Design, synthesis, and cytotoxicity of ibuprofen-appended benzoxazole analogues against human breast adenocarcinoma.

A library of novel ibuprofen-appended benzoxazole analogues (7a-l) was synthesized a series of nitration, reduction, and condensation-cyclization reactions and screened for their anticancer activity against human breast cancer MCF-7 and MDA-MB-231 cell lines using as a standard reference. Compounds 7h and 7j displayed outstanding activity against the MCF-7 cell line with an IC value of 8.92 ± 0.