773 results match your criteria: "Overactive Bladder in Children"
Re: Anirban Dey, Georgios Georgiadis, Justin Umezurike, et al. Mirabegron Versus Placebo and Other Therapeutic Modalities in the Treatment of Patients with Overactive Bladder Syndrome-A Systematic Review. Eur Urol Focus. In press. https://doi:10.1016/j.euf.2024.09.012.
Eur Urol Focus
December 2024
Department of Pediatric Surgery, Chengdu Women's and Children's Central Hospital, University of Electronic Science and Technology of China, Chengdu, China. Electronic address:
Two-year efficacy and safety outcomes of the pivotal OASIS Study using the Revi System for treatment of urgency urinary incontinence.
J Urol
November 2024
BlueWind Medical Inc., Park City, Utah, USA.
Article Synopsis
Low-value practices in primary care: a cross-sectional study comparing data between males and females in Spain.
BMJ Open
November 2024
RICAPPS - Red de Investigación en Cronicidad, Atención Primaria y Prevención y Promoción de la Salud, San Juan de Alicante, Spain.
Article Synopsis
- The study addresses the global issue of overuse of medical services, focusing on low-value practices (LVPs) in primary care, which can harm patients and undermine healthcare quality.
- Conducted in Alicante, Spain, the research analyzed digital medical records from nearly a million patients to compare the frequency of LVPs prescribed to males versus females in 2022.
- Findings revealed that females received significantly more LVPs (5.27%) than males (4.00%), with specific practices commonly leading to potential patient harm, highlighting the need for gender-sensitive approaches in clinical training and research.
Translation, cross-cultural adaptation, and psychometric properties of the Spanish version of the dysfunctional voiding score symptoms (DVSS-Sp) questionnaire in a pediatric chilean sample.
Braz J Phys Ther
December 2024
Departamento de Ciencias de la Rehabilitación, Universidad de La Frontera, Temuco, Chile. Electronic address:
Article Synopsis
- The DVSS questionnaire, used for assessing dysfunctional voiding and incontinence, was translated and culturally adapted into Spanish for pediatric use (DVSS-Sp).
- The study involved 248 participants and confirmed the DVSS-Sp's validity by demonstrating good internal consistency and a strong diagnostic capacity through various statistical analyses.
- The final version of the DVSS-Sp identified two main factors: Overactive Bladder symptoms and Dysfunctional Elimination symptoms, showing promising results for effectively evaluating these conditions in Spanish-speaking children.
Effect of standard urotherapy to children with overactive bladder on quality of life.
World J Urol
October 2024
Department of Pediatric Surgery Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, No.1617, Riyue avenue, Qinyang District, Chengdu, 611731, China.
Article Synopsis
- * A total of 107 children, aged between 2 and 13, were analyzed using the Pediatric Incontinence Questionnaire (PINQ) to measure their QoL before and one month after treatment.
- * Results showed a significant improvement in the QoL scores after one month of urotherapy, highlighting the importance of monitoring the QoL in children with OAB for better management and support.
Response to Treatment with Botulinum Neurotoxin A (BoNT-A) in Children and Adolescents with Neurogenic Lower Urinary Tract Dysfunction and Idiopathic Overactive Bladder: A Systematic Review and Meta-Analysis.
Toxins (Basel)
October 2024
Urology Clinic, Department of Surgery, Dentistry, Paediatrics and Gynaecology, University of Verona, Azienda Ospedaliera Universitaria Integrata di Verona, Piazzale Aristide Stefani 1, 37126 Verona, Italy.
Article Synopsis
- Botulinum neurotoxin A (BoNT-A) is being increasingly used to treat neurogenic lower urinary tract dysfunctions and overactive bladder in children and adolescents, which is a growing area in urology.
- A systematic review analyzed various studies from databases like PubMed and Scopus to evaluate BoNT-A's effectiveness in improving urinary incontinence and urodynamic parameters in this age group.
- Results showed that among 1521 patients, there was a significant improvement in urinary incontinence scores by about 75% within 3-6 months after treatment, with no major adverse effects reported.
Efficacy of high-dose vitamin D supplementation vs. solifenacin or standard urotherapy for overactive bladder dry in children: a secondary analysis of a randomized clinical trial.
