296 results match your criteria: "Osteoporosis Involutional"

Article Synopsis
  • * Researchers found that women with vertebral fractures had fewer teeth at the start and lost more teeth over time compared to those without fractures.
  • * No significant difference in tooth loss was observed between women with nonvertebral fractures and those without fractures, suggesting that vertebral fractures might be a stronger risk factor for tooth loss.
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Introduction: To investigate the differences in the incidence rates of suspected stage 0/1 osteonecrosis of the jaw (ONJ) and incidence risk of relevant clinical findings of suspected stage 0 ONJ between patients treated with sequential therapy comprising weekly teriparatide for 72 weeks followed by alendronate for 48 weeks vs. those who received monotherapy with alendronate for 120 weeks.

Materials And Methods: Suspected stage 0/1 ONJ was defined by non-specific symptoms.

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Although nitric oxide (NO) is a known factor that regulates the bone physiology, few and discordant results have been obtained in human studies evaluating the effect of nitrates on bone health. We investigated for the relationship between serum NOx level and incident osteoporotic fracture rate prospectively in a cohort consisting of Japanese women. A total of 871 subjects (67.

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Introduction: Available evidence on favorable nutritional factors for preventing osteoporosis remains controversial. Considering the recent increases in life expectancy, we investigated the relationship between incident osteoporotic fractures and dietary habits in early and late postmenopausal phase women.

Materials And Methods: Subjects were Japanese postmenopausal outpatients recruited at a primary care institution in Nagano Prefecture (Nagano Cohort Study).

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Unlabelled: Japanese postmenopausal women with symptomatic periodontal disease had a significantly smaller increase in the T-score for total hip bone density than those without periodontal disease during medication therapy for osteoporosis. Intervention to treat symptomatic periodontal disease before and/or during osteoporosis therapy could maintain the effect of osteoporosis medications.

Purpose: Women with periodontal disease may be more likely to develop osteoporosis.

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Article Synopsis
  • The study investigates whether an increase in bone mineral density (BMD) from a combination treatment of alendronate and alfacalcidol reduces fracture risk in osteoporosis patients compared to alendronate alone.
  • Out of 412 patients analyzed, a slight relationship was identified where BMD increases correlated with lowering fracture risk, but the overall effect was minimal (up to 2.8% attributable to BMD changes).
  • The findings suggest that the fracture risk reduction due to alfacalcidol may not primarily rely on increased BMD, implying other underlying mechanisms could play a role.
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Pentosidine (PEN) and carboxymethyl-lysine (CML) are well-recognized advanced glycation end products (AGEs). However, how these AGEs affect the pathophysiology of osteoporosis and osteoporotic fractures remains controversial. This cross-sectional study aimed to investigate the associations of PEN and CML with bone markers, bone mineral density (BMD), and osteoporotic fractures in postmenopausal women from the Nagano Cohort Study.

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Article Synopsis
  • * This study aimed to create a mathematical model that predicts long-term fracture risk after receiving zoledronic acid or a placebo, using short-term bone markers like TRACP-5b and bone mineral density (BMD).
  • * The results indicated that both TRACP-5b and BMD can effectively predict fracture risk in osteoporosis patients, with TRACP-5b being more beneficial as it acts as an earlier marker, ultimately helping clinicians better inform patients about their treatment response.
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Marrow adipocytes and osteoblasts differentiate from common mesenchymal progenitors in a mutually exclusive manner, and diversion of these progenitors toward adipocytes in old age has been proposed to account for the decline in osteoblasts and the development of involutional osteoporosis. This idea has been supported by evidence that thiazolidinedione (TZD)-induced activation of PPARγ, the transcription factor required for adipocyte differentiation, increases marrow fat and causes bone loss. We functionally tested this hypothesis using C57BL/6J mice with conditional deletion of PPARγ from early mesenchymal progenitors targeted by the Prx1-Cre transgene.

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Accumulating evidence has shown that patients with lifestyle diseases such as type 2 diabetes mellitus, chronic kidney disease, and chronic obstructive pulmonary disease are at increased risk of osteoporotic fracture. Fractures deteriorate quality of life, activities of daily living, and mortality as well as a lifestyle disease. Therefore, preventing fracture is an important issue for those patients.

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Article Synopsis
  • A randomized trial was conducted to compare the efficacy and safety of two treatments for osteoporosis in elderly women: minodronate (a bisphosphonate) and raloxifene (a selective estrogen receptor modulator).
  • The study involved 3,896 participants aged over 60, assessing outcomes such as various types of fractures, bone density, and quality of life over two years.
  • Results showed that minodronate significantly improved lumbar spine bone mineral density compared to raloxifene, but the incidence of serious adverse reactions was slightly higher in the raloxifene group.
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In this post hoc analysis of the Denosumab Fracture Intervention Randomized Placebo-Controlled Trial (DIRECT) in Japanese postmenopausal women and men with osteoporosis, we evaluated the relationship between vertebral fracture risk and both bone mineral density (BMD) T-score and percent change after 24 months of denosumab treatment at total hip, femoral neck, and lumbar spine. Logistic regression analysis was performed and the proportion of treatment effect explained by BMD in vertebral fracture risk was estimated. The results demonstrate that both total hip BMD T-score and change can be strong predictors of subsequent fracture risk, and that total hip BMD change explained 73%, while T-score explained 23%, of the treatment effect.

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Introduction: In anti-osteoporosis drug trials, vitamin D and calcium (Ca) are common supplements; however, the optimal dose of each is unclear. Using data from the randomized, double-blind, placebo-controlled DIRECT trial, we assessed whether baseline serum 25-hydroxy vitamin D (25[OH]D) level influences the efficacy of denosumab co-administered with vitamin D and Ca.

Materials And Methods: In this prespecified sub-analysis, subjects with primary osteoporosis who received denosumab or placebo, plus vitamin D (≥ 400 IU/day) and Ca (≥ 600 mg/day), were classified as 25(OH)D deficient (< 20 ng/mL), insufficient (≥ 20 to < 30 ng/mL), and sufficient (≥ 30 ng/mL).

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Objective: This randomized, clinical trial investigated whether zoledronic acid combined with oral health maintenance can improve periodontal disease associated with osteoporosis, thus reducing the risk of tooth loss.

Methods: Participants were those of the ZONE (ZOledroNate treatment in efficacy to osteoporosis) study. None of the participants had symptomatic periodontal disease at baseline.

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Osteoporosis is an age-associated disease characterised by low bone mineral density (BMD) and micro-architectural deterioration leading to enhanced fracture risk. Conventional dual-energy X-ray absorptiometry (DXA) analysis has facilitated our understanding of BMD reduction in specific regions of interest (ROIs) within the femur, but cannot resolve spatial BMD patterns nor reflect age-related changes in bone microarchitecture due to its inherent averaging of pixel BMD values into large ROIs. To address these limitations and develop a comprehensive model of involutional bone loss, this paper presents a fully automatic pipeline to build a spatio-temporal atlas of ageing bone in the proximal femur.

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