621 results match your criteria: "Oral Granular Cell Tumors"
Malignant granular cell tumour of floor of mouth (non-neural in origin) - A rare case report and review of literature.
SAGE Open Med Case Rep
November 2024
Department of Pathology, University College of Medical Sciences, New Delhi, India.
Five cases of non-neuronal granular cell tumours of the oral cavity are documented in the literature. Additionally, one case of a non-neuronal granular cell tumour with features of malignancy was described. A malignant granular cell tumour is a rare neoplasm and counterpart of a benign granular cell tumour.
View Article and Find Full Text PDFExpression of CD68 and CD163 in malignant epithelial cells of oral squamous cell carcinoma: Phenotypic shift or mere cell fusion.
Pathol Res Pract
November 2024
Egyptian Ministry of Health, Tanta Ophthalmology Hospital, Tanta, Egypt. Electronic address:
Article Synopsis
- The study investigates the transformation of cancer cells in oral squamous cell carcinoma (OSCC) from an epithelial to a mesenchymal state, which enhances their mobility and ability to spread.
- Researchers focused on the expression of specific macrophage antigens, CD68 and CD163, in both cancer cells and tumor-associated macrophages (TAMs).
- Findings revealed that these antigens were present not only in TAMs but also in many OSCC epithelial cells, suggesting a possible link between macrophage characteristics and increased cancer metastasis.
From prenatal diagnosis to surgical treatment: two case reports of congenital granular cell epulis.
Pathol Oncol Res
July 2024
Department of Oral and Maxillofacial Surgery, Qi Lu Hospital of Shandong University, Jinan, Shandong, China.
Article Synopsis
- This study discusses a coordinated approach to treating two infants born with congenital granular cell epulis (CGCE), identified through ultrasound during pregnancy.* -
- A team of specialists, including surgeons and pediatricians, collaborated to create a treatment plan, leading to successful removal of the oral masses after cesarean delivery.* -
- Immunohistochemical analysis of the removed lesions provided key insights, highlighting the significance of early prenatal diagnosis for managing this rare condition.*
Case Report of a Benign Granular Cell Tumor Resembling Breast Carcinoma in a Young Woman: A Diagnostic Challenge.
Case Rep Oncol
June 2024
Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Article Synopsis
- - Granular cell tumors (GCTs) are rare and generally benign tumors associated with Schwann cells, found in various body tissues, with only 1-2% being malignant.
- - A 34-year-old woman presented with a 1.5 × 2-cm mass in her breast, initially suspected to be cancer, but was later confirmed as a benign GCT through pathology, leading to successful breast-conserving surgery.
- - This case emphasizes the need for precise diagnosis to avoid unnecessary aggressive treatments for benign conditions mistaken for cancer.
Oral granular cell tumor: a collaborative clinicopathological study of 61 cases.
Oral Maxillofac Surg
September 2024
Department of Dentistry, State University of Paraíba (UEPB), Campina Grande, Brazil.
Article Synopsis
- Granular Cell Tumor (GCT) is a rare benign oral lesion, often misdiagnosed due to its similarity to other conditions, highlighting the need for more awareness on its prevalence and characteristics.
- A study at six diagnostic centers in Brazil and Argentina analyzed 61 GCT cases, predominantly in females (73.8%), with most tumors on the tongue, presenting as painless nodules or papules in various colors and sizes.
- Histopathological analysis revealed distinctive cell characteristics, with low agreement between clinical and histological diagnoses, but no local recurrences were noted during the follow-up period.
Granular cell tumor of the brachial nerve in a dog: A case report.
Braz J Vet Med
May 2024
Veterinarian, Kitasato University School of Veterinary Medicine, Department of Small Animal Surgery 2, Japan.
Article Synopsis
- * During surgery to remove the mass, heavy bleeding occurred and part of the brachial nerve was also removed due to the tumor’s attachment.
