Macrophage Ferroptotic Resistance Is Required for the Progression of Infantile Hemangioma.

Background: Ferroptosis is a programmed cell death caused by iron-dependent accumulation and cellular lipid peroxides, which is different from apoptosis and pyroptosis. This study investigated the possible effect of ferroptotic response in the pathogenesis of infantile hemangioma (IH).

Methods And Results: The staining level of 4-hydroxynonenal (4-HNE), the marker of ferroptotic cells, was significantly increased in the involutive IH samples compared with the proliferative samples (9 proliferative versus 12 involutive lesions, =0.

Efficacy and safety of oral propranolol and topical timolol in the treatment of infantile hemangioma: a meta-analysis and systematic review.

Background: Propranolol, a nonselective β-blocker, is the first-line treatment for infantile hemangioma (IH). Topical timolol has recently been proposed as a novel IH treatment with fewer adverse effects. This study was conducted to compare the efficacy and safety of oral propranolol and topical timolol for treating IH.

Diagnosis and Treatment of Infantile Hemangioma from the Primary Care Paediatricians to the Specialist: A Narrative Review.

Infantile haemangiomas (IHs) affect 3-10% of infants, 10% of whom need topical or systemic beta-blocker therapy. Propranolol is the first choice for IHs with a high risk of complications. Since more than half of IHs leave a permanent mark, to reduce outcomes, it is essential to start oral propranolol (2-3 mg/kg/day in 2 doses/day) within the 5th month of life (i.

The Diagnostic Considerations and Clinical Management of Lower Lip Swellings in Adolescents: A Narrative Review.

This article outlines a systematic workflow for the clinical management of lip swellings, ensuring an accurate diagnosis and appropriate treatment plan. The process involves a thorough clinical examination and necessary diagnostic investigations such as imaging and biopsy, which will guide treatment decisions. Depending on the findings, treatment may range from conservative management to surgical excision.

Rebound Growth of Infantile Hemangiomas after Propranolol versus Atenolol Treatment: A Retrospective Study.

Introduction: Propranolol is the first-line treatment for complicated infantile hemangioma (IH). Rebound growth following propranolol discontinuation is reported in 6-25% of patients. Atenolol is considered an effective alternative to propranolol.

A case report of an oral hemangioma with unusual features.

Key Clinical Message: A 26-year-old patient with swelling on the lingual surface of the mandible in the incisors area was referred to the Faculty of Dentistry at Mashhad University of Medical Sciences. After conducting clinical, radiographic, and pathological examinations, the patient was diagnosed with capillary hemangioma. This study explores the clinical manifestation and unusual behavior of intraoral hemangioma.

Intravascular Papillary Endothelial Hyperplasia (Masson's Tumor) as a Rare Entity on Upper Lip: A Case Report and Review.

Masson's tumor is a benign intravascular lesion of proliferating endothelial cells that accounts for 2% of vascular and subcutaneous lesions. It manifests clinically as a bluish swelling, resembling a mucocele or hemangioma. Intravascular papillary endothelial hyperplasia (IPEH) was coined by Clearkin and Enzinger in 1976 to describe reactive vascular expansion, following traumatic vascular stasis mimicking angiosarcoma.

Diagnostic Techniques for Infantile Subglottic Hemangiomas: A Scoping Review.

Objective: Infantile subglottic hemangioma (SGH) poses a risk of airway compromise if untreated. Traditionally, operative endoscopy (OH) diagnoses SGH, but since the discovery of beta-blockers' efficacy in treating infantile hemangiomas (IHs) in 2008, and advances in endoscopic technology, nonoperative methods have emerged. This review identifies endoscopic practices for diagnosing and monitoring infantile SGH during the oral beta-blocker treatment era.

Most common congenital syndromes with facial asymmetry: A narrative review.

Symmetry is present in various aspects of everyday life. A symmetrical face is considered attractive, whereas a lack of facial symmetry is regarded as a source of functional and aesthetic problems. Most of the people exhibit slight asymmetries, but some of them reveal severe asymmetries.

Use of modified human hemangioma tissue cultures and human umbilical vein endothelial cell cultures to gain mechanistic insights into imiquimod treatment for infantile hemangioma.

Infantile hemangiomas (IH) are a common entity encountered by dermatologists, otolaryngologists, and other surgeons. Oral propranolol is a mainstay of treatment for IH and is well-tolerated, though propranolol-refractory IH and other drug-related adverse events are documented and can limit its usage. There are few in vitro testing systems for putative treatment agents.

Central hemangioma of the maxilla: variance in clinical and radiographic features.

Central hemangioma is a rare benign proliferation of blood vessels most often seen in the vertebral column and skull, but rarely in the jaws. It mainly occurs in the second decade of life with a female predilection. The diagnosis of central hemangioma is challenging due to its variable clinical and radiological characteristics and low incidence in the jaws.

Ayurvedic management of hemangiomatous ulcer: A case report.

The most frequent infantile tumor is a hemangioma, and its most common complication is ulceration. A quickly progressing ulcer called a hemangioma can also result in secondary infection. The mechanism of ulcer formation is unknown but is thought to develop during the rapid growth phase.

Cryocarboxy Surgery: A New Armamentarium in the Treatment of Infantile Hemangiomas of the Lips.

Background: Cryotherapy was reported in the treatment of infantile hemangiomas by many studies using liquid nitrogen as a cryogen.

Objective: To evaluate the outcome of cryo-carboxy surgery in treatment of infantile lip hemangiomas.

Methods: In this study, we present the use of carbon dioxide as the cryogen in 50 patients with infantile hemangiomas of the lips with successful results.

Infantile Subglottic Hemangioma: A Case ReportInfantile Subglottic Hemangioma: A Case Report.

Subglottic hemangiomas are rare benign vascular tumors of infancy which involve the airway. It is a subtype of infantile hemangiomas and is a potentially life-threatening condition with a mortality rate of 50% if left untreated. Hence, early intervention in this condition is essential.