The value of returning a sample of the Martian atmosphere.

The elemental and isotopic abundances of major species in the Martian atmosphere have been determined, but analyses often lack sufficient precision, and those of minor and trace species are frequently not well known. Many important questions about the evolution and current state of Mars require the kind of knowledge that can be gained from analysis of a returned sample of the Martian atmosphere. Key target species include the noble gases, nitrogen, and various species containing carbon, hydrogen, and oxygen, such as methane.

Constraining the history of water and climate on Mars through light element stable isotope analysis of volatiles in returned martian samples.

Much has been learned about Mars through data returned from space missions and analyses of martian meteorites. There are, however, many questions still outstanding which cannot currently be answered-including the issue of whether there is, or was, life on Mars. The return of a cache of samples-including of the atmosphere-from separate locations in Jezero Crater and with differing petrogeneses will provide the international community with the opportunity to explore part of the evolutionary history of Mars in great detail.

Short-term and long-term fluoride stress induce differential molecular and transcriptional regulation and variable ranges of fluoride tolerance in two indica rice () varieties.

The aim of this study was to decipher the reprogramming of protective machineries and sulfur metabolism, as responses to time-dependent effect of fluoride stress for 10 and 20days in two indica rice (Oryza sativa ) varieties. Unregulated accumulation of fluoride via chloride channels (CLC1 and CLC2) in 10-day-old (cv. Khitish) and 20-day-old (cv.

Ghrelin: An Emerging Therapy for Heart Failure.

Objective: Ghrelin is emerging as a promising therapeutic option for heart failure (HF) due to its potent inotropic, anabolic, and cardioprotective properties. This review aims to critically examine the available clinical evidence on ghrelin therapy in HF, while also incorporating key findings from preclinical studies that support its therapeutic potential.

Methods: A comprehensive search was conducted in PubMed and the Cochrane Library up to September 15, 2024, using the keywords "heart failure" and "ghrelin.

Exploring the effects of financial stress on undergraduate nursing students in Scotland.

The sharp increase in the cost of living in the UK over the past few years has affected all populations, including higher education students. Many higher education students, including nursing students, are experiencing financial difficulties and concerns, which adversely affect their mental health and can cause them to consider leaving their course. This article reports the findings of an online survey undertaken in one university in Glasgow, Scotland, that aimed to explore the effects of financial stress on second and third-year nursing students.

Inferring Multi-slice Spatially Resolved Gene Expression from H&E-stained Histology Images with STMCL.

Spatial transcriptomics has significantly advanced the measurement of spatial gene expression in the field of biology. However, the high cost of ST limits its application in large-scale studies. Using deep learning to predict spatial gene expression from H&E-stained histology images offers a more cost-effective alternative, but existing methods fail to fully leverage the multimodal information provided by Spatial transcriptomics and pathology images.

Novel transfer learning based bone fracture detection using radiographic images.

A bone fracture is a medical condition characterized by a partial or complete break in the continuity of the bone. Fractures are primarily caused by injuries and accidents, affecting millions of people worldwide. The healing process for a fracture can take anywhere from one month to one year, leading to significant economic and psychological challenges for patients.

Theoretical study of Ti and Cr as candidate assisted metals for mechanical exfoliation of monolayer transition metal dichalcogenides.

Because of its dimensional characteristics, two-dimensional (2D) materials exhibit many special properties. The key to researching their features is to prepare high-quality larger-area monolayer 2D materials. Metal-assisted mechanical exfoliation method offers the possibility.

Optimizing Kernel Extreme Learning Machine based on a Enhanced Adaptive Whale Optimization Algorithm for classification task.

Data classification is an important research direction in machine learning. In order to effectively handle extensive datasets, researchers have introduced diverse classification algorithms. Notably, Kernel Extreme Learning Machine (KELM), as a fast and effective classification method, has received widespread attention.

Eco-friendly Synthesis of Iron Oxide Nanoparticles Using Parietaria alsinifolia Extracts and Evaluation of Biological Applications.

The current research was conducted to synthesize Parietaria alsinifolia-mediated iron oxide nanoparticles (P.A@FeONPs) using the green and eco-friendly protocol. The biosynthesized P.

The synergistic interaction effect between biochar and plant growth-promoting rhizobacteria on beneficial microbial communities in soil.

Excessive use of chemical fertilizers and extensive farming can degrade soil properties so that leading to decline in crop yields. Combining plant growth-promoting rhizobacteria (PGPR) with biochar (BC) may be an alternative way to mitigate this situation. However, the proportion of PGPR and BC at which crop yield can be improved, as well as the improvement effect extent on different eco-geographic region and crops, remain unclear.

What does "sustainable seafood" mean to seafood system actors in Japan and Sweden?

