Development and validation of a model for early survival prediction following liver transplantation based on donor and recipient characteristics.

Background: Circulating cytokine levels not only correlate with the progression of liver disease but also serve as indicators for the infection status of the body. Growing evidence points to the connection between donor cytokines and graft function following transplantation. This study set out to explore the clinical significance of donor cytokines in predicting liver transplantation prognosis.

Association between nonalcoholic fatty liver disease and increased glucose-to-albumin ratio in adults without diabetes.

Background: Nonalcoholic fatty liver disease (NAFLD) affects approximately 30% of individuals globally. Both serum glucose and albumin were demonstrated to be potential markers for the development of NAFLD. We hypothesized that the risk of NAFLD may be proportional to the glucose-to-albumin ratio (GAR).

Ultrastructural changes of donor livers in liver transplantation indicate hepatocytes injury.

The use of electron microscopy (EM) can provide details about cells and tissue down to the nanometer level. We aim to observe ultrastructural changes in the donor liver by EM and analyze the relationship with prognosis. Data from 89 liver transplant recipients were collected and analyzed for recovery of graft function.

procurement of porcine abdominal multiple organ block for normothermic machine perfusion: a technique for avoiding initial cold preservation.

Background: Normothermic machine perfusion (NMP) is a technique that maintains organs with normal metabolism, and organ function can be better preserved. The study of multiple-organ NMP is rarely reported. Multiple organ block (MOB) is a self-perfusing system for maintaining multiple organs , and porcine MOBs have been successfully preserved for 18 to 37 h.

An Alternative Surgical Technique of Native Hepatectomy in Liver Transplantation.

BACKGROUND Orthotopic liver transplantation has become the procedure of choice for end-stage liver disease. There are 3 commonly used methods of vena cava anastomosis. Here, we report a new technique for native hepatectomy.

Application of ischaemia-free liver transplantation improves prognosis of patients with steatotic donor livers - a retrospective study.

The use of steatotic livers in liver transplantation (LT) is controversial. Ischaemia-free liver transplantation (IFLT) has obvious advantages for the recovery of allograft function. The aim of this study was to examine the effect of liver grafts with steatosis on outcome and the effect of IFLT with steatotic livers.

Analysis of preoperative circulating tumor cells for recurrence in patients with hepatocellular carcinoma after liver transplantation.

Background: Liver transplantation (LT) is an effective option for hepatocellular carcinoma (HCC) and end-stage liver cirrhosis. However, organ shortage and tumor recurrence are the main obstacles limiting its popularization and application in HCC patients. Testing for circulating tumor cells (CTCs) would be a valuable strategy to predict the recurrence and metastasis of HCC after LT.

Comparison of Tacrolimus and Cyclosporine Combined With Methotrexate for Graft Versus Host Disease Prophylaxis After Allogeneic Hematopoietic Cell Transplantation.

Background: After patients receive hematopoietic stem cell transplantation (HSCT), both cyclosporine (CsA) and tacrolimus (TAC) in combination with methotrexate (MTX) are recommended as the standard prophylaxis strategy for graft versus host disease (GVHD) by the European Group of Blood and Marrow Transplantation. However, the advantage of TAC combined with MTX lacks conclusive evidence.

Methods: We searched online databases for studies comparing CsA + MTX and TAC + MTX in patients who received HSCT.

Advances in T follicular helper and T follicular regulatory cells in transplantation immunity.

B cells play a crucial role in alloreactivity of organ transplant rejection and graft versus host diseases (GVHD). Over the past decade, it has been well recognized that B-cell infiltration in allografts and de novo donor-specific antibodies (DSA) were strongly associated with severe graft rejection and loss, as well as glucocorticoid resistance. Emerging evidence has demonstrated that Follicular T helper (Tfh) cells are key effectors to promote the proliferation and differentiation of B cells into antibody-producing plasmablasts and memory B cells.

[Clinical analysis on multivisceral transplantation].

Objective: To assess the indication, surgical and post-operative complications of the multivisceral transplantation.

Methods: The post-transplant complications of 8 patients who underwent multivisceral transplantation between May 2004 and May 2010 were analyzed. There were 7 male and 1 female, aged from 28 to 65 years.

Model for end-stage liver disease versus the Child-Pugh score in predicting the post-transplant 3-month and 1-year mortality in a cohort of Chinese recipients.

Purpose: This study evaluated the performance of the model for end-stage liver disease (MELD) in predicting post-transplant survival in a cohort of Chinese patients, and compared its predictive ability with that of the Child-Pugh score.

Methods: The study enrolled 117 adult Chinese patients undergoing liver transplantation for benign end-stage liver diseases from January 1998 to January 2007 to evaluate the baseline characteristics and outcomes.

Results: In a median follow-up duration of 90 weeks (range 0.

Fate of atrial septal defect in children with end-stage liver disease undergoing living donor liver transplantation.

Background And Objective: The course of atrial septal defects (ASD) in children undergoing liver transplantation is poorly described. Our objective was to present our experience in living donor liver transplantation (LDLT) in children with type II ASD.

Patients And Methods: Between June 1994 and December 2006, 18/140 (12.