Successful myomectomy during pregnancy for the indication of acute lower abdominal pain with red degenerative myoma or ovarian torsion? "Case report".

Uterine fibroids are benign tumors, arising from uterine smooth muscle cells. They are one of the most common benign tumors of the female genital tract among childbearing women, occurring in 20%-50% of women of reproductive age. The association of uterine myomas with pregnancy is high.

Factors responsible for dropout in the Ponseti method of clubfoot treatment: A cross-sectional study.

Background: The Ponseti method for clubfoot treatment is a non-surgical treatment with a successful outcome. However, many children are not able to complete Ponseti treatment due to various barriers and are termed dropout children. This study aimed to find out the factors responsible for dropout from clubfoot treatment in Peshawar, Pakistan.

Neuronal Cell Rearrangement During Aging: Antioxidant Compounds as a Potential Therapeutic Approach.

Aging is a natural process that leads to time-related changes and a decrease in cognitive abilities, executive functions, and attention. In neuronal aging, brain cells struggle to respond to oxidative stress. The structure, function, and survival of neurons can be mediated by different pathways that are sensitive to oxidative stress and age-related low-energy states.

Evaluation of olfactory and visual cues for conservation biological control of crape myrtle bark scale in urban landscapes.

Background: Acanthacoccus lagerstroemiae (crape myrtle bark scale, CMBS) is an exotic scale insect that feeds on the sap of crape myrtle trees. Heavy infestations of CMBS reduce flowering and honeydew promotes sooty mold growth on the leaves and branches, reducing the aesthetic value of crape myrtle trees in urban landscapes. Lady beetles (Coleoptera: Coccinellidae) are generalist predators that feed on CMBS.

Intraoperative thrombus formation in the artificial tube graft in a fenestrated extracardiac Fontan procedure-to trust our eyes or instincts?

Unlabelled: Appearance of a thrombus in the graft intraoperatively during Fontan surgery is not reported and warrants careful evaluation. Our patient was an 18-year-old lady who underwent fenestrated extracardiac Fontan surgery. Intraoperatively, transesophageal echocardiography revealed an echogenic structure inside the conduit.

Mushroom Poisoning and Acute Liver Injury: A Case-Based Review.

Mushrooms have always found their way into our dining plates due to their exotic looks and edibility. It is also one of the food items that can lead to fatal hepatotoxicity if the wrong species is picked up. Mushroom poisoning is frequently seen in forest adventure seekers and presents with variable time frames, mainly with acute gastrointestinal symptoms.

Widespread gene-environment interactions shape the immune response to SARS-CoV-2 infection in hospitalized COVID-19 patients.

Genome-wide association studies performed in patients with coronavirus disease 2019 (COVID-19) have uncovered various loci significantly associated with susceptibility to SARS-CoV-2 infection and COVID-19 disease severity. However, the underlying -regulatory genetic factors that contribute to heterogeneity in the response to SARS-CoV-2 infection and their impact on clinical phenotypes remain enigmatic. Here, we used single-cell RNA-sequencing to quantify genetic contributions to -regulatory variation in 361,119 peripheral blood mononuclear cells across 63 COVID-19 patients during acute infection, 39 samples collected in the convalescent phase, and 106 healthy controls.

Assessing the Efficacy of Modified CT Severity Index Versus Conventional CT Severity Index in Determining Severity and Clinical Outcomes of Chronic Obstructive Pulmonary Disease (COPD).

Aims The aim of this study was to evaluate the severity of chronic obstructive pulmonary disease (COPD) using the computed tomography severity index (CTSI) and the modified CTSI (MCTSI) and to assess their correlation with clinical outcome measures. Additionally, the study aimed to compare the diagnostic performance of these indices in predicting moderate to severe COPD, based on patient outcomes. Materials and methods In this prospective study, conducted between November 2023 and March 2024, two radiologists, blinded to clinical outcomes, independently assessed CTSI and MCTSI.

Complex Indirect Carotid-Cavernous Fistula With Contralateral Ophthalmic Manifestations.

A carotid-cavernous fistula (CCF) involves an abnormal communication between the carotid artery and the cavernous sinus. For indirect CCF, it usually occurs in post-menopausal women. Contralateral symptoms for indirect CCF are rare.

Antibiotic Stewardship in Hospital-Acquired Pneumonia.

Background Antimicrobial resistance and incorrect use of antibiotics may worsen hospital-acquired pneumonia (HAP), which is a serious illness associated with healthcare and is related to higher rates of morbidity and death. Objective This study aimed to evaluate the effectiveness of antibiotic stewardship programs (ASPs) in optimizing the treatment of HAP, focusing on improving patient outcomes and reducing resistance. Methodology A prospective cohort study was conducted from August 2022 to July 2023.

Metformin and risk of adverse pregnancy outcomes among pregnant women with gestational diabetes in the United Kingdom: A population-based cohort study.

Aims: Metformin is increasingly used off-label as the treatment of gestational diabetes (GDM). Our objective was to determine if metformin versus insulin initiation is associated with the adverse pregnancy outcomes.

Materials And Methods: We conducted a retrospective cohort study using data from the Clinical Practice Research Datalink, its pregnancy register, and Hospital Episode Statistics from 1998 to 2018.

