107,206 results match your criteria: "Oregon; Oregon Health & Science University[Affiliation]"

Objectives: Tendinopathy and fasciopathy are common conditions that can result in time-loss injury in athletes. This study aimed to determine if preseason sonographic abnormalities of the patellar tendon, Achilles tendon and plantar fascia are associated with future time-loss injuries in collegiate athletes.

Methods: National Collegiate Athletic Association Division I athletes from three institutions participated in this 3-year prospective, observational study.

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Background: Billions of dollars have been spent implementing regulations to reduce traffic-related air pollution (TRAP) from exhaust pipe emissions. However, few health studies have evaluated the change in TRAP emissions and associations with infant health outcomes. We hypothesize that the magnitude of association between vehicle exposure measures and adverse birth outcomes has decreased over time, parallelling regulatory improvements in exhaust pipe emissions.

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In this multi-center sinonasal malignancies (SNM) cohort, the Sino-nasal Outcome Test has a correlation with the University of Washington Quality of Life (UWQOL) for assessing QOL. The use of both instruments remains recommended to provide complete and complementary information. Future design of an easy-to-use tool specific to SNM is needed to encompass all aspects of QOL.

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Background: Nasal discharge is one of the cardinal symptoms of chronic rhinosinusitis, impacting over 50% of patients. For patients with symptoms refractory to standard medical therapy, endoscopic sinus surgery is an option. The objective of this study is to characterize how nasal discharge improves after surgery in patients with chronic rhinosinusitis.

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Article Synopsis
  • Fall risk and cognitive impairment are common issues in Parkinson's disease, necessitating effective treatments.
  • The study evaluated the safety and efficacy of TAK-071, a targeted medication, in individuals with Parkinson's who also experience these challenges.
  • Despite not showing significant improvement in gait variability, TAK-071 was found to enhance cognitive function, marking a potential positive outcome for patients.
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  • This study examined how the volume of operative vaginal deliveries (OVDs) at hospitals in California from 2008 to 2020 affects adverse outcomes for both birthing individuals and newborns.
  • It categorized hospital OVD volume into low (less than 5.2%), medium (5.2%-7.4%), and high (7.4% or more), finding that lower volume hospitals had a higher incidence of complications such as obstetric anal sphincter injuries and adverse neonatal outcomes.
  • The research utilized extensive data from birth certificates and hospital records to analyze trends, highlighting the need for improvements in obstetric care based on hospital performance.
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Multi Targeted Activity of Cocculus hirsutus through Modulation of DPP-IV and PTP-1B Leading to Enhancement of Glucose Uptake and Attenuation of Lipid Accumulation.

Appl Biochem Biotechnol

January 2025

Tissue Culture and Drug Discovery Laboratory, Department of Biotechnology, Anna University, Chennai, 600 025, India.

Article Synopsis
  • Multi-targeted therapies are increasingly recognized for their effectiveness in treating complex diseases such as Type 2 diabetes and obesity, utilizing multiple mechanisms to enhance benefits while minimizing side effects.
  • The study investigates the potential of Cocculus hirsutus methanol extract (CME) and its hydromethanolic fraction (HMF), revealing significant inhibition of key enzymes related to glucose metabolism and insulin signaling, which indicates their potential in improving metabolic health.
  • HMF was particularly effective, showing improved glucose uptake, increased insulin sensitivity through GLUT4 expression, and reduced lipid accumulation by inhibiting adipogenesis regulators, marking its promise as a therapeutic option.
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Objective: Disability stigma has been linked with adverse chronic and acute health outcomes in people with disabilities. The present study updated the widely used Attitudes Toward Disabled Persons measure (to the revised Attitudes Toward People With Disabilities [ATPD] scale) among health care professionals and validated the measure using a disability stigma framework.

Design: A survey with 272 health care professionals and students was conducted.

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Purpose: A projection-resolved optical coherence tomography angiography (PR-OCTA) algorithm with slab-specific strategy was applied in polypoidal choroidal vasculopathy (PCV) to differentiate between polyp and branching vascular network (BVN) and improve polyp detection by en face OCTA.

Methods: Twenty-nine participants diagnosed with PCV by indocyanine green angiography (ICGA) and 30 participants diagnosed with typical neovascular age-related macular degeneration (nAMD) were enrolled. Polyps were classified into three categories after using the slab-specific PR algorithm.

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The inability to predict futility in hemorrhaging trauma patients using 4-hour transfusion volumes and rates.

