2,422 results match your criteria: "Ovarian Dysgerminomas"

The aim of this retrospective multicentric case series is to describe the CT findings of ovarian neoplasia in dogs. Twenty dogs with pre- and postcontrast CT exams and cytological/histological diagnosis of ovarian neoplasia were included. Five dogs presented with bilateral tumors, for a total of 25 neoplasms: 15 carcinomas (4 bilateral), 4 granulosa cell tumors, 2 poorly differentiated malignant neoplasia (bilateral), 2 luteomas, 1 teratoma, 1 dysgerminoma.

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[Clinicopathological significance of SOX2 and FOXG1 expression patterns in ovarian immature teratomas].

Zhonghua Bing Li Xue Za Zhi

December 2024

Department of Pathology, Third Hospital, School of Basic Medical Sciences, Peking University Health Science Center, Beijing100191, China.

To investigate the relationship between the expression patterns of SOX2 and FOXG1 and the differentiation/development level of neural components in immature teratoma and to determine the clinical significance and potential application of this correlation in a clinical setting. We conducted a comprehensive whole transcriptome sequencing analysis to identify differentially expressed genes (DEGs) across various subtypes of ovarian germ cell tumors. Additionally, immunohistochemical staining of paraffin-embedded tissue sections was employed to assess the nuclear staining pattern of SOX2 and FOXG1 proteins within the tumor tissues.

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Usefulness of pelvic lymphadenectomy in staging of ovarian dysgerminoma.

Cir Cir

November 2024

Servicio de Oncología Ginecológica, Unidad Médica de Alta Especialidad HGO 4 Luis Castelazo Ayala. Instituto Mexicano del Seguro Social, Ciudad de México, México.

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Ovarian cancer in children and adolescents: A unique clinical challenge.

Eur J Surg Oncol

October 2024

Division of Gynaecology and Obstetrics, Department of Gynaecology University Medical Centre Ljubljana, Slajmerjeva 3, 1000, Ljubljana, Slovenia; Medical Faculty, University of Ljubljana, Vrazov Trg 2, 1000, Ljubljana, Slovenia.

Article Synopsis
  • - Ovarian cancer in children and adolescents is uncommon and requires a specialized approach, involving a team of healthcare providers to address its unique diagnostic and treatment challenges.
  • - Diagnosis often involves imaging tests and tumor markers, while surgical treatments should prioritize fertility preservation whenever possible, along with tailored chemotherapy based on the type of cancer and its stage.
  • - Early detection leads to high survival rates of over 90%, but ongoing follow-up is essential to monitor for recurrence and manage any long-term side effects from treatment.
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  • - Ovarian germ cell tumors (OVGCTs) represent 28% of ovarian cancers in Saudi Arabia, with malignant types having a 13% diagnosis rate; patients with recurrent tumors often face a grim prognosis due to aggressive characteristics.
  • - This study uniquely investigates PD-L1 expression in OVGCTs, analyzing samples from 34 tumors to understand its role in the tumor microenvironment, immune cell presence, and cancer stem cells' relation to overall clinical outcomes.
  • - Results show that dysgerminomas have higher PD-L1 levels than yolk sac tumors, correlating with greater immune cell infiltration and better prognoses, contributing to the potential for immunotherapy in ovarian cancer treatment.
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Article Synopsis
  • Gonadoblastoma is a rare tumor made up of sex cord and primitive germ cells, mainly found in individuals with 46,XY gonadal dysgenesis, but can also occur in those with a 46,XX karyotype.
  • A case study describes a 14-year-old girl with an uncommon virilizing ovarian tumor, leading to the removal of both ovaries and tubes, which was confirmed as bilateral gonadoblastoma with additional dysgerminoma on one side.
  • It's important to consider malignant gonadal tumors in patients with 46,XX karyotype and virilization, and a gonadal biopsy may be necessary even if tests seem normal.
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Objective: To analyze and improve the accuracy of preoperative assessment and intraoperative frozen-section analysis (FSA) for malignant ovarian germ cell tumors (MOGCTs), especially in the context of fertility preservation.

Methods: A retrospective review of 48 women aged under 40 years, diagnosed with MOGCTs, and treated at Chonnam National University Hospital between July and December 2022 was conducted. The results of preoperative magnetic resonance imaging (MRI), measurement of serum tumor markers (α-fetoprotein [AFP], β-human chorionic gonadotropin, lactate dehydrogenase [LDH], cancer antigen [CA] 125, CA 19-9, CA 72-4, carcinoembryonic antigen), and intraoperative FSA were compared with the final pathology diagnosis.

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Dysgerminoma with Syncytiotrophoblastic Giant Cells Associated with a Concurrent Ectopic Pregnancy.

