1,563 results match your criteria: "Otto von Guericke Universitat Magdeburg[Affiliation]"

[Content and quality of web-based health information for the prevention and prediction of food allergies in children: A systematic evaluation].

Z Evid Fortbild Qual Gesundhwes

January 2025

Klinik und Poliklinik für Kinder- und Jugendmedizin der Universität Regensburg, KinderUniKlinik Ostbayern (KUNO), Klinik St. Hedwig, Barmherzige Brüder Regensburg, Regensburg, Deutschland; Wissenschafts- und Entwicklungscampus Regensburg (WECARE), Klinik St. Hedwig, Barmherzige Brüder Regensburg, Regensburg, Deutschland.

Introduction: Web-based health information can support health-related decisions if it is of high quality, i. e. accurate, understandable and barrier-free.

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Digital learning resources are in increasing demand, especially in the light of the planned reform of the medical licensing regulations for 2028. In a pilot project, we digitised and evaluated a logbook for students in their practical year (PJ).The aim of this study is to evaluate the digital and non-digital PJ logbooks.

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A20, an ubiquitin-editing enzyme, plays a pivotal role in regulating cell signaling and immune responses. Dysregulated A20 expression has been associated with various pathological conditions, including inflammatory diseases and malignancies, where its expression levels often correlate with differing prognoses in solid tumors. This study aimed to explore the expression and cellular localization of A20 in both nonpathological and diseased human gastric tissues to gain deeper insights into its involvement in gastric pathologies.

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[Virtual reality in liver surgery-Planning, advanced training, testing].

Chirurgie (Heidelb)

January 2025

Klinik für Allgemein‑, Viszeral- und Transplantationschirurgie, Universitätsmedizin Mainz, Mainz, Deutschland.

Anatomical structures of the liver could be reconstructed three dimensionally from preoperative cross-sectional imaging for over 20 years. This three-dimensional (3D) representation not only optimizes the preoperative planning options but also the communication of specific operation-relevant structures can be improved using 3D models. In addition to a plastic and interactive visualization of 3D organ models, the disruptive technology of virtual reality (VR) can also provide a possibility for structured training and further education regarding surgical anatomy of the liver and operation planning.

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In Germany, a substantial reform of emergency care is strictly recommended. Regulation of patient flows into the ambulatory and stationary sectors remains a major issue.In the OPTINOFA project funded by Innovationsfunds, a new triage system was developed for a structured primary evaluation of both urgency and care level of emergency cases.

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[Prioritization of research questions in health crises-presentation of a concept developed during the COVID-19 pandemic].

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz

January 2025

Institut für Evidenz in der Medizin, Universitätsklinikum Freiburg, Medizinische Fakultät, Albert-Ludwigs-Universität Freiburg, Freiburg, Deutschland.

In acute crises such as the COVID-19 pandemic, scientific questions need to be addressed quickly in order to protect the health of the population and to maintain the function of the healthcare system. The prevailing urgency and the large number of issues to be addressed, combined with the limitation of time, personnel, or monetary resources make prioritization indispensable. In the COVID-19 Evidence Ecosystem (CEOsys) project initiated by the University Medicine Network (NUM), a procedure for the rapid prioritization of questions was used specifically for evidence syntheses and clinical guideline recommendations, which was further developed in the follow-up project PREparedness and Pandemic Response in Germany (PREPARED).

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Recommendations for the quantitative basic evaluation of mind-body medicine courses for university students - results of a consensus-based, systematic decision-making process by experts.

BMC Med Educ

November 2024

Institute of Social Medicine, Epidemiology and Health Economics, Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Background: There is an increasing range of mind-body medicine (MBM) courses in Germany to support university students in dealing with stress. The evaluation of these varies and often only has a small number of participants due to the limited group size of the courses. The aim of this project was the development of a quantitative basic evaluation that can be used across all sites that conduct MBM courses.

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[Children and adolescents with post-COVID-19 condition: A qualitative study on the experiences and satisfaction with treatment in a model project in Bavaria (Post-COVID Kids Bavaria)].

Z Evid Fortbild Qual Gesundhwes

December 2024

Wissenschafts- und Entwicklungscampus Regensburg (WECARE), Klinik St. Hedwig, Barmherzige Brüder, Regensburg, Deutschland; Institut für Sozialmedizin und Gesundheitssystemforschung, Otto von Guericke Universität Magdeburg, Magdeburg, Deutschland.

Background: Against the background of inadequate healthcare provision for children and adolescents with post-COVID-19 syndrome (PCS), a model project was initiated in Bavaria (PoCoKiBa: Post-COVID Kids Bavaria), offering specialized diagnostics and care. The aim of this study was to explore and describe the experiences and satisfaction of children and adolescents with PCS, as well as their parents, with the healthcare provided in the model project.

