768 results match your criteria: "Osteoporosis and Spinal Cord Injury"

Introduction: Osteoporosis is a common yet underdiagnosed condition that increases fracture risk and disability. It is particularly prevalent in individuals with musculoskeletal and neurological disorders due to factors like immobility and disuse. Despite its impact, awareness of osteoporosis remains low, especially in this high-risk population.

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Neurogenic Aging After Spinal Cord Injury: Highlighting the Unique Characteristics of Aging After Spinal Cord Injury.

J Clin Med

November 2024

Spinal Cord Injury and Disorders Center, Richmond VA Medical Center, Spinal Cord Injury & Disorders Service, 1201 Broad Rock Blvd, Richmond, VA 23249, USA.

Emanating from several decades of study into the effects of the aging process after spinal cord injury (SCI), "accelerated aging" has become a common expression as the SCI accelerates the onset of age-related pathologies. However, the aging process follows a distinct trajectory, characterized by unique patterns of decline that differ from those observed in the general population without SCI. Aging brings significant changes to muscles, bones, and hormones, impacting overall physical function.

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Osteoporosis and osteopenia in young adults with spinal cord injury: The necessity of an early bone mineral density checkup.

J Spinal Cord Med

December 2024

Department of Physical Medicine and Rehabilitation, National Rehabilitation Center, Seoul, Republic of Korea.

To identify the prevalence and risk factors for low bone density (LBD) in young adults with spinal cord injury (SCI). Retrospective cross-sectional study. National Rehabilitation Center in Seoul, Korea.

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Objectives: To describe lumbar spine (LS) trabecular bone score (TBS) values after SCI, and to explore the differences in fractures risk assessment between FRAX® and TBS-adjusted FRAX® in individuals living with chronic SCI.

Methods: Baseline dual-energy x-ray absorptiometry (DXA) scans from an established cohort were acquired using a Hologic Discovery QDR 4500. TBS measurements were performed using the TBS iNsight software version 2.

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Bone loss in patients with spinal cord injury: Incidence and influencing factors.

Chin J Traumatol

November 2024

School of Rehabilitation, Capital Medical University, Beijing, 100068, China; Department of Spine and Spinal Cord Surgery, China Rehabilitation Research Center, Beijing, 100068, China.

Purpose: To investigate the incidence and influencing factors of bone loss in patients with spinal cord injury (SCI).

Methods: A retrospective case-control study was conducted. Patients with SCI in our hospital from January 2019 to March 2023 were collected.

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Bone Health following Spinal Cord Injury: A Clinical Guide to Assessment and Management.

Phys Med Rehabil Clin N Am

February 2025

Department of Physical Medicine and Rehabilitation, Johns Hopkins School of Medicine; International Center for Spinal Cord Injury, Kennedy Krieger Institute, 716 North Broadway, Suite 404, Baltimore, MD 21205, USA. Electronic address:

Article Synopsis
  • Bone mineral density significantly decreases after spinal cord injuries, starting soon after paralysis begins and accelerating rapidly.
  • A variety of factors contribute to this bone loss, including mechanical, neurological, hormonal, blood vessel-related, and medication influences.
  • Dual x-ray absorptiometry is a cost-effective method to measure bone density changes, and while treatments exist to help prevent or reverse bone loss, their effectiveness can vary.
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Optimizing Musculoskeletal Management Following Spinal Cord Injury: Best Practices in Practice Management.

Phys Med Rehabil Clin N Am

February 2025

Division of Physical Medicine and Rehabilitation, Department of Neurosurgery, UofL Health Frazier Rehab Institute, University of Louisville, 220 Abraham Flexner Way, Louisville, KY 40202, USA. Electronic address:

Article Synopsis
  • Musculoskeletal pain affects 50% to 81% of individuals with spinal cord injury (SCI) and can hinder mobility, social life, and contribute to depression.
  • Many people with SCI rely heavily on their upper body for daily tasks, leading to decreased independence, especially in cases of severe pain.
  • Common musculoskeletal issues associated with SCI include muscle atrophy, decreased bone density, spasticity, and overuse injuries, but research on these conditions in the SCI population is limited.
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Osteoporosis is one of the detrimental effects of spinal cord injury (SCI), leading to bone loss. It has already been established that superparamagnetic nanoparticles when exposed to an external magnetic field (MF) show strong magnetisation and promote locomotor recovery. The aim of the present study is to explore the role of magnetised nanoparticles in ameliorating SCI-induced osteoporosis.