J Trauma Acute Care Surg

February 2025

From the Department of Surgery (J.-M.V., T.W.C., B.A.C.), McGovern Medical School, University of Texas Health Science Center, Houston, Texas; Department of Epidemiology (B.L.R.-R., S.R.W.) and Department of Surgery (J.W.C.), University of Pennsylvania, Philadelphia, Pennsylvania; Donald D. Trunkey Center for Civilian and Combat Casualty Care (M.A.S.), Oregon Health & Science University, Portland, Oregon; Department of Surgery, Ernest E. Moore Shock Trauma Center at Denver Health (E.E.M.), University of Colorado Health Sciences Center, Denver, Colorado; Department of Surgery (N.N.), University of Miami/Jackson Memorial Hospital, Miami, Florida; and Department of Surgery (J.L.S.), Trauma and Transfusion Medicine Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania.

Background: Blood shortages and utilization stewardship have motivated the trauma community to evaluate futility cutoffs during massive transfusions (MTs). Recent single-center studies have confirmed meaningful survival in ultra-MT (≥20 U) and super-MT (≥50 U), while others advocate for earlier futility cut points. We sought to evaluate whether transfusion volume and intensity cut points could predict 100% mortality in a multicenter analysis.

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Background And Objectives: Decompressive hemicraniectomy is a common emergent surgery for patients with stroke, hemorrhage, or trauma. The typical incision is a reverse question mark (RQM); however, a retroauricular (RA) incision has been proposed as an alternative. The widespread adoption ofthe RA incision has been slowed by lack of familiarity and concerns over decompression efficacy.

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Article Synopsis
  • Understanding the evolution of genomic variation is essential for creating effective conservation strategies for threatened species, focusing on connectivity, demographic changes, and environmental adaptation.
  • The study analyzed genomic variation in Fraxinus latifolia, a riparian tree facing threats from the invasive emerald ash borer, by sequencing over 1000 individuals from 61 populations.
  • Results showed strong population structure and low genetic diversity, suggesting that this patchy distribution could hinder the species' long-term evolutionary potential, underscoring the importance of conserving genomic diversity for future restoration efforts.
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Background: Flow-through flaps (FTFs) are an advanced technique in which a free flap is anastomosed to the pedicle of another free flap to reconstruct extensive head and neck defects when recipient vessels are scarce.

Methods: A multi-institutional cohort of FTFs used for head and neck reconstruction were reviewed. For comparison, FTF outcomes were compared to free flaps that required vein grafts (VG) to reach distant recipient vessels.

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  • Wildfire regimes are altering, raising concerns for aquatic ecosystems and fish species, as predicting fish responses can be complex due to multiple wildfire impacts.
  • Whole-ecosystem approaches like food web modeling can help understand these interactions, showing how different wildfire severities affect aquatic life dynamics in streams.
  • Simulations reveal that wildfires can have varying effects on periphyton, invertebrates, and fish biomass, influenced by fire severity and environmental changes, indicating a need to consider context when assessing wildfire impacts on aquatic ecosystems.
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The reaction between molybdenum(ii) acetate and 5-aminoisophthalic acid (HIso-NH) afforded [MoO(μ-O)(Iso-NH)], a novel molybdenum(v) metal-organic polyhedron (MOP) with a triangular antiprismatic shape stabilized by intramolecular N-H⋯O hydrogen bonds. The synthesis conditions, particularly the choice of solvent and reaction time, led to the precipitation of the Mo(v)-MOP in five distinct crystalline forms. These forms vary in their packing arrangements, co-crystallized solvent molecules, and counter-cations, with three phases containing dimethylammonium (dma) and the other two containing diethylammonium (dea).

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Cystic artery pseudoaneurysms are a rare but life-threatening entity that commonly occurs as a sequela to acute cholecystitis. We present a case of a 52-year-old male with a past medical history of decompensated alcoholic liver cirrhosis who underwent a transjugular liver biopsy (TJLB) after correction of his baseline coagulopathy. On post-operative day one, the patient had significant blood loss with an inappropriate response to blood transfusions and without an identifiable source of bleeding.

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The Relationship Between Quantitative Ischemia, Early Revascularization, and Major Adverse Cardiovascular Events: A Multicenter Study.

JACC Adv

January 2025

Department of Medicine (Division of Artificial Intelligence in Medicine), Biomedical Sciences, and Imaging, Cedars-Sinai Medical Center, Los Angeles, California, United States.

Background: Observational data have suggested that patients with moderate to severe ischemia benefit from revascularization. However, this was not confirmed in a large, randomized trial.

Objectives: Using a contemporary, multicenter registry, the authors evaluated differences in the association between quantitative ischemia, revascularization, and outcomes across important subgroups.

