Development of a 3D Tumor Spheroid Model from the Patient's Glioblastoma Cells and Its Study by Metabolic Fluorescence Lifetime Imaging.

Unlabelled: Patient-specific tumor models are a promising platform for studying the mechanisms of oncogenesis and personalized selection of drugs. In case of glial brain tumors, development and use of such models is particularly relevant as the effectiveness of such tumor treatment remains extremely unsatisfactory. was to develop a model of a 3D tumor glioblastoma spheroid based on a patient's surgical material and to study its metabolic characteristics by means of fluorescence lifetime imaging microscopy of metabolic coenzymes.

Minimally Invasive (Epivastus) Approach for Total Knee Arthroplasty.

Unlabelled: was to assess the efficiency of a developed minimally invasive (epivastus) approach in total knee arthroplasty (TKA) by comparing its early results with those of a standard medial mediapatellar approach (MMPA).

Materials And Methods: A single-center, comparative randomized prospective study involved 127 patients, who underwent TKA using MMPA (n=62) and a modified minimally invasive epivastus approach (n=65) within the period from January to December, 2022. The study groups were comparable by gender, age, BMI, gonarthrosis stage, and knee joint functioning parameters.

Sagittal Balance Parameters after Anterior Cervical Discectomy with Spondylodesis and Arthroplasty Using Endocarbon Endoprosthesis: Results of Randomized Study.

Unlabelled: was to examine the effect of cervical segment mobility on spinal sagittal balance parameters after cervical total disc arthroplasty (CTDA) and anterior cervical discectomy and fusion (ACDF) using the first domestic intervertebral disc endoprosthesis.

Materials And Methods: The randomized prospective study included 98 patients (48 with CTDA, 50 with ACDF). Implants used: intervertebral disc endoprosthesis or intervertebral fusion cage (Endocarbon; NPP "MedInzh", Russia).