826 results match your criteria: "Onycholysis"
Efficacy of Nonablative Bipolar Radiofrequency in the Treatment of Fingernail Psoriasis.
Dermatol Surg
December 2024
Department of Dermatology, Kasr Al-Ainy Psoriasis Unit, Faculty of Medicine, Cairo University, Giza, Egypt.
Background: Psoriasis is a common chronic systemic disease affecting the skin, nails, and joints. Nails are commonly associated with a greater severity of the disease. Radiofrequency (RF) is a nonionizing radiation that provides energy originating from electric current to generate heat inside the dermis with anti-inflammatory effects.
View Article and Find Full Text PDFAcantholytic Dyskeratotic Acanthoma of the Nail Revealed by a Longitudinal Erythronychia.
Skin Appendage Disord
December 2024
Dermatology Department, Habib Thameur Hospital, "Genodermatoses and Cancers LR12SP03", Tunis, Tunisia.
Introduction: Focal acantholytic dyskeratosis is a distinctive histological pattern first described by Ackerman in 1972, consisting of focal suprabasal clefts in the epidermis and dyskeratotic cells at all levels of the epidermis with hyperkeratosis and parakeratosis. The first case of subungual acantholytic dyskeratosis acanthoma (ADA) was reported in 1990. This subungual variant is a very rare entity.
View Article and Find Full Text PDFCelebrating Diversity: Unveiling the Characteristics of Nail Psoriasis and Nail Lichen Planus in 30 Patients With Skin of Color.
Dermatol Pract Concept
October 2024
Dermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy.
Introduction: Dermatological conditions affecting the nails can manifest differently in individuals with distinct skin tones. This often leads to difficulty in the recognition of nail diseases, especially in people with skin of color (SoC), who are not well represented in the literature.
Objectives: Our aim was to provide dermatologists with useful clues for prompt recognition and diagnosis of nail psoriasis (NPso) and nail lichen planus (NLP) in people with SoC.
Janus kinase 1 inhibitor abrocitinib for isolated nail lichen planus: a case report and literature review.
J Dermatolog Treat
December 2024
Department of Dermatology, First Medical Center of Chinese PLA General Hospital, Beijing, China.
Aim: This study aims to evaluate the efficacy and safety of the Janus kinase 1 (JAK1) inhibitor abrocitinib for treating nail lichen planus (NLP) and to review available case reports documented in English.
Methods: We reported the first case of a patient with isolated NLP treated with the selective JAK1 inhibitor abrocitinib. The patient received 100 mg of oral abrocitinib daily.
Case Report: Alpha6 Integrin Disorder Presenting in Childhood with Nail Dysplasia and Onycholysis But No History of Fragile or Bullous Skin Changes.
Glob Med Genet
December 2024
Division of Genetics and Metabolism, Department of Pediatrics, University of Florida College of Medicine, Gainesville, Florida, United States.
Article Synopsis
Use of the Brannock device to detect differences in foot length in patients with traumatic nail disease.
J Am Acad Dermatol
November 2024
Department of Dermatology, Weill Cornell Medicine, New York, New York. Electronic address:
[Onychopapilloma : Diagnosis and surgical treatment of a rare nail tumor].
Dermatologie (Heidelb)
December 2024
Klinik und Poliklinik für Dermatologie und Allergologie, Universitätsklinikum Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Deutschland.
We report on two cases of nail tumors associated with onychorrhexis, distal V‑shaped onycholysis, and subungual keratosis. Surgical exposure was performed in each case to confirm the diagnosis. Histopathological examination revealed skin changes consistent with onychopapilloma.
View Article and Find Full Text PDFSuccessful treatment of nail psoriasis with topical roflumilast: A case report.
SAGE Open Med Case Rep
October 2024
Division of Dermatology, University of Calgary, Calgary, AB, Canada.
Nail psoriasis occurs in approximately half of all cases of plaque psoriasis and manifests with onychodystrophy, which includes morphological features of onycholysis, subungual hyperkeratosis, oil drop sign, pitting, splinter hemorrhages, leukonychia, and crumbling of the nails. Nail psoriasis can have a significant adverse impact on quality of life. However, nail psoriasis is often refractory to both local and systemic therapies, making it challenging to treat.
View Article and Find Full Text PDFNail changes in patients receiving systemic isotretinoin therapy.
Sci Rep
October 2024
Dermatology and Venereology, Ankara Training and Research Hospital, Health Sciences University, Hacettepe Mh. Ulucanlar Cd. No: 89, Altındağ/Ankara, Turkey.
Article Synopsis
- - The study investigated nail changes caused by isotretinoin treatment in 200 patients with acne vulgaris, comparing 100 on isotretinoin and 100 on topical treatments.
- - Results showed that 34% of patients on isotretinoin experienced nail changes, with onychoschizia being the most common, while only 11% in the topical group had similar issues.
- - Nail changes associated with isotretinoin are linked to the total dose taken, not the duration of treatment, but these changes are completely reversible after stopping the medication.
A Real-World Study on Adverse Reactions of Belimumab Based on the FDA Adverse Event Reporting System Database.
