4 results match your criteria: "Oregon Health and Sciences Univ.[Affiliation]"

Insignificant response of the fetal placental circulation to arterial hypotension in sheep.

J Appl Physiol (1985)

October 2011

Heart Research Center CH15H, Div. of Cardiovascular Medicine, Oregon Health and Sciences Univ., Portland, OR 97239, USA.

Infusion of the angiotensin-converting enzyme inhibitor enalaprilat into fetal sheep caused a profound arterial hypotension within days. Five fetal lambs were infused with enalaprilat for 8 days starting at day 128 of gestation. Total accumulated dose was 0.

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The fetal heart is highly sensitive to changes in mechanical load. We have previously demonstrated that increased cardiac load can stimulate cell cycle activity and maturation of immature cardiomyocytes, but the effects of reduced load are not known. Sixteen fetal sheep were given either continuous intravenous infusion of lactated Ringer solution (LR) or enalaprilat, an angiotensin-converting enzyme inhibitor beginning at 127 days gestational age.

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Intravascular infusions of plasma into fetal sheep cause arterial and venous hypertension.

J Appl Physiol (1985)

September 2005

Heart Research Center, Dept. of Physiology and Pharmacology, L334, Oregon Health and Sciences Univ., Portland, OR 97239, USA.

Fetal volume control is driven by an equilibrium between fetal and maternal hydrostatic and oncotic pressures in the placenta. Renal contributions to blood volume regulation are minor because the fetal kidneys cannot excrete fluid from the fetal compartment. We hypothesized that an increase in fetal plasma protein would lead to an increase in plasma oncotic pressure, resulting in an increase in fetal arterial and venous pressures and decreased angiotensin levels.

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Function curve of the membranes that regulate amniotic fluid volume in sheep.

Am J Physiol Heart Circ Physiol

July 2005

Dept. of Physiology & Pharmacology, L334, Oregon Health and Sciences Univ., Portland, OR 97239, USA.

Seven singleton 120-day fetal lambs were prepared with a shunt from the lung to the gastric end of the esophagus, a bladder catheter, and multiple amniotic fluid and vascular catheters. The urachus was ligated. Beginning 7 days later, amniotic fluid volumes were determined by drainage, followed by replacement with 1 liter of lactated Ringer (LR) solution.

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