World J Urol
October 2024
Department of Urology, Children's Hospital of Chongqing Medical University, 136 Zhongshan Road, Chongqing, 400014, PR China.
Article Synopsis
- The study aimed to evaluate the effectiveness of high-dose vitamin D supplementation (VDS) combined with standard urotherapy (SU) in treating pediatric overactive bladder dry (OAB-dry) in children with specific vitamin D levels and severe symptoms.
- In a secondary analysis involving 303 children, those receiving VDS + SU showed significantly better improvements in voiding frequency compared to groups receiving either solifenacin (SOL) + SU or SU alone.
- The findings suggest that high-dose VDS plus SU offers notable therapeutic advantages for children with specific vitamin D levels and heightened symptom severity, outperforming the other treatment options.
Prevalence and allergy-related risk factors of overactive bladder in children in Northeast China.
Front Public Health
October 2024
Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China.
Article Synopsis
- The study aimed to determine how common overactive bladder (OAB) is among children aged 5-14 in Northeastern China and to explore its allergy-related risk factors.
- A survey conducted in April 2022 included 1,394 children, focusing on various medical conditions, including OAB and allergies, to analyze the prevalence and contributing factors.
- Results showed a 10.7% prevalence of OAB, with associated risk factors being allergic asthma, atopic dermatitis, anaphylactic conjunctivitis, and urticaria, suggesting that managing allergies could help prevent and treat OAB.
Efficacy of Biofeedback Therapy for Giggle Incontinence in Children: How Many Sessions Are Required?
Neurourol Urodyn
October 2024
Department of Pediatric Surgery, Sancaktepe Sehit Prof. Dr. İlhan Varank Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.
Article Synopsis
- Giggle incontinence (GI) is an involuntary urination condition that occurs during laughter, and this study evaluates the effectiveness of biofeedback (BF) therapy as a treatment method.
- A retrospective analysis of medical records from children receiving BF therapy revealed a significant improvement in GI symptoms, with an 80% complete response after completing all therapy sessions.
- The study concludes that at least eight BF therapy sessions are necessary for effective treatment, indicating that the therapy could be a valuable option for managing this condition.
Comment on "Anticholinergic Burden in Patients Treated for Overactive Bladder: Second-Line Therapy with Tibial Nerve Stimulation as a Solution".
Int Urogynecol J
October 2024
Department of Pediatric Surgery, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 611731, China.
Contemporary Outcomes of a National Fetal Spina Bifida Surgery Service.
Prenat Diagn
December 2024
Fetal Medicine Unit, Department of Obstetrics and Gynaecology, Mount Sinai Hospital and University of Toronto, Toronto, Canada.
Article Synopsis
- The study aimed to evaluate the outcomes of fetuses who had open fetal spina bifida surgery in Canada, collecting data on treatment needs and various developmental aspects post-surgery.
- A total of 41 fetuses underwent the procedure from 2017 to 2022, with 24 providing follow-up data at a median age of 46.5 months; results revealed mixed outcomes including a significant need for bladder management and varied motor skills.
- The findings highlighted that while many children displayed typical communication and problem-solving abilities, a majority faced delays in gross motor development, reflecting similar results to previous studies like the MOMs trial.
The Orexin OX Receptor-Dependent Pathway Is Implicated in the Development of Overactive Bladder and Depression in Rats Exposed to Corticosterone.
Neurourol Urodyn
October 2024
Second Department of Gynecology, Medical University of Lublin, Lublin, Poland.
Article Synopsis
- * Various tests including the forced swim test, cystometry, and biochemical analyses were conducted to evaluate the impact of a 7-day TCS administration on bladder function and depressive behaviors.
- * Results indicate that TCS improved bladder overactivity and reversed depressive signs, suggesting a potential link between the orexin system and both urinary bladder function and depression.
Particularities of spasticity in myelomeningocele patients.
Childs Nerv Syst
December 2024
"C.N.S. Alliance" Research Group, Athens, Greece.
Article Synopsis
- Myelomeningocele (MMC) is a significant congenital defect affecting the central nervous system, often leading to spasticity in children, impacting about 20% of them.
- The article reviews causes and clinical manifestations of spasticity in MMC patients, highlighting issues like limb spasticity and neurogenic bladder that affect their mobility and quality of life.