- * Pathological analysis confirmed the mass as a granular cell tumor (GCT), which is rare in non-oral locations, and while most GCTs are benign, they can mimic malignant tumors and pose surgical risks.
Expression of p120 - catenin in oral squamous cell carcinoma and apparently normal mucosa adjacent to oral squamous cell carcinoma.
J Clin Exp Dent
April 2024
Senior Resident, Department of Public Health Dentistry, Government Dental College & Hospital, Hyderabad, India.
Article Synopsis
- The study investigates the role of p120 catenin in the development and progression of Oral Squamous Cell Carcinomas (OSCC) by comparing its expression in OSCC tissues and adjacent apparently normal mucosa (ANMAOSCC).
- Results showed that over 80% of OSCC cases expressed p120, while all ANMAOSCC samples maintained expression, highlighting a significant difference in the cellular localization of p120 between the two groups.
- The atypical staining pattern of p120 in OSCC suggests a loss of cell adhesion and may serve as a potential biomarker for assessing the malignant potential of these tumors.
Sclerosing epithelioid fibrosarcoma of the jaw: a case report and literature review.
Oral Surg Oral Med Oral Pathol Oral Radiol
September 2024
Associate Professor, Director of Oral Pathology, Temple University School of Medicine, Pathology Department/Oral Pathology, Philadelphia, PA, USA. Electronic address:
Article Synopsis
- Sclerosing epithelioid fibrosarcoma (SEF) is a very rare type of cancer, primarily affecting the deep soft tissues of the lower body, with limited occurrences in the head and neck region, particularly the oral and maxillofacial area.
- A case study of a 52-year-old man revealed a radiolucent lesion near his left lower molar, initially mistaken for a common dental issue, discovered to be SEF after he had a history of the tumor in his skull.
- The study emphasizes that SEF should be considered in the differential diagnosis for high-grade tumors in the oral region, highlighting the significance of immunohistochemical stains like MUC-4 for
Oral Granular Cell Tumor: A Case Report with Emphasis on Pseudoepitheliomatous Hyperplasia in Oral Lesions.
J Dent (Shiraz)
March 2024
Research Center, Dental School Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Article Synopsis
- A granular cell tumor (GCT) is a benign neoplasm primarily affecting the dorsum of the tongue, mostly occurring in adult females, and typically presents as a painless, slow-growing nodule.* -
- Histopathological examination reveals large, polygonal cells with granular cytoplasm and can show pseudoepitheliomatous hyperplasia (PEH), which complicates the diagnosis as it mimics squamous cell carcinoma (SCC).* -
- Understanding the characteristics of PEH is crucial for accurate diagnosis and treatment of oral lesions, highlighting the need for greater awareness among oral pathologists regarding this condition.*
Granular cell tumor of the larynx.
Am J Med Sci
April 2024
Department of Oral and Maxillofacial Surgery, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, China. Electronic address:
Central Granular Cell Odontogenic Tumor of the Mandible: An Uncommon Presentation.
Cureus
December 2023
Oral Pathology and Microbiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND.
Article Synopsis
- * The tumor is characterized by the presence of large granular cells that appear eosinophilic and granular under a microscope.
- * The report discusses an atypical case of CGCOT found in a 38-year-old male, detailing its clinical, radiological, pathological features, and the immunohistochemical analysis conducted on the tumor.
Lip Granular Cell Tumor (GCT) in a Pediatric Patient: Critical Literature Review on Pediatric Intraoral GCT and Acquired and Congenital Intraoral Non-Neural GCT.
Indian J Otolaryngol Head Neck Surg
December 2023
Oral Pathology, Department of Stomatology, Public Oral Health, and Forensic Dentistry, Ribeirão Preto Dental School (FORP/USP), University of São Paulo, Avenida do Café, S/N, Ribeirão Preto, SP 14040-904 Brazil.
Article Synopsis
- Granular cell tumor (GCT) is a rare benign tumor that originates from Schwann cells, commonly found in areas like the oral cavity and skin.
