41 results match your criteria: "Oxford Radcliffe Hospitals Trust[Affiliation]"

Temozolomide in the treatment of solid tumours: current results and rationale for dosing/scheduling.

Crit Rev Oncol Hematol

March 2005

The Churchill Hospital, CRUK Medical Oncology Unit, Oxford Radcliffe Hospitals Trust, Headington, Oxford OX37LJ, UK.

This review examines the current evidence for the use of temozolomide in the treatment of solid tumours. The possible molecular and clinical advantages of temozolomide are identified and the molecular mechanism of temozolomide resistance is explored. Attempts to maximise efficacy have led to manipulation of both dosage and drug scheduling and the evidence for the various strategies is reviewed.

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The National Clinician Scientist Scheme was devised to enable future leaders of academic medicine to continue post-doctoral research and at the same time complete their specialist registrar training. The awards are generously funded by the major grant-giving bodies and are held in a variety of specialties in academic departments across the UK. Award winners are given the suffix A to add to their existing national training number (NTN) achieved in open competition in the relevant specialty.

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A case of posterior spinal ligament rupture associated with a general anaesthetic for a laparoscopic cholecystectomy is reported. The role of the general anaesthetic in this case is discussed and a review of the literature is presented.

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General anaesthesia in a patient with Brugada syndrome.

Br J Anaesth

November 2002

Nuffield Department of Anaesthetics and Department of Cardiology, Oxford Radcliffe Hospitals Trust, Oxford, OX3 9DU, UK.

The successful administration of a combined general and epidural anaesthetic to a patient with Brugada syndrome is reported. A review of the literature is presented.

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Central venous catheter removal: procedures and rationale.

Br J Nurs

April 2003

Parenteral Nutrition and Line Insertion Service, Oxford Radcliffe Hospitals Trust, Oxford.

The use of central venous catheters (CVCs) has become fairly commonplace within both the hospital and community setting. The removal of these devices is often a task performed without much teaching and the procedure to follow is passed on from one nurse to another with little or no research on which to base actions. This article describes the potential complications associated with CVC removal and methods to prevent them.

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Is there MHC Class II restriction of the response to MHC Class I in transplant patients?

Transplantation

February 2002

Transplantation Immunology, Oxford Transplant Centre, Churchill Hospital, Oxford Radcliffe Hospitals Trust, United Kingdom.

Background: In this study, we evaluated distinct HLA-DRB1 alleles to determine class II restriction of the production of HLA-A2-specific antibodies in renal transplant patients.

Methods: Data from 217 renal transplant patients who received an HLA-A2-mismatched renal graft were analyzed with regard to HLA-A2 humoral responsiveness. High-resolution DNA typing of class II HLA-DR alleles was performed by polymerase chain reaction-sequence-specific primer.

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Selecting the correct intravenous device: nursing assessment.

Br J Nurs

April 2001

Department of Parenteral Nutrition and Vascular Access, Oxford Radcliffe Hospitals Trust, Headington, Oxford.

This article provides information for nursing and medical teams involved in the selection of intravenous (i.v.) devices for patients requiring venous access.

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Complications of central venous catheters: nursing care.

Br J Nurs

May 2001

Parenteral Nutrition and Line Insertion Service, Oxford Radcliffe Hospitals Trust.

There are increasing numbers of patients, both at home and in the hospital, receiving intravenous therapy via long-term central venous catheters. Although fairly commonplace, there are many potential complications associated with the insertion and use of these catheters. This article describes the insertion and postinsertion-related complications of these devices.

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Lower limb amputation. 4: Some ethical considerations.

Br J Nurs

February 1998

Vascular Unit, John Radcliffe Hospital, Oxford Radcliffe Hospitals Trust.

For some people the prospect of amputation may offer an escape from the constant pain, infection and disability which have been part of their lives for many years. However, other may regard death as a preferable option. Denying treatment when the alternative prognosis is death causes much debate among healthcare professionals, families and carers.

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This article, the third in a series on lower limb amputation, examines the role of the nurse in the pre- and postoperative care of patients undergoing amputation. The nurse has an integral role not only in providing care but also in liaising with other members of the multidisciplinary team in order to ensure that the person undergoing the amputation feels prepared for both the operation and discharge home. Amputation may greatly distort an individual's vision of him/herself as a person, a partner and a parent; ways in which this distortion can be minimized are explored.

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This is the second of four articles on lower limb amputation. The first article (Vol 6(17): 970-7) discussed the indications for amputation and briefly outlined the treatment options that may be tried before the amputation stage is reached. This second article examines the factors that need to be addressed once the decision to amputate has been made.

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Lower limb amputation. 1: indications and treatment.

Br J Nurs

December 1997

Vascular Unit, John Radcliffe Hospital, Oxford Radcliffe Hospitals Trust.

Lower limb amputation is performed predominantly to alleviate acute and chronic limb ischaemia caused by vascular disease, poorly controlled diabetes or, occasionally, infection. Atherosclerosis is the primary cause of chronic arterial ischaemia and the most common reason for amputation. The vascular nurse has an important role in reducing the need for amputation, by providing information on health promotion and illness prevention to patients with vascular insufficiency to halt progression to amputation.

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