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Screening of orthopedic medicines identifies raloxifene hydrochloride as a novel ferroptosis inhibitor for spinal cord injury therapy.

Int Immunopharmacol

December 2024

Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China; Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou, Zhejiang Province, China; The Second School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang Province, China. Electronic address:

Spinal cord injury (SCI) is a severe condition that can lead to irreversible central nervous system damage. Spinal cord injury patients frequently present with coexisting orthopedic conditions, and many of them also have underlying bone and joint diseases. Recent studies have identified ferroptosis as a significant contributor that exacerbates the progression of spinal cord injury.

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Background: Postmenopausal osteoporosis (PMOP) is the most common form of primary osteoporosis among women, and the associated pain often drives patients to seek clinical intervention. Numerous studies have highlighted the unique clinical benefits of exercise therapy (ET) in alleviating PMOP-related pain. However, bibliometric analyses examining collaboration, development trends, and research frontiers in the field of ET for PMOP pain remain scarce.

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The Ambivalent Role of miRNA-21 in Trauma and Acute Organ Injury.

Int J Mol Sci

October 2024

Department of Trauma, Hand and Reconstructive Surgery, University Hospital Frankfurt, Goethe University, 60486 Frankfurt am Main, Germany.

Since their initial recognition, miRNAs have been the subject of rising scientific interest. Especially in recent years, miRNAs have been recognized to play an important role in the mediation of various diseases, and further, their potential as biomarkers was recognized. Rising attention has also been given to miRNA-21, which has proven to play an ambivalent role as a biomarker.

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Optimal Management of Osteoporosis in the Spinal Cord (Injury) Population.

Endocrinol Metab Clin North Am

December 2024

Department of Public Health Sciences, Loyola University, Maywood, IL 60153, USA; Edward Hines Jr. VA Hospital, Hines, IL 60141, USA. Electronic address:

Spinal cord injury (SCI) leads to significant bone loss resulting in osteoporosis and an increased risk of fractures below the level of injury. It is imperative to screen for osteoporosis in all individuals with SCI starting immediately after the acute injury. Although data are limited, clinicians are encouraged to discuss preventative treatment in the acute SCI period and to treat osteoporosis when diagnosed.

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We previously reported an ability of low-intensity vibration (LIV) to improve selected biomarkers of bone turnover and gene expression and reduce osteoclastogenesis but lacking of evident bone accrual. In this study, we demonstrate that a prolonged course of LIV that initiated at 2 weeks post-injury and continued for 8 weeks can protect against bone loss after SCI in rats. LIV stimulates bone formation and improves osteoblast differentiation potential of bone marrow stromal stem cells while inhibiting osteoclast differentiation potential of marrow hematopoietic progenitors to reduce bone resorption.

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Article Synopsis
  • - A quasi-experimental study tested the effects of photobiomodulation (a type of laser therapy) on bone mineral density (BMD) in eight patients with complete spinal cord injury and osteoporosis, applying the treatment on one side of the body and using the other side as a control.
  • - The treatment involved using a specific type of laser at various energy densities based on the bone's depth from the skin and was administered three times weekly for eight weeks, with BMD and vitamin D levels measured at the start, after treatment, and weeks later.
  • - Results showed significant BMD improvements in the proximal-femur and forearm regions, along with increased vitamin D levels, although no changes were noted in other areas or
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Article Synopsis
  • * A study of 427 SCI patients analyzed demographic and injury-related factors to understand patterns of bone loss over time, utilizing advanced testing methods and statistical analysis.
  • * Key risk factors for bone loss identified include older age, female gender, low body mass index, and lower scores on the Korean Spinal Cord Independence Measure, suggesting these factors may require closer monitoring in this population.
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Article Synopsis
  • Accelerated bone loss is common in the first 2-3 years after traumatic spinal cord injury (TSCI), especially in the distal femur and proximal tibia, with limited studies focused on treating this condition.
  • A study conducted from 2018 to 2023 involved two groups: an 'acute interventional cohort' receiving zoledronic acid (ZOL) and a 'chronic non-interventional cohort' not receiving treatment, both monitored for bone mineral density (BMD) over time.
  • Results showed that the acute group, despite receiving ZOL, experienced significant BMD decline at 12 and 48 months, indicating that this treatment did not effectively prevent bone loss, highlighting the need for further research on
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Health consequences associated with poor diet and nutrition in persons with spinal cord injuries and disorders.

