230 results match your criteria: "Oral Health Research Institute[Affiliation]"

Objectives: Daily-use fluoride products are first-line protection against enamel wear from dietary-acid exposure (DAE). This study aimed to understand effects of fluoride concentration, fluoride salt, product form and ingredients in daily-use products on remineralisation and demineralisation, via network meta-analysis (NMA) of 14 studies using one well-established in-situ model. Remineralisation (surface-microhardness recovery, SHMR) after treatment, and protection against subsequent demineralisation (acid-resistance ratio, ARR) were measured.

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Objective: A preliminary clinical evaluation of the efficacy, comfort, and adverse reactions of two mandibular advancement devices (MADs) in the treatment of Obstructive Sleep Apnea (OSA).

Methods: Forty patients with mild-to-severe OSA were recruited and randomly divided into two groups. They were treated with Shark-fin or Silensor MAD, respectively.

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Article Synopsis
  • Taste dysfunction is a common symptom in individuals with long COVID, with 20-25% experiencing persistent issues, particularly with bitter taste perception.
  • The study found that people with long COVID had significantly lower levels of salivary gustin, a protein that affects taste, which correlated with a reduced ability to taste bitterness.
  • Sonic hedgehog (SHH) and other specific cell markers were identified in saliva, indicating potential mechanisms behind taste dysfunction in long COVID patients.
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Effect of Zinc on improving silver diamine fluoride-derived tooth discoloration in vitro.

BMC Oral Health

November 2024

Department of Public and Ecosystem Health, College of Veterinary Medicine, Cornell University, Ithaca, NY, 14853, USA.

Background: Silver Diamine Fluoride (SDF) is effective for arresting dental caries, presenting a valuable non-invasive treatment option in dentistry. Despite its therapeutic advantages, a significant drawback is the tooth discoloration that follows its application, which can affect patient acceptance. Addressing this aesthetic concern without diminishing the treatment's efficacy remains challenging in dental practice.

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Trueness and adaptation of screw-retained implant-supported monolithic zirconia crowns fabricated using 3-dimensional gel deposition.

J Prosthet Dent

January 2025

Professor, School/Hospital of Stomatology, Zhejiang Chinese Medical University, Hangzhou, Ningbo Dental Hospital/Ningbo Oral Health Research Institute, Ningbo, PR China. Electronic address:

Statement Of Problem: Implant-supported monolithic zirconia restorations manufactured using the additive 3-dimensional (3D) gel deposition technique have been introduced. However, studies determining the trueness and adaptation of implant-supported crowns made with the technique are lacking.

Purpose: The purpose of this in vitro study was to evaluate the trueness and adaptation of implant-supported zirconia crowns fabricated using additive 3D gel deposition in comparison with zirconia crowns made with the widely used subtractive milling technique.

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Purpose: Although bone morphogenetic protein-2 (BMP-2) possesses potent osteoinductivity, there have been some concerns on the safety of BMP-2 and BMP-2-incorporated bone substitutes used for bone formation. On the other hand, BMP-2-loaded calcium phosphate cement (BMP-2@CPC) has been developed and used for bone regeneration in oral implantology. Therefore, this study aims to investigate this product's biocompatibility and clinical safety after being used in maxillofacial surgery.

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Article Synopsis
  • The study examines the role of phase variation in the oipA gene of Helicobacter pylori, which is associated with IL-8 induction and gastric inflammation, in the context of H. pylori's overall virulence and potential links to gastric cancer.
  • Using two different strains, the research differentiates between natural and in vitro-induced phase variations of the oipA gene, discovering that while natural variations don’t significantly impact IL-8 induction or cell elongation, in vitro changes do show effects on cell morphology.
  • The findings highlight the complexity of genetic interactions influencing the virulence of H. pylori, suggesting that oipA phase variation plays a crucial, yet nuanced role in bacterial pathogenicity and warrants further investigation into
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Introduction: Little literature exists on graduates' application to practice for explicit critical thinking skills learned in dental school.

Purposes: Discern the (1) degree to which graduates apply explicit critical thinking skillsets in practice; (2) degree of adaptation of critical thinking skillsets to practice; (3) frequency of use for critical thinking skillsets in practice; and (4) perceptions to improve critical thinking learning guidance in dental school.

