Gene expression profiles of nasal polyps associated with allergic rhinitis.

Background: Nasal polyp (NP) is a common and frequently occurring disease in otorhinolaryngology head and neck surgery, the pathogenesis of which remains unclear. Differentially expressed genes of mucosal tissues from NP, allergic rhinitis (AR), and normal nasal cavities were screened out by oligonucleotide chip technique and verified by real-time polymerase chain reaction (PCR) and immunohistochemical staining.

Objective: To study gene expression profiles of nasal polyps associated with AR and explore the pathogenic mechanisms of NP at the level of molecular biology.