Pharmacoepidemiol Drug Saf
October 2024
Hunan Drug Inspection Center, Changsha, Hunan Province, China.
Article Synopsis
- The investigation analyzes data from the FDA's Adverse Event Reporting System (FAERS) to assess real-world adverse reactions related to Belimumab, aiming to enhance clinical safety in its use.
- Over 19,825 adverse drug event reports pertaining to Belimumab were analyzed, revealing that the majority of affected patients were females aged 18 to 64.9 years, with systemic disorders and infections being the most reported issues.
- The study highlights significant adverse reactions not listed on product labeling, such as hypersensitivity and herpes zoster infections, suggesting the need for improved communication on these risks in clinical settings.*
Subungual Acantholytic Dyskeratotic Acanthoma: A Case Report and Literature Review.
Skin Appendage Disord
October 2024
Skin Health Institute, Carlton, VIC, Australia.
Introduction: Subungual acantholytic dyskeratotic acanthoma is a rare benign tumor of epidermal keratinocytes characterized by acantholysis and dyskeratosis. Only 7 other cases have been published in the literature.
Case Presentation: A 29-year-old male presented with painful erythronychia and onycholysis of the left thumbnail.
Current Knowledge on Nail Involvement in Autoimmune Bullous Disorders.
Skin Appendage Disord
October 2024
Dermatology Departement, Saint Pierre and Brugmann University Hospitals, Université Libre de Bruxelles, Brussels, Belgium.
Article Synopsis
- Nail involvement in autoimmune bullous disorders presents diverse symptoms, often differing from skin manifestations, such as paronychia, onychomadesis, and onycholysis without blisters.
- Various autoimmune conditions like pemphigus vulgaris and bullous pemphigoid can cause nail changes, and the presence of Langerhans cells in the nails is noteworthy due to its unique immunological aspects.
- Diagnosing these nail issues typically requires histopathological and immunofluorescence tests, and researchers stress the need for more studies to improve treatment strategies for affected individuals.
Article Synopsis
- - Porphyria cutanea tarda (PCT) is a common chronic skin condition often related to hepatitis C, but this case presents a rare instance triggered by hepatitis E virus (HEV) infection, leading to symptoms like skin fragility and blistering.
- - The patient was treated with erythrocytapheresis and hydroxychloroquine, which were effective therapies, showcasing erythrocytapheresis as a good alternative to traditional phlebotomy.
- - This case highlights the importance of considering HEV as a potential cause of PCT and suggests that erythrocytapheresis could be a promising treatment method in cases linked to viral infections.
Nail Changes Following Valproate Therapy.
Kathmandu Univ Med J (KUMJ)
September 2024
Department of Dermatology, Pokhara Academy of Health Sciences, Pokhara, Nepal.
Article Synopsis
- Valproic acid is commonly used to treat seizure disorders, mood disorders, and migraines.
- Changes in nails, such as onycholysis and discoloration, are rare side effects of sodium valproate.
- These nail changes occur regardless of patient age, dose, or treatment duration, but they can reverse after stopping the medication.
Nailfold capillaroscopy for diagnosis of onychodystrophies: A prospective cross-sectional study.
J Am Acad Dermatol
January 2025
Department of Dermatology, Weill Cornell Medicine, New York, New York. Electronic address:
Article Synopsis
- Nail diseases pose significant physical and emotional challenges, but diagnosing them is difficult due to vague clinical signs, prompting the need for better diagnostic methods like nailfold capillaroscopy.
- This study aimed to analyze capillary changes in various nail conditions (like nail psoriasis and onychomycosis) and compare them to control groups based on demographic and clinical factors.
- Results indicated that specific nail conditions show distinct capillary patterns, suggesting that nailfold capillaroscopy could be a valuable, noninvasive tool to help diagnose and manage nail disorders more effectively.
Nail Bed Regeneration by Excision of Distal Scarred Matrix in a Patient with Porphyria Cutanea Tarda.
Plast Reconstr Surg Glob Open
August 2024
University of Calgary, Department of Surgery, Section of Plastic Surgery, Calgary, Alberta.
Article Synopsis
- * A case involving a patient with onycholysis caused by porphyria cutanea tarda is discussed where a technique from 2003 was implemented to successfully lengthen the nail bed.
- * The procedure involved removing a crescent-shaped piece of the nail bed from all five fingers on the right hand in one surgery, which was found to be effective and met the patient's expectations.
Dermatological toxicities of talquetamab, a new bispecific antibody: case series and literature review.
J Dtsch Dermatol Ges
September 2024
Dermatology Department, Hospital Universitario y Politécnico La Fe, Valencia, Spain.
Unilateral Onychodystrophy and Puffy Fingers: Think about Carpal Tunnel Syndrome.
Skinmed
August 2024
Department of Dermatology, Habib Thameur Hospital, Research Unit "Genodermatoses and cancers LR12SP03", University of Tunis El Manar, Tunis, Tunisia.
Article Synopsis
- An 87-year-old man with chronic renal failure developed progressively dystrophic changes in his left fingernails over two years.
