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Definition and consequences of locally advanced breast cancer.

Curr Opin Support Palliat Care

March 2014

aDivision of Medical Oncology, The Ottawa Hospital Cancer Centre, University of Ottawa and The Ottawa Hospital Research Institute, Ottawa bWomens College Research Institute, Toronto, Ontario, Canada.

Purpose Of Review: Locally advanced breast cancer (LABC) represents the most advanced stage breast cancer that is still potentially curable with surgery, radiation, and systemic therapy. The purpose of this review is to discuss LABC in the context of modern practice with a focus on its definition and potential consequences.

Recent Findings: There is no one encompassing definition for this disease, but in general cancers of the breast are considered to be locally advanced if they are large and/or have infiltrated into adjacent tissues (the overlying skin or underlying muscles) and/or are found to have extensive locoregional lymph node involvement.

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