Disabil Rehabil

September 2024

Department of Veterans Affairs, Center of Innovation for Complex Chronic Healthcare (CINCCH), Edward Hines Jr. VA Hospital, Hines, IL, USA.

Article Synopsis
  • The study explores the health impacts of poor diet on individuals with spinal cord injuries and disorders (SCI/D) by conducting in-depth interviews with healthcare providers.
  • Key findings highlight seven major health consequences linked to inadequate nutrition, including weight gain, cardiometabolic issues, bowel dysfunction, and poor mental health.
  • The authors recommend increasing awareness among SCI/D patients regarding these risks and the need for tailored nutrition interventions to address these health issues.
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Spinal cord injury (SCI) often leads to osteoporosis due to factors like immobilization and hormonal imbalances. Calcium supplements are prescribed to help maintain bone health, but their efficacy may be limited. This study investigated whether resveratrol (RSV), a polyphenolic compound, could enhance the protective effects of calcium supplements on SCI-induced osteoporosis via the SIRT1/FOXO3a pathway, which regulates bone metabolism.

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The biomedical applications of nanozymes in orthopaedics based on regulating reactive oxygen species.

J Nanobiotechnology

September 2024

Department of Spine Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China.

Article Synopsis
  • * The review focuses on four specific nanozymes in orthopaedics, highlighting their catalytic mechanisms and recent developments in treating conditions like osteoarthritis, osteoporosis, and spinal injuries.
  • * It also discusses the future potential and challenges of applying nanozymes in biomedical fields, aiming to enhance their effectiveness in treating orthopedic diseases.
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Article Synopsis
  • This study examines a new treatment strategy, involving one-level modified osteotomy combined with shoulder lifting correction, for severe kyphosis in patients with advanced ankylosing spondylitis (AS), addressing challenges linked to traditional two-level osteotomies.* -
  • A retrospective review of 70 patients treated from 2012 to 2022 showed significant improvements in spinal alignment and pelvic parameters post-surgery, with key metrics indicating a restored sagittal balance and better overall spinal health.* -
  • The results included a notable reduction in global kyphosis from 90.6° to 35.6° and significant clinical improvements in disability and quality of life as measured by established indices, demonstrating the effectiveness of the proposed treatment approach
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Lumbar Spine Densitometry in People with Spinal Cord Injury: Investigation of Potential Sources of Errors.

J Clin Densitom

October 2024

Department of Kinesiology and Health Sciences, University of Waterloo, Waterloo, ON, Canada; KITE Research Institute, University Health Network, Toronto, Canada; Rehabilitation Sciences Institute, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada; Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada. Electronic address:

Article Synopsis
  • Individuals with spinal cord injury (SCI) commonly experience significant bone loss, but lumbar spine bone mineral density (BMD) can appear normal or even high, prompting concerns about measurement errors.
  • A study analyzed DXA scans from 58 participants with chronic SCI to identify potential errors affecting lumbar spine BMD measurements at baseline and after 2 years.
  • Findings showed that 93% of scans had at least one error source, with common issues including facet sclerosis and difficulties in accurately detecting bone edges, suggesting the need to reconsider the use of lumbar spine BMD for assessing fracture risk in SCI patients.
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