64 results match your criteria: "Oral Melanoacanthoma"
Oral melanoacanthoma: Clinicopathological and immunohistochemical features of a case series and a scoping review.
J Oral Pathol Med
November 2023
Department of Oral Pathology and Surgery, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Article Synopsis
- * Histological findings included epithelial acanthosis and melanin incontinence, with TRP2-positive melanocytes found in all cases, while T-lymphocytes predominantly outnumbered B-lymphocytes.
- * A broader scoping review identified 85 additional cases, predominantly in females and black-skinned individuals, suggesting that oral melanoacanthoma primarily affects the buccal mucosa and may arise from specific immune cell involvement.
Habitual khat chewing and oral melanoacanthoma: A case report.
World J Clin Cases
January 2023
Postgraduate, College of Dentistry, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi Arabia.
Article Synopsis
- Habitual khat chewing can lead to various changes in oral tissues, including a rare condition called oral melanoacanthoma, which is a benign pigmentation in the mouth.
- A case study of a 26-year-old male showcased this link, as his regular khat use triggered the development of oral melanoacanthoma, confirmed through medical history and biopsy.
- The study emphasizes that chronic khat chewing is a significant extrinsic factor contributing to oral tissue changes, highlighting the need for awareness of its potential health risks.
Melanoacanthoma, Plasma Cell Cheilitis and Langerhans Cell Hyperplasia on the Lower Lip: An Unusual Association and Immunohistochemical Analysis.
Indian J Dermatol
January 2022
Oral Pathology, Department of Stomatology, Public Oral Health, and Forensic Dentistry, Ribeirão Preto Dental School (FORP/USP), University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Article Synopsis
- Oral melanoacanthoma is a rare lesion with increased keratinocyte growth and melanin-rich dendritic melanocytes, while plasma cell cheilitis (PCC) is an inflammatory condition characterized by a dense infiltration of plasma cells, mainly affecting the lower lip.
- The study presents a unique case of a 59-year-old male with an unusual combination of melanoacanthoma, PCC, and Langerhans cell hyperplasia (LCHyp) occurring on the lower lip, showcasing the varied nature of these lesions.
- Histological analysis utilized stains like Fontana-Masson and HMB-45 to identify dendritic melanocytes, along with markers like MUM1/IRF4 to show plasma
Focal melanocytic lesions of the oral mucosa: An epidemiological and morphological study.
Oral Dis
October 2023
Division of Oral and Maxillofacial Pathology, School of Dentistry, University of São Paulo, São Paulo, Brazil.
Article Synopsis
- This study examined the clinical and histopathological features of focal oral melanocytic lesions over an 18-year period at a Brazilian pathology center.
- A total of 339 lesions were identified, with melanotic macules and melanocytic nevi being the most common types, predominantly affecting white-skinned women.
- The research highlighted that lesions often appeared as small macules, primarily on the lip vermilion and palate, with melanomas occurring in older patients and larger in size.
Oral Melanoacanthoma: Case Series of 33 Cases and Review of the Literature.
Head Neck Pathol
June 2023
Department of Oral and Maxillofacial Diagnostic Services, University of Florida College of Dentistry, 1395 Center Dr, Gainesville, FL, 32610-0414, USA.
Article Synopsis
- Oral melanoacanthoma (OM) is a rare, benign growth involving keratinocytes and melanocytes, requiring biopsy for accurate diagnosis and differentiation from other conditions.
- This study presents the largest known series of OM cases, analyzing demographics, clinical characteristics, and microscopic findings from 33 cases diagnosed between 1998 and 2020.
- Findings showed a mean patient age of 38.7 years, with the majority being female, and most lesions located in the buccal mucosa, appearing primarily as asymptomatic brown/black macules.
[Pigmented lesions of the mucosa].
Dermatologie (Heidelb)
September 2022
Hautklinik, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Ulmenweg 18, Erlangen, Deutschland.
Article Synopsis
- - Pigmented lesions in the mouth are common and can be confusing for both patients and doctors due to their varied causes and potential risks, including malignancy.
- - These lesions can be categorized as either focal (like melanotic macules or nevi) or multifocal/diffuse (often linked to drugs or medical conditions), with some being benign and others necessitating further investigation.
- - Understanding the characteristics and causes of these lesions is crucial for accurately assessing their nature and determining whether additional testing is required for diagnosis.
Multifocal Intraoral Melanoacanthomas: Two Case Reports and a Literature Review.
Cureus
July 2022
Department of Oral and Maxillofacial Surgery, King Khalid Hospital, Alkharj, SAU.
Article Synopsis
- * The lesion can appear brown to black and usually does not require treatment, with no known malignant potential.
- * Diagnosing multifocal oral melanoacanthoma (MOMA) is generally straightforward, whereas solitary cases might need a biopsy for proper identification, as highlighted by two reported cases featuring an unusual location.
Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Tumours of the Oral Cavity and Mobile Tongue.
Head Neck Pathol
March 2022
Department of Oral Pathology, Faculty of Dental Sciences, University of Peradeniya, Peradeniya, Sri Lanka.