Paroxysmal Hypertension: A Grave Cause.

A 62-year-old lady was referred with the diagnosis of hypertensive encephalopathy. She had episodes of paroxysms of hypertension while on the ventilator with normal saturations. She underwent a battery of tests to identify the cause of the paroxysms.

Meta-Analysis Comparing Immediate Versus Staged Complete Revascularization for ST-Elevation Myocardial Infarction With Multivessel Disease.

Patients with ST-segment elevation myocardial infarction (STEMI) frequently present with multivessel coronary artery disease (CAD) during primary percutaneous coronary intervention, and the optimal timing of complete revascularization (CR) in these cases remains uncertain. This study aims to assess major adverse cardiovascular events (MACEs) and procedural complications in patients with STEMI with multivessel CAD who underwent immediate (index procedure) versus staged CR. We conducted a systematic review and meta-analysis of randomized controlled trials comparing immediate to staged CR in STEMI and multivessel CAD.

An adaptive enrichment design using Bayesian model averaging for selection and threshold-identification of predictive variables.

Precision medicine is transforming healthcare by offering tailored treatments that enhance patient outcomes and reduce costs. As our understanding of complex diseases improves, clinical trials increasingly aim to detect subgroups of patients with enhanced treatment effects. Biomarker-driven adaptive enrichment designs, which initially enroll a broad population and later restrict to treatment-sensitive patients, are gaining popularity.

Characterization of ZAT12 protein from Prunus persica: role in fruit chilling injury tolerance and identification of gene targets.

PpZAT12, a transcription factor differentially expressed in peach varieties with distinct susceptibility tochilling injury (CI), is a potential candidate gene for CI tolerance by regulating several identified gene targets. ZAT (zinc finger of Arabidopsis thaliana) proteins play roles in multiple abiotic stress tolerance in Arabidopsis and other species; however, there are few reports on these transcription factors (TFs) in fruit crops. This study aimed to evaluate PpZAT12, a C2H2 TF up-regulated in peach fruit by a heat treatment applied before postharvest cold storage for reducing chilling injury (CI) symptoms.

Reproducible protein quantitation of 270 human proteins at increased depth using nanoparticle-based fractionation and multiple reaction monitoring mass spectrometry with stable isotope-labelled internal standards.

Here we show that when using a mix of 274 light synthetic peptide standards (NAT) as surrogates for 270 human plasma proteins, as well as stable isotope-labelled standards (SIS) as normalizers (both from MRM Proteomics Inc.) for targeted quantitative analysis by liquid chromatography multiple reaction monitoring mass spectrometry (LC/MRM-MS), the Seer Proteograph™ platform allowed for the enrichment and absolute quantitation of up to an additional 62 targets (median) compared to two standard proteomic workflows without enrichment, representing an increase of 44%. The nanoparticle-based fractionation workflow resulted in improved reproducibility compared to a traditional proteomic workflow with no fractionation (median 8.

Metacarpophalangeal Joint Dislocations Two Cases, Two Stories.

Introduction: Metacarpophalangeal (MCP) joint dislocation and its pathoanatomy was first discussed in detail in an article written by Kaplan et al . ,in 1957. They had identified certain features of complex, that is irreducible MCP joint dislocation through closed method to differentiate from a simple MCP joint dislocation, that is MCP joint dislocation that can be reduced by closed method.

Blackish Discoloration of Articular Cartilage during Total Knee Replacement; a Case Report.

Introduction: Alkaptonuria is a rare metabolic disorder that follows an autosomal recessive genetic inheritance pattern. It is distinguished by the buildup of homogentisic acid in tissues due to deficient homogentisic acid oxidase enzyme activity. The excess homogentisic acid is expelled through urine, darkening it on oxidation.

Public-Private Partnership Model in Delivering Quality Health Care and Medical Education - An Enduring Success Story for the Past Seven Decades.

Public-private partnerships (PPPs) are integral to the National Health Mission (NHM). Kasturba Medical College (KMC), Mangalore, was the first private institution in India to embrace the PPP model way back in 1953. The then Government of Madras permitted KMC Mangalore to partner with the 2 district hospitals - the Government Wenlock and the Lady Goschen Hospitals.

Non-alcohlic Fatty Liver Disease (NAFLD): Is it a Dormant Volcano or Tip of an Iceberg?

Non-alcoholic fatty liver disease (NAFLD), a major cause of chronic liver disease, is known to affect a quarter of the global adults. Natural history of NAFLD shows interindividual variation, traditionally it progresses from simple steatosis to steatohepatitis to fibrosis/cirrhosis and finally yet rarely to hepatocellular carcinoma. It is largely a lifestyle-related disease and is often labeled as the hepatic manifestation of metabolic syndrome.

Adaptation of potato cultivars to phosphorus variability and enhancement of phosphorus efficiency by Bacillus subtilis.

Background: Plants utilize a variety of mechanisms to adapt to fluctuations in phosphorus (P) availability. Potatoes, in comparison to other crops, often display reduced phosphorus use efficiency (PUE) due to their underdeveloped root systems; therefore, understanding the mechanisms underlying PUE is critical for improving it. This study aimed to evaluate the morphological and physiological responses of potatoes to different P levels, with a focus on root system alterations and PUE.