Methods: From October to December 2022, seven focus group discussions were conducted via video conference or in person with a total of 32 participants (19 children/adolescents, twelve mothers, one father).

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With the Network of University Medicine (NUM) and the Medical Informatics Initiative (MII), the BMBF is funding two pioneering, structure-building research measures that are now being merged. The data integration centers (DIZ) of the MII are to be consolidated in the NUM. The aim is to establish a standardized research infrastructure within which the existing data from the clinical routine care of the 36 German university hospitals, from clinical cohorts and clinical-epidemiological studies can be used for various research questions upon request and via coordinated processes.

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Rotational dynamics of a disk in a thin film of weakly nematic fluid subject to linear friction.

Eur Phys J E Soft Matter

September 2024

Institut für Physik, Otto-von-Guericke-Universität Magdeburg, Universitätsplatz 2, Magdeburg, 39106, Germany.

Dynamics at low Reynolds numbers experiences recent revival in the fields of biophysics and active matter. While in bulk isotropic fluids it is exhaustively studied, this is less so in anisotropic fluids and in confined situations. Here, we combine the latter two by studying the rotation of a disk-like inclusion in a uniaxially anisotropic, globally oriented, incompressible two-dimensional fluid film.

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The Azide-Wittig Reaction.

Angew Chem Int Ed Engl

December 2024

Leibniz Institute for Catalysis (LIKAT), Albert-Einstein-Str. 29a, 18059, Rostock, Germany.

The introduction of heteroatoms into conjugated organic molecules is an important strategy to tune their reactivity and physical properties. In this realm triazabutadienes (TBDs) of the general from RC=N-N=NR' are an interesting class of compounds, however, general synthetic protocols for their generation are limited. Based on the serendipitous finding that the sterically encumbered azide Mes*N (Mes*=2,4,6-tBuCH) reacted with PMe in the presence of an aromatic aldehyde to form a TBD, we now report on the "Azide-Wittig" reaction.

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[Young Adult Cancer Patients (AYA): Preferences for Outpatient Psychosocial Care and Gender-Specific Differences - Results from the AYA-LE study].

Psychother Psychosom Med Psychol

November 2024

Abteilung für Medizinische Psychologie und Medizinische Soziologie, Universitätsklinikum AöR, Mitteldeutsches Krebszentrum (CCCG), Universität Leipzig.

Objective Of The Study: To investigate the importance of individual topics in outpatient care services and the preferences for their design from the perspective of young adults with cancer (AYA="adolescents and young adults") in Germany.

Methodology: A total of 514 AYAs aged 18-39 years were surveyed twice over a 12-month period (t1=immediately after acute treatment, t2=12 months post-treatment) regarding the importance and satisfaction with topics such as anxiety, the impact of the illness on partnerships/family and social environment, future perspectives, personal coping strategies, sexuality, and desire for children/fertility, as well as the types of care services. The subjective importance and satisfaction with the care topics and services were analyzed using variance and moderator analyses.

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Maximized response by structural optimization of soft elastic composite systems.

PNAS Nexus

September 2024

Institut für Physik, Otto-von-Guericke-Universität Magdeburg, Universitätsplatz 2, Magdeburg 39106, Germany.

Soft actuators triggered in a wire-and contactless way advance soft robotics, for instance, concerning microsurgical perspectives. For optimal performance in this and other contexts, maximized stimuli-responsiveness is frequently desirable. We demonstrate on the example of soft magnetoelastic systems how analytical theoretical measures in combination with computer simulations provide tools to develop optimized components.

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Background And Aims: The optimal antithrombotic therapy in patients with device-detected atrial fibrillation (DDAF) is unknown. Concomitant vascular disease can modify the benefits and risks of anticoagulation.

Methods: These pre-specified analyses of the NOAH-AFNET 6 (n = 2534 patients) and ARTESiA (n = 4012 patients) trials compared anticoagulation with no anticoagulation in patients with DDAF with or without vascular disease, defined as prior stroke/transient ischaemic attack, coronary or peripheral artery disease.

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Background: Short and rare episodes of atrial fibrillation (AF) are commonly detected using implanted devices (device-detected AF) in patients with prior stroke or transient ischemic attack (TIA). The effectiveness and safety of oral anticoagulation in patients with prior stroke or TIA and device-detected AF but with no ECG-documented AF is unclear.

Methods And Results: This prespecified analysis of the NOAH-AFNET 6 (Non-Vitamin K Antagonist Oral Anticoagulants in Patients With Atrial High Rate Episodes) trial with post hoc elements assessed the effect of oral anticoagulation in patients with device-detected AF with and without a prior stroke or TIA in the randomized, double-blind, double-dummy NOAH-AFNET 6 trial.

