7 results match your criteria: "Otorhinolaryngology Institute of Shanghai Jiaotong University[Affiliation]"
Relationships between apolipoprotein E and insulin resistance in patients with obstructive sleep apnoea: a large-scale cross-sectional study.
Nutr Metab (Lond)
July 2024
Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Sleep Disordered Breathing, Otorhinolaryngology Institute of Shanghai JiaoTong University, Shanghai, 200233, China.
Article Synopsis
- This study examined the links between obstructive sleep apnoea (OSA), insulin resistance (IR), and apolipoprotein E (APOE) in a large group of participants.
- OSA severity was found to correlate with increased obesity, dyslipidaemia, higher APOE levels, and higher IR, with APOE levels also positively linked to OSA-related indices.
- The findings suggest that APOE may contribute to IR, acting as a risk factor, especially in men, and that IR serves as a mediator in the relationship between OSA and APOE.
T266M variants of ANGPTL4 improve lipid metabolism by modifying their binding affinity to acetyl-CoA carboxylase in obstructive sleep apnea.
Ann Med
December 2024
Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Sleep Disordered Breathing, Otorhinolaryngology Institute of Shanghai JiaoTong University, Shanghai, China.
Background: Angiopoietin-like protein 4 (ANGPTL4) is recognized as a crucial regulator in lipid metabolism. Acetyl-CoA carboxylases (ACACAs) play a role in the β-oxidation of fatty acids. Yet, the functions of ANGPTL4 and ACACA in dyslipidemia of obstructive sleep apnea (OSA) remain unclear.
View Article and Find Full Text PDFOverall Obesity Not Abdominal Obesity Has a Causal Relationship with Obstructive Sleep Apnea in Individual Level Data.
Nat Sci Sleep
October 2023
Central Laboratory of Shanghai Eighth People's Hospital, Xuhui Branch of Shanghai Sixth People's Hospital, Shanghai, People's Republic of China.
Objective: Both obstructive sleep apnea (OSA) and obesity are highly prevalent worldwide, and are intrinsically linked. Previous studies showed that obesity is one of the major risk factors for OSA, but the causality of the relationship is still unclear. The study was to investigate the causal relationships of overall obesity and abdominal obesity with OSA and its quantitative traits.
View Article and Find Full Text PDFMelatonin attenuates chronic intermittent hypoxia-induced intestinal barrier dysfunction in mice.
Microbiol Res
November 2023
Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Sleep Disordered Breathing, Otorhinolaryngology Institute of Shanghai JiaoTong University, Yishan Road 600, Shanghai 200233, China.
Background And Purpose: Chronic intermittent hypoxia (CIH) triggers subclinical intestinal barrier disruption prior to systemic low-grade inflammation. Increasing evidence suggests therapeutic effects of melatonin on systemic inflammation and gut microbiota remodelling. However, whether and how melatonin alleviates CIH-induced intestinal barrier dysfunction remains unclear.
View Article and Find Full Text PDF[Advances in genome-wide association studies on obstructive sleep apnea hyponea syndrome].
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
November 2022
Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Sleep Disordered Breathing, Otorhinolaryngology Institute of Shanghai JiaoTong University, Shanghai 200233, China.
[Ototoxic effects of streptomycin in vestibular organotypic cultures].
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
January 2009
Department of Otorhinolaryngology, Affiliated Sixth People's Hospital, Shanghai Jiaotong University, Otorhinolaryngology Institute of Shanghai Jiaotong University, Shanghai 200233, China.
Objective: To investigate the ototoxic effects of streptomycin in vestibular organotypic cultures.
Methods: F344 rats with age at postnatal day three or four were used for this study. The maculae of saccule and utricle were routinely dissected out and cultured with serum-free medium containing various dose of streptomycin for 24 hours.
[Duration-tuning of the neurons in the inferior colliculus of guinea pigs and the role of gamma-aminobutyric acid mediated inhibition].
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
December 2007
Department of Otorhinolaryngology, Affiliated Shanghai Sixth People's Hospital of Shanghai Jiaotong University, Otorhinolaryngology Institute of Shanghai Jiaotong University, Clinical Auditory Center of Shanghai, Shanghai 200233, China.
Objective: To evaluate duration tuning in the inferior colliculus (IC) of guinea pigs and the role of GABA-mediated inhibition on this tuning.
Methods: Totally 23 healthy albino guinea pigs of either sex were employed in this study. After anesthesia, spikes of neurons in inferior colliculus were recorded using five-barrel glass-pipettes.