- Effective management of spasticity can involve both medical and surgical treatments, emphasizing the importance of a multidisciplinary approach and early rehabilitation strategies for better outcomes.
The Management of Children and Adolescents with Overactive Bladder Refractory to Treatment with Parasacral Transcutaneous Electrical Nerve Stimulation.
Int Braz J Urol
November 2024
Centro de Distúrbios Urinários Infantis (CEDIMI), Escola Bahiana de Medicina e Saúde Pública, Salvador, Bahia, Brasil.
Article Synopsis
- - This study investigated how children aged 4-17 with overactive bladder (OAB) responded to various treatments after not completing sessions of parasacral TENS (pTENS).
- - Out of 30 children, 70% received single treatments, with 57% achieving complete symptom resolution and 28% having partial success, while 30% still faced bothersome symptoms.
- - Results showed that more intensive therapies led to better outcomes, with a significant decrease in Dysfunctional Voiding Scoring System scores and an increase in patient satisfaction reported through Visual Analogue Scale scores.
Safety and effectiveness of mirabegron for children and adolescents with refractory idiopathic overactive bladder for improving urinary symptoms: a systematic review.
Cent European J Urol
February 2024
Division of Urology, Department of Surgery, UROGIV Research Group, School of Medicine, Universidad del Valle, Cali, Colombia.
Article Synopsis
- - The study aimed to evaluate the safety and effectiveness of mirabegron for treating urinary symptoms in children with refractory overactive bladder (OAB).
- - A systematic review was conducted using multiple medical databases, assessing only studies that included children and adolescents using mirabegron without a control group, with findings showing high rates of improvement and safety.
- - The conclusions suggest that mirabegron is a promising alternative treatment for children with refractory OAB, especially for those who cannot tolerate traditional antimuscarinic medications.
Botulinum Neurotoxin Type A in paediatric non-neurogenic therapy resistant overactive bladder: a cohort study.
Int Urol Nephrol
September 2024
Department of Clinical Medicine, Aarhus University, Palle Juul-Jensens Boulevard 11, 8200, Aarhus N, Denmark.
Introduction And Objective: Intradetrusor Botulinum Neurotoxin Type A (BoNT-A) is an increasingly applied treatment modality for overactive bladder (OAB) in children with refractory urinary incontinence. Despite that, evidence is sparse, and the potential not fully understood. The aim of this study was to evaluate the effectiveness and safety of intradetrusor injection in children with refractory functional OAB and urinary incontinence.
View Article and Find Full Text PDFBoys with bladder dysfunction may have posterior urethral valves - A simple framework to aid investigation.
J Pediatr Urol
December 2024
Perth Children's Hospital, 15 Hospital Ave, Nedlands, Western Australia, 6009, Australia; Division of Surgery, Medical School, University of Western Australia, Crawley, Western Australia Australia; Institute for Paediatric Perioperative Excellence, University of Western Australia, Crawley, Western Australia Australia.
Background: Bladder dysfunction (BD) is a common presenting complaint to paediatric urology outpatient clinics, accounting for up to 47% of referrals and affecting one in ten children of toilet training age. Boys with bladder dysfunction have been shown to have higher rates of posterior urethral valves (PUV) however when to consider cystourethroscopy in this group is unclear.
Objective: Our primary aim was to assess the likelihood of detecting PUV in a cohort of boys of toilet training age presenting to a paediatric urologist with symptoms of bladder dysfunction.
Hansen solubility parameters and quality-by-design oriented optimized cationic nanoemulsion for transdermal drug delivery of tolterodine tartrate.
Int J Pharm
October 2024
Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Article Synopsis
- Tolterodine tartrate (TOT) is an anti-muscarinic medication used to treat urinary urgency and overactive bladder in various patient populations, but oral delivery can cause side effects.
- Researchers developed cationic nanoemulsions for transdermal delivery of TOT, using Hansen solubility parameters (HSP) and quality by design (QbD) to optimize the formulation.
- The optimized formulation (CNE-TOT-6) showed effective drug release, higher bioavailability in a rat model, and improved safety without skin toxicity, suggesting its potential as a treatment for overactive bladder.
The True Impact of Voiding Dysfunctions after Transobturator Sub-Urethral Tape Procedures: A Systematic Review of Literature.
