Investigating the feasibility and effectiveness of bacterial culture in negative pressure wound drainage fluid.

Purpose: To analyze the feasibility and effectiveness of bacterial culture in negative pressure wound drainage (NPWD) fluid in patients with Pyogenic Vertebral Osteomyelitis (PVO).

Methods: A retrospective analysis was performed on 17 patients with PVO who were treated with negative pressure drainage at the Department of Orthopedics in our hospital from January 1, 2018 to December 31, 2021. Data was obtained while the patients were in the hospital, including 12 males and 5 females with an average age of 57.

Understanding Orthopaedic Infections: A Conceptual Approach.

Background: Memorizing mounds of facts without having an effective conceptual framework to store them is often an unsuccessful learning style because memory frequently fails without understanding. To accomplish this goal, we offer a framework of ideas called "concept maps". Of the many strategies for metacognition (that is, thinking about thinking), concept mapping is proven to improve meaningful and independent learning.

Rare case of resistant associated meningitis due to intrathecal catheter.

Background: (AX) is an aerobic Gram-negative opportunistic bacteria known to inhabit various environments and is most commonly associated with nosocomial infections in immune-compromised patients. Although rare, AX can cause a variety of neurological infections, such as meningitis, ventriculitis, and osteomyelitis. Intravascular catheters, intrathecal pumps, and contaminated surgical instruments are potential vectors for such patients.

Septic Arthritis of the Temporomandibular Joint in a Geriatric Patient: A Case Report.

Septic arthritis of the temporomandibular joint is a rare pathology. There is no consensus in the literature regarding etiopathogenesis and treatment. Pain, swelling, trismus, and mandibular deviation are common.

The art of biodegradable polymer design for the treatments against osteomyelitis.

Osteomyelitis arises from the incomplete treatment of the external wounds in the healing process, while bacterial infections persist within the bone marrow, leading to abscess formation. Osteomyelitis treatments generally involve three main aspects: rapid bactericidal action, sustained bacteriostasis, and induction of bone regeneration. However, current treatment methods, which often combine surgical debridement with long-term high-dose intravenous antibiotic administration or poly(methyl methacrylate) (PMMA) beads antibiotic therapy, suffer from significant drawbacks and limitations.

Randomized Clinical Trial to Compare Cryopreserved and Lyopreserved Umbilical Cord Tissue to Treat Complex Diabetic Foot Wounds.

To compare the incidence of infection, wound closure and time to wound closure in patients treated with cryopreserved (CPUT) and lyopreserved umbilical tissue (LPUT) in complex diabetic surgical wounds. This single-blinded 12-week randomized clinical trial compared cryopreserved and lyopreserved amniotic cord tissue to treat complex diabetic foot wounds. LPUT or CRAT was applied at baseline and again after four weeks.

Presumed tuberculosis spondylitis with sternal involvement.

Tuberculosis Spondylitis, also known as Pott's Disease, is an extrapulmonary form of tuberculosis (TB) that affects the spine. Sternal involvement is rare and accounts for only 0.3 % of cases.

A rare case report: Pott's Puffy tumor and Lemierre's syndrome with intracranial complications in an adult male.

Pott Puffy Tumor (PPT) is extremely rare, yet potentially severe condition characterized by osteomyelitis of the frontal bone associated with one or multiple subperiosteal abscesses, primarily from nasosinusitis. It is characterized by localized frontal swelling accompanied by a subperiosteal abscess. Clinicians and radiologists do not widely recognize this complication of frontal sinusitis and, hence it is likely to be overlooked in clinical practice.

[Histopathological diagnostics of infections in rheumatology].

The histopathological differential diagnoses of inflammatory infectious and inflammatory noninfectious diseases of the musculoskeletal system, particularly infectious and noninfectious arthritis, soft tissue inflammation and osteomyelitis in rheumatology are presented with a focus on the differential diagnostic possibilities and limitations; however, a diverse spectrum of pathogenic mechanisms underly these diseases, which can present with similar inflammatory response patterns. This wide spectrum of inflammatory pathogenesis of infectious and noninfectious diseases includes diseases such as rheumatoid arthritis, gouty arthritis, osteomyelitis and pyoderma gangrenosum, which cannot clinically be manifested thus necessitating a histopathological clarification. In terms of tissue sampling the following general principle applies: the larger the tissue sample and the more diverse the sites of tissue extraction, the more conclusive are the histopathological diagnostics.