- A case study of a 13-year-old boy with a nodular lesion on the upper lip showed GCT with significant perineural involvement, but no signs of pseudocarcinomatous squamous hyperplasia.
- Immunohistochemical analysis indicated negative ALK expression, while Rb and INI1 remained positive; further research is recommended to explore the relationship between GCTs and other tumors, particularly non-neural variants.
Antiangiogenics in Malignant Granular Cell Tumors: Review of the Literature.
Cancers (Basel)
October 2023
Instituto de Investigacion Sanitaria Fundacion Jimenez Diaz (IIS/FJD), 28015 Madrid, Spain.
Article Synopsis
- * Pazopanib is the most commonly used systemic therapy for GCTs, showing disease control in 80% of patients and an objective response in 40% during a median treatment time of seven months.
- * Molecular studies indicate that the effectiveness of pazopanib may be linked to genetic factors that enhance certain signaling pathways, and while there are other targeted therapies, pazopanib remains a promising treatment option for advanced GCTs.
Utility of MUC4 in the diagnosis of secretory carcinoma of salivary glands.
Ann Diagn Pathol
December 2023
Department of Pathology and Laboratory Medicine Aga Khan University Hospital Karachi, Pakistan. Electronic address:
Article Synopsis
- The study analyzed 22 cases of SC to evaluate the effectiveness of MUC4 as a diagnostic marker, alongside other stains like S100 and mammaglobin, finding MUC4 to be positive in 90% of SC cases with high sensitivity and specificity.
- The results suggest MUC4 is a valuable tool that can help pathologists differentiate SC from other similar tumors, potentially improving diagnostic accuracy.
Protrusion deviation due to intramuscular granular cell tumor of the tongue.
Oral Oncol
December 2023
Department of Oral and Maxillofacial Surgery, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, China. Electronic address:
Hypervascular floor of mouth tumor: Rare presentation of oral cavity squamous cell carcinoma.
Am J Otolaryngol
December 2023
Department of Orthopaedic and Plastic Surgery, Wright State University, 30 E Apple St, suite 2200, Dayton, OH 45409, United States of America. Electronic address:
Article Synopsis
- Oral squamous cell carcinoma (OSCC) is the most common form of cancer in the oral cavity, often appearing as a red or white ulcerative growth.
- Early-stage OSCC can be disguised as benign vascular tumors, leading to missed diagnoses and delays in treatment.
- This case report describes a patient misdiagnosed with a benign vascular tumor that was actually an invasive SCC, aiming to raise awareness about the diverse ways OSCC can present.
Intraoral Lipoma: A Case Report.
J Pharm Bioallied Sci
July 2023
Department of Oral Medicine and Radiology, Bharati Vidyapeeth (Deemed to be University) Dental College and Hospital, Navi Mumbai, Maharashtra, India.
The soft tissue tumor lipoma is quite frequent. Although it is the most mesenchymal tumor of the trunk and proximal regions of the extremities, it is quite uncommon to find it on the oral mucosa, accounting for just 1% to 5% of benign oral tumors. There is no specific location that is more prone to lipoma development in the mouth.
View Article and Find Full Text PDFTrue Oncocytic Acinic Cell Carcinoma: A Case Image.
Head Neck Pathol
September 2023
Department of Pathology, University of Pittsburgh School of Medicine, University of Pittsburgh Medical Center, 200 Lothrop Street, A616 Scaife Hall, Pittsburgh, PA, USA.
Article Synopsis
- A 67-year-old female with a history of chronic lymphocytic leukemia presented with painful swelling in her right parotid gland, which was diagnosed as acinic cell carcinoma (AciCC) after a biopsy.
- Imaging revealed metastatic lung nodules confirming the spread of AciCC, leading to extensive surgical intervention that included a radical parotidectomy and neck dissection.
- The tumor exhibited specific histological features, strong immunohistochemical reactivity, and electron microscopy findings, supporting the classification of AciCC, while concurrent CLL/SLL was found in lymph nodes without tumor involvement.
