557 results match your criteria: "Oral Manifestations of Drug Reactions"
[Chronic urticaria as an atypical reaction after a vespid bite].
Rev Alerg Mex
June 2024
Unidad de Alergia, Hospital Universitario Fundación Alcorcón, Madrid, España.
Article Synopsis
- - A 56-year-old woman experienced severe itching and widespread hives after being stung by wasps, which required extensive treatment over 12 weeks with antihistamines and corticosteroids.
- - Allergy testing indicated that she had a normal tryptase level and was sensitized to venom from Polistes dominula, a type of wasp.
- - The patient began venom immunotherapy specific to Polistes dominula, which successfully prevented any further episodes of hives after treatment.
A Case of Bullous Pemphigoid with Significant Infiltration of CD4-Positive T Cells during Treatment with Pembrolizumab, Accompanied by Pembrolizumab-Induced Multi-Organ Dysfunction.
Diagnostics (Basel)
September 2024
Department of Dermatology, International University of Health and Welfare Narita Hospital, Chiba 286-0124, Japan.
Article Synopsis
- Immune checkpoint inhibitors (ICIs) can activate T cells in the body, which may lead to unwanted side effects called immune-related adverse events (irAEs), with skin problems being common.
- A unique case involved a 70-year-old woman who developed serious multi-organ issues, including a rare skin condition called bullous pemphigoid, after taking pembrolizumab, a type of ICI.
- The case shows that these side effects can happen even years after starting treatment, and it suggests we need to pay more attention to how multiple organs can be affected by ICIs and how to manage these risks.
SARS-CoV-2 as a trigger of IgA vasculitis: a clinical case and literature review.
Rheumatol Int
November 2024
Department of Physical Medicine and Rehabilitation, University of Health Sciences, Adana Health Practice and Research Center, Adana, Türkiye.
Article Synopsis
- - COVID-19, caused by SARS-CoV-2, impacts global health and is linked to various autoimmune disorders, complicating its respiratory effects.
- - A case study of a 53-year-old man illustrates the onset of IgA vasculitis (IgAV) associated with SARS-CoV-2, presenting symptoms like rashes, joint pain, and abdominal issues.
- - Treatment with intravenous and oral methylprednisolone led to significant improvement, and the article highlights the importance of recognizing IgAV in COVID-19 patients for better diagnosis and management.
Dupilumab as Therapeutic Option in Polysensitized Atopic Dermatitis Patients Suffering from Food Allergy.
Nutrients
August 2024
Dermatology Unit, Department of Clinical Internal Anesthesiological and Cardiovascular Sciences, "Sapienza" University of Rome, 00161 Rome, Italy.
Article Synopsis
- IgE-mediated food allergies involve a type 1 immune response triggered by certain foods, resulting in a variety of symptoms that can vary in severity, including severe reactions like anaphylactic shock.
- This pilot study examined the effects of dupilumab, an antibody treatment approved for atopic dermatitis, on patients with both AD and food allergies, focusing on their allergic sensitization profiles.
- Results indicated a significant reduction in specific IgE levels and molecular allergen components after 16 weeks of dupilumab treatment, suggesting potential benefits in managing allergic symptoms among patients with multiple sensitivities.
Granulomatous mastitis during pregnancy with sudden onset of gait difficulty and erythema nodosum: A case report and review of the literature.
J Obstet Gynaecol Res
October 2024
Department of Obstetrics and Gynecology, Kurume University School of Medicine, Kurume, Japan.
Article Synopsis
- - Granulomatous mastitis (GM) is a benign breast condition that can look like breast cancer, and in this case, a pregnant woman experienced symptoms including a breast mass, severe foot pain, and erythema nodosum (EN) on her legs.
- - The 31-year-old Japanese woman faced walking difficulties due to the pain and swelling, and she was initially worried her breast mass could be cancer based on ultrasound results.
- - A biopsy confirmed GM instead of cancer, and treatment with oral prednisolone led to improvement in her arthritis and EN symptoms within two days.
The Occurrence of Etoricoxib-Induced Stevens-Johnson Syndrome With Oral Manifestations in a Female Patient: A Case Study.
Cureus
June 2024
Oral Medicine/Pathology, Aristotle University of Thessaloniki, Thessaloniki, GRC.
Article Synopsis
- Stevens-Johnson Syndrome (SJS) is a rare and potentially fatal reaction that affects the skin and mucous membranes, often linked to medication use, like etoricoxib in the reported case.
- A 46-year-old female patient experienced severe oral pain and ulcerations after taking etoricoxib for back pain, leading to her emergency visit at a dental school in Greece.
- Treatment included corticosteroids, which alleviated her symptoms, while the case underscores the need for monitoring drug-related adverse effects to enhance patient safety.
