7 results match your criteria: "Ottawa Hospital Research Insitute[Affiliation]"
Author Correction: Octyl itaconate enhances VSVΔ51 oncolytic virotherapy by multitarget inhibition of antiviral and inflammatory pathways.
Nat Commun
December 2024
Department of Biomedicine, Aarhus University, 8000, Aarhus C, Denmark.
Background: Depression is a common nonmotor complication in Parkinson's disease (PD). However, few studies have evaluated the efficacy of first-line psychological therapies for depression in this patient population.
Objectives: This randomized controlled trial evaluated the efficacy of interpersonal psychotherapy (IPT), an empirically validated intervention for depression that focuses on the bidirectional relationship between mood disturbance and interpersonal and social stressors.
Octyl itaconate enhances VSVΔ51 oncolytic virotherapy by multitarget inhibition of antiviral and inflammatory pathways.
Nat Commun
May 2024
Department of Biomedicine, Aarhus University, 8000, Aarhus C, Denmark.
Article Synopsis
- Researchers discovered that 4-octyl itaconate (4-OI) can enhance the effects of an oncolytic virus, VSVΔ51, in resistant cancer cells and models, leading to better treatment outcomes.
- The mechanism involves 4-OI suppressing antiviral immunity in cancer cells by modifying specific proteins, which suggests that combining metabolite-derived drugs with oncolytic viruses could significantly improve cancer treatment.
Conversion Strategy for LI-RADS Category 5 Observations across Versions 2014, 2017, and 2018.
Radiology
May 2023
From the Department of Radiology, Duke University School of Medicine, Durham, NC (S.M.G.); Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada (R.G.A.); The Ottawa Hospital Research Insitute, Clinical Epidemiology Program, Ottawa, ON, Canada (E.L., M.D.F.M.); Clinical Epidemiology Program (H.D.), and University of Ottawa Departments of Radiology and Epidemiology (M.D.F.M.), Ottawa Hospital Research Institute, Ottawa, ON, Canada; Department of Diagnostic Radiology, Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada (A.F.C.); Department of Diagnostic Radiology, Dalhousie University, Halifax, NS, Canada (A.F.C.); Juravinski Hospital and Cancer Centre, Hamilton Health Sciences, McMaster University, Hamilton, ON, Canada (C.B.v.d.P.); Faculty of Health Sciences, Queen's University, Kingston, ON, Canada (J.P.S.); Departments of Radiology and Medicine and Center for Advanced Magnetic Resonance Development, Duke University Medical Center, 2301 Erwin Rd, Durham, NC 27701 (M.R.B.); and Department of Radiology, University of North Carolina, Chapel Hill, NC (M.R.B.).
Letter to the editor: Multicentre external validation of the Canadian Syncope Risk Score to predict adverse events and comparison with clinical judgement.
Emerg Med J
June 2022
Department of Emergency Medicine, University of Ottawa, Ottawa, Ontario, Canada
Economic evaluations of palliative care models: A systematic review.
Palliat Med
January 2020
Bruyère Research Institute, Ottawa, ON, Canada.
Background: Palliative care aims to improve quality of life by relieving physical, emotional, and spiritual suffering. Health system planning can be informed by evaluating cost and effectiveness of health care delivery, including palliative care.
Aim: The objectives of this article were to describe and critically appraise economic evaluations of palliative care models and to identify cost-effective models in improving patient-centered outcomes.
Planimetric hematoma measurement in patients with intraventricular hemorrhage: is total volume a preferred target for reliable analysis?
Stroke
July 2012
Division of Neurology, Department of Medicine, University of Ottawa & Ottawa Hospital Research Insitute, Civic Campus, Room C2182b, 1053 Carling Ave, Ottawa, Ontario, Canada.
Background And Purpose: Reliable quantification of both intracerebral hemorrhage and intraventricular hemorrhage (IVH) volume is important for hemostatic trials. We evaluated the reliability of computer-assisted planimetric volume measurements of IVH.
Methods: Computer-assisted planimetry was used to quantify IVH volume.