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Background: Patients with systemic right ventricle (SRV), either d-transposition of the great arteries following an atrial switch procedure or congenitally corrected transposition of the great arteries, develop severe right ventricular dysfunction, prompting appropriate medical therapy. However, the efficacy of beta-blockers and angiotensin receptor blockers or angiotensin-converting enzyme inhibitors (ACEI) in SRV patients is unproven.

Objectives: The objective of this study was to determine the effects of ACEI/ARB and beta-blockers on outcomes in SRV patients after accounting for likely cofounders affecting their use.

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Multidimensional relationships between sensory perception and cognitive aging.

Front Aging Neurosci

December 2024

Department of Psychology, Game Design, and Physical Therapy, Movement and Rehabilitation Services, Northeastern University, Boston, MA, United States.

A growing literature suggests that declines in sensory/perceptual systems predate cognitive declines in aging, and furthermore, they are highly predictive for developing Alzheimer's disease and Alzheimer's related dementias (ADRD). While vision, hearing, olfaction, and vestibular function have each been shown to be related to ADRD, their causal relations to cognitive declines, how they interact with each other remains to be clarified. Currently, there is substantial debate whether sensory/perceptual systems that fail early in disease progression are causal in their contributions to cognitive load and/or social isolation or are simply coincident declines due to aging.

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The doctor will polygraph you now.

Npj Health Syst

December 2024

Center for Interventional Oncology, Clinical Center, National Institutes of Health (NIH), Bethesda, MD USA.

Artificial intelligence (AI) methods have been proposed for the prediction of social behaviors that could be reasonably understood from patient-reported information. This raises novel ethical concerns about respect, privacy, and control over patient data. Ethical concerns surrounding clinical AI systems for social behavior verification can be divided into two main categories: (1) the potential for inaccuracies/biases within such systems, and (2) the impact on trust in patient-provider relationships with the introduction of automated AI systems for "fact-checking", particularly in cases where the data/models may contradict the patient.

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(Black Cumin) Oil: A Case Report and Analysis Exploring Severe Cutaneous Manifestations and Implications for Patient Care.

J Clin Aesthet Dermatol

December 2024

Drs. Johnston and Shangraw are with Frontier Dermatology in Salem, Oregon.

In the past three decades, there has been a remarkable surge in the popularity and use of herbal medicines. However, despite their widespread use, herbal remedies remain inadequately regulated, exposing consumers to potential adverse effects. This case series examines eight patients with severe cutaneous manifestations resulting from the topical application of (black cumin) oil, emphasizing the critical significance of patch testing, thorough history-taking regarding exposures and herbal supplement usage, and the necessity for enhanced regulatory measures.

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Quantifying form resistance is essential for estimating summer low and bankfull flow from stream survey channel morphology.

Geomorphology (Amst)

December 2024

Retired: U.S. Environmental Protection Agency, Office of Research and Development, Center for Public Health and Environmental Assessment, Pacific Ecological Systems Division, 200 SW 35th Street, Corvallis, OR 97333, USA.

Reliable estimates of low flow and flood discharge at ungaged locations are required for evaluating stream flow alteration, designing culverts and stream crossings, and interpreting regional surveys of habitat and biotic condition. Very few stream gaging stations are located on small, remote streams, which typically have complex channel morphology. Adequate gaging is also lacking on larger streams that are remote, smaller than those typically gaged, or have channel morphology not conducive to installation of gages.

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Eggshell recognition in parental birds is vital for nest management, defense against brood parasitism, optimal embryonic development, and minimizing disease and predation risks. This process relies on acceptance thresholds balancing the risk of rejecting own eggs against the benefit of excluding foreign ones, following signal detection theory. We investigated the role of object shape in egg rejection decisions among three host species of the brown-headed cowbird (Molothrus ater), each with a varying known response to parasitic eggs.

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Evaluating the quantum optical properties of solid-state single-photon emitters is a time-consuming task that typically requires interferometric photon correlation experiments. Photon correlation Fourier spectroscopy (PCFS) is one such technique that measures time-resolved single-emitter line shapes and offers additional spectral information over Hong-Ou-Mandel two-photon interference but requires long experimental acquisition times. Here, we demonstrate a neural ordinary differential equation model, g2NODE, that can forecast a complete and noise-free interferometry experiment from a small subset of noisy correlation functions.

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The phospholipid membrane-water partition coefficients () and equilibrium binding affinities for human serum albumin (HSA) of 60 structurally diverse perfluoroalkyl and polyfluoroalkyl substances (PFAS) were evaluated through laboratory measurements and modeling to enhance our understanding of PFAS distribution in organisms. Per- and polyfluoroalkyl carboxylic acids exhibited a 0.36 ± 0.

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