Skin-Related Adverse Reactions Induced by Oral Antidiabetic Drugs-A Review of Literature and Case Reports.
Pharmaceuticals (Basel)
June 2024
Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Jagiellońska 4, 41-200 Sosnowiec, Poland.
Article Synopsis
- - Type 2 diabetes (T2DM) is a growing global health issue that affects various organs, including the skin, and is typically treated with oral hypoglycemic medications tailored to each patient’s needs and other health conditions.
- - Antidiabetic drugs can cause cutaneous adverse reactions (CADRs), ranging from mild skin irritations to severe conditions like DRESS syndrome and Stevens-Johnson syndrome, often due to drug hypersensitivity or similar drug structures.
- - Understanding and recognizing the dermatological effects of CADRs is crucial for effective clinical management, particularly in older patients with T2DM, as timely identification can lead to necessary treatment changes, like stopping the offending medication.
Retrospective clinical study analysis of skin adverse reactions related to epidermal growth factor receptor inhibitors.
Transl Cancer Res
June 2024
First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
Article Synopsis
- EGFR inhibitors are important in treating cancer but often cause severe dermatological adverse events (dAEs) that can lead to treatment discontinuation, emphasizing the need for better understanding and management.* -
- A study at The First Affiliated Hospital of Guangxi Medical University from 2020 to 2022 analyzed 120 cancer patients on EGFRIs, revealing that 84.2% experienced dAEs, with the most common effects being skin rashes and nail lesions.* -
- The research highlighted significant risk factors influencing the timing of dAEs, such as drug type, ethnicity, and occupation, leading to the development of a predictive model for these adverse effects.*
Jaw osteoporosis: Challenges to oral health and emerging perspectives of treatment.
Biomed Pharmacother
August 2024
State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China. Electronic address:
Article Synopsis
- * Traditional treatments like bisphosphonates can improve bone quality, but they come with risks, such as osteonecrosis of the jaw, which complicates dental treatment options.
- * New treatment approaches, including gut microbial regulation and herbal medicine, show promise in improving jaw osteoporosis while reducing side effects, prompting a need for further research in oral health management.
Exploration and Evaluation of Adverse Drug Reactions Documented in a Tertiary-Care Hospital in Chennai: An In-Depth Retrospective Observational Study.
Cureus
May 2024
Department of Pharmacology, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND.
Article Synopsis
- Adverse drug reactions (ADRs) are a significant risk associated with medication use, being a leading cause of death in hospitalized patients, highlighting the need for improved safety in drug administration.* -
- The study, conducted at Saveetha Medical College in Chennai, involved analyzing reported ADRs from January 2019 to February 2024, using various assessment scales to categorize and evaluate the data collected.* -
- A total of 252 ADRs were identified, predominantly affecting females aged 20-40, with the highest occurrences linked to obstetrics and gynecology and most ADRs arising from antimicrobial drugs.*
PD-1 Inhibitor Induced Hypertrophic Lichen Planus: A Case Report.
Drugs R D
June 2024
Department of Dermatology, University of Minnesota, Minneapolis, WV, USA.
Article Synopsis
- * A detailed case study of a 64-year-old man highlighted that skin lesions can evolve in appearance and misdiagnosis can occur; thus, clinicians should be cautious when diagnosing SCC in patients on PD-1 therapy.
- * Treatment with clobetasol ointment and oral acitretin resulted in full resolution of the skin lesions, emphasizing the importance of recognizing and correctly managing lichenoid reactions from PD-1 inhibitors.
Adverse events reporting of XPO1 inhibitor - selinexor: a real-word analysis from FAERS database.
Sci Rep
May 2024
Department of Hematology, The First Affiliated Hospital of Xi'an Jiaotong University, No. 277 Yanta West Road, Xi'an, 710061, Shaanxi, China.
Article Synopsis
- Selinexor, the first oral nuclear export inhibitor, is gaining traction in treating malignant tumors but lacks thorough research on its adverse events (ADEs).
- A study using FAERS data from July 2019 to June 2023 identified 4,392 ADE reports linked to selinexor, with 2,595 classified as severe outcomes, primarily affecting the gastrointestinal system, causing myelosuppression, and leading to various nonspecific symptoms.
- The research uncovered 124 signals related to selinexor ADEs, with 10 of the significant signals not previously mentioned in the drug's instructions, illustrating the need for more comprehensive safety evaluations for clinicians and better patient care.
Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) after administration of corticosteroids: Case series and review of literature.
Contact Dermatitis
August 2024
Department of Dermatology, University Allergy Center, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Article Synopsis
- The text discusses a rare skin reaction, symmetrical drug-related intertriginous and flexural exanthema (SDRIFE), that can occur after taking corticosteroids, specifically prednisolone, as shown in four case studies from a German dermatology center.
