7 results match your criteria: "Otorhinolaryngology Institute of Shanghai Jiao Tong University[Affiliation]"
Renalase rs2296545 variant improve hypertension susceptibility by modifying binding affinity to catecholamines in obstructive sleep apnea.
Hypertens Res
November 2024
Central Laboratory of Shanghai Eighth People's Hospital, Xuhui Branch of Shanghai Sixth People's Hospital, Caobao Road 8, Shanghai, 200235, China.
Article Synopsis
- Obstructive sleep apnea (OSA) is linked to high blood pressure (hypertension) and researchers studied a protein called renalase to understand this connection in a Chinese population.
- They found that people with severe OSA had higher levels of renalase in their blood, and those levels affected blood pressure differently depending on whether someone had OSA or not.
- A specific genetic variation known as rs2296545 was also found to increase the risk of hypertension in people with severe OSA by changing how well renalase interacts with other important chemicals in the body.
Multiple Allergic Rhinitis Single Nucleotide Polymorphism Variants are Associated with Sleep-Breathing Parameters in Men with Obstructive Sleep Apnea: A Large-Scale Study.
Nat Sci Sleep
July 2024
Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Sleep Disordered Breathing, Otorhinolaryngology Institute of Shanghai Jiao Tong University, Shanghai, 200233, People's Republic of China.
Article Synopsis
- Sleep-disordered breathing is more common in individuals with allergic rhinitis (AR), and this study aimed to explore the genetic links between AR and obstructive sleep apnea (OSA) symptoms in men.
- Researchers analyzed data from 5,322 men who snored, examining genetic variations (SNPs) related to AR and their impact on sleep-related breathing parameters.
- Key findings showed that the SNP rs12509403 increased the risk for OSA and was linked to worse sleep-breathing indicators, while rs7717955 seemed to reduce that risk, suggesting that genetics may help explain why people with AR are more susceptible to OSA.
Melatonin mediates intestinal barrier dysfunction and systemic inflammation in moderate-severe OSA patients.
Ann Med
December 2024
Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Background: Intestinal barrier dysfunction and systemic inflammation are common in obstructive sleep apnoea (OSA). We aimed to investigate the role of melatonin, an anti-inflammatory mediator, in mediating the relationships between OSA, intestinal barrier dysfunction and systemic inflammation.
Methods: Two hundred and thirty-five male participants who complained with sleep problems and underwent whole night polysomnography at our sleep centre between 2017 and 2018 were enrolled.
genetic variants are associated with respiratory- and sleep-related parameters in Chinese patients with obstructive sleep apnea.
Front Neurosci
May 2023
Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Introduction: Obstructive sleep apnea (OSA) has been associated with psychiatric disorders, especially depression and posttraumatic stress disorder (PTSD). genetic variants have been previously reported to confer the risk of depression and PTSD. This study aimed to investigate the association of single nucleotide polymorphisms (SNPs) in the gene with OSA and OSA-related quantitative traits.
View Article and Find Full Text PDF[Sleep quality and sleep disturbances in Chinese pregnant women: a multicenter cross-sectional study].
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
March 2022
Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Jiao Tong University School of Medicine Affiliated Sixth People's Hospital, Shanghai 200233, China Otorhinolaryngology Institute of Shanghai Jiao Tong University, Shanghai 200233, China Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai 200233, China.
This study aims to investigate the sleep quality of pregnant women in Xuhui District, Shanghai, and the related factors of sleep disturbances during pregnancy. From February 2019 to February 2021, we used online integrated sleep questionnaire (including PSQI, BQ, ESS, AIS) in Shanghai Jiao Tong University School of Medicine Affiliated Sixth People's Hospital, The International Peace Maternity and Child Health Hospitals of China Welfare Institution, and Shanghai Eighth People's Hospital, to investigate the sleep quality across pregnancy. We also collected maternal physical examination results, childbearing history, sociodemographic, and other clinical data.
View Article and Find Full Text PDF[Progress of dopamine in obstructive sleep apnea hypopnea syndrome].
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
July 2017
Department of Otorhinolaryngology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Otorhinolaryngology Institute of Shanghai Jiao Tong University, Shanghai 200233, China.
The etiology and pathogenesis of sleep obstructive apnea hypopnea syndrome (OSAHS) is not yet definitive, evidence shows that the dysfunction of pharyngeal nerve and the atonia of the muscle innervated by these nerve could play an important role in the progress of OSAHS. Dopamine is a neurotransmitter in the central nervous system which significantly affects the sleep-awake regulation. So far mounting evidence shows that dopamine has a potential role in the modulation of hypoglossal nucleus.
View Article and Find Full Text PDF[Correlation between reduction of distortion product otoacoustic emission and percentage of outer hair cell missing in chinchillas].
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
February 2009
Department of Otorhinolaryngology, Affiliated Sixth People's Hospital, Shanghai Jiao Tong University, Otorhinolaryngology Institute of Shanghai Jiao Tong University, Shanghai 200233, China.
Objective: To explore the quantitative relationship between the reduction of distortion product otoacoustic emission (DPOAE) and the percentage of outer hair cell loss.
Methods: Coadministration of cisplatin (0.2 mg/kg) and ethacrynic acid (40 mg/kg) were used to establish a cochlear lesion model in chinchillas.