- His clinical examination revealed various nail abnormalities and edema in the left hand, but his right nails and other tests showed no signs of infection or autoimmune disorders.
- A diagnosis of carpal tunnel syndrome (CTS) was made to explain the changes in his left hand's fingernails and related symptoms, leading to a referral for surgical evaluation.
Nail Psoriasis: Clinical Features and Severity Assessment.
Ann Dermatol
August 2024
Department of Dermatology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
Article Synopsis
- - Nail psoriasis is significant in psoriasis diagnosis, exhibiting symptoms like pitting and discoloration in the nail matrix, and issues like onycholysis in the nail bed, assessed mainly by the Nail Psoriasis Severity Index (NAPSI).
- - The NAPSI tool is widely used for evaluating severity but has limitations, leaving out symptoms like Beau's lines and nail fold psoriasis, which are important for understanding nail psoriasis activity.
- - In clinical trials, NAPSI scores are utilized to measure improvements, but researchers need to be cautious when interpreting results due to the tool's limitations and varying assessment methods.
Nail and distal interphalangeal joint involvement parallel each other in psoriatic arthritis.
J R Coll Physicians Edinb
September 2024
Department of General Medicine, 21st Century Hospital, Vapi, Gujarat, India.
Dermoscopic Nail Changes in Psoriasis, Lichen Planus, and Lichen Striatus.
Skin Appendage Disord
August 2024
Private Dermatology Practice, Lugano/Bellinzona, Switzerland.
Article Synopsis
- Onychoscopy is a non-invasive technique used to better diagnose nail disorders like nail psoriasis and lichen planus, providing detailed visual insights beyond a standard clinical examination.
- In nail psoriasis, key onychoscopic features include pitting, onycholysis with a red border, and specific patterns like salmon patches, while nail lichen planus shows signs like onychorrhexis and longitudinal melanonychia.
- There is limited literature on the use of onychoscopy for nail lichen striatus, and the features observed can vary between fingernails and toenails.
Onychomycosis in Diabetics: Prevalence, Clinical Features and Spectrum of Causative Fungi in South-Eastern Nigeria.
West Afr J Med
April 2024
Dermatology sub-Department, University of Nigeria Teaching Hospital, Ituku-ozalla, Enugu Nigeria.
Introduction: Onychomycosis is a fungal infection of the nail unit and one of the common nail diseases that occurs commonly in diabetic patients. It poses a threat of diabetic foot complications to diabetics and negatively affects the quality of life of the patients.
Objectives: The overall aim of the study was to determine the prevalence and clinical features of onychomycosis in diabetics, as well as the spectrum of causative fungi in Nigeria as compared with age and sex-matched controls.
The spectrum of cutaneous toxicities related to novel genitourinary cancer therapies.
Crit Rev Oncol Hematol
August 2024
Vita-Salute San Raffaele University, Milan, Italy; Department of Medical Oncology, IRCCS Ospedale San Raffaele, Milan, Italy.
Article Synopsis
- - Genitourinary cancers (GUCs) such as renal cell carcinoma, urothelial carcinoma, and prostate cancer have rapidly evolving treatments that can lead to significant skin-related side effects, referred to as cutaneous adverse events (AEs).
- - A literature review analyzed various therapies, including immune checkpoint inhibitors and antiangiogenic drugs, finding common AEs like rashes and itching, with unique skin reactions linked to specific treatments.
- - Recognizing and managing these dermatologic AEs is crucial, as they can affect patients' quality of life and treatment adherence, emphasizing the need for teamwork among healthcare providers in monitoring and addressing these skin issues.
Green nail: Etiology and treatment of chloronychia.
Hand Surg Rehabil
April 2024
Brugmann University Hospital, Brussels, Belgium. Electronic address:
Article Synopsis
- "Green nails" or chloronychia is mainly caused by Pseudomonas bacteria, leading to a green discoloration of the nail along with other symptoms.
- The condition shows a typical triad of green nails, chronic paronychia (inflammation of the skin around the nail), and onycholysis (separation of the nail from its bed).
- Treatment involves removing the detached nail, applying a 2% sodium hypochlorite solution to the nail bed, and keeping the area dry by wearing latex gloves over cotton ones during daily tasks.
[Cutaneous adverse events to systemic anticancer therapies : Hand-foot syndrome and nail changes].
Dermatologie (Heidelb)
June 2024
Universitäts-Klinik für Dermatologie, Venerologie, Allergologie und Phlebologie, Johannes Wesling Klinikum Minden, Minden, Deutschland, 32427.
Article Synopsis
- Hand-foot syndrome (HFS) and nail changes are common side effects of cancer treatments, with two main types identified: chemotherapy-associated and kinase-inhibitor-associated HFS.* -
- The first type involves painful skin reactions due to sweat gland toxicity, while the second leads to callus-like thickening from mechanical pressure, with management strategies including avoiding stress, using topical treatments, and cooling during infusions.* -
- The review highlights the effects on various parts of the nail during treatment and provides guidance on preventing and managing HFS and nail disorders in cancer patients.*