Knee kinematics during gait in patients with discoid lateral meniscus: a systematic review.

Introduction: The aim of this study was to evaluate the difference between symptomatic discoid lateral meniscus (DLM) and healthy knees in terms of gait analysis.

Evidence Acquisition: A systematic review was conducted from the electronic databases PubMed/MEDLINE, EMBASE and Scopus. The review was performed on studies that reported data on kinematics, gait analysis, biomechanics in discoid lateral meniscus, before and after surgery.

Is it possible to return to skiing following long-construct spinal deformity surgery?

Background: Alpine skiing requires flexibility, endurance, strength and rotational ability, which may be lost after long fusions to the pelvis for adult spinal deformity (ASD). ASD patients may worry about their ability to return to skiing (RTS) postoperatively. There is currently insufficient data for spine surgeons to adequately address questions about when, or if, their patients might RTS.

Sacral Alar-Iliac (SAI) screw diameter is not associated with pelvic fixation failure for neuromuscular scoliosis patients.

Purpose: Determine if Sacral Alar-Iliac (SAI) screw diameter is associated with pelvic fixation failure in pediatric patients with neuromuscular scoliosis (NMS) treated with posterior spinal fusion (PSF).

Methods: NMS patients from a single institution who underwent PSF with bilateral SAI screw fixation from 2010 to 2021 were retrospectively reviewed. Clinical parameters, SAI screw sizes, and radiographic outcomes were analyzed.

A bibliometric analysis of the 50 most cited articles on acromioclavicular joint reconstruction.

The aim is to identify the 50 most cited papers and thus the most influential papers pertaining to ACJ reconstruction, and specifically, analysing the level of evidence (LOE), article content, journals occurring, and countries represented within the 50 most cited. A search of the Web of Science database was carried out using the following terms: "Acromioclavicular joint" OR "AC joint" (Topic) AND Reconstruction OR Repair (Topic). The top 50 relevant articles were analysed in relation to citations, citation density, geographic origin of the article, year published, and article type.

Hydrogen Sulfide (HS) Generated in the Colon Induces Neuropathic Pain by Activating Spinal NMDA Receptors in a Rodent Model of Chronic Constriction Injury.

Neuropathic pain (NP) imposes a significant burden on individuals, manifesting as nociceptive anaphylaxis, hypersensitivity, and spontaneous pain. Previous studies have shown that traumatic stress in the nervous system can lead to excessive production of hydrogen sulfide (HS) in the gut. As a toxic gas, it can damage the nervous system through the gut-brain axis.

Diagnostic ultrasonography of upper extremity dynamic compressive neuropathies in athletes: A narrative review.

Purpose: This narrative review identifies and summarizes current evidence for diagnostic ultrasonographic evaluation of upper extremity dynamic compressive neuropathies affecting athletes.

Methods: Relevant literature was identified using the PubMed database and then summarized.

Results: The compressive neuropathies affecting athletes we identified included: neurogenic thoracic outlet syndrome, pectoralis minor syndrome, quadrilateral space syndrome, suprascapular nerve entrapment, proximal median nerve entrapment or bicipital aponeurosis/lacertus fibrosus (lacertus syndrome), radial tunnel syndrome, and cubital tunnel syndrome.

Undervaluation of Perioperative Work for ACL Reconstruction by Relative Value Scale Update Committee Methodology in a Single Surgeon's Practice.

Objectives: The purpose of this study was to determine the accuracy of the Relative Value Update Committee (RUC) and Centers for Medicare & Medicaid Services current times and work relative value units (wRVUs) for the perioperative work involved in anterior cruciate ligament (ACL) reconstruction by directly timing perioperative tasks as they occur in real time.

Methods: The RUC was contacted to obtain a list of perioperative tasks and the corresponding times allotted for the tasks involved in arthroscopically aided ACL reconstruction (Current Procedural Terminology code 29888). The tasks that occurred both inside and outside the operating room were timed by the attending physician as the event occurred.

Retinoid-impregnated nanoparticles enable control of bone growth by site-specific modulation of endochondral ossification in mice.

Growth-plate (GP) injures in limbs and other sites can impair GP function and cause deceleration of bone growth, leading to progressive bone lengthening imbalance, deformities and/or physical discomfort, decreased motion and pain. At present, surgical interventions are the only means available to correct these conditions by suppressing the GP activity in the unaffected limb and/or other bones in the ipsilateral region. Here, we aimed to develop a pharmacologic treatment of GP growth imbalance that involves local application of nanoparticles-based controlled release of a selective retinoic acid nuclear receptor gamma (RARγ) agonist drug.

Pain and Functional Outcome After Microsurgical Decompression of Lumbar Spinal Stenosis: Very Short- and Long-Term Postoperative Analysis.

Study Design: Multicenter, prospective observational cohort study.

Objectives: 109 patients with lumbar spine stenosis (LSS) undergoing minimally invasive decompression in 6 different centers (Germany, Italy, USA).

Methods: The demographic, surgical and clinical data was collected.

RNA G-quadruplex structure-based PROTACs for targeted DHX36 protein degradation and gene activity modulation in mammalian cells.