Effective Compression and a Minimally Invasive Rail Plate to Optimize Bone Transport in Distraction Osteogenesis: New Concepts.

Background: Bone transport in distraction osteogenesis is an effective, well-known procedure. However, bone compression is an aspect of this technique for which there is no objective information. The lack of direct bone compression measurements may result in a lack of uniformity in the bone transport process, which can result in its ineffective application and may be contributing to its underutilization.

Childhood Familial Mediterranean Fever in the United States: Spectrum of Clinical Phenotypes and MEFV Genotypes in a Cohort From Southeast Michigan.

Objectives: The aim of this study was to report the spectrum of Familial Mediterranean Fever (FMF) in children living in Southeast Michigan.

Methods: We reviewed prerecorded data in medical records of FMF patients. Statistical analysis of the data included Fisher exact test, Pearson χ 2 procedure, parametric independent samples t test, and parametric analysis of variance using SPSS Version 29.

GARRE'S OSTEOMYELITIS OF LONG BONE IN ADULT.

Garre's osteomyelitis is a rare form of chronic osteomyelitis characterized by sclerosing and periosteal reaction of the affected bone. We report a case of a 35-year-old woman who presented with left tibial pain and swelling for 18 months. She was diagnosed with Garre's osteomyelitis of the mid-shaft tibia based on radiological and histopathological findings.

Delayed Morbidity Associated With Surgical Management of Urosymphyseal Fistula.

Objective: To characterize and identify factors associated with long-term morbidity of definitive urosymphyseal fistula (USF) treatment.

Methods: Retrospective chart review of a single institution database identified 57 patients who underwent operative treatment of USF between 2009 and 2022 with at least 90 days of follow-up. Delayed complications were considered those occurring ≥90 days following surgery.

Prosthetic Condyle with Concurrent Microvascular Reconstruction for Mandibular Disarticulation Defects: A Retrospective Series.

Introduction: Reconstruction of mandibular disarticulation defects is a challenging area of head and neck surgery, with a variety of options available for replacement of the condylar head. The gold standard is autogenous reconstruction of the condyle-ramus unit. The use of a prosthetic condylar head is controversial, but in challenging cases, and those with a likely poor prognosis it may be considered and can achieve a good functional result.

Skull base osteomyelitis: HBO as a therapeutic concept Effects on clinical and radiological results.

Introduction: Skull base osteomyelitis is a rare but potentially life-threatening disease. It usually occurs as a complication of severe otitis externa or infection in the nasopharynx, often in immunocompromised patients. The therapeutic strategy is complex, patient-specific and requires interdisciplinary cooperation.

Bone regeneration and dental implant surgeries in florid cemento-osseous dysplasia: A case report.

Cemento-osseous dysplasia (COD) is a benign fibro-osseous pathology in which fibrous connective tissues, osteoid and cementum-like materials, replace bone. Concerning the hypovascularization and increased mineralization of bone that occurs in these patients, the clinician may face two types of problems: infectious complications such as osteomyelitis and increased implant failure. The present study aims to report the successful and innovative management of a COD patient complicated by mandibular osteomyelitis and the implant rehabilitation of this area.

Efficacy of Bone Regeneration Cell Therapy Using Mesenchymal Stem Cells Originating from Embryonic Stem Cells in Animal Models; Bone Defects and Osteomyelitis.

Background: Bone defects are commonly encountered due to accidents, diseases, or aging, and the demand for effective bone regeneration, particularly for dental implants, is increasing in our aging society. Mesenchymal stem cells (MSCs) are promising candidates for regenerative therapies; however, obtaining sufficient quantities of these cells for clinical applications remains challenging. DW-MSCs, derived from embryonic stem cells and developed by Daewoong Pharmaceutical, exhibit a robust proliferative capacity even after extensive culture.