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Patient-Reported Outcome Measures in Chronic Spontaneous Urticaria, Angioedema, and Atopic Dermatitis.

J Allergy Clin Immunol Pract

October 2024

Division of Pediatric Allergy, Clinical Immunology and Dermatology, Department of Pediatrics, McGill University Health Center, Montreal Children's Hospital, Montreal, Quebec, Canada.

Reducing the burden of disease for patients and families requires being able to measure health status changes related to disease severity, control, and response to treatment over time. Patient-reported outcomes are patient perceptions of their health status. Such perceptions are critical to decision making.

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[Things are Moving Forward! But History is not Yet Made].

Gesundheitswesen

August 2024

Department für Versorgungsforschung, Fakultät für Medizin und Gesundheitswissenschaft, Carl von Ossietzky Universität Oldenburg, Oldenburg, Germany.

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Purpose: The treatment of early miscarriage with medication is effective and low in side effects. Nevertheless, no uniform dosage regimen has yet been established, nor has it been possible to determine whether previous pregnancies and births with their respective modes of delivery play a role in the effectiveness of Misoprostol. This study aimed to find predictive parameters for successful treatment with Misoprostol in early miscarriage.

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Article Synopsis
  • Prophages significantly influence the characteristics of pathogenic bacteria, yet their ecological and evolutionary roles, particularly in bacteria linked to gastric cancer, are not well understood.
  • A comprehensive analysis of 1,011 complete clinical genomes revealed that 29.5% contain prophages, with only 32.2% being complete, and their distribution varies by geography and ancestry but not by the disease status of hosts.
  • The study uncovered mechanisms of prophage inactivation and proposed a new model for regulating the lysogenic-lytic cycle, providing a deeper understanding of how prophages impact bacterial genetics and adaptation.
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Removal of surface-attached micro- and nanobubbles by ultrasonic cavitation in microfluidics.

Ultrason Sonochem

October 2024

State Key Laboratory of Hydroscience and Engineering, and Department of Energy and Power Engineering, Tsinghua University, 100084 Beijing, China. Electronic address:

Article Synopsis
  • * At frequencies above 200 kHz, these bubbles show no significant response, whereas at 100 kHz-200 kHz, they interact with ultrasonic cavitation bubbles, merging and detaching from the substrate.
  • * Theoretical analysis indicates that the movement of cavitation bubbles is influenced by acoustic radiation forces, highlighting the effective removal of surface bubbles through ultrasound.
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Glycometabolic reprogramming-induced XRCC1 lactylation confers therapeutic resistance in ALDH1A3-overexpressing glioblastoma.

Cell Metab

August 2024

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, P.R. China; Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing 100070, P.R. China; China National Clinical Research Center for Neurological Diseases, Beijing 100070, P.R. China; Brain Tumor Center, Beijing Institute of Brain Disorders, Capital Medical University, Beijing 100070, P.R. China; Beijing Engineering Research Center of Targeted Drugs and Cell Therapy for CNS Tumors, Beijing 102600, P.R. China; Chinese Glioma Genome Atlas Network (CGGA) and Asian Glioma Genome Atlas Network (AGGA), Beijing 100070, P.R. China. Electronic address:

Article Synopsis
  • Patients with high ALDH1A3-expressing glioblastoma show limited response to standard chemoradiotherapy, making it vital to explore resistance mechanisms for better treatment options.
  • The interaction between ALDH1A3 and PKM2 promotes PKM2's tetramerization and lactate production, which aids in DNA repair by enhancing the function of XRCC1 through its lactylation.
  • A small molecule, D34-919, disrupts the ALDH1A3-PKM2 interaction, improving the effectiveness of chemoradiotherapy by increasing apoptosis in GBM cells, highlighting a new potential therapeutic target.
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The consumption of fructose is increasing day by day. Understanding the impact of increasing fructose consumption on the small intestine is crucial since the small intestine processes fructose into glucose. ∆9-Tetrahydrocannabinol (THC), a key cannabinoid, interacts with CB1 and CB2 receptors in the gastrointestinal tract, potentially mitigating inflammation.

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We describe the synthesis, solid state and electronic structures of a series of tunable five-membered cationic and charge-neutral inorganic heterocycles featuring a PCN core. 1-Aza-2,3,4-triphospholenium cations [(PR)N(H)CR'], [1] (R' = Me, Ph, 4-MeOCH, 4-CFCH) were formed as triflate salts by the formal [3 + 2]-cyclisation reactions of strained cyclic triphosphanes (PR) (R = Bu, 2,4,6-MeCH (Mes), 2,6- PrCH (Dipp), 2,4,6- PrCH (Tipp)) with nitriles R'CN in the presence of triflic acid. The corresponding neutral free bases (PR)NCR' (2) were readily obtained by subsequent deprotonation with NEt.

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