5 results match your criteria: "Osaka Univ Graduate School of Medicine[Affiliation]"
Article Synopsis
- Cerebral small vessel disease (cSVD) is a major contributor to stroke and dementia, and currently lacks specific treatments, prompting a study using Mendelian randomization to identify protein associations.
- The research combined cerebrospinal fluid (CSF) and plasma data with genetic studies to identify 49 proteins linked to cSVD, highlighting 16 that appeared in both fluids and showing connections to immune response and extracellular matrix pathways.
- Notably, many identified proteins were associated with stroke and dementia, with some already having known drug targets, paving the way for potential new biomarkers and therapies for cSVD.
A web-based questionnaire survey on the influence of coronavirus disease-19 on the care of patients with muscular dystrophy.
Neuromuscul Disord
September 2021
TMC, National Center of Neurology, Psychiatry, 4-1-1 Ogawa-higashi, Kodaira, Tokyo 187-0031, Japan.
To clarify the influence of coronavirus disease-19 (COVID-19) on the care of muscular dystrophy patients, we performed a questionnaire survey that was posted on the internet on May 11, 2020. By the end of July 2020, 542 responses had been collected. Approximately 30% of patients postponed regular consultations, and one-quarter of patients who received consultation more than once a month used telephone consultations.
View Article and Find Full Text PDFBiochemical and Clinical Predictive Approach and Time Point Analysis of Hepatobiliary Phase Liver Enhancement on Gd-EOB-DTPA-enhanced MR Images: A Multicenter Study.
Radiology
November 2016
From the Department of Radiology, Kinki University Faculty of Medicine, Osaka, Japan (M.O., T.M.); Dept of Radiology, Juntendo Univ, Faculty of Medicine, Tokyo, Japan (R.K.); Dept of Diagnostic Radiology, Inst of Biomedical and Health Sciences, Hiroshima Univ, Hiroshima, Japan (Y.N.); Dept of Diagnostic Imaging and Nuclear Medicine, Kyoto Univ Graduate School of Medicine, Kyoto, Japan (H.I.); Dept of Radiology and Services, Gifu Univ Hosp, Gifu, Japan (S.G.); Dept of Radiology, School of Medicine, Fujita Health Univ, Toyoake, Japan (R.H.); Dept of Radiology, Nihon Univ School of Medicine, Tokyo, Japan (H.H.); Dept of Radiology, Faculty of Medicine, Fukuoka Univ, Fukuoka, Japan (Y.S.); Depts of Radiology (A.K.) and Advanced Medical Imaging (O.M.), Graduate School of Medical Science, Kanazawa Univ, Kanazawa, Japan; Dept of Radiology, Shinshu Univ School of Medicine, Matsumoto, Japan (Y.F.); Dept of Central Endoscopy and Ultrasound, Nara Medical Univ Hosp, Nara, Japan (N.M.); Dept of Radiology, Osaka Medical College, Takatsuki, Japan (M.Y.); Dept of Radiology, Univ of Yamanashi School of Medicine, Chuo, Japan (T.I.); Dept of Radiology, Kawasaki Medical School, Kurashiki, Japan (A.H.); Dept of Radiology, Osaka Univ Graduate School of Medicine, Suita, Japan (M.H.); and Div of Radiology, Dept of Pathophysiological and Therapeutic Science, Faculty of Medicine, Tottori Univ, Yonago, Japan (S.F.).
Purpose To identify biochemical factors associated with liver enhancement over time on gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance (MR) images and predict the optimal time point of the hepatobiliary phase in various clinical settings. Materials and Methods This study was approved by the institutional review boards, and written informed consent was obtained from the 1903 patients enrolled. Simple and multiple logistic regression analyses were performed to investigate the biochemical factors associated with liver-to-spleen contrast (LSC) of at least 1.
View Article and Find Full Text PDFAntinecrotic and antiapoptotic effects of hepatocyte growth factor on cholestatic hepatitis in a mouse model of bile-obstructive diseases.
Am J Physiol Gastrointest Liver Physiol
February 2007
Division of Molecular Regenerative Medicine, Dept of Biochemistry and Molecular Biology, Osaka Univ Graduate School of Medicine, Yamadaoka 2-2-B7, Suita, Osaka, Japan.
Cholestasis, an impairment of bile outflux, frequently occurs in liver diseases. In this process, an overaccumulation of bile acids causes hepatocyte necrosis and apoptosis, leading to advanced hepatitis. Hepatocyte growth factor (HGF) is mitogenic toward hepatocytes, but it is still unclear whether HGF has physiological and therapeutic functions during the progression of cholestasis.
View Article and Find Full Text PDFNonspecific interstitial pneumonia: correlation between thin-section CT findings and pathologic subgroups in 55 patients.
Radiology
October 2002
Department of Radiology, Osaka Univ Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0825, Japan.
Purpose: To characterize thin-section computed tomographic (CT) findings of pathologic subgroups of nonspecific interstitial pneumonia (NIP) in a sizeable number of patients.
Materials And Methods: The study included 55 cases of pathologically proven NIP. The 55 cases were categorized histologically into four grades: grade 1, interstitial inflammation without fibrosis (n = 6); grade 2, interstitial inflammation predominating over fibrosis (n = 16); grade 3, fibrosis predominating over inflammation (n = 5); and grade 4, fibrosis only (n = 28).