The fifth chapter of the upcoming fifth edition of the 2022 World Health Organization Classification of Tumours of the Head and Neck titled Tumours of the oral cavity and mobile tongue, has had some modifications from the 2017 fourth edition. A new section "Non-neoplastic Lesions", introduces two new entries: necrotizing sialometaplasia and melanoacanthoma. The combined Oral potentially malignant disorders and Oral epithelial dysplasia section in the 2015 WHO has now been separated and submucous fibrosis and HPV-associated dysplasia are also discussed in separate sections.
View Article and Find Full Text PDFCase Report of Conjunctival Melanoacanthoma.
Cornea
July 2022
Department of Ophthalmology, Dell Medical School, University of Texas, Austin, TX.
Article Synopsis
- The study focuses on a rare condition called conjunctival melanoacanthoma, aiming to provide detailed insights as it hasn't been thoroughly documented before.
- A 34-year-old Hispanic man presented with a painless, pigmented lesion in the eye, which was excised and analyzed, revealing signs of melanocyte growth and tissue changes.
- There is only one previous case reported in literature, leading to a lack of established treatment guidelines for managing this condition.
Case Report: A rare presentation and diagnosis of gingival melanoacanthoma caused by teeth whitening strips: A Case Report.
F1000Res
May 2021
Preventive Dental Science Department, College of Dentistry, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
Article Synopsis
- Oral melanoacanthoma is a rare pigmented lesion that usually appears on the buccal mucosa and can mimic melanoma due to its rapid onset and progression.
- A case of a 21-year-old female with gingival melanoacanthoma was linked to the use of teeth whitening strips, which irritated the mucosal tissues and increased melanocyte activity.
- Diagnosis requires a tissue biopsy to rule out malignancy, and treatment involves eliminating irritants and considering oral melanoacanthoma in the differential diagnosis of pigmented lesions in the gums.
Oral pigmented lesions: a retrospective analysis from Brazil.
Med Oral Patol Oral Cir Bucal
May 2021
Department of Oral Diagnosis and Pathology Federal University of Rio de Janeiro School of Dentistry Av. Carlos Chagas Filho 373, Prédio do CCS, Bloco K, 2° andar, Sala 56 Ilha da Cidade Universitária, Rio de Janeiro/RJ. 21.941-902
Article Synopsis
- - A study was conducted to analyze the occurrence and types of pigmented lesions in the oral mucosa within a Brazilian population over a 45-year period, finding that only 0.99% of diagnosed lesions were pigmented.
- - The study revealed that out of 761 pigmented lesions, 46.1% were melanocytic and 53.9% non-melanocytic, with a higher prevalence in females aged 40-70, and the most common lesions identified were amalgam tattoos and melanotic macules.
- - The results are consistent with previous research, underscoring the importance of understanding oral pigmented lesions to improve diagnostic capabilities and patient management in clinical practice.
A Unique Presentation of Gingival Melanoacanthoma: Case Report and Review of Literature.
Cureus
March 2020
Periodontics, Maulana Azad Institute of Dental Sciences, New Delhi, IND.
Melanoacanthoma is a benign, deeply pigmented condition of the oral mucosa characterized by the proliferation of melanocytes and keratinocytes. A 60-year-old male, with no history of systemic diseases or medical treatment, presented with an asymptomatic diffuse pigmentation involving the maxillary and mandibular gingiva. The histopathology of the anomalous pigmented area was analyzed and the dendritic melanocytes expressed positively for Masson-Fontana, S-100, and HMB-45.
View Article and Find Full Text PDFClinical and histopathological study of the oral multifocal melanoacanthoma: A case report.
J Clin Exp Dent
April 2019
MSc, PhD. Professor Department of Dentistry, State University of Paraíba, Campina Grande, Paraíba, Brazil.
Article Synopsis
- * After a biopsy revealed melanin-containing dendritic cells, the diagnosis was confirmed as multifocal oral melanoacanthoma.
- * The study emphasizes the need for careful differential diagnosis between this condition and other pigmented lesions, such as melanoma, especially as new lesions appeared during a 28-month follow-up.
Black and Brown: Non-neoplastic Pigmentation of the Oral Mucosa.
Head Neck Pathol
March 2019
Louisiana State University, 1100 Florida Avenue, New Orleans, LA, 70119, USA.
Article Synopsis
- Black and brown pigmentation in the oral mucosa can arise from various non-cancerous factors, which may include both internal (endogenous) and external (exogenous) pigments.
- Examples of conditions causing pigmentation include smoker's melanosis, drug-related changes, and systemic diseases, while external causes like amalgam tattoos and black hairy tongue are also noted.
- Clinicians face challenges in diagnosing these pigmented lesions, and a biopsy is recommended when the cause cannot be clearly determined from a visual examination.
A rare case of oral melanoacanthoma.
J Oral Maxillofac Pathol
January 2018
Department of Oral Pathology and Microbiology, Sardar Patel Postgraduate Institute of Dental and Medical Sciences, Lucknow, Uttar Pradesh, India.
Article Synopsis
- - Oral melanoacanthoma is a rare and pigmented lesion that can mimic cancer due to its quick growth and sudden onset.