J Clin Med
August 2024
Research Unit of Gynaecology, Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, 00128 Rome, Italy.
: Transobturator techniques are frequently used for the surgical treatment of female stress urinary incontinence (SUI), due to their high success rates and few intraoperative complications. However, controversial results have been reported in the literature regarding their incidence. The aim of this study is to analyze the real incidence and trend over time of such complications, especially voiding dysfunctions and overactive bladder (OAB) symptoms.
View Article and Find Full Text PDFThe Association of Adverse Pregnancy Outcomes With Overactive Bladder Anticholinergics.
Urogynecology (Phila)
August 2024
Department of Obstetrics and Gynecology, Western University, London, Ontario, Canada.
Importance: The pregnancy safety and teratogenicity of overactive bladder (OAB) anticholinergic medications in humans are unknown.
Objective: The aim of this study was to determine if the use of OAB anticholinergics during pregnancy was associated with adverse pregnancy outcomes or congenital malformation.
Study Design: Using routinely collected health care data from Ontario, Canada, we conducted a retrospective cohort study and identified women aged 18-45 years who gave birth between 2004 and 2022 and were eligible for provincial drug benefits.
The value of home-uroflowmetry in evaluation of voiding function in children with overactive bladder.
J Pediatr Urol
July 2024
Paediatric Urodynamic Centre and Department of Urology, The First Affiliated Hospital of Zhengzhou University, Henan 450052, China; Henan Joint International Paediatric Urodynamic Laboratory, Henan 450052, China. Electronic address:
Introduction: Overactive bladder (OAB) in children is clinically common and seriously affects the physical and mental health of children. The voiding frequency (VF) is an important basis for the diagnosis of OAB. The emergence of home-uroflowmetry (HUF) has allowed the patients to record the VF while recording the uroflowmetry at home, and the voiding at home can show the real voiding situation.
View Article and Find Full Text PDFThird-Line Therapeutic Interventions for Non-Neurogenic Bladder Dysfunction in Children.
Curr Urol Rep
December 2024
Department of Urology, The Ohio State University Wexner Medical Center, Columbus, OH, U.S..
Purpose Of Review: The aim of this article is to review considerations and efficacy of third-line treatments for pediatric non-neurogenic bladder dysfunction, including Botulinum toxin A (BoTNA), Posterior Tibial Nerve Stimulation (PTNS), and Sacral Neuromodulation (SNM).
Recent Findings: Federal Drug Administration approval for use of beta-3-agonists in overactive detrusor activity in pediatric patients may provide an additional step prior to third-line therapies. New long-term data on pediatric SNM efficacy, complications, and revision rates will provide valuable information for counseling families.
Low-Intensity Ultrasound Tibial Nerve Stimulation Suppresses Bladder Activity in Rats.
Neuromodulation
July 2024
Department of Rehabilitation, Yuying Children's Hospital, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China; Department of Urology, China Rehabilitation Research Center, Beijing, China; The Second Clinical Medical College, Wenzhou Medical University, Wenzhou, Zhejiang, China; Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China; University of Health and Rehabilitation Sciences, Qingdao, Shandong, China; School of Rehabilitation, Capital Medical University, Beijing, China. Electronic address:
Article Synopsis
Immediate and continued results of parasacral transcutaneous electrical nerve stimulation in paediatric patients with overactive bladders.
J Pediatr Urol
October 2024
Department of Paediatrics, Nephrology and Hypertension Medical University of Gdansk, M. Skłodowskiej-Curie 3a, 80-210 Gdańsk, Poland. Electronic address:
Article Synopsis
Tolterodine Tartrate Loaded Cationic Elastic Liposomes for Transdermal Delivery: In Vitro, Ex Vivo, and In Vivo Evaluations.
Pharm Res
August 2024
Department of Pharmaceutics and Industrial Pharmacy, College of Pharmacy, Taif University, Taif, 21944, Saudi Arabia.
Objective: Tolterodine tartrate (TOTA) is a first-line therapy to treat overactive urinary bladder (OAB). Oral delivery causes high hepatic clearance, xerostomia, headache, constipation, and blurred vision. We addressed Hansen solubility parameter (HSP) and Design Expert oriented optimized cationic elastic liposomes for transdermal application.
View Article and Find Full Text PDF