- The study involved allergy tests on patients, evaluating reactions to different corticosteroids and using classification systems to analyze potential cross-reactivity among them.
- The findings suggest that while corticosteroid-induced type IV hypersensitivity reactions like SDRIFE are uncommon, they can happen, and individualized assessments are essential for managing these reactions effectively, including considering alternative treatments and the possible need for emergency corticosteroids.
Article Synopsis
- The study aimed to understand how to diagnose and treat IgG4-related diseases (IgG4-RD) that mainly affect lymph nodes.
- A patient suspected of having lymphoma was analyzed, revealing reactive hyperplasia in lymph nodes and high levels of IgG4, leading to a diagnosis of IgG4-RD.
- The research concluded that while histopathology is crucial for diagnosis, a comprehensive evaluation of clinical symptoms, serum IgG4 levels, and imaging is necessary to avoid misdiagnoses, with short-term steroid therapy as an option for unclear cases.
How to Define and Manage Low-Risk Drug Allergy Labels.
J Allergy Clin Immunol Pract
May 2024
Centre for Antibiotic Allergy and Research, Department of Infectious Diseases, Austin Health, Heidelberg, VIC, Australia; Department of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia; The National Centre for Infections in Cancer, Peter MacCallum Cancer Centre, Parkville, VIC, Australia.
Article Synopsis
- Risk stratification in drug allergy categorizes reactions into low, moderate, and high risk based on various factors like reaction timing, management needs, and individual patient characteristics.
- Despite numerous frameworks for assessing drug allergies, especially for penicillin, there is no global consensus, leading to differing methods across allergy centers.
- The review highlights low-risk drug allergies related to certain antibiotics and chemotherapeutics, advocating for risk-based approaches in diagnosis and management, including the use of direct oral challenges for low-risk individuals.
Alpha-gal syndrome: when treatment of hypovolemic shock can lead to anaphylaxis.
Allergol Immunopathol (Madr)
May 2024
Immunology Unit, University Hospital, Azienda Ospedaliera Universitaria Integrata Verona, Italy;
Article Synopsis
- Delayed anaphylaxis due to alpha-gal syndrome, triggered by the ingestion of red meat, has become more common, linked to an immune reaction from tick bites.
- A case study revealed severe allergic reactions, including anaphylaxis and hypovolemic shock, due to a gelatin-containing drug given during emergency surgery.
- The report emphasizes the need for better communication regarding risks associated with medical products for patients with alpha-gal syndrome and urges manufacturers to clearly label the origins of their ingredients.
Minimally Invasive Semiconductor Laser Surgery Combined with 5-ALA Photodynamic Therapy for a Chronic Hyperplastic Candidiasis Patient Who Is Ineffective to Antifungal Therapy.
Photobiomodul Photomed Laser Surg
June 2024
State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School and Hospital of Stomatology, Wuhan University, China.
Article Synopsis
- * A case study demonstrated the successful treatment of CHC in a 30-year-old man using a combination of semiconductor laser pretreatment and 5-amino-levulinic acid (5-ALA) photodynamic therapy (PDT) after traditional antifungal treatment failed.
- * The treatment showcased positive results with minimal side effects, no signs of recurrence or malignancy during follow-up, suggesting this approach may offer a promising solution for CHC patients unresponsive to standard antifungals.
4'-fluorocannabidiol associated with capsazepine restrains L-DOPA-induced dyskinesia in hemiparkinsonian mice: Contribution of anti-inflammatory and anti-glutamatergic mechanisms.
Neuropharmacology
June 2024
Department of Basic and Oral Biology, FORP, Campus USP, University of São Paulo, Ribeirão Preto, Brazil. Electronic address:
Article Synopsis
- - The study tested two compounds, 4'-fluorocannabidiol (4'-F-CBD) and HU-910, to see if they could help with l-DOPA-induced dyskinesia (LID) by reducing striatal inflammation and correcting glutamate issues in mice with Parkinson's-like symptoms.
- - Results showed that only the combination of 4'-F-CBD and the TRPV1 antagonist capsazepine (CPZ) effectively reduced LID and normalized certain glutamate transporter markers, while HU-910 and other CB2 agonists were ineffective.
- - While both compounds lowered inflammation markers in the brain, they did not independently prevent LID, suggesting that anti-inflammatory properties alone are not enough
Safety of direct oral provocation test to delabel reported mild beta-lactam allergy in infants.
Allergol Immunopathol (Madr)
March 2024
Allergy and Clinical Immunology Department, Centro Hospitalar e Universitário do Porto, Porto, Portugal.
