8,002 results match your criteria: "Overactive Bladder - Treatment"

Purpose: To assess efficacy and safety of URO-902, an investigational gene therapy expressing the α subunit of the large-conductance Ca-activated K channel, in a phase 2a placebo-controlled trial in women with overactive bladder (OAB).

Materials And Methods: Women, 40‒79 years, with OAB and urge urinary incontinence (UUI) who were refractory to OAB medications were randomized to single-dose URO-902 24 and 48 mg or placebo administered by intradetrusor injection via cystoscopy under local anesthesia. Efficacy endpoints included change from baseline to week 12 in mean daily micturitions, urgency episodes, UUI episodes, and patient-reported outcomes.

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Despite the close and clinically confirmed association between depression and overactive bladder, it remains unclear whether this affective disorder is a factor causing overactive bladder or whether overactive bladder is a specific symptom of psychosomatic disorders. This study examined the effects of repeated corticosterone administration on the occurrence of symptoms associated with depression and overactive bladder. Additionally, we examined whether administering TC-G 1008, an antidepressant that selectively activates the GPR39 receptor, could alleviate corticosterone-induced depression-like behavior and detrusor overactivity-related changes in cystometric measurements.

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Aim: To assess clinical outcomes in terms of first to second-stage conversion rates, revision rates, and complications for all patients undergoing sacral neuromodulation of the lower urinary tract for the past five years at the Queen Elizabeth Hospital Birmingham.

Method: This is a retrospective observational study. Only patients with the first stage of sacral neuromodulation between January 2017 and January 2023 were included in the study.

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Purpose: The artificial urinary sphincter (AUS) remains the gold standard to treat stress urinary incontinence related to sphincter insufficiency in patients with neurogenic lower urinary tract dysfunction (NLUTD). This study aims to assess the incidence of de novo neurogenic detrusor overactivity or low bladder compliance after AUS implantation in adult spinal cord injured patients.

Methods: Retrospective observational study, descriptive by analysis of the medical records of patients followed in a department of Neuro-Urology from January 01, 2003 to March 31, 2023.

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Article Synopsis
  • * A new microwave-assisted spectrofluorimetric technique was developed using environmentally friendly solvents and a fluorescent probe to reduce organic waste, meeting industry validation standards.
  • * The proposed method was found to be user-friendly, cost-effective, and environmentally sustainable, effectively minimizing ecological impact while providing reliable drug analysis.
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Aims: OnabotulinumtoxinA (onabotA) is an approved treatment for overactive bladder (OAB). This chart review study aims to determine treatment persistence in patients receiving onabotA (100 U) via a reduced injection-site paradigm distributed across ≤ 3 injection sites.

Methods: This study was a single site, noninterventional, retrospective chart review evaluating adult female OAB patients refractory to behavioral modification and pharmacotherapy before receiving ≥ 1 treatment with onabotA (100 U) via 1-3 injections between July 2017 and June 2021.

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Introduction And Hypothesis: Various treatment options are currently available for the management of stress urinary incontinence (SUI). This study was aimed at determining the effectiveness and safety profile of Bulkamid, and identify predictive factors of clinical success.

Methods: This retrospective study conducted in two French urogynecology university centers between September 2019 and December 2023 included all patients with urinary incontinence who received Bulkamid.

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Purpose: This study evaluates the effectiveness of artificial urinary sphincter (AUS) implantation following transperineal reanastomosis in men with vesicourethral anastomotic stenosis (VUAS) and stress urinary incontinence (SUI) after radical prostatectomy (RP), focusing on long-term explantation rates and urinary continence.

Methods: Patients treated between 2009 and 2020 were retrospectively analyzed. Those undergoing AUS implantation post-transperineal reanastomosis for recurrent VUAS, excluding cases with prior pelvic irradiation and overactive bladder, were included.

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Neuromodulation has been used in the treatment of various pelvic organ dysfunctions for almost 40 years and several placebo-controlled studies have confirmed its clinical effect. Many neuromodulation methods using different devices and stimulation parameters, targeting different neural structures have been introduced, but only a limited number have been adopted into routine clinical use. A substantial volume of basic research and clinical studies addressing specific effects of neuromodulation in the treatment of overactive bladder (OAB) have been published to date; however, their mechanistic implications have not been comprehensively summarized.

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Introduction: The boom in surgery for benign prostatic hyperplasia using Holmium laser enucleation (HoLEP) has reduced length of hospitalization, catheterization duration and the risk of bleeding, with comparable results to the old gold standard. The aim of this study is to evaluate the evolution of medium-term functional results after HoLEP.

Method: Retrospective monocentric observational study in patients who underwent HoLEP surgery from 2014 to 2019.

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Transcutaneous Tibial Nerve Stimulation for Urge Incontinence: A Randomized Clinical Trial.

Urogynecology (Phila)

December 2024

From the Department of Obstetrics and Gynecology, Kaiser Permanente.

Importance: Overactive bladder is a distressing syndrome that significantly affects quality of life. Transcutaneous tibial nerve stimulation (TTNS) has been proposed as a home-based, patient-centered therapy that could improve access to treatment for this condition.

