Behavior of compounds leached from tire tread particles under simulated sunlight exposure.

Tire tread particles are microplastics (< 5 mm) and leach organic chemicals into aquatic environments. It is important to understand the behavior of tire wear compounds in sunlight-exposed waters in terms of their persistence, removal, and transformation. Therefore, we conducted photolysis experiments with leachates from laboratory-generated tire tread particles (TTP) over 72 h in a solar simulator to evaluate the behavior of leached compounds and fluorescent components over time.

Detecting novel plant pathogen threats to food system security by integrating the Plant Reactome and remote sensing.

Plant diseases constantly threaten crops and food systems, while global connectivity further increases the risks of spreading existing and exotic pathogens. Here, we first explore how an integrative approach involving plant pathway knowledgegraphs, differential gene expression data, and biochemical data informing Raman spectroscopy could be used to detect plant pathways responding to pathogen attacks. The Plant Reactome (https://plantreactome.

Evidence for microbially-mediated tradeoffs between growth and defense throughout coral evolution.

Background: Evolutionary tradeoffs between life-history strategies are important in animal evolution. Because microbes can influence multiple aspects of host physiology, including growth rate and susceptibility to disease or stress, changes in animal-microbial symbioses have the potential to mediate life-history tradeoffs. Scleractinian corals provide a biodiverse, data-rich, and ecologically-relevant host system to explore this idea.

Long-term impact of tillage on microbial communities of an Eastern European Chernozem.

As conservation agricultural practices continue to spread, there is a need to understand how reduced tillage impacts soil microbes. Effects of no till (NT) and disk till (DT) relative to moldboard plow (MP) were investigated in a long-term experiment established on Chernozem. Results showed that conservation practices, especially NT, increased total, active and microbial biomass carbon.

SNP rs6543176 is associated with extreme human longevity but increased risk for cancer.

Using whole-genome sequencing (WGS) might offer insights into rare genetic variants associated with healthy aging and extreme longevity (EL), potentially pointing to useful therapeutic targets. In this study, we conducted a genome-wide association study using WGS data from the Long Life Family Study and identified a novel longevity-associated variant rs6543176 in the SLC9A2 gene. This SNP also showed a significant association with reduced hypertension risk and an increased, though not statistically significant, cancer risk.

Exposure of Mycobacteriodes abscessus clones to mucin affects bacterial phenotype.

In the past 20 years infections caused by Mycobacterioides abscessus have become increasingly common in patients with chronic lung conditions. The microorganisms are also resistant to a number of antibiotic classes, making treatment challenging. To begin understanding how the bacterium adapts to the lung environment, pure colonies of M.

Construction and optimization of health behavior prediction model for the older adult in smart older adult care.

Introduction: With the intensification of global aging, health management for the older adult has become a significant societal concern. Addressing challenges such as data diversity, health status complexity, long-term dependence, and data privacy is crucial for predicting older adult health behaviors.

Methods: This study designs and implements a smart older adult care service model incorporating modules like multimodal data fusion, data loss processing, nonlinear prediction, emergency detection, and privacy protection.

Abrupt changes in biomass burning during the last glacial period.

Understanding the causes of past atmospheric methane (CH) variability is important for characterizing the relationship between CH, global climate and terrestrial biogeochemical cycling. Ice core records of atmospheric CH contain rapid variations linked to abrupt climate changes of the last glacial period known as Dansgaard-Oeschger (DO) events and Heinrich events (HE). The drivers of these CH variations remain unknown but can be constrained with ice core measurements of the stable isotopic composition of atmospheric CH, which is sensitive to the strength of different isotopically distinguishable emission categories (microbial, pyrogenic and geologic).

The progression of basaltic-rhyolitic melt storage at Yellowstone Caldera.

Yellowstone Caldera is one of the largest volcanic systems on Earth, hosting three major caldera-forming eruptions in the past two million years, interspersed with periods of less explosive, smaller-volume eruptions. Caldera-forming eruptions at Yellowstone are sourced by rhyolitic melts stored within the mid- to upper crust. Seismic tomography studies have suggested that a broad region of rhyolitic melt extends beneath Yellowstone Caldera, with an estimated melt volume that is one to four times greater than the eruptive volume of the largest past caldera-forming eruption, and an estimated melt fraction of 6-28 per cent.

Infrared nanosensors of piconewton to micronewton forces.

Mechanical force is an essential feature for many physical and biological processes, and remote measurement of mechanical signals with high sensitivity and spatial resolution is needed for diverse applications, including robotics, biophysics, energy storage and medicine. Nanoscale luminescent force sensors excel at measuring piconewton forces, whereas larger sensors have proven powerful in probing micronewton forces. However, large gaps remain in the force magnitudes that can be probed remotely from subsurface or interfacial sites, and no individual, non-invasive sensor is capable of measuring over the large dynamic range needed to understand many systems.

Host response to cholestyramine can be mediated by the gut microbiota.

The gut microbiota has been implicated as a major factor contributing to metabolic diseases and the response to drugs used for the treatment of such diseases. In this study, we tested the effect of cholestyramine, a bile acid sequestrant that reduces blood cholesterol, on the murine gut microbiota and metabolism. We also explored the hypothesis that some effects of this drug on systemic metabolism can be attributed to alterations in the gut microbiota.