Indian J Surg Oncol

September 2024

Department of Pathology, Jawaharlal Nehru Medical College and Hospital, AligarhMuslimUniversity, Aligarh, Uttar Pradesh India.

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Ovary dysgerminoma is one of the most good prognosis malignant tumor, which has a 5-year overall survival rate exceeding to 90%. Generally, the incidence of ovarian dysgerminoma (OD) is relatively low, accounting for ~0.6% of all ovarian tumors.

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-positive 45,X/46,XY karyotype in a phenotypically Turner-like Chinese adolescent female with ovarian dysgerminoma and gonadoblastoma.

J Pediatr Endocrinol Metab

August 2024

Department of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University, Sichuan Province Engineering Technology Research Center of Molecular Diagnosis of Clinical Diseases, Molecular Diagnosis of Clinical Diseases Key Laboratory of Luzhou, Sichuan, China.

Article Synopsis
  • The study presents a rare case of a Chinese girl with a 45,X/46,XY mosaicism who developed malignant tumors, including dysgerminoma and gonadoblastoma, associated with this genetic condition.
  • The girl exhibited symptoms typical of Turner syndrome and underwent a gonadectomy, with no complications reported during follow-up.
  • The findings suggest a link between Y chromosome microdeletions in gonadal tissue and the severity of symptoms in 45,X/46,XY mosaicism, underscoring the need for thorough genetic testing.
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  • Women aged 40 years and older diagnosed with malignant ovarian germ cell tumors experience poorer outcomes compared to younger patients (15-39 years), reflecting higher risks and severity of their conditions.
  • The study utilized the National Cancer Database from 2004-2016 to analyze care patterns and survival rates across different age groups, focusing on four common tumor types.
  • Results indicated older women were more likely to face additional health issues, advanced disease stages, and less effective treatments, contributing to a significantly higher risk of death from their diagnosis.
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Dysgerminoma of the ovary.

Minerva Obstet Gynecol

July 2024

Department of Obstetrics and Gynecology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

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Article Synopsis
  • * MRI plays a crucial role in identifying ovarian dysgerminoma, showing it as a large, solid mass with characteristic fibrovascular septa, aiding in diagnosis.
  • * The article discusses two cases of patients who experienced pelvic pain, where imaging revealed a right ovarian mass that was confirmed through surgery and histological analysis.
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Key Clinical Message: Fertility-sparing surgery and appropriate adjuvant chemotherapy for advanced malignant ovarian germ cell tumors have excellent survival results and promising reproductive and obstetric outcomes.

Abstract: This case report aims to demonstrate the potential feasibility and success of fertility-sparing surgery (FSS) coupled with adjuvant chemotherapy in treating advanced malignant ovarian germ cell tumor (MOGCT), focusing on pure dysgerminoma, fertility, and achieving spontaneous pregnancy. The patient was a 23-year-old female who initially presented with complaints of abdominal distension and a palpable mass and was subsequently diagnosed with advanced MOGCT.

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[Genetic characteristics of ovarian malignant germ cell tumors].

Zhonghua Bing Li Xue Za Zhi

June 2024

Department of Pathology, School of Basic Medical Sciences, Third Hospital, Peking University Health Science Center, Beijing 100191, China.

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Germ cell tumors encompass a broad spectrum of neoplasms arising from germ cell lineage, demonstrating varying histological profiles and clinical presentations. These tumors encompass a range of benign and malignant entities. While global trends provide insights into their prevalence, specific regional variations, such as those within North-Western India, remain less explored.

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microRNAs (miRNAs) are small endogenous noncoding RNAs, and alterations in their expression may contribute to oncogenesis. Discovering a unique miRNA pattern holds the potential for early detection and novel treatment possibilities in cancer. This study aimed to evaluate miRNA expression in pediatric patients with gonadal germ cell tumors (GCTs), focusing on characterizing the miRNA profiles of each histological subtype and identifying a distinct histological miRNA signature for a total of 42 samples of pediatric gonadal GCTs.

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Article Synopsis
  • The study evaluates gonadoblastoma by examining clinical features, pathological morphology, and immunohistochemical characteristics through three patient cases treated between 2014 and 2020.
  • The cases involved phenotypical females with varied chromosomal types and presented with specific microscopic features like small nests of primitive germ cells and sex cord-like cells.
  • The findings suggest that gonadoblastoma is a rare tumor often linked with gonadal hypoplasia, and the study emphasizes the need for better understanding and accurate diagnosis to avoid misclassifications with similar tumors.
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Component Patterns and Survival Outcomes in Patients with Mixed Malignant Ovarian Germ Cell Tumors: A Retrospective Cohort Study.

Clin Oncol (R Coll Radiol)

June 2024

National Clinical Research Center for Obstetric and Gynecologic Diseases, Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, People's Republic of China. Electronic address:

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