4,412 results match your criteria: "Ovarian Hyperstimulation Syndrome"

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease primarily impacting women of childbearing age. While pregnancy and hormonal stress can trigger SLE flare-ups, the effects of assisted reproductive therapies (ARTs) on SLE patients are not well defined. We conducted a search of PubMed/Medline, Embase, and CENTRAL until March 20, 2024, to find observational studies assessing the prevalence of SLE flares and pregnancy outcomes following ARTs.

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Article Synopsis
  • Infertility linked to polycystic ovary syndrome (PCOS) poses a major issue for women, with new evidence-based treatments transforming how it's managed.
  • Recent advancements in drug treatments have influenced clinical practices significantly, particularly in treating infertility related to PCOS.
  • Key developments include the use of metformin, choosing between clomiphene citrate and letrozole for ovulation induction, new gonadotropin options for IVF, and the standardization of elective embryo transfer in susceptible patients.
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In vitro maturation of oocytes: what is already known?

Biol Reprod

October 2024

Department of Gynecology and Obstetrics, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil.

Article Synopsis
  • - ARTs help couples with fertility issues by manipulating eggs and embryos in a lab, with controlled ovarian stimulation being a common procedure that sometimes leads to complications like ovarian hyperstimulation syndrome (OHSS)! - In vitro maturation (IVM) has been developed to minimize the risk of OHSS, especially beneficial for women with polycystic ovary syndrome (PCOS) and those needing fertility preservation due to cancer treatments! - Recent improvements in IVM techniques, including hormone use, have boosted success rates for pregnancy and improved outcomes for newborns, making it a promising option in assisted reproductive technology!
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Article Synopsis
  • The study focuses on Polycystic Ovary Syndrome (PCOS), a common reproductive hormone disorder in women that can lead to a heightened risk of ovarian hyperstimulation syndrome (OHSS) during fertility treatments.
  • It included a retrospective analysis of 200 PCOS patients, with 118 exhibiting a high ovarian response (HOR) and 82 showing a normal response (NOR), revealing significant differences in hormone levels and characteristics between the two groups.
  • Key findings showed that HOR patients had higher levels of anti-Müllerian hormone (AMH) and displayed more oocytes and elevated inflammatory markers during controlled ovarian stimulation, suggesting the involvement of CCL25/CCR9 in high ovarian response.*
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Article Synopsis
  • An early start of ovarian stimulation is needed only if doctors plan to transfer a fresh embryo, while many are now moving to frozen embryo transfers, which can make treatments easier and more personalized.
  • Luteal phase stimulation, which begins after ovulation, is becoming more popular, but it has its own pros and cons as more people try it.
  • There are concerns about getting pregnant without realizing it while starting stimulation, and using stimulation medications can cause some health risks, but it can also work well for many patients.
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[Fertility preservation in patients with hematopoietic diseases].

Rinsho Ketsueki

October 2024

Department of Hematology/Supportive Care Team for AYA Generation, Osaka International Cancer Institute.

Article Synopsis
  • * In Japan, the Japan Society for Fertility Preservation has developed comprehensive guidelines, a national registry, and a financial support system for fertility preservation efforts.
  • * Effective fertility preservation in these patients requires collaboration between oncology and onco-fertility experts, addressing unique challenges like treatment timing and potential risks associated with fertility preservation procedures.
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The clinical diversity of primary hypothyroidism presenting as a spontaneous ovarian hyperstimulation syndrome.

Endocrinol Diabetes Metab Case Rep

July 2024

Department of Endocrinology, Diabetes and Metabolism, Christian Medical College, Vellore, Tamil Nadu, India.

Article Synopsis
  • * The study reviewed five patients with untreated hypothyroidism who showed complications like multicystic ovaries and delayed bone age, with some experiencing severe symptoms like menorrhagia and ovarian torsion.
  • * Early detection and a collaborative approach between gynecology and endocrinology are crucial for managing spontaneous OHSS, which can be life-threatening but is easy to treat with proper care.
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Article Synopsis
  • * A comprehensive review of literature from 1990 to 2024 identified risk factors for OHSS, such as age and body weight, and indicated that using a GnRH antagonist reduces the risk compared to traditional protocols, although mild to moderate OHSS can still occur.
  • * Effective management of OHSS requires early diagnosis, consideration of psychological impacts, and adherence to evidence-based guidelines for patient care to ensure both safety and legal compliance.
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Ischemic events are infrequent in patients with ovarian hyperstimulation syndrome.