Objective: We aimed to determine the efficacy of 12 weeks of TTNS versus sham therapy in reducing symptomatic bother in ambulatory women with urgency urinary incontinence.

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Article Synopsis
  • - Lower urinary tract dysfunction can arise after neurological disorders, impacting patients' quality of life; myasthenia gravis (MG) studies are rare and mostly consist of case reports detailing various urinary symptoms like incontinence and retention.
  • - A case study is presented of a 68-year-old female with MG who experienced stress urinary incontinence; despite attempts at pelvic floor rehabilitation, no improvement was seen, leading to surgery consideration.
  • - This report emphasizes the link between MG and lower urinary tract issues, highlighting the need for better awareness and tailored management strategies for patients suffering from these conditions.
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Article Synopsis
  • OnabotulinumtoxinA detrusor injection (OnabotA DI) is a treatment for patients with overactive bladder issues that was approved 10 years ago, often performed under local anesthesia (LA) or general anesthesia (GA).
  • In a study of 104 patients, those under LA reported higher anxiety and pain compared to those under GA, particularly during the first injection, but surprisingly still preferred LA despite these concerns.
  • The findings highlighted a notable decrease in anxiety for repeat injections with LA, suggesting that familiarity with the procedure could ease patient anxiety over time, even though pain was significantly lower with GA.
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Low-value practices in primary care: a cross-sectional study comparing data between males and females in Spain.

BMJ Open

November 2024

RICAPPS - Red de Investigación en Cronicidad, Atención Primaria y Prevención y Promoción de la Salud, San Juan de Alicante, Spain.

Article Synopsis
  • The study addresses the global issue of overuse of medical services, focusing on low-value practices (LVPs) in primary care, which can harm patients and undermine healthcare quality.
  • Conducted in Alicante, Spain, the research analyzed digital medical records from nearly a million patients to compare the frequency of LVPs prescribed to males versus females in 2022.
  • Findings revealed that females received significantly more LVPs (5.27%) than males (4.00%), with specific practices commonly leading to potential patient harm, highlighting the need for gender-sensitive approaches in clinical training and research.
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A Deep Analysis of the Pelvic Floor Motor Response in Sacral Neuromodulation Linking It to Outcome.

Neuromodulation

November 2024

Department of Urology, Antwerp University Hospital, Edegem, Belgium; Department of Urology, Antwerp Surgical Training, Anatomy and Research Centre, Faculty of Medicine and Health Sciences, Anatomy, University of Antwerp, Antwerp, Belgium. Electronic address:

Article Synopsis
  • The study focused on how pelvic floor muscle (PFM) responses during sacral neuromodulation (SNM) programming could enhance the treatment of patients with overactive bladder or urinary retention.
  • It involved 64 women, with a success rate of 80%, and measured the relationship between sensory and motor thresholds and treatment outcomes.
  • The results indicated that lower motor thresholds and specific PFM response amplitudes were linked to better treatment improvement, suggesting that monitoring these factors could optimize therapy delivery.
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Objective: To report our experience of outpatient periurethral injections of Bulkamid under local anesthesia in the office in female patients for stress urinary incontinence (SUI). Polyacrylamide hydrogel (Bulkamid) is a relatively recent bulking agent which may have a better safety profile than previous generations.

Methods: The data of all women who underwent outpatient periurethral Bulkamid injections under local anesthesia in the office at a single academic center were collected prospectively between November 2019 and August 2023.

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Article Synopsis
  • The study aimed to assess the risk of developing dementia associated with different anticholinergic drugs prescribed for overactive bladder among older adults in England.
  • Utilizing data from the Clinical Practice Research Datalink, researchers conducted a nested case-control study involving over 170,000 patients diagnosed with dementia, alongside matched controls without dementia.
  • Results indicated a slightly elevated risk of dementia (odds ratio of 1.18) linked to anticholinergic drug use, with a higher risk observed in men compared to women.
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Overactive bladder (OAB) is a syndrome consisting of urgency, usually accompanied by urinary frequency and nocturia, with or without urgent incontinence, in absence of a causative infection or pathological conditions. The prevalence of OAB is approximately 11-19% in both men and women, and leads to a significant negative effect on health-related quality of life. The prevalence of OAB increases with age.

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Objective: The purpose of this study was to evaluate the effectiveness of the drugs Solifenacin and Vesusten in relation to the treatment of neurogenic bladder overactivity in multiple sclerosis (MS).

Materials And Methods: A prospective, single-site, single-center, placebo-controlled, parallel-group, comparative clinical trial was conducted. The study included 41 MS patients of both sexes aged 18-50 years with urodynamically confirmed detrusor overactivity.

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This review is devoted to the pathogenetic basis and clinical results of the use of a new domestic innovative drug Vesusten, which is based on polypeptides made of animal bladder tissue, for the treatment of patients with overactive bladder. Data are given regarding the epidemiology, pathogenesis factors and current treatment methods. The mechanisms of peptide regulation of physiological processes in humans are also described.

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