RNA G-quadruplexes (rG4s) are non-canonical secondary nucleic acid structures found in the transcriptome. They play crucial roles in gene regulation by interacting with G4-binding proteins (G4BPs) in cells. rG4-G4BP complexes have been associated with human diseases, making them important targets for drug development.

Effectiveness of clindamycin-based exposure strategies in experimental mature staphylococcal biofilms.

Unlabelled: Due to increasing antimicrobial resistance and side effects caused by current standard antimicrobial regimens used for treatment of prosthetic joint infection (PJI), alternative options are urgently needed. We aimed to investigate the effect of clindamycin in different exposure strategies against in an mature biofilm model. In short, 7-day biofilms were generated on polystyrene plates and titanium-aluminum-vanadium discs using a clinical PJI isolate.

Patient and physical therapists' views on physical rehabilitation exercise in the early phase after total hip arthroplasty: a qualitative interview study.

Purpose: Physical rehabilitation exercises (PRE) are commonly prescribed early after total hip arthroplasty (THA), but the fundamental effectiveness of PRE has been questioned. As little is known about stakeholder perceptions of PRE, the aim was to explore patients' and physical therapists' perceptions of using PRE in the early period after THA.

Methods: A qualitative interview study was conducted.

Human serum albumin microspheres synchronously loaded with ZIF-8 and triptolide (TP) for the treatment of intrahepatic cholangiocarcinoma.

Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver tumor and remains a fatal malignancy in most patients. Only 20% to 30% of patients can be treated with potentially curative surgical resection. Local therapies such as radioembolization and hepatic arterial perfusion may be a more effective treatment strategy.

Robotic-Assisted Medial Unicompartmental Knee Arthroplasty in an Outpatient Setting.

There were 63 outpatient medial unicompartmental knee arthroplasties (UKAs) performed by Mako robotic assistance by six surgeons. There were 40 men and 23 women who had a mean age of 65.1 years (range, 38 to 80).

Effect of a tailored exercise programme on kinematics and kinetic knee injury risk during different side-cutting.

Despite the high incidence of knee injuries reported in non-professional sports, the implementation of specific training programmes aimed at mitigating the kinematic and kinetic factors associated with these injuries remains limited. To determine the effects of a tailored exercise programme on kinematic and kinetic variables during side-cutting activities. Fifty-seven physically active participants were randomised into control group (CG; n: 28) that received no intervention, and an experimental group (EG; n: 29), that performed an individualised exercise programme that included a combination of strength, neuromuscular, proprioceptive, eccentric training and whole-body vibration (WBV) exercises.

MRI Analysis of the Wrist: Does the Presence of Palmaris Longus Affect Median Nerve Position?

Background: Understanding the median nerve's position relative to surrounding anatomy is essential; however, there are many variations among individuals. This study assesses differences in median nerve position with or without palmaris longus (PL). We hypothesize that PL presence alters median nerve position, resulting in a greater distance to the skin volar surface, a decreased distance to the radius volar surface, and an increased distance to the flexor carpi radialis (FCR).

Leptin potentiates bone loss at skeletal sites distant from focal inflammation in female ob/ob mice.

Leptin increases focal inflammation and osteolysis induced by polyethylene particles in leptin-deficient ob/ob mice suggesting the adipokine, an important immune modulator, contributes to orthopedic implant failure. Focal inflammation leads to bone loss at distant skeletal sites, and it is plausible that leptin also contributes to this response. We tested this possibility in 6-week-old female ob/ob mice (6-8/group) by evaluating bone architecture, turnover, and gene expression 12 days following surgical placement of polyethylene particles over calvaria.

Role of interleukin-4 receptor α polymorphism in patients with asthma and its correlation with asthma severity.

Asthma is a heterogeneous disease characterized by chronic airway inflammation. It is defined by the history of respiratory symptoms such as wheeze, shortness of breath, chest tightness, and cough that vary over time and intensity, together with variable expiratory airflow limitation. A personal history or a family history of allergy is the factor most strongly associated with the development of asthma.

Analysis of pediatric hand injuries in a tertiary care children's hospital.

Pediatric hand traumas are common injuries in childhood. The incidence and type of injury vary with age. In our country, there are only two publications in which only crush is examined in etiology.

Unraveling of cannulated screw threads during fixation of medial epicondyle humerus fractures in adolescents: short communication.

Cannulated screws have significant advantages, including ease of insertion and increased accuracy, during fracture fixation. Unraveling of screw threads is an uncommon complication related to cannulated screws. This single-institution case series aims to highlight four cases of unraveling of cannulated screw threads during the fixation of medial epicondyle humerus fractures in adolescents.

Analysis of Delirium Risk Assessment Tools for Prediction of Postoperative Delirium Following Lumbar Spinal Fusion.

Study Design: Retrospective cohort study.

Objective: Evaluate the utility of Delirium Risk Assessment Score (DRAS), Delirium Risk Assessment Tool (DRAT), and Delirium Elderly At-Risk (DEAR) in patients undergoing posterior lumbar interbody fusions.

Background: Surgical interventions can place patients at risk for postoperative delirium (POD), an acute and often severe cognitive impairment associated with poor outcomes.