Clinicopathological and immunohistochemical analysis of maxillofacial granular cell tumor.
Hua Xi Kou Qiang Yi Xue Za Zhi
August 2023
State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Oral Pathology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Article Synopsis
- The study aimed to investigate the clinicopathological features of maxillofacial granular cell tumors (GCT) using immunohistochemical staining to assist in diagnosis.
- Researchers analyzed seven cases of GCT, focusing on their microscopic features and tested various markers (like S-100 and CD68) to understand their characteristics better.
- The results showed that GCT tumors have a unique histological structure, and the immunohistochemical markers can aid in diagnosis, suggesting a positive prognosis after surgical removal, as none of the follow-up cases showed recurrence.
Granular cell tumor of the tongue: Case report.
J Dent Sci
July 2023
Department of Dentistry, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
Expression of Connexin 43 in Granular Cell Tumors of the Skin, Tongue and Esophagus.
Dermatopathology (Basel)
June 2023
Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, 97080 Würzburg, Germany.
Article Synopsis
- Granular cell tumors (GCT) are rare tumors that originate from Schwann cells and can occur in various organs, including the skin, tongue, and esophagus, but their exact causes are not well understood.
- A study was conducted to investigate the expression of the gap junction protein Connexin 43 (Cx43) in GCT across these locations, finding that all samples showed moderate to strong expression with a characteristic cytoplasmic staining pattern.
- The findings indicate that Cx43 may have a significant role in the development of GCT, suggesting further research could enhance understanding of this tumor type.
Case report: Abrikossoff's tumor of the facial skin.
Front Med (Lausanne)
May 2023
Clinical Medical Department, Faculty of Medicine and Pharmacy, "Dunărea de Jos" University, Galaţi, Romania.
Article Synopsis
- - Abrikossoff tumors, or granular cell tumors, arise from Schwann cells and are most commonly found in the oral cavity, though they can also occur in other parts of the body like the skin, breast, and central nervous system.
- - These tumors usually affect individuals between 30 and 50 years old, are slightly more common in females, and are primarily benign, with malignant cases being rare (less than 2%).
- - Diagnosis is made through immunohistochemical tests, and treatment typically involves surgical removal; however, chemotherapy and radiotherapy may be needed for malignant tumors, although their effectiveness isn’t well established. The text includes a case study of a 12-year-old girl with a benign GCT
Anesthetic management of congenital epulis in a newborn: a case report.
Ann Med Surg (Lond)
May 2023
Kathmandu University School of Medical Sciences, Dhulikhel Hospital, Dhulikhel, Nepal.
Article Synopsis
- The text discusses congenital epulis, a granular cell tumor found in newborns that develops in the gum area.
- It presents a case of a 4-day-old baby with a large epulis that posed challenges for airway management during surgery.
- The conclusion highlights that, while congenital epulis can cause difficult airways, intubation can be successfully performed with careful handling of the tumor during general anesthesia.
Adamantinoma-Like Ewing Sarcoma Mimicking Merkel Cell Carcinoma in the Parotid Gland: A Diagnostic Pitfall.
Int J Surg Pathol
February 2024
Department of Pathology and Laboratory Medicine, Henry Ford Health, Detroit, MI, USA.
Article Synopsis
- - Adamantinoma-like Ewing sarcoma (ALES) is a rare type of cancer that shares genetic features with Ewing sarcoma but displays histological characteristics similar to epithelial tumors, making it difficult to diagnose.
- - A case study highlights a 33-year-old woman with a right-sided parotid mass, where a CT scan revealed a 17mm tumor leading to surgery, with histopathology showing malignant features that initially suggested metastatic Merkel cell carcinoma.
- - Molecular testing confirmed ALES due to specific rearrangements, emphasizing the importance of recognizing this cancer to prevent misdiagnosis and ensure appropriate treatment and management compared to other head and neck malignancies.