J Stroke Cerebrovasc Dis

September 2024

Clinical and Translational Neuroscience Unit, Department of Neurology, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, 520 East 70th Street, Starr Pavilion, 607, New York, NY, 10021, USA. Electronic address:

Background: Case reports describe arterial thrombosis including ischemic stroke associated with severe ovarian hyperstimulation syndrome (OHSS), but the prevalence of major ischemic events during or shortly after OHSS is unknown.

Methods: Using publicly available administrative datasets in the United States between 2015 and 2020, we conducted two separate cross-sectional studies of patients with OHSS. We included all patients with OHSS.

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Objectives: To summarize the best evidence for the management of ovarian hyperstimulation syndrome in patients undergoing assisted reproductive therapy.

Methods: Evidence related to the management of ovarian hyperstimulation syndrome in patients undergoing assisted reproductive therapy, including guidelines, clinical decision, best clinical practice, systematic evaluation, expert consensus and evidence summary and related original research were systematically searched in UpToDate, BMJ Best Practice, World Health Organization (WHO) website, Guidelines International Network (GIN), National Institute for Health and Clinical Excellence (NICE) website, National Guidelines website, American Society for Reproductive Medicine (ASRM) website, New York Academy of Sciences (NYAS) website, Joanna Briggs Institute (JBI) database, Cochrane Library, CINAHL, PubMed, Wanfang database, CNKI, and China Biomedical Literature Database from inception to May 31, 2024. Two researchers independently evaluated the quality of the literature, and a senior researcher made the final decision for literature inclusion.

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Severe ovarian hyperstimulation syndrome following sole gonadotropin-releasing hormone (GnRH) agonist trigger: a case series and literature review.

Arch Gynecol Obstet

November 2024

Department of Obstetrics and Gynecology, Lis Hospital for Women's Health, Tel Aviv. Sourasky Medical Center, affiliated to the Faculty of Medicine, Tel Aviv University, 6423906, Tel Aviv, Israel.

Article Synopsis
  • The study reports three cases of early severe ovarian hyperstimulation syndrome (OHSS) in patients treated with a GnRH antagonist protocol using a GnRH agonist trigger, which led to hospitalization and peritoneal drainage.
  • All three patients displayed severe symptoms like abdominal distension and required supportive care; they showed significant improvement and complete recovery within 20 days post-hospitalization.
  • The findings emphasize that using a GnRH agonist trigger may not fully prevent OHSS, indicating that clinicians should remain vigilant in managing such risks, even without administering hCG.
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The effect of intravenous calcium gluconate on the prevention of ovarian hyperstimulation syndrome. (A randomized clinical trial).

J Gynecol Obstet Hum Reprod

December 2024

Associate Professor, Fellowship of Infertility, Supporting the Family and the Youth of Population Research Core, Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Objective: Oral Cabergoline and intravenous Calcium have the potential to prevent Ovarian Hyperstimulation Syndrome (OHSS) in assisted reproductive technology by regulating the activity of the Vascular Endothelial Growth Factor (VEGF) receptor. The purpose of this study was to examine the effect of Cabergoline with intravenous Calcium versus oral Cabergoline alone on the overall rate of OHSS.

Methods: This study is a randomized clinical trial which was carried out in Milad Infertility Center affiliated with Mashhad University of Medical Sciences, Mashhad, Iran between April 2016 and January 2018.

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A case study of transneovaginal oocyte retrieval after novel Lee's neovaginoplasty in Mayer-Rokitansky-Küster-Hauser syndrome.

Taiwan J Obstet Gynecol

September 2024

Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Linkou Medical Center and Chang Gung University, Taoyuan, Taiwan. Electronic address:

Objective: Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a rare congenital disorder that results in vaginal agenesis. Lee's neovaginoplasty is a novel surgery for reconstructing the vagina. Transneovaginal oocyte retrieval completely changes the scope of fertility for patients with MRKH syndrome who have undergone neovaginal reconstruction.

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Purpose: To support doctors in counselling women with genetic predisposition for breast or gynecologic cancers on endocrine interventions.

Methods: Evidence on the safety of endocrine interventions for fertility treatment, contraception, hormone replacement therapy after risk-reducing salpingo-oophorectomy (RRSO) or treatment of symptoms during peri- and postmenopause was analysed for carriers of probably pathogenic and pathogenic variants in BRCA1 or BRCA2 (BRCA1/2-pV), in other breast and ovarian cancer genes and the Lynch Syndrome. Cancer risks were compared with data on risks for the general population.

