazone derivatives of chromone-3- carbaldehyde have been designed and synthesized by the cyclization of thiosemicarbazone derivatives of chromone-3-carbaldehydes with 4'-substituted-2-bromo acetophenones.

Methods: All these derivatives were evaluated for antioxidant activity by their direct scavenging activity objects to reactive oxygen species such as DPPH, and nitric oxide, as well as antiinflammatory activity by a protein denaturation method. Most of these synthesized compounds have shown significant antioxidant activity, among which the compounds 5b, 5c, 5e, 5g, and 5j showed very good antioxidant activities in comparison with the standard ascorbic acid.

Design, synthesis, docking studies and biological screening of 2-pyrimidinyl-2, 3-dihydro-1-naphtho [1, 2-][1, 3] oxazines as potent tubulin polymerization inhibitors.

A series of novel substituted 2-pyrimidinyl-2,3-dihydro-1-naphtho[1,2-][1, 3]oxazine analogs have been designed and synthesized based on structure-activity relationships from 2-naphthol, substituted pyrimidinyl amines and formalin through ring closure by one-pot three component reaction. These derivatives were evaluated for their cytotoxicity, cell cycle assay and their inhibitory effect on tubulin polymerization. From the MTT assay, it is clear that most of the synthesized compounds displayed potent cytotoxic activities on HeLa (cervical cancer) and B16F10 (melanoma) cancerous cell lines.

5K CT Images on Fractured Limbs: A Dataset for Medical Imaging Research.

Imaging techniques widely use Computed Tomography (CT) scans for various purposes, such as screening, diagnosis, and decision-making. Of all, it holds true for bone injuries. To build fully automated Computer-Aided Detection (CADe) and Diagnosis (CADx) tools and techniques, it requires fairly large amount of data (with gold standard).