Nitrogen use efficiency underlies cross-ecosystem variation in marine primary production.

The supply of nitrogen (N) and the efficiency with which it is used by phytoplankton serve as two fundamental controls on the productivity of many marine ecosystems. Shifts in nitrogen use efficiency (NUE) can decouple primary production from N-supply but how NUE varies across systems is poorly known. Through a global synthesis of how total N (TN) is apportioned among phytoplankton, particulate, dissolved inorganic, and dissolved organic pools, we demonstrate that NUE underlies broad variations in primary production.

Sequential Pore Functionalization in MOFs for Enhanced Carbon Dioxide Capture.

The capture of carbon dioxide (CO) is crucial for reducing greenhouse emissions and achieving net-zero emission goals. Metal-organic frameworks (MOFs) present a promising solution for carbon capture due to their structural adaptability, tunability, porosity, and pore modification. In this research, we explored the use of a copper (Cu(II))-based MOF called .

Cross-contamination Risks in Dry Produce Packinghouses: Efficacy of Alcohol-based Sanitizers to Reduce Salmonella and Potential Surrogates on Relevant Surface Materials.

A 2020 Salmonella outbreak was epidemiologically linked to red onions; however, insufficient cleaning and sanitation in the packinghouse expanded the recall to include all onions handled by the packing house in the preceding 3 months. Our objective was to evaluate the efficacy of dry sanitizers to reduce cross-contamination risk on food contact surfaces (FCSs) found in postharvest packing areas. Transfer of Salmonella and potential surrogates (Escherichia coli, Enterococcus faecium) to and from onions to FCS materials (high-density polypropylene, polyester-nylon conveyor belts, plywood) was quantified.

A Naturalistic Examination of the Acute Effects of High-Potency Cannabis on Emotion Regulation Among Young Adults: A Pilot Study.

Objective: Despite the popular public perception that cannabis use may be beneficial for relieving mental health symptoms, the empirical evidence remains equivocal. Various legal hurdles limit the ability to research whether acute high-potency cannabis use affects mental health-related processes. Therefore, the current study used a novel methodology to examine the acute effects of high-potency cannabis flower on emotion regulation.

Accelerating antiviral drug discovery: early hazard detection with a dual zebrafish and cell culture screen of a 403 compound library.

The constant emergence of new viral pathogens underscores the need for continually evolving, effective antiviral drugs. A key challenge is identifying compounds that are both efficacious and safe, as many candidates fail during development due to unforeseen toxicity. To address this, the embryonic zebrafish morphology, mortality, and behavior (ZBE) screen and the SYSTEMETRIC® Cell Health Screen (CHS) were employed to evaluate the safety of 403 compounds from the Cayman Antiviral Screening Library.

Testing the Dispersal-Origin-Status-Impact (DOSI) scheme to prioritise non-native and translocated species management.

Assessing actual and potential impacts of non-native species is necessary for prioritising their management. Traditional assessments often occur at the species level, potentially overlooking differences among populations. The recently developed Dispersal-Origin-Status-Impact (DOSI) assessment scheme addresses this by treating biological invasions as population-level phenomena, incorporating the complexities affecting populations of non-native species.

Outdoor nitrogen dioxide exposure and longitudinal health status trajectory in the Canadian National Population Health Survey.

Few studies have examined the association between air pollution and the trajectory of global health status measures related to the functional impacts of chronic disease. To address this gap, we examined the trajectory of the Health Utilities Index (HUI) over 17 years of follow-up among Canadian National Population Health Survey (NPHS) participants. Annual average nitrogen dioxide (NO) exposures from a national land use regression surface were mapped to 15,631 NPHS participants at their place of residence provided at each follow-up.

Annotation of RxLR Effectors in Oomycete Genomes.

Pathogens have evolved effector proteins to suppress host immunity and facilitate plant infections. RxLR effectors are small, secreted effector proteins with conserved RxLR and dEER amino acid motifs at the N terminus and highly variable C termini and are commonly found in oomycete species. We provide computational approaches to annotate RxLR candidate effector genes in a genome assembly in FASTA format with an available GFF file.

Impaired renal transporter gene expression and uremic toxin excretion as aging hallmarks in cats with naturally occurring chronic kidney disease.

Aging leads to nephron senescence and chronic kidney disease (CKD). In cats, indoxyl sulfate (IxS) has been previously quantified and associated with CKD, and little is known about tubular transporters. Two cohorts of cats aged 6 to 21 years were enrolled.

Nitrogen Deposition Weakens Soil Carbon Control of Nitrogen Dynamics Across the Contiguous United States.

Anthropogenic nitrogen (N) deposition is unequally distributed across space and time, with inputs to terrestrial ecosystems impacted by industry regulations and variations in human activity. Soil carbon (C) content normally controls the fraction of mineralized N that is nitrified (ƒ), affecting N bioavailability for plants and microbes. However, it is unknown whether N deposition has modified the relationships among soil C, net N mineralization, and net nitrification.