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Ovarian hyperstimulation syndrome.

CMAJ

September 2024

Departments of Emergency Medicine (Rosenberg), Family Medicine (Rangwala), and Obstetrics and Gynecology (Magee), University of Ottawa, Ottawa, Ont.

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Optimized personalized management approach for moderate/severe OHSS: development and prospective validation of an OHSS risk assessment index.

Hum Reprod

October 2024

Department of Obstetrics and Gynecology, Center for Reproductive Medicine, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Study Question: Can a simplified ovarian hyperstimulation syndrome (OHSS) risk assessment index be developed and validated with sufficient discrimination of moderate/severe OHSS from those without OHSS?

Summary Answer: This easy-to-use OHSS risk assessment index shows good discriminative power and high calibration accuracy in internal and external validation cohorts.

What Is Known Already: An early alert and risk stratification is critical to prevent the occurrence of OHSS. We have previously developed a multi-stage smartphone app-based prediction model to evaluate the risk of OHSS, but app use might not be so convenient in many primary institutions.

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GnRH agonist-only trigger, compared to dual trigger, reduces oocyte retrieval rate in high responders without affecting cumulative live birth rate.

Front Endocrinol (Lausanne)

September 2024

Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology and Women's Health, Taichung Veterans General Hospital, Taichung, Taiwan.

Introduction: This study compared, in high responders undergoing IVF treatment, GnRH agonist-only trigger and dual trigger on oocyte retrieval rate and cumulative live birth rate (LBR). The aim was to determine if the GnRH agonist-only triggers had provided outcomes comparable to dual trigger, while minimizing the risk of ovarian hyperstimulation syndrome (OHSS).

Materials And Methods: A retrospective, matched case-control study was conducted at Taichung Veterans General Hospital, Taiwan, including women who underwent IVF/ICSI between January 1, 2014, and December 31, 2022.

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Calcium channel blockers are generally considered safe for use during pregnancy. They have several indications, including second-line therapy for lowering blood pressure and tocolytic therapy. We present the case of a 24-year-old woman, G1P0, with a twin gestation at 22 weeks, who presented with acute respiratory distress.

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: Polycystic ovarian syndrome (PCOS) is a widespread endocrine disorder affecting 5-18% of females in their childbearing age. The aim of this study is to assess the efficacy of combining a low dosage of human chorionic gonadotropin (HCG) along with clomiphene citrate (CC) for stimulating ovulation in infertile women diagnosed with CC-resistant PCOS. : A randomized controlled trial was carried out on 300 infertile CC-resistant PCOS women.

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To exlplore the association between the baseline luteinizing hormone/follicle stimulating hormone (LH/FSH) ratio of polycystic ovary syndrome (PCOS) and in vitro fertilisation-embryo transfer outcomes. This was a retrospective cohort study. A total of 2 868 PCOS patients were enrolled, all of the participants were patients in The First Affiliated Hospital of Anhui Medical University Hospital from October 2015 to October 2021.

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From Ovarian Hyperstimulation to the Discovery of a Liver Nodule.

Cureus

July 2024

Obstetrics and Gynecology, Unidade Local de Saúde (ULS) de Coimbra, Coimbra, PRT.

Article Synopsis
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Objective: The aim of the present study was to investigate the incidence of intrahepatic cholestasis of pregnancy (ICP) as well as neonatal outcomes between conception via in vitro fertilization (IVF) compared with spontaneous conception (SC) and screen the risk factors of ICP in IVF.

Methods: This retrospective cohort study included 4467 puerperae who conceived via IVF, and 28 336 puerperae who conceived spontaneously and linked the information from neonates. The general linear model (GLM), multivariate logistic regression analysis, a forest plot, and nomogram were used to assess impact factors and risk prediction.

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Causal relationship between OHSS and immune cells: A Mendelian randomization study.

J Reprod Immunol

September 2024

Department of Histology and Embryology, School of Preclinical Medical, Zunyi Medical University, Zunyi, Guizhou, China. Electronic address:

Objective: To confirm the causal relationship between immune cells and Ovarian Hyperstimulation Syndrome.

Design: Obtaining data, collecting single nucleotide polymorphisms, detecting instrumental variables heterogeneity, assessing causality, and assessing bidirectional causality.

Subjects: A two sample Mendelian study to confirm the causal relationship between immune cells and Ovarian Hyperstimulation Syndrome.

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