The Role of Plain Radiography in Diagnosing Brodie's Abscess: Clinical Image.

Plain radiographs can still be of considerable diagnostic value for recognizing Brodie's abscess, especially in resource constrained settings.

A Rare Case of Tissierella praeacuta Bacteremia in the Context of Lower Extremity Cellulitis.

()is a gram-variable obligate anaerobe. In this case report, we describe the first documented case of bacteremia in a patient with sepsis resulting from lower extremity cellulitis without concomitant osteomyelitis. During the inpatient course, the patient was treated with IV vancomycin, cefepime, and ertapenem, in addition to surgical debridement and incision and drainage of his foot wound.

Application of 3D-printed porous prosthesis for the reconstruction of infectious bone defect with concomitant severe soft tissue lesion: a case series of 13 cases.

Background: Treating infectious bone defects combined with large soft-tissue lesions poses significant clinical challenges. Herein, we introduced a modified two-stage treatment approach involving the implantation of 3D-printed prostheses and flap repair to treat large segmental infectious tibial bone defects.

Method: We conducted a retrospective study of 13 patients treated at our center between April 2018 and March 2022 for tibial infections owing to posttraumatic infection and chronic osteomyelitis combined with soft tissue defects.

Delayed and recurrent surgical site infection from resorbed bone fragment after autologous cranioplasty: a case report.

Decompressive craniectomy is one of the most common procedures for managing severe traumatic brain injury. Cranioplasty plays a vital role in restoring the integrity of the skull and preventing complications that may arise after a decompressive craniectomy. This case report presents a 24-year-old woman who underwent cranioplasty with a cryopreserved autologous bone flap.

Increasing Incidence of Serious Head and Neck Infections Among US Children, 2018-2023.

There has been a significant, post-pandemic increase in the incidence of serious head and neck infections (HNI) among children aged < 18 years since 2021, compared with the stable incidence of non-transmissible osteomyelitis and serious HNI in adults from 2018 to 2023. The etiology of this increase requires further study.

Popliteal Neurovascular Bundle Medialization and Axial Flap Rotation to Avoid Bone Impingement in Tibial Turn-up Plasty: A Case Report.

A 33-year-old male patient developed distal femur chronic osteomyelitis with massive bone loss after an open grade-3b fracture. Following several failed treatments to eradicate infection, a tibial turn-up procedure was performed to provide a stable and functional stump. To avoid neurovascular problems, the popliteal vessels and sciatic nerve were moved medially, and the flap was rotated externally to decrease the collapse.

A new evidence-based design-of-experiments approach for optimizing drug delivery systems with exemplification by emulsion-derived Vancomycin-loaded PLGA capsules.

This paper introduces an evidence-based, design-of-experiments (DoE) approach to analyze and optimize drug delivery systems, ensuring that release aligns with the therapeutic window of the medication. First, the effective factors and release data of the system are extracted from the literature and meta-analytically undergo regression modeling. Then, the interaction and correlation of the factors to each other and the release amount are quantitatively assessed.

Prevalence of Complications Due to Transphyseal Hematogenous Osteomyelitis.

Background: Transphyseal hematogenous osteomyelitis (THO) is a common infectious condition, being present in 25% of patients with hematogenous osteomyelitis. A large proportion of pediatric hematogenous osteomyelitis infections can spread through the growth cartilage and therefore may be potentially responsible for growth disorders, leading to limb-length discrepancy or angular deformities. The purpose of the present study was to identify both the prevalence of complications caused by transphyseal osteomyelitis and factors influencing their occurrence.

Evaluating the effectiveness of advanced platelet-rich fibrin, photobiomodulation, pentoxifylline, and Alveogyl in the treatment of alveolar osteitis: a randomized controlled clinical trial.

Background: Alveolar osteitis is a type of small-scale osteomyelitis of the alveolar bone that occurs after tooth extraction, the etiology of which remains unknown, and alternative methods are being investigated for its treatment. The aim of this study was to compare the effectiveness of advanced platelet-rich fibrin (A-PRF), photobiomodulation (PBM), and Alveogyl (butamben, idoform, eugenol), which have shown success in the treatment of alveolar osteitis, with that of pentoxifylline (PTX) to determine whether PTX could be an alternative treatment for alveolar osteitis.

Methods: This study included 80 healthy volunteers diagnosed with alveolar osteitis in the extraction sockets of their mandibular first, second, and third molars.

EVALUATING ORAL AND MAXILLOFACIAL HEALTH CHALLENGES IN INTRAVENOUS DRUG USERS: A CROSS-SECTIONAL STUDY OF DRUG REPLACEMENT THERAPY PARTICIPANTS AND NON-PARTICIPANTS.

Introduction: Intravenous drug use has a significant impact on oral and maxillofacial health, often resulting in complications like tooth loss and osteomyelitis. This study investigates the differences in oral health between drug users enrolled in replacement therapy and those not yet participating, with the goal of assessing the impact of structured treatment programs.

Aim: to evaluate and compare the prevalence of oral and maxillofacial complications among drug users involved in replacement therapy and those newly registering for treatment.

Optimal Duration of Antibiotic Therapy for Primary Osteomyelitis Discitis: A Systematic Review and Network Meta-Analysis.

Study Design: Systematic Review and Network-Meta-analysis.

Purpose: This study aimed to systematically review the literature on management of primary osteomyelitis discitis and perform a network meta-analysis comparing the efficacy of different antibiotic treatment durations.

Background: Primary osteomyelitis discitis is a challenging condition with varying management strategies.