Methods: Five critical thinking exercises/skillsets were selected that had been in place over 5 years with at least one paper: geriatrics, treatment planning, technology decision making, ethics, evidence-based dentistry; each followed concepts from an emulation model in critical thinking.

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Introduction And Aims: Artificial intelligence (AI) has been adopted in the field of dental restoration. This study aimed to evaluate the time efficiency and morphological accuracy of crowns designed by two AI-powered software programs in comparison with conventional computer-aided design software.

Methods: A total of 33 clinically adapted posterior crowns were involved in the standard group.

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Relationship of buccolingual inclination between the alveolar bone and first molar in different vertical facial types: A CBCT study.

J Stomatol Oral Maxillofac Surg

October 2024

School of Stomatology, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China; The Stomatology Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China. Electronic address:

Background: This study aimed to investigate the differences in the buccolingual inclination and transverse width of maxillary and mandibular first molars among different vertical facial types.

Methods: In all, 78 samples were divided into three groups based on the GoGn-SN angle: the low-angle group (n = 26, mean age=24.21±5.

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Epigenome-wide association study of fluoride exposure during early adolescence and DNA methylation among U.S. children.

Sci Total Environ

October 2024

University of Cincinnati, College of Medicine, Department of Environmental and Public Health Sciences, Cincinnati, OH, USA. Electronic address:

Article Synopsis
  • * The Cincinnati Childhood Allergy and Air Pollution Study analyzed urine samples and blood DNA methylation to investigate the impact of fluoride on the epigenome in early adolescents, focusing on CpG loci related to DNA methylation.
  • * Results showed that higher fluoride concentrations were linked to differential methylation of specific genes associated with psychiatric outcomes and cognition, particularly in females, indicating that fluoride may influence epigenetic changes during adolescence, but further research is needed to understand the functional impacts.
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Statement Of Problem: Different techniques have been used to record the locations of dental implants, yet research examining the clinical outcomes of posterior implant-supported prostheses generated by different techniques, particularly concerning their fit, is lacking.

Purpose: The purpose of this self-controlled study was to evaluate the clinical outcomes of closed tray impression making and intraoral scanning for single posterior implant-supported restorations.

Material And Methods: Eighty-two participants with a single missing posterior tooth were included.

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Statement Of Problem: While the presence of a ferrule has been reported to be essential for post-and-core restorations, many extensively damaged teeth lack complete ferrules. The outcome of post-and-core restorations for these teeth remains uncertain.

Purpose: The purpose of this retrospective clinical study was to assess the outcome of cast alloy post-and-cores and knife-edged crowns for the restoration of teeth lacking complete ferrules.

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Objectives: Conceptualizing the next patient interaction is logical, essential, and largely done intuitively with limited literature. The first objective is to elicit student thought experiences to four questions. The secondary objective is to classify responses for respective questions and to review faculty assessments.

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Background: Self-glazed zirconia (SZ) restorations are made by a novel additive three-dimensional gel deposition approach, which are suitable for a straightforward completely digital workflow. SZ has recently been used as minimally invasive veneer, but its clinical outcomes have not been clarified yet. This study aimed to evaluate the preliminary clinical outcomes of SZ veneers compared with the widely used lithium disilicate glass-ceramic veneers made by either pressing (PG) or milling (MG) process.

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Characteristics of tin-containing fluoride toothpastes related to erosive tooth wear protection.

J Dent

April 2024

Department of Restorative Dentistry, University of São Paulo, School of Dentistry, Av. Prof. Lineu Prestes 2227, São Paulo, SP 05508-000, Brazil. Electronic address:

Objectives: To assess the effect of different tin-containing toothpastes on the control of erosive tooth wear in enamel and dentin.

Methods: Enamel and dentin slabs were randomly distributed into 7 experimental groups (n = 10/substrate): C-: negative control (Artificial saliva); AmF (regular fluoridated toothpaste without tin); Sn-1 (SnF/NaF); Sn-2 (SnF/NaF/SnCl); Sn-3 (SnCl/NaF); Sn-4 (SnF/SnCl); Sn-5 (SnCl/AmF/NaF/chitosan). Specimens were submitted to 5-day erosion-abrasion cycling.

