85 results match your criteria: "Oral Florid Papillomatosis"
Oral Malignant Acanthosis Nigricans: An Early Diagnostic Sign for Ovarian Carcinoma: A Case Report.
Clin Cosmet Investig Dermatol
February 2024
Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510280, People's Republic of China.
Article Synopsis
- * A rare case described a patient with malignant acanthosis nigricans and mild oral papillomatosis, which was concurrent with ovarian carcinoma, highlighting the importance of recognizing subtle symptoms for early diagnosis.
- * There are few known instances of malignant AN associated with ovarian cancer, so dental specialists should be aware of the possibility of underlying malignancies in patients showing significant oral growths, especially in older individuals.
Mohs micrographic surgery for verrucous carcinoma: a review of the literature.
Arch Dermatol Res
March 2023
Department of Dermatology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Article Synopsis
- - Verrucous carcinoma is a rare, low-grade type of squamous cell carcinoma that generally does not spread (metastasize) to other parts of the body but can grow aggressively in the local area.
- - The study analyzed 38 cases of verrucous carcinoma treated with Mohs micrographic surgery, showing a local recurrence rate of 16%, with only a small percentage having lymph node metastasis (3%).
- - Due to the high rates of local recurrence associated with traditional wide local excision, Mohs surgery is recommended as the preferred treatment, but more research is needed to compare the effectiveness of Mohs and wide local excision.
Oral florid papillomatosis: Topical treatment with 5% imiquimod in orabase.
Clin Exp Dent Res
August 2022
Department of Oral and Maxillofacial Surgery, Virgen Macarena University Hospital, Seville, Spain.
Article Synopsis
- - A 74-year-old woman with florid oral papillomatosis (OFP) was treated with imiquimod 5% after refusing surgery, using the treatment on alternate days for 16 weeks, alongside hyaluronic acid gel.
- - At the 2-year follow-up, there were no side effects or signs of recurrence in the treated area.
- - This case suggests that topical imiquimod 5% could be a viable alternative treatment for recurrent OFP in patients unwilling to undergo surgery, though ongoing monitoring is essential.
Malignant acanthosis nigricans and diseases with extensive oral papillary hyperplasia.
Clin Exp Dermatol
April 2022
Department of Oral Medicine, Stomatological Hospital, Southern Medical University, Guangzhou, China.
Article Synopsis
- Oral papillary lesions can be various developmental or neoplastic conditions that are difficult to diagnose early for oral medicine specialists.
- Malignant acanthosis nigricans (MAN) is a rare skin disorder that can indicate hidden tumors and presents with papillary lesions in the oral mucosa.
- Due to the complexity of early signs and lack of understanding, oral medicine specialists need to gather medical histories and perform systematic examinations to avoid misdiagnosis.
Activating HRAS mutation in a case of inverted ductal papilloma of the salivary gland.
Pathol Int
December 2021
Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Article Synopsis
- The exact cause of IDP is still unknown due to its rarity, but recent findings suggest a potential link to oncogenic mutations.
- The discovery of HRAS mutations in a case of oral IDP, along with previous findings of BRAF mutations in related tumors, indicates that the MAP-kinase pathway may play a role in the development of these benign papillary neoplasms.
Oral verrucous carcinoma arising from pemphigus vulgaris: A rare coincidence.
Oral Oncol
January 2022
Department of Pathology, Emam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
Malignant Acanthosis Nigricans: An Indicator of Internal Malignancy.
J Coll Physicians Surg Pak
September 2019
Department of Dermatology, Pak Emirates Military Hospital, Rawalpindi, Pakistan.
Article Synopsis
- * Malignant acanthosis nigricans is a serious condition linked to certain types of cancer, particularly gastric adenocarcinoma, and can show additional symptoms like tripe palms and skin growths.
- * This case report discusses a unique instance of a patient with malignant acanthosis nigricans, tripe palms, and oral lesions related to a rare form of liver bile duct cancer.
A Case of Oral Florid Papillomatosis (Verrucous Carcinoma) With Lack of Evidence for Human Papillomavirus Involvement.
Am J Dermatopathol
August 2019
Department of Dermatology, Rambam Health Care Campus and The Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel.
[Precancerous lesions of the buccal epithelium].
Ann Dermatol Venereol
February 2017
Service de pathologie, hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris, France.
Article Synopsis
- Squamous cell carcinomas of the oral cavity and lips are the fifth most common cancer in France and have a poor prognosis if diagnosed late.
- Between 10% and 80% of these carcinomas develop from existing precancerous lesions.
- The WHO classifies these lesions into two categories: precursor lesions associated with intraepithelial neoplasia and "at risk" lesions like lichen planus and submucosal oral fibrosis.
Verrucous Carcinoma - Observations on 4 Cases.