Article Synopsis
- * Researchers analyzed data from 151 infants, finding that most reactions were associated with common infections, with amoxicillin being the most implicated drug, and the majority presenting with mild skin reactions.
- * Results showed that DPT is a safe procedure, as only 2% of the tests resulted in a positive allergy reaction, suggesting that many suspected allergies may actually not be valid.
Adverse Effects of Natural Products in the Oral Mucosa and Face: A Scoping Review.
J Integr Complement Med
August 2024
Department of Restorative Dentistry, Federal University of Paraiba, João Pessoa, Paraíba, Brazil.
Article Synopsis
- This scoping review examined adverse reactions in the oral mucosa and face caused by natural products, following specific guidelines for systematic reviews.
- A total of 706 studies were initially identified, but only 28 studies met the eligibility criteria, highlighting cases primarily between 1976 and 2022 across 19 countries.
- The review found that propolis and garlic were the natural products most commonly associated with adverse effects, leading to issues like eczema, chemical burns, and ulcerations in 50 reported patients, predominantly female.
Achilles' Heel of currently approved immune checkpoint inhibitors: immune related adverse events.
Front Immunol
February 2024
Department of Pharmacy, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China.
Article Synopsis
- Immunotherapy, particularly immune checkpoint inhibitors (ICIs), has advanced cancer treatment but also led to increased immune-related adverse events (irAEs).
- Common side effects of irAEs include skin issues, hormone problems, digestive issues, and liver damage, while severe cases can result in life-threatening conditions affecting the nervous, heart, and lung systems.
- Effective management of irAEs requires careful monitoring and may involve glucocorticoid treatment, with the potential need to halt ICI therapy; a multidisciplinary approach is essential for addressing the diverse impacts of these events.
Diagnosis and management of immune mediated liver injury from checkpoint inhibitors.
Curr Opin Gastroenterol
May 2024
Division of Gastroenterology and Hepatology, Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Article Synopsis
- The review highlights the incidence and management of immune-mediated liver injury from checkpoint inhibitors (ILICI), affecting 10-15% of oncology patients during immunotherapy.
- Most patients present with mild liver enzyme elevations and improve after stopping the medication or with short-term corticosteroids, while a smaller percentage may experience severe hepatotoxicity that requires more intensive treatment.
- A thorough evaluation is recommended to rule out other liver disease causes, and most patients recover well from ILICI with appropriate management strategies.
Integrating antimicrobial photodynamic therapy into the adjuvant phototherapeutic approach for orofacial manifestations of toxic epidermal necrolysis and Stevens-Johnson syndrome.
Photodiagnosis Photodyn Ther
April 2024
Graduate Program in Implantology, University of Santo Amaro, School of Dentistry. São Paulo, SP, Brazil. Electronic address:
Article Synopsis
- Toxic Epidermal Necrolysis (TEN) and Steven-Johnson Syndrome (SJS) are severe and potentially life-threatening skin reactions triggered by medications, making their treatment difficult.
- This study examines two cases of children with TEN and SJS who were treated with a combination of antimicrobial photodynamic therapy (aPDT) and photobiomodulation therapy (PBMT), in addition to regular supportive care.
- The treatment led to notable improvement in the children's oral health within a few days, allowing them to begin eating again, suggesting that aPDT and PBMT might effectively support recovery from oral injuries caused by TEN and SJS.
Delayed low-dose methotrexate excretion in a rheumatoid arthritis patient: A case report and literature review.
Medicine (Baltimore)
January 2024
Department of Clinical Pharmacy, Xiangtan central hospital, Xiangtan, China.
Article Synopsis
- * A 66-year-old male with rheumatoid arthritis and COPD experienced anemia and was diagnosed with methotrexate-induced bone marrow suppression after receiving low-dose MTX.
- * Therapeutic monitoring showed critical methotrexate levels, leading to interventions like calcium folinate and blood transfusions, resulting in no recurrence of complications after a month.
A controlled clinical study on efficacy and safety of periocular triamcinolone acetonide injection for treating ocular myasthenia gravis.
BMC Ophthalmol
January 2024
Department of Opthalmology, Aier Eye Hospital of Wuhan University, No. 481, Zhongshan Road, Wuchang District, Wuhan, 430060, China.
Article Synopsis
- The study evaluates the effectiveness and safety of peribulbar triamcinolone acetonide injections for treating ocular myasthenia gravis (OMG) compared to traditional oral therapies.
- 22 OMG patients received the injections and showed significant reductions in symptoms, such as ptosis and ophthalmoplegia, after 4 weeks of treatment.
- While the injection resulted in better minimal manifestations status (MMS) than oral therapy, further research is needed to evaluate its long-term effectiveness and safety.