Post-endoscopic sphincterotomy delayed bleeding occurs in patients with just 1-day interruption of direct oral anticoagulants or hemodialysis.

Objective: Endoscopic sphincterotomy (EST), especially when anticoagulants are used, carries a significant risk of delayed bleeding. However, the relationship between the use of antithrombotic agents, including direct oral anticoagulants, and post-EST bleeding remains unclear. This study aimed to identify the risk factors for post-EST delayed bleeding when antithrombotic agents were administered according to the guidelines.

Isolated hypoglossia: Oromandibular Limb Hypogenesis Syndrome Type 1 A - A Rare Case Report.

Hypoglossia is a rare developmental anomaly of tongue. It is usually associated with various syndromes and other anomalies. Most common association of hypoglossia is with limb deformity and these disorders are collectively grouped as Oro Mandibular Limb Hypogenesis (OLHS) Syndrome.

Pain perception and morbidity after peri-implant surgeries in patients with and without temporomandibular disorder - A clinical study.

Background: Temporomandibular disorder (TMD) involves various conditions affecting the anatomy and functional characteristics of the temporomandibular joint (TMJ). Hence, this study evaluated pain perception and morbidity after dental implant surgeries in patients with and without TMD.

Material And Methods: It is a prospective randomized clinical trial with 50 participants with and without TMD, randomly selected for rehabilitation procedures with dental implants.

The expression of Methyltransferase-like 3 in dentigerous cyst and ameloblastoma.

Background: N6-methyladenosine (m6A), the most abundant internal RNA modification in mammals, plays a critical role in many forms of cancer. Methyltransferase-like 3 (METTL3) serves as the main catalytic subunit of the m6A writer and plays a role in the progression of head and neck squamous cell carcinoma. To date, the role of METTL3 in odontogenic lesions has never been investigated.

Bioactive silicon-based dental gel associated with a calcium booster for dentin hypersensitivity treatment: A randomized clinical study.

Background: Dentin hypersensitivity affects a significant portion of the world's population, causing pain and negatively impacting oral health and quality of life This clinical study investigated the effectiveness of a desensitizing fluoride silicon-rich dental gel associated with a calcium booster.

Material And Methods: In this single-blind, randomized, parallel-group clinical trial, forty-eight volunteers diagnosed with dentin hypersensitivity and qualified to participate were randomized into 2 groups: (1) fluoride silicon-rich dental gel (REFX Technology)/calcium booster (Si/Ca protocol); (2) Pumice stone diluted in saline. A draw was carried out between the right and left sides of the patients so that either a prophylaxis with the dental gel associated with calcium or with fine pumice stone diluted in saline was carried out.

Incidence of bleeding during and after two non-surgical periodontal therapy schemes in patients with recent acute coronary syndrome on dual antiplatelet therapy: A pilot study.

Background: This study aimed to compare the incidence of bleeding using two periodontal treatment protocols in patients with recent Acute Coronary Syndrome (ACS).

Material And Methods: This is an interim analysis of a double-blind controlled clinical trial evaluating two periodontal treatment schemes in patients with recent ACS treated with different dual antiplatelet regimens: Clopidogrel+ASA, Prasugrel+ASA and Ticagrelor+ASA. After randomisation six patients (22 quadrants) were treated with Scheme A (scaling and root planning-SRP) and six patients (21 quadrants) with Scheme B (ultrasonic scaling-US).

A survey of lip lesions diagnosed in a single institution: A clinicopathological study.

Background: The aim of this study was to assess the clinicopathological features of lip lesions diagnosed in a single Oral Pathology service in Brazil.

Material And Methods: It was a cross-sectional study based on secondary data. Between 2000 and 2019, all lip lesions diagnosed in an Oral Pathology service in Brazil were analyzed.

Digital analysis of the relationship between maximum bite force and 3-dimensional arrangement of mandibular first molars.

Background: Bite force is one of the important factors that determine the chewing efficiency of molars. This study aimed to investigate the relationship of the maximum bite force (MBF) to the 3-dimensional (3D) arrangement of the first mandibular molars in Angle's class I healthy adults using a digital protocol.

Material And Methods: Subjects were 33 adults (16 males and 17 females) aged 18-25, with Angle's class I occlusions and healthy dentitions.

Survival of teeth with external cervical resorption after Internal and External Repair: A Systematic Review.

Background: To analyze the survival rate of teeth affected by invasive cervical resorption after internal and external repair.

Material And Methods: A search was conducted in PubMed/Medline, Web of Science, Embase, Scopus, the Cochrane Library, and gray literature at the DANS Easy Archive until September 2023. The selected studies were subjected to risk assessment of bias, and the quality of evidence was assessed using the Newcastle Ottawa Scale.

South African parents' views on oral, signing, and bilingual communication for Deaf or hard-of-hearing children.

Background: Parents of Deaf or hard-of-hearing (DHH) children are faced with a plethora of overwhelming decisions concerning their children, particularly during the early stages of development. Among these decisions are those concerning assistive devices and the modes of communication for their child.

Objectives: The aim of this study was to explore the perceptions of parents of DHH children towards the various modes of communication for their children within the South African context.

Oral Opportunistic Infection Induced by Stress and Silent Type 2 Diabetes Mellitus in Young Adult Patient: A Case Report.

Introduction: Opportunistic infections (IO) are infections of microbiota (fungi, viruses, bacteria, or parasites) that generally do not cause disease but turn into pathogens when the body's defense system is compromised. This can be triggered by various factors, one of which is due to a weakened immune system due to Diabetes Mellitus (DM), which increases the occurrence of opportunistic infections, especially in the oral cavity. Fungal (oral candidiasis) and viral (recurrent intraoral herpes) infections can occur in the oral cavity of DM patients.

A Case of IgA Nephropathy in a Patient With Sarcoidosis: Confirmation of Glomerular Galactose-Deficient IgA1 Deposition.

A 63-year-old Japanese housewife was admitted to our hospital because of hematuria and proteinuria lasting for 3 months. At the age of 59 years, she was diagnosed with neurosarcoidosis at another hospital, and she received oral glucocorticoid therapy for 1 year. Her serum angiotensin-converting enzyme (ACE) and 1, 25-dihydroxyvitamin D levels were elevated.

Mycoplasma Pneumonia Complicated by Stevens-Johnson Syndrome: A case report.

Mycoplasma pneumoniae is a leading cause of a community-acquired respiratory illness occurring in children with manifestations occurring throughout the year but peaking in summer and early fall. Predominantly affecting school-aged children, the infection presents as pneumonia, featuring fever, cough, dyspnea, and sore throat. Extrapulmonary manifestations such as Stevens-Johnson have been rarely associated with mycoplasma pneumoniae infection presenting with ocular, oral, and genital involvement.

Chronic Kidney Disease-Associated Pruritus Burden: A Patient Survey Study.

Rationale & Objective: Chronic kidney disease-associated pruritus (CKD-aP) is a common, underrecognized condition in patients with chronic kidney disease (CKD), especially those receiving hemodialysis (HD). The present study analyzed the clinical treatment journey and overall burden of pruritus among patients with CKD-aP.

Study Design: Cross-sectional, patient-reported online survey.

Efficacy and safety of a proprietary extract in skin health - a randomized, placebo-controlled clinical study in healthy volunteers.

Objectives: The concept of beauty from within is a growing trend in the market and people now look for oral supplements that can enhance the well-being of skin from within. Within this principle, a proprietary pomegranate extract (Grantria), standardized to ellagic acid, punicic acid and punicalagin, was developed using ADOP (Advanced Oil-Powder) technology and was clinically evaluated for its efficacy and safety in healthy adults.

Methods: This evaluation was carried out as a randomized, placebo-controlled clinical study for 60 days at a daily dose of 300 mg.

Analysis of the efficacy of lactulose combined with polyethylene glycol in the treatment of functional constipation.

Objectives: This study focuses on analyzing the efficacy of lactulose oral solution combined with Macrogol 4000 Powder in the treatment of functional constipation (FC).

Methods: A total of 125 FC patients were selected, with 60 cases in a control group, who were treated with lactulose oral solution alone, and 65 cases in a research group, who were treated with lactulose oral solution combined with Macrogol 4000 Powder. The two groups were analyzed and compared in terms of efficacy, symptom recovery, Bristol Stool Form Scale (BSFS) and Wexner Constipation Scale (WCS) scores, adverse effects, serum indices, and Patient Assessment of Constipation Quality of Life (PAC-QOL).

A Literature Review on Oral Lumenoscopy: A Non-invasive Method for Diagnosing Oral Potentially Malignant Disorders.

Dentistry still faces difficulties in diagnosing oral precancer and cancer, especially when it comes to early phase changes or disease detection, evaluation, and treatment. In essence, oral lumenography is the process of identifying oral lesions using a chemiluminescent light source and a toluidine blue labeling system. Since neoplastic epithelial cells have a changed nuclear-cytoplasmic ratio, acetic acid dehydration brings out this nuclear density and gives the tissue an "acetowhite" look.