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Background: Retention of doctors is a global challenge and doctors working in different departments may face different problems. The study aimed to explore the turnover behavior and intention and correlated factors among Chinese dentists and medical doctors in other clinical fields.

Methods: A cross-sectional study was conducted online in 5 regions of China from March 12th to April 12th, 2020.

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Immune responses are crucial to maintaining tissue homeostasis upon tissue injury. Upon various types of challenges, macrophages play a central role in regulating inflammation and tissue repair processes. While an immunomodulatory role of Wnt antagonist Dickkopf1 (DKK1) has been implicated, the role of Wnt antagonist DKK1 in regulating macrophage polarization in inflammation and the tissue repair process remains elusive.

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Impact of toothbrush head configuration and dentifrice abrasivity on non-carious cervical lesions in-vitro.

J Dent

January 2024

Department of Cariology and Operative Dentistry, Indiana University School of Dentistry, Oral Health Research Institute, 415 Lansing Street, Indianapolis, IN 46202, USA. Electronic address:

Article Synopsis
  • This study aimed to explore how different toothbrush head designs and the abrasiveness of toothpaste affect the formation of non-carious cervical lesions (NCCLs) on teeth in a lab setting.
  • Researchers tested 15 combinations of toothbrush configurations and toothpaste abrasivity on extracted teeth to assess dental volume loss after simulated brushing.
  • Results showed that certain toothbrushes paired with high-abrasive toothpaste led to greater tooth damage, with specific head designs like flat-trimmed causing the most wear, while others like cross-angled/flex showed less damage with low-abrasive toothpaste.
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Article Synopsis
  • * Four types of denture materials (compression-molded, injection-molded, 3D-printed, and milled) were tested with either polished or glazed finishes, followed by 50,000 brushing strokes to simulate wear.
  • * Results showed that polished compression-molded materials had the highest hardness, while glazed treatments enhanced hardness across the board, but roughness increased after brushing, especially more with polished surfaces.
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Purpose: To compare the effects of two denture adhesive formulations on the bite force required to dislodge a maxillary denture in adult participants during a 13-h test period.

Materials And Methods: Twenty-two participants with a fair-to-poor fitting maxillary denture opposed by natural dentition or a stable mandibular denture were enrolled in this single-center, randomized, double-blind, two-treatment, 4-period crossover study. Participants were randomly assigned a product usage sequence so that each participant used each product twice during the 4-day test period.

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Article Synopsis
  • Dental caries, a prevalent disease caused by oral biofilms, persists despite fluoride use, but iron oxide nanoparticles (ferumoxytol) can degrade these biofilms with hydrogen peroxide.
  • When combined with stannous fluoride, ferumoxytol significantly enhances the inhibition of biofilm growth and enamel damage compared to using either treatment alone.
  • This combination is effective in controlling dental caries in live subjects at much lower concentrations and shows no negative effects on surrounding tissues or the oral microbiome, highlighting its potential as a safe and efficient treatment for oral health.
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Effect of pH of In-Office Bleaching Gels and Timing of Fluoride Gel Application on Microhardness and Surface Morphology of Enamel.

Int J Dent

September 2023

Department of Cariology, Operative Dentistry and Dental Public Health, Oral Health Research Institute, Indiana University School of Dentistry, Indianapolis, IN, USA.

Article Synopsis
  • - The study aimed to evaluate the microhardness of enamel treated with two different pH bleaching agents and the impact of fluoride therapy before and after bleaching treatments.
  • - Eighty bovine incisors were split into eight groups to test various combinations of bleaching agents and fluoride treatments, with hardness measured at three intervals and assessed using statistical analysis.
  • - Results indicated that Pola Office bleaching resulted in the greatest enamel softening, while applying 2% NaF gel afterward effectively restored some enamel hardness, although the fluoride treatment after Pola Office+ had minimal benefits.
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Purpose: To describe and discuss the benefits and drawbacks of various dental caries diagnostic techniques, including the use of intraoral scanners for caries diagnosis based on near-infrared imaging (NIR) technology.

Material And Methods: A MEDLINE search from 1980-2023 focused on dental caries diagnostic techniques, emphasizing intraoral scanners using NIR technology. Alternative caries detection methods were also evaluated for their advantages and limitations, enabling a comparison with NIR.

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