Curr Health Sci J
March 2016
Pathology Department, University of Medicine and Pharmacy of Craiova.
Article Synopsis
- Verrucous carcinoma (VC) is a rare and slow-growing type of well-differentiated squamous cell carcinoma that appears in forms like oral florid papillomatosis and Buschke-Löwenstein tumor.
- The condition affects both the skin and mucous membranes and is commonly associated with HPV, although its exact cause remains unclear.
- Surgical removal with clear margins is the main treatment, and patients require regular check-ups every three months to monitor for recurrence, as VC often returns despite low risk for spreading to other parts of the body.
[Verrocous mass on the tongue: oral florid papillomatosis].
Enferm Infecc Microbiol Clin
February 2015
Servicio de Enfermedades Infecciosas, Hospital Universitario Carlos Haya, Málaga, España.
[Oral florid papillomatosis].
Rev Clin Esp
December 2012
Servicio de Dermatología, Hospital Universitario Ramón y Cajal, Madrid, España.
Palliative treatment of paraneoplastic acanthosis nigricans and oral florid papillomatosis with retinoids.
J Drugs Dermatol
September 2010
Department of Dermatology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
Article Synopsis
- Malignant acanthosis nigricans (MAN) is a rare skin condition linked to cancer, causing thickened, darkened skin and wart-like growths in the mouth, which can make eating and drinking difficult.* -
- There is no targeted treatment for MAN, but addressing the underlying cancer may improve symptoms, with varying degrees of success.* -
- In a reported case, a patient with MAN related to gastric adenocarcinoma was treated with oral retinoids, leading to significant improvements in skin symptoms and overall patient functionality.*
Novel laboratory mouse papillomavirus (MusPV) infection.
Vet Pathol
March 2011
Advanced Centre for Treatment Research and Education in Cancer, Kharghar, Navi Mumbai, India.
Article Synopsis
- Most papillomaviruses (PVs) are known to cause cancer, with at least 100 human PV types identified and numerous strains in animals like rodents.
- A study in India revealed a case of florid papillomatosis in a colony of nude mice, showing lesions around the nose and mouth that resembled classical papillomas.
- The presence of a novel mouse papillomavirus (MusPV) was confirmed through genetic analysis, marking the first documentation of a PV-related disease in laboratory mice.
Treatment of oral florid papillomatosis with systemic administration of photocarcinorin: an effective photodynamic therapy.
Photomed Laser Surg
December 2010
Department of Dermatology, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing, China.
Article Synopsis
- The study aimed to assess the safety and effectiveness of the photosensitizer Photocarcinorin (PsD-007) for treating oral florid papillomatosis (OFP), a rare disease marked by multiple growths.
- The treatment involved intravenously administering Photocarcinorin to a 59-year-old woman, followed by monthly laser therapy for three months, resulting in significant lesion reduction.
- The results indicated that systemic photodynamic therapy (PDT) is a promising and safe option for managing OFP, with minor side effects reported.
Sialadenoma papilliferum with potentially malignant features.
J Clin Pathol
April 2010
Division of Pathology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, Saitama 350-0283, Japan.
Article Synopsis
- - Sialadenoma papilliferum (SP) is generally a benign lesion that grows slowly, but in this report, an unusual case showed rapid enlargement and features that made it resemble a verrucous carcinoma.
- - Radiographic assessments revealed bone resorption in the mandible, indicating a more aggressive behavior than typical SP cases, which raises questions about its classification.
- - The study highlights atypical histological characteristics, suggesting that SP may have malignant potential and complicates the understanding of SP by referencing four other cases where malignancy was associated with it in different contexts.
[Multimodal ablative therapy of florid oral papillomatosis].
J Dtsch Dermatol Ges
June 2008
Hautklinik, Klinikum Kassel GmbH, Kassel.
Multifocal papillomavirus epithelial hyperplasia: successful treatment with CO2 laser therapy combined with interferon alpha-2b.
Int J Dermatol
September 2003
Department of Dermatology, Ankara University Medical Faculty, Ankara, Turkey.
Article Synopsis
- HPV infections in the oral mucosa show different clinical and histopathologic characteristics depending on the HPV type and the severity of the infection.
- These infections are known by various names like focal epithelial hyperplasia and oral florid papillomatosis, with a newer term, multifocal papillomavirus epithelial hyperplasia (MPVEH), used for a childhood variant marked by large papillomatous lesions.
- Despite looking benign, MPVEH requires early diagnosis and treatment due to its potential to worsen and develop into malignancy.
Extensive papillomatosis of the bovine upper gastrointestinal tract.
J Comp Pathol
April 2004
Department of Veterinary Pathology, Glasgow University Veterinary School, Scotland.
