3 results match your criteria: "Ospedale Clinicizzato Santissima Annunziata[Affiliation]"
Glutathione and glutathione-dependent enzymes: From biochemistry to gerontology and successful aging.
Ageing Res Rev
December 2023
Dipartimento di Medicina e Scienze dell'Invecchiamento, and Laboratorio di Fisiopatologia dello Stress Ossidativo, Center for Advanced Studies and Technology (CAST, former CeSI-MeT, Center of Excellence on Aging), Università degli Studi "G. d'Annunzio" Chieti Pescara, U.O.C. Medicina Generale 2, Ospedale Clinicizzato "Santissima Annunziata", Via dei Vestini, 66100 Chieti, Italy. Electronic address:
The tripeptide glutathione (GSH), namely γ-L-glutamyl-L-cysteinyl-glycine, is an ubiquitous low-molecular weight thiol nucleophile and reductant of utmost importance, representing the central redox agent of most aerobic organisms. GSH has vital functions involving also antioxidant protection, detoxification, redox homeostasis, cell signaling, iron metabolism/homeostasis, DNA synthesis, gene expression, cysteine/protein metabolism, and cell proliferation/differentiation or death including apoptosis and ferroptosis. Various functions of GSH are exerted in concert with GSH-dependent enzymes.
View Article and Find Full Text PDFAssociation of serum bilirubin with oxidant damage of human atherosclerotic plaques and the severity of atherosclerosis.
Clin Exp Med
February 2018
Dipartimento di Medicina e Scienze dell'Invecchiamento, Università degli Studi "G. d'Annunzio" Chieti Pescara, 66100, Chieti, Italy.
Bilirubin has protective effects against atherosclerotic cardiovascular diseases hypothetically due to its antioxidant-antilipoperoxidative properties. Thus, we investigated whether serum bilirubin is associated with oxidant damage, namely lipid peroxidation, of human atherosclerotic plaques and the severity of atherosclerosis. In this regard, we correlated the levels of serum total bilirubin (STB), direct (conjugated) bilirubin (SDB) and indirect (unconjugated) bilirubin (SIB) with those of fluorescent damage products of lipid peroxidation (FDPL) and lipid hydroperoxides (LOOH) of 32 endarterectomy-derived carotid atherosclerotic plaques.
View Article and Find Full Text PDFAddressing the need for increased adherence to multiple sclerosis therapy: can delivery technology enhance patient motivation?
Expert Opin Drug Deliv
September 2009
University Gabriele d'Annunzio of Chieti-Pescara, Ospedale Clinicizzato Santissima Annunziata, c/o Centro Sclerosi multipla (VII livello, corpo A), Department of Oncology and Neuroscience, Chieti, Italy.
Background: Several injectable disease-modifying drugs are available for the treatment of multiple sclerosis (MS) to control disease progression and reduce relapse frequency and severity. However, the benefits offered by treatment may be compromised by suboptimal levels of adherence to prescribed regimens.
Objective: To examine what is now known about adherence to MS therapies, and to discuss how technological advances may affect adherence in the future, with reference to examples from other therapy areas.