- - Clinically, it appears as a brown-black lesion, while histological examination shows thickening of the outer layer of skin (acanthosis) and an increase in certain pigment-producing cells (dendritic melanocytes).
- - Because of its atypical characteristics, a biopsy is essential to confirm that it is not malignant.
Pigmented lesions of the oral mucosa: A cross-sectional study of 458 histopathological specimens.
Oral Dis
November 2018
Department of Oral Pathology and Surgery, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Article Synopsis
- This study aimed to assess the clinical and histopathological characteristics of pigmented oral mucosal lesions over a 64-year period.
- The research involved reviewing 34,127 archived specimens, finding that only 458 (1.34%) were pigmented lesions, primarily affecting middle-aged women.
- The most common types of lesions identified were amalgam tattoos, melanotic macules, and nevi, predominantly located on the cheek mucosa and often appearing as small, flat spots.
Gingival melanoacanthoma associated with pseudomelanocytic nests: Expanding the clinicopathological spectrum of a recently described oral lesion.
J Cutan Pathol
May 2018
Oral Pathology, Department of Stomatology, Public Oral Health, and Forensic Dentistry, Ribeirão Preto Dental School (FORP/USP), University of São Paulo - Avenida do Café, São Paulo, Brazil.
Laugier-Hunziker Syndrome Presenting with Metachronous Melanoacanthomas.
Head Neck Pathol
June 2019
Department of Oral Diagnostic Sciences, School of Dental Medicine, University at Buffalo, The State University of New York, 355 Squire Hall, 3435 Main Street, Buffalo, NY, 14214-3008, USA.
Article Synopsis
- Laugier-Hunziker syndrome (LHS) is a rare, non-cancerous condition marked by progressive pigmentation of mucous membranes.
- A case study tracked a patient over 7 years, noting oral melanoacanthomas and cyclical changes in oral melanotic macules.
- The report emphasizes the importance of distinguishing LHS from other pigmentation-related conditions to ensure effective patient treatment.
Oral melanoacanthoma of the palate: An unusual presentation of an uncommon entity.
JAAD Case Rep
March 2018
Department of Oral and Maxillofacial Surgery, Columbia University Medical Center, New York, New York.
In vivo intraoral reflectance confocal microscopy of an amalgam tattoo.
Dermatol Pract Concept
October 2017
Dermatology Service, Memorial Sloan Kettering Cancer Center, Hauppauge, NY, USA.
Article Synopsis
- The majority of oral pigmentations, like nevi and amalgam tattoos, are benign, but rare mucosal melanomas can be deadly, making it crucial to differentiate between the two.
- Reflectance confocal microscopy (RCM) is a non-invasive imaging technology that helps identify benign versus malignant pigmented lesions in both skin and oral mucosa, though certain areas in the mouth are challenging to evaluate.
- This case report discusses a patient with a history of melanomas and an oral amalgam tattoo that was analyzed using a new intraoral microscopy probe, highlighting its distinct features compared to oral melanomas.
Oral melanoma and other pigmentations: when to biopsy?
J Eur Acad Dermatol Venereol
February 2018
Dermatology, Department of Experimental Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
Article Synopsis
- Oral pigmentations (OPs) are often overlooked, yet they are crucial for diagnosing oral melanoma and identifying systemic diseases through careful oral cavity examinations.
- OPs are categorized into two main types: focal (like amalgam tattoo and melanocytic nevi) and diffuse (such as physiological pigmentations and drug-induced hyperpigmentations).
- The text emphasizes the importance of distinguishing between common OPs and oral mucosal melanoma (OMM), highlighting lesions that may require biopsy or need to be regularly monitored.
Multifocal oral melanoacanthoma associated with Addison's disease and hyperthyroidism: a case report.
Arch Endocrinol Metab
October 2017
Divisão de Patologia Oral, Universidade Federal do Ceará (UFC), Fortaleza, CE, Brasil.
Article Synopsis
- Oral melanoacanthoma is a rare, benign, and pigmented lesion often linked to mucosal irritation and was identified for the first time in a patient with both Addison's disease and Graves' disease.
- The patient exhibited multiple pigmented oral lesions, initially thought to be related to Addison's disease, but were confirmed as oral melanoacanthoma through biopsy and specialized tests.
- This case suggests a reactive nature of oral melanoacanthoma and emphasizes the importance of examining endocrine disorders in patients presenting with this condition.
Oral pigmentation in physiologic conditions, post-inflammatory affections and systemic diseases.
G Ital Dermatol Venereol
October 2018
Section of Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy -
Article Synopsis
- Melanocytes in the oral mucosa produce low levels of pigment, leading to commonly unnoticed conditions, which can range from harmless pigmentation to serious diseases like melanoma.
- Diagnosing oral pigmentations (OP) is difficult; a thorough medical history and general dermatological check-up are essential, and if unclear, a biopsy may be necessary to rule out severe conditions.
- The review classifies benign OPs into two types: diffuse (like physiological pigmentation and drug-induced hyperpigmentation) and localized (such as amalgam tattoos and melanocytic nevi), highlighting the need for better examination of the oral cavity in dermatological practices.