[Prognostic factors of malignant lymphoma].

Advances in staging and more refined radiation techniques and the combination chemotherapy have lead marked improvement of survival of patients with Hodgkin's disease and non-Hodgkin's lymphoma. The important prognostic factors used for choosing treatment programs are stage, histology, tumor bulk and the site of involvement for patients with early stage disease. Tumor bulk is considered as an important variable when patients are treated with radiation therapy alone.

[Meningeal gliomatosis--clinical features and results of treatment].

Fifteen (15.6%) patients of 97 with malignant glioma developed meningeal gliomatosis during at least 2 years after the initial treatment. The time between the first surgery and diagnosis of meningeal gliomatosis was less than 1 year in 10 cases, 1 to 2 years in 2 and over 2 years in 2.

[A review of childhood cases of malignant lymphoma in Osaka, Japan].

Fifty-one cases of malignant lymphomas in patients under 20 years of age have been reviewed in Osaka, Japan. The breakdown of these cases revealed 6 cases (11.8%) of Hodgkin's disease (HD) and 45 cases (88.

[Radiotherapy of squamous cell carcinomas of the tongue--a statistical review].

The cases of 36 patients referred for radiotherapy of the tongue after an excisional biopsy or after an inadequate excision of the tongue cancer have been reviewed. In 32 patients treated by radiotherapy, the actuarial survival rate at five years was 86%, and the local rate control, was 82%. The local control rate for those treated by interstitial radiotherapy (Int.

[Treatment of head and neck cancer with twice-a-day fractionation].

Fifty patients with locally advanced head and neck cancer were treated with twice-a-day fractionation (1.0-1.5 Gy 2 times daily, 5 days per week).

[Results of the radiotherapy of Hodgkin's disease (Analysis of cases at Osaka University Hospital)].

A total of 32 patients of Hodgkin's disease treated mainly by radiotherapy at the Department of Radiology, Osaka University Hospital from 1971 through 1985 were analyzed. Five- and ten-year survival rates for all patients were 91%, 78%; Clinical Stage I (15 patients): 93%, 83%; Stage II (8 pts.): 100%, 100%; Stage III (9 pts.

[Results of the radiotherapy of Hodgkin's disease (a JLRTG report). Japan Lymphoma Radiation Therapy Group].

A total of 234 patients of Hodgkin's disease treated at 7 institutions from 1972 through 1985 were analyzed. Male to female ratio was 157: 77, mean age was 39.8 years, and overall 5- and 10-year survival were 67% and 56%, respectively.

[Results of radiation therapy of stage II non-Hodgkin's lymphoma of the Waldeyer's ring: a report of the Japanese Lymphoma Radiation Therapy Study Group].

A retrospective analysis of 245 patients with stage II non-Hodgkin's lymphoma of the Waldeyer's ring treated between 1972 and 1985 was performed. Treatment consisted of radiation therapy alone in 96 patients and 149 patients were treated with chemotherapy combined. Five-year survival and relapse-free survival rates were 57% and 50%, respectively.

[Results of radiation therapy of stage I-II non-Hodgkin's lymphoma localized in the head and neck: Osaka University Hospital experience].

A retrospective analysis of 251 patients (stage I: 125; stage II: 126) with non-Hodgkin's lymphoma localized in the head and neck and treated between 1971 and 1985 was performed. Of these, 28 patients (11%) had histology of low-grade malignancy, and 218 (87%) had intermediate malignancy. Waldeyer's ring was the most frequent site of involvements (114 cases), extranodal site (91), and cervical lymph node(s) (46) in the order.

[Results of radiation therapy of stage I-II non-Hodgkin's lymphoma localized in the head and neck--a report of the Japanese Lymphoma Radiation Therapy Study Group].

A retrospective analysis of 1514 patients with non-Hodgkin's lymphoma treated between 1972 and 1985 was performed. Of these cases, 114 with histology of low-grade malignancy and 750 with intermediate malignancy were localized in the head and neck. All patients received definitive course of radiation therapy, including 390 cases with adjuvant chemotherapy.

[The role of radiation therapy in the management of non-Hodgkin's lymphoma].

For patients with stage I-II malignant lymphoma with low-grade malignancy, five-year survival rates after radiation therapy are 75-100%. For patients with intermediate malignancy, five-year survival rates after radiation therapy alone are 70-100% for patients with pathological stage I-II and 45-75% for clinical stage I-II. Radiation dose to the tumor at least 40 Gy was required to produce consistent local control.

[Late complications of radiation therapy in patients with malignant lymphoma].

The improvement on the treatment of malignant lymphoma have led to prolonged survival for many patients. However, they are at risk of late complications of the disease and treatment. Impaired function due to radiation-induced injury of normal tissues, such as cardiac, pulmonary, or thyroid dysfunction, becoming manifest at few months to years after treatment.

[The role of radiation therapy in the management of the Hodgkin's disease].

Radiation therapy has curative potential for patients with stage I-II disease, and five-year relapse-free survival rate in excess of 80% can be expected. Despite an advantage of chemotherapy combined with radiation therapy in improving relapse-free survival, no significant advantage has yet been demonstrated in allover survival. Patients with stage IIIA1 may also be treated radiation therapy alone with results of five-year survival rate of 53-60%.

[Results of the treatment of localized non-Hodgkin's lymphoma originated in the thyroid gland].

A total of 38 cases of localized non-Hodgkin's lymphoma originated in the thyroid gland were treated at the Department of Radiology, Osaka University Hospital from 1967 through 1986. There were 18 males and 20 females, and age ranged from 15 to 78, averaging 58 years. Fifteen cases were classified as clinical stage I and 23 as stage II.

[Stromal sarcoma of the breast following augmentation mammoplasty--a case report].

A case of a stromal sarcoma of the breast that developed after augmentation mammoplasty is presented. A 55-year-old woman, who had received mammoplasty twenty years earlier, was referred to our hospital due to a mass in her left breast. A diagnosis of myxoid sarcoma was determined by an incisional biopsy and a radical mastectomy was performed.

[Subcutaneous fibrosis induced by external irradiation of carcinoma of the uterine cervix].

Two-hundreds and seventy-six patients who were treated with external irradiation alone or combined with intracavitary irradiation and were alive 2-18 years were examined concerning to late complications in the lower abdominal wall. Moderate or severe subcutaneous fibrosis occurred in 14% of the patients. They were not observed below subcutaneous dose of 44 Gy.

Heterogeneous response in hepatic sinusoidal blood flow to acute ethanol ingestion in rats.

The effect of ethanol ingestion on the hepatic sinusoidal blood flow velocity was investigated in rats, using in vivo microscopy system with dual-slit photometric method. In steady state, before ethanol ingestion, the hepatic sinusoidal blood flow velocity determined at 18 points ranged widely from 54 to 245 micron/sec and the mean value was 144 +/- 13 micron/sec. After acute ethanol ingestion (1g/kg), the averaged sinusoidal blood flow velocity increased significantly to 197 +/- 17 micron/sec, while the width of sinusoids showed no apparent change.