Article Synopsis
- Extensive papillomatosis cases were observed in a heifer from Scotland and a steer from England, with lesions found from the mouth to the reticulum.
- While papillomatosis is common in Scottish cattle that graze on bracken fern, this is the first report of similar cases in English cattle.
- Histopathological exams revealed the papillomas had distinct features of papillomavirus infection, and Bovine papillomavirus type 4 (BPV-4) was confirmed through molecular analysis.
Malignant conversion of florid oral and labial papillomatosis during topical immunotherapy with imiquimod.
Med Microbiol Immunol
August 2003
Department of Dermatology and Venereology, Faculty of Medicine, University of Rostock, Augustenstrasse 80-84, 18055 Rostock, Germany.
Article Synopsis
- A 61-year-old woman with severe oral papillomatosis underwent surgery for squamous-cell cancer of the mouth in 1996, but benign lesions reappeared several times until 2000.
- She received topical treatment with imiquimod cream, but due to irritation, the treatment was adjusted, and ultimately, despite efforts, her lesions worsened and were confirmed as cancerous.
- After wide surgical excision of the tumors and lymph nodes, followed by plastic surgery for reconstruction, she showed no signs of recurrence or metastasis 24 months later.
Animal models of papillomavirus pathogenesis.
Virus Res
November 2002
Department of Veterinary Pathology, Institute of Comparative Medicine, Glasgow University, UK.
Article Synopsis
- Tumorigenesis caused by papillomavirus (PV) was first shown in rabbits and cattle, but the idea that viruses could cause cancer in humans was largely ignored until the late 1970s when some viruses were finally recognized as 'tumour viruses.'
- In 1995, the WHO officially acknowledged that HPV types 16 and 18 are carcinogenic to humans, thanks to studies of animal PVs that served both as disease agents and models for human infection.
- Animal PVs can lead to severe diseases in livestock and pets, such as teat papillomatosis in cattle and equine sarcoids, highlighting the importance of ongoing research to understand these infections and their impacts on animal health.
Florid cutaneous and mucosal papillomatosis with acanthosis nigricans revealing a primary lung cancer.
J Eur Acad Dermatol Venereol
May 2000
Istituto di Dermatologia, Università di Roma La Sapienza, Italy.
Article Synopsis
- An 80-year-old patient presented with diffuse hyperpigmentation and thickening of the skin, along with warty and papillomatous lesions, indicating a condition known as acanthosis nigricans (AN).
- Biopsies confirmed a diagnosis of malignant AN, which is often linked to internal malignancies, and the patient showed elevated levels of tumor markers.
- Imaging revealed a large lung tumor, and cytological analysis indicated non-small cell lung carcinoma, suggesting that AN can sometimes be associated with rare cancer types like lung cancer, in addition to more common associations like gastric adenocarcinoma.
Coexistence of acanthosis nigricans and the sign of Leser-Trélat in a patient with gastric adenocarcinoma: a case report and literature review.
J Am Acad Dermatol
February 2000
Department of Dermatology, King's College Hospital, London, United Kingdom.
Article Synopsis
- A 69-year-old man diagnosed with stage-IV gastric adenocarcinoma exhibited severe acanthosis nigricans and the sign of Leser-Trélat, both of which are unusual indicators of underlying malignancy.
- The patient's skin conditions were prominent, affecting not just his skin but also mucous membranes, and they appeared 6 months before the cancer diagnosis.
- Following chemotherapy, both the acanthosis nigricans and Leser-Trélat signs improved, indicating they were paraneoplastic effects associated with the tumor; however, the patient ultimately passed away 7 months after treatment.
Malignant acanthosis nigricans with florid papillary oral lesions.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
April 1996
Division of Oral Medicine and Radiology, Faculty of Dentistry, McGill University, Montreal, Québec, Canada.
Article Synopsis
- - Acanthosis nigricans is a skin condition characterized by dark, velvety plaques that can indicate underlying health issues, including hormonal disorders and certain cancers.
- - It can affect the skin and mucous membranes, sometimes leading to noticeable growths in the mouth.
- - A case study illustrates how pigmented skin lesions from this condition led to the diagnosis of gastric adenocarcinoma, but unfortunately, no effective treatment exists for the condition itself.
[Verrucous carcinoma. Nosologic aspects, apropos of 4 cases].
Ann Dermatol Venereol
January 1996
Service de Dermatologie, CHRU Dijon.
Article Synopsis
- The article discusses the complexity of diagnosing verrucous carcinomas, which can have different names based on their location and clinical presentation.
- It presents four case studies of patients with varying forms of this skin disease, highlighting different triggers and symptoms, such as trauma and HPV presence.
- The authors emphasize the importance of accurate diagnosis through comprehensive biopsy and state that surgical treatment and ongoing monitoring are essential for managing this type of cancer.*