Effect of Time to Surgery on Surgical Site Infection in Open Distal Radius Fractures: A Review of the ACS Trauma Quality Improvement Program Database.

Introduction: Managing open distal radius fractures (DRFs) poses challenges. While preventing surgical site infection (SSI) involves prompt antibiotic administration and thorough irrigation and debridement, the impact of urgent intervention on reducing postoperative infection rates is debated. We hypothesize that timing of surgery does not significantly affect the incidence of SSI in open DRF treated within or after 24 hours from time of injury.

Risk factors and rates of revision amputation following ischemic lower major limb amputations: A 10-year retrospective analysis.

Objectives: This study aimed to evaluate the rates and risk factors associated with revision amputation following ischemic lower major limb amputations, focusing on cases related to peripheral arterial disease.

Patients And Methods: This retrospective study included 253 patients (174 males, 79 females; mean age: 73.1±12.

Investigation of Antibiotic-Releasing Biodegradable Composite Bone Cements for Treating Experimental Chronic Maxillofacial Bone Infection.

Chronic osteomyelitis of the maxillofacial bones (i.e., jaw bones) is a persistent infection that requires effective treatment.

[Effects of personalized oral stents in intensity-modulated radiation therapy treatment].

Purpose: To explore the effects of personalized oral stents in intensity-modulated radiation therapy (IMRT) treatment.

Methods: Totally 108 patients with nasopharyngeal carcinoma treated with IMRT at Nanjing Gaochun People's Hospital from January 2021 to December 2023 were selected. Using a random number table method, the patients were divided into experimental group (n=54) using personalized oral stents and control group (n=54) using simple mouthpieces.

Preadmission systemic antibiotic treatment in necrotizing otitis externa (NOE).

Purpose: Necrotizing otitis externa (NOE) is a serious life-threatening infection, with Pseudomonas (PA) aeruginosa being the primary causative agent. Over the last two decades the use of systemic anti-PA antibiotics expanded substantially and are now prescribed regularly by physicians. Meanwhile, studies indicate shifting trends in the incidence of the offending pathogen in NOE.

Conventional radiography for the assessment of focal bone lesions of the appendicular skeleton: fundamental concepts in the modern imaging era.

Bone lesions of the appendicular skeleton can be caused by primary benign or malignant tumors, metastases, osteomyelitis, or pseudotumors. Conventional radiography plays a crucial role in the initial assessment of osseous lesions and should not be underestimated even in this era of modern complex and advanced imaging technologies. Combined with patient age, clinical symptoms and biology, and lesion features including location, solitary versus multiplicity, density, margin (transitional zone evaluated with Lodwick-Madewell grading score), and, if present, the type of periosteal reaction and matrix mineralization can narrow the differential diagnosis or offer a likely diagnosis.

Impact of a nurse practitioner-led dedicated outpatient parenteral antibiotic therapy clinic on patient outcomes and administrative workload: a retrospective cohort study.

Background: Outpatient parenteral antibiotic therapy (OPAT) enhances patient safety, improves outcomes, and reduces healthcare costs by decreasing 30-day readmissions and adverse events. However, the optimal structure and follow-up protocols for OPAT programs remain undefined. Identifying high-risk patients for readmission and managing adverse drug events (ADEs) are critical components of OPAT care.

A Rare Bacteremia in a Patient With Osteomyelitis and Sacral Ulcer: A Case Report of Tissierella praeacuta and Parvimonas micra.

and are anaerobic bacteria rarely encountered in clinical practice, making their identification in bacteremia significant. These organisms are typically found in the human gut and oral flora and are generally considered low-virulence. However, in patients with compromised immunity or significant comorbidities, they can lead to severe infections, including bacteremia.

Tissierella Bacteremia in the Setting of Polymicrobial Osteomyelitis.

We present a case of bacteremia in the setting of polymicrobial osteomyelitis. is a Gram-variable bacterium that has been rarely documented as the etiologic organism in human infections such as septic arthritis or otitis media, and even more rarely reported as an organism associated with bacteremia. The patient presented with septic shock and the physical exam was notable for gangrene of bilateral feet.

Seasonal trends of pyogenic spondylodiscitis in Japan: a nationwide inpatient database study.

Objectives: The aims of this study were 1) to investigate seasonal epidemiological variations of pyogenic spondylodiscitis, including Methicillin-resistant Staphylococcus aureus (MRSA) infection, in Japan, and 2) to evaluate associated inpatient outcomes.

Methods: We performed a retrospective nationwide study using data from the Japanese Diagnosis Procedure Combination (DPC) inpatient database, covering the period from 2010 to 2022. The parameters assessed were seasonal incidence, demographic characteristics, inpatient mortality, complications, and medical costs.

Recreational Facilities as Reservoirs for Multidrug-Resistant Staphylococcus aureus.

Antibiotic-resistant pathogens in public settings present a growing risk to human health. Staphylococcus aureus often asymptomatically colonizes human skin, while virulent strains cause soft tissue infections, osteomyelitis, endocarditis, and are associated with cystic fibrosis. Here we investigated the presence and distribution of multidrug-resistant S.

Osteomyelitis and Septic Arthritis of the Upper Extremity in Pediatric Patients.

Purpose Of Review: For pediatric osteomyelitis and septic arthritis, 10-24% of cases occur in the upper extremity (UE). Due to delays in presentation and diagnosis, UE infections are often more complex and severe than infections of the lower extremity (LE). This review evaluates the literature from the past 6 years related to pediatric osteomyelitis and septic arthritis of the UE and provides a guide for professionals managing these conditions in children.