Optimizing Propranolol Therapy for Infantile Hemangiomas: The Role of the Multidisciplinary Team.

Background: Oral propranolol therapy is currently the first choice for infants with infantile hemangiomas (IHs) requiring systemic treatment. This study aims to evaluate the safety and effectiveness of oral propranolol therapy for IHs and to assess the role of a multidisciplinary medical team in supporting optimal treatment.

Materials And Methods: Clinical data were retrospectively reviewed from medical records in 150 Japanese infants with IH treated with propranolol orally at Toranomon Hospital.

Gut Microbiome Alterations Following Oral Serum-Derived Bovine Immunoglobulin Administration in the Management of Dysbiosis.

Introduction: Inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) are chronic disorders of the gastrointestinal tract associated with gut microbiota dysbiosis and inflammation. Serum-derived bovine immunoglobulin (SBI) is used to manage IBS and IBD and has shown prebiotic-like effects in ex vivo models. Re-establishing a healthy gut microbiome with novel treatments like SBI could help treat the underlying causes of these diseases leading to higher and sustained patient response.

Gabapentin as an Adjunctive Therapy in Managing Visceral Hyperalgesia, Severe Feeding Intolerance, and Malnutrition in an Infant: A Case Presentation and Literature Review.

A two-month-old developmentally normal full-term female presented with severe feeding intolerance, progressive weight loss, and persistent fussiness, leading to multiple emergency department visits and eventual hospitalization. Initial evaluations, including laboratory tests and imaging, were unremarkable, prompting a series of diagnostic and therapeutic interventions. A multidisciplinary approach, including empiric gastroesophageal reflux disease (GERD) therapy, was started.

Corynebacterium minutissimum as a Rare Cause of Tibial Osteomyelitis: A Case Report and Literature Review.

Osteomyelitis is commonly caused by pathogens like , but rare organisms such as , typically associated with superficial skin infections, can also be implicated. Recognizing these atypical pathogens presents diagnostic and therapeutic challenges, especially in the presence of orthopedic hardware. We conducted a literature review yielding 25 studies and encompassing 797 patient cases, which highlights the emerging role of species in osteomyelitis, particularly following trauma or surgical interventions.

An Unusual Case of Giant Polymicrobial Shoulder Abscess Developing Two Decades After an Insect Bite: The Role of Chronic Intermittent Swelling as a Predisposing Factor.

Shoulder abscesses, commonly resulting from bacterial infections, can occasionally present with atypical etiologies and delayed onset. We report a rare case of a massive polymicrobial shoulder abscess developing two decades after an insect bite, emphasizing its clinical presentation, diagnostic approach, and surgical management. A 65-year-old female presented with severe, progressively worsening right shoulder pain, a 20 cm swelling, and purulent discharge persisting for 15 days.

Automated xeno-free chondrogenic differentiation from human embryonic stem cells: Enhancing efficiency and ensuring high-quality mass production.

Introduction: Repairing damaged cartilage poses significant challenges, particularly in cases of congenital cartilage defects such as microtia or congenital tracheal stenosis, or as a consequence of traumatic injury, as the regenerative potential of cartilage is inherently limited. Stem cell therapy and tissue engineering offer promising approaches to overcome these limitations in cartilage healing. However, the challenge lies in the size of cartilage-containing organs, which necessitates a large quantity of cells to fill the damaged areas.

Hygrometry behavior during high-flow nasal oxygen therapy and non-invasive mechanical ventilation: A narrative review of bench to clinical studies.

Recently, there has been growing interest in knowing the best hygrometry level during high-flow nasal oxygen and non-invasive ventilation (NIV) and its potential influence on the outcome. Various studies have shown that breathing cold and dry air results in excessive water loss by nasal mucosa, reduced mucociliary clearance, increased airway resistance, reduced epithelial cell function, increased inflammation, sloughing of tracheal epithelium, and submucosal inflammation. With the Coronavirus Disease 2019 pandemic, using high-flow nasal oxygen with a heated humidifier has become an emerging form of non-invasive support among clinicians.

Incident thrombocytopenia and bleeding risk in elderly patients with atrial fibrillation on direct oral anticoagulants: insights from the ATHEROsclerosis in Atrial Fibrillation study.

Background: The bleeding risk of patients with atrial fibrillation (AF) changes over time. Most studies thus far evaluated only the baseline bleeding risk with discordant results. The impact of incident thrombocytopenia during direct oral anticoagulant (DOAC) therapy and its relation to bleeding has not been previously investigated.