"Sustainability" can mean different prioritisations of society, environment and economy to different people. As one of the largest globally traded food commodities, for seafood, these differences could have large implications. The study captures different understandings of "sustainable seafood" among 29 key actors along the seafood supply chain-government, NGOs, industry bodies, retailers and producers-using a novel cross-country application of Q method in Japan and Sweden.

Single-cell RNA sequencing identifies CXADR as a fate determinant of the placental exchange surface.

The placenta is the critical interface between mother and fetus, and consequently, placental dysfunction underlies many pregnancy complications. Placental formation requires an adequate expansion of trophoblast stem and progenitor cells followed by finely tuned lineage specification events. Here, using single-cell RNA sequencing of mouse trophoblast stem cells during the earliest phases of differentiation, we identify gatekeepers of the stem cell state, notably Nicol1, and uncover unsuspected trajectories of cell lineage diversification as well as regulators of lineage entry points.

Measurement and characterization of internal delamination defects in CFRP based on line laser thermography frequency domain analysis.

Carbon fiber reinforced polymers (CFRPs) are widely used in fields such as aviation and aerospace. However, subtle defects can significantly impact the material's service life, making defect detection a critical priority. In this paper, delamination defects in CFRP are detected using line laser infrared thermography, and a defect characterization algorithm that combines differential thermography with a frequency-domain filter is proposed.

Stereospecific Radical Bromination of ß-Aryl Alcohols with Thiourea Additives Through A Serendipitous Discovery of A 1,2-Aryl Migration.

The development of new protocols for stereospecific and stereoselective halogenation transformations by mild reaction conditions is a highly desirable research target for the chemical and pharmaceutical industries. Following the straightforward methodology for directly transforming a wide scope of alcohols to alkyl bromides and chlorides using substoichiometric amounts of thioureas and N-halo succinimides (NXS) as a halogen source in a single step, we noticed that in apolar solvents bromination of chiral secondary alcohols did not produce the expected racemates. In this study, the stereochemical aspects of the bromination reaction were examined.

Assessing integrated water reuse efficiency towards SDG6 and influencing factors.

Improving water reuse efficiency from a recycling perspective is claimed to be a better way to alleviate global water scarcity and water pollution. This study opens the internal "black box" of China's water reuse system driven and decomposes water reuse system into water use, wastewater treatment and reclaimed water reuse stages, and selects input-output indicators based on SDG6. Then, it proposes a dynamic three-stage DEA model to assess the water reuse efficiency.

Turn TRAIL Into Better Anticancer Therapeutic Through TRAIL Fusion Proteins.

Background: TNF-related apoptosis-inducing ligand (TRAIL) belongs to the tumor necrosis factor superfamily. TRAIL selectively induces apoptosis in tumor cells while sparing normal cells, which makes it an attractive candidate for cancer therapy. Recombinant soluble TRAIL and agonistic antibodies against TRAIL receptors have demonstrated safety and tolerability in clinical trials.

Multidisciplinary team meetings: dynamic routines that (re)make palliative care.

Multidisciplinary team meetings are part of the everyday working life of palliative care staff. Based on ethnographic material from community and hospital palliative care teams in England, this article examines these meetings as dynamic routines. Although intended to have a prescribed format to review deaths and collect standardised information to monitor service performance, in practice, the content and conduct of the meetings were fluid, reflecting how this structure did not always match the concerns held by the team.

Lung cancer risk and its potential association with PM in Bagmati province, Nepal-A spatiotemporal study from 2012 to 2021.

Background: Despite examining the role of an association between particulate matter and lung cancer in low-income countries, studies on the association between long-term exposure to particulate matter and lung cancer risk are still contradictory. This study investigates the spatiotemporal distribution patterns of lung cancer incidence and potential association with particulate matter (PM) in Bagmati province, Nepal.

Methods: We performed a spatiotemporal study to analyze the LC - PM association, using LC and annual mean PM concentration data from 2012 to 2021.

Exploring coach and parent transformational leadership and their associations with social identity in adolescents.

The main objective of this study was to explore the associations between the transformational leadership of coaches and parents and adolescent athletes' social identity and examine the roles of gender and the stage of adolescence in these relationships. Furthermore, this study aimed to provide empirical evidence on measurement invariance across gender and the adolescent stage in the adapted Spanish version of the Social Identity Questionnaire for Sport (SIQS). The sample consisted of 656 athletes (299 males and 357 females) from 12 to 18 years old (M = 15.

Gatekeeping or Provider Choice for Sustainable Health Systems? A Literature Review on Their Impact on Efficiency, Access, and Quality of Services.

As early as 1978, the World Health Organization set primary healthcare as the basis on which health systems should be built worldwide. However, the health systems of the different countries show considerable variations in terms of the implementation of gatekeeping from primary to secondary healthcare and direct access to specialists and hospital care. This literature review attempts to present the gatekeeping system with references to the UK, Sweden, the Netherlands, and Germany